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Chen Yang, MD

@cygupath_md

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Pathologist - UHN/University of Toronto. Specializes in GU Pathology. T&RT are own opinion and not medical advise.

Canada
Joined April 2011
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 year
#Prostate is, by far, the most common specimen type in the workflow of genitourinary #pathologists. One of the major concerns is missing #cancer, resulting in false negative diagnosis. Common pitfalls summarized below. #surgpath #pathX #pathtwitter #pathology #gupath 🧵1/12
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Chen Yang, MD
@cygupath_md
25 days
@GuannanTiffany I don’t recall, but maybe :)
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@cygupath_md
Chen Yang, MD
@cygupath_md
25 days
Immunohistochemistry stains for GATA3 and p63, as show here, is positive in the spindle cell component and the glandular component, but negative in the neuroendocrine component.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
This is a kidney tumor with papillary and tubular architecture. The tumor cells are clear to eosinophilic. What would be your differential diagnosis?#GUpath #pathX #Pathtwitter #Pathology
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Chen Yang, MD
@cygupath_md
1 month
@natginger9 Yes, for me, prostate biopsies also warrant looking back again just to see if I missed anything.
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Chen Yang, MD
@cygupath_md
1 month
This is a case of cervical gastric type adenocarcinoma, which is a type of HPV-negative adenocarcinoma. The positive CDX2 might lead one down the wrong track but this is why in cases with metastatic disease, the history is most crucial to making the diagnosis.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
RT @VarshaManuchaMD: Leydig cell tumor Gorgeous intranuclear and cytoplasmic inclusions ~ Reinke crystals ! #GUpath
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Chen Yang, MD
@cygupath_md
1 month
@Sunny32660726 WT-1 was also negative in this case.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
The patient had a history of cervical adenocarcinoma. However, the tumor cells are positive for CDX-2; while negative for HR-HPV ISH and p16. There is also diffuse p53 positivity. Does that change your diagnosis? #GUpath #pathX #Pathtwitter #Pathology
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
@amalasar86 On our differential as well, more workup results and history to follow.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
@kriyer68 Was not done, but this was a female patient.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
@GuannanTiffany It is adenocarcinoma, some more history and workup to follow.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
@RazaHoda Wow, without history, I would have not have even thought of that.
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
RT @yalepathology: We have unexpected opening for a Pathology Fellowship in the Renal/Genitourinary field for the 2025-2026 academic year.…
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@cygupath_md
Chen Yang, MD
@cygupath_md
1 month
When the history fits, this diagnosis in the kidney is quite straightforward to make (and more indolent). #GUpath #pathX #PathTwitter
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Chen Yang, MD
@cygupath_md
1 year
Interesting, it seems like I have been blocked by the author of the original post. It says a lot when people block others just because they disagree with their "take" or "opinion." Hard to believe one is not biased if he/she acts this way.
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