Enfu Hui
@hui_enfu
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Associate Professor @UCSanDiego @ucsdbiosciences Biologist, husband, dad, nerd 🤓, and 🎾 fan.
UC San Diego
Joined August 2015
Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading this work, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for collaboration.See also excellent media report by @mario_maguilera
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RT @immunologyUCSD: The Program in Immunology welcomes Dr. Joseph Sun @SunLab_Official from @MSKCancerCenter and @WeillCornell. Please joi…
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RT @takaki_komiyama: 663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that s…
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RT @Dushek: Our work by Anna Huhn @annagesine is now published @NatureComms ! We show that the antigen contributes…
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RT @SciImmunology: Scientists have identified functional differences between human and mouse #PD1, which could impact preclinical research…
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@Elliot_Philips @SciImmunology @MasubuchiTakeya @Elliot_Philips Thank you for sharing with me your beautiful paper. The evolution of PD-L2 is intriguing!
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@fulop_dan Thanks @Danfulop ! Here is the more scientific phylogenetic tree shown in the paper, with more extensive and accurate information. The image in the original post is a human generated cover candidate that highlights the rodent specific attenuation of PD-1 activity.
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RT @MasubuchiTakeya: Excited to share our latest paper describing the functional divergence of PD-1 across species. Thank you for @hui_enfu…
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RT @ucsdbiosciences: Today in Science Immunology: Much of our knowledge of PD-1, a leading cancer target, comes from studies in mice. @UCSa…
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RT @LabWaggoner: A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity @SciImmunol…
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RT @WallaceUcsf: Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains…
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RT @LiGanLab: Excited to share our work, new in @ScienceMagazine: We explored how sex chromosomes, gonadal hormone…
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RT @Ulrike_Boehm: 🔬 Are you eager to dive into the world of light microscopy and learn from top-notch microscopists about its essential tec…
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