Hollfelder Lab
@hollfelderlab
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Hollfelder research group @Cam_Biochem @Cambridge_Uni. Chemical and Cellular Synthetic Biology: From Mechanism to Droplet Microfluidics (and Back)
Cambridge
Joined October 2017
RT @iDEC2024: 🎉 The highly anticipated iDEC Festival 2024 is happening on October 26-27 in Cambridge! 📍 Three distinguished scholars will d…
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Our take on the future of enzyme discovery: On synergy between ultrahigh throughput screening and machine learning in biocatalyst engineering - now published in Faraday Discussions
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Thank you for continued wonderful collaboration(s)!
@CamBiochem @hollfelderlab @Thav_Lab @MedCambridge @OPIGlets Great technology from @hollfelderlab for antibody discovery and, as always, pleasure to collaborate with them. Credit to Aleksei, Paul and Gwen from our side for protein work, biophysics and structural biology.
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RT @CamBiochem: A Nature Biotechnology article by @hollfelderlab, @Thav_Lab, @HyvonenGroup, @MedCambridge, @OPIGlets establishes new techno…
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RT @CamBiochem: A massive thank you to @francesarnold for visiting us last week and for delivering a wonderful Alkis Seraphim Lecture and t…
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Remkes Scheele et al. make a new reaction accessible to large scale screening by tuning a DNA-aptamer to provide a fluorogenic read-out: Ultrahigh Throughput Evolution of Tryptophan Synthase in Droplets via an Aptamer Sensor | ACS Catalysis
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Wonderful breakfast chat on scientific life in general with @francesarnold, moderated by our researchers Lise Boursinhac, Josephin Holstein and Clara Munger. No doubt she has energy enough for a plenary talk this afternoon!
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RT @martanapio: Check out our preprint on YeastIT, a new system for continuous evolution, addressing the challenge of biased mutational spe…
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RT @Bluetools_EU: Who are we? Bluetools brings together five top European companies, eight university teams, and one private training orga…
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RT @LeDillingeur: Happy to see our paper from @hollfelderlab out in @NatureComms. In this work we describe a #DirectedEvolution method for…
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Looking forward to interacting and collaborating with the BlueRemediomics initiative!
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By evolving a promiscuous hydrolase recruited from a metagenomic library @JDSchnettlerF et al. show how a catalytic triad, more familiar from esterases and proteases, can also enable efficient phosphate triester hydrolyis.
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@JDSchnettlerF et al. show how an enzyme recruited from metagenomes can be rapidly evolved for a non-natural purpose. Ultrahigh-Throughput Directed Evolution of a Metal-Free α/β-Hydrolase with a Cys-His-Asp Triad into an Efficient Phosphotriesterase
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@LeDillingeur et al develop a display technology that enables selection for catalytic turnover by proteases: Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture
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Stefanie Neun at al demonstrate (in collab with @HyvonenGroup) how droplet microfluidics can identify functions in metagenomic libraries that were not predicted by sequence-based methods. The quest for correct, comprehensive annotation starts here ...
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Esther Richter et al. integrate acoustic sorting with absorbance detection for more rapid ultrahigh throughput droplet screening. Great collaboration led by Thomas Franke’s group in Glasgow @EVOdrops_ITN
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What to do when there are just too many mutants to be characterised - Stefanie Neun, @liisavanvliet & collab @FGieLab bring droplets to the rescue: HT Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform
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