George Cresswell
@gcresswell
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Principal Investigator at @StAnna_CCRI. Fascinated by the plasticity of cancer genomes and how it interacts with how they evolve.
Vienna, Austria
Joined May 2010
1. Delighted to present work from my time in @AndreaSottoriva's lab, now in @NatureCancer! A big effort also led by @javierfermat and Nick Trahearn. We combined genomics + digital pathology to measure evolution in a prostate cancer (PCa) clinical trial.
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Sounds like an amazing opportunity!
In Milan @humantechnopole we opened core-funded computational Group Leader positions in one or more of bioimage analysis, spatial ‘omics, AI for genomes and proteins, computational simulations of cells and tissues. Come to lead your research programme!
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What a great event! Thank you so much for the opportunity to be a part of it!
Thank you to our four international speakers—Paola Scaffidi, Alex Kentsis (@oleg8r), Judith Zaugg (@zauggj), and @iannisaifantis1—as well as our PIs, @PKameneva, and @gcresswell, for their thought-provoking and engaging presentations, as well as @MedUni_Wien for hosting us!
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Thank you for hosting and inviting me! I very much enjoyed a great day chatting about the overlaps between popgen and cancer evolution!
Our #PhD students are excited for a #Vienna local speaker @gcresswell tomorrow! Title: "#Cancer evolution: Basic principles to clinical implications." See full schedule for our #popgen seminar series and sign up for streaming links here #evolution
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Cool lab! Cool work!
What if we could look at a human tissue image🔬and quantify its biological age?🧬 And how could we get the same insights without collecting a tissue sample? In our new @biorxivpreprint, we create "tissue clocks" ⏳to do just that! 📝 #aging #tissue 🧵below
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Fantastic opportunity!! Come join us!
My lab @StAnna_CCRI is recruiting for a new #Postdoc scientist. This time we are looking for a genomics data analysis wizard. Come join our wonderful and interdisciplinary team, and help us resolve mysteries at the crossroads of #devbio and #cancer.
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RT @cancerbits: My lab @StAnna_CCRI is recruiting for a new #Postdoc scientist. This time we are looking for a genomics data analysis wizar…
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RT @DSeruggia: First pre-print from the lab! Together with @lucapinello and @danielevanbauer we developed CRISPR-CLEAR, an experimental an…
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An excellent opportunity with a great scientist and person. 🙂
PhD position alert 🚨 I am looking for 2 PhD students to join my group on cancer initiation at @StAnna_CCRI. #FWF funded project using human iPSC, origins and transcript omics. We have very supportive and collaborative environment in lively Vienna. Apply!
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RT @PKameneva: PhD position alert 🚨 I am looking for 2 PhD students to join my group on cancer initiation at @StAnna_CCRI. #FWF funded proj…
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11. Huge thanks to all co-authors! It was a real team effort! Special thanks to Kat Webb for PCa expertise and a big thank you to @AndreaSottoriva and David Dearnaley for conceptualising and guiding the project. Cancer evolution isn’t just cool, it’s also meaningful for patients!
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4. The IMRT trial (Royal Marsden) studied toxicity in locally advanced PCa and was key to our study. Diagnostic 12-needle biopsies from IMRT patients provided multi-sampled tumour, and we assessed genetic profiles alongside matched tissue slides, linking genotype and phenotype.
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3. We know that cancer's ability to evolve drives recurrence, but can it be used to make predictions? In this paper we measure PCa "evolvability" at diagnosis and study the relationship between mutations and phenotype to, ultimately, forecast patient outcome up to a decade later.
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2. Cure rates for locally advanced PCa vary between patients. To identify patients that will present with aggressive recurrences many years later we need better predictors of risk, and to test them we need large cohorts of patients with long-term follow-up and clinical info.
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