Chris Chang
@christhechang
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Happy birthday @CarolynBertozzi! Still beaming with joy with the @NobelPrize news, Latimer Hall is the home of #bioorthogonal chemistry! Great memories of another birthday celebration with @UCB_Chemistry friends @GroupFrancis @MChangGroup
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Happy belated 80th birthday symposium held this weekend for Judith Klinman @klinmanlab, a pioneer in enzyme catalysis, metals in biology, and for women in chemistry. A dear mentor since the time she hired me at @UCB_Chemistry when she was chair. She is a legend!
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Happy and proud to celebrate 19 great years @UCB_Chemistry @berkeleyMCB with the past and present group! @MillerChemBio @ThoiLab @chembioBryan @apswong @TimothyASu @Cowboy_Chemist @enicholschem @michelb247 @Linlab_ZJU @AllegraAron @cheri_ackerman 1/n
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New from the lab! We identify hydrogen peroxide as a transcellular signal with an activity-based sensing/labeling strategy to map its transfer from microglia to neurons @PNASNews @UCB_Chemistry @berkeleyMCB @Cowboy_Chemist
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Formaldehyde as a signal to regulate epigenetics via SAM biosynthesis! Excited to share this study led by @VanhaN_Pham and @chembiokevin @UCB_Chemistry @berkeleyMCB with @DanNomura @LucPontel @carlosgarciapri @ManelEsteller and KJ Patel. 1/n.
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Congratulations to our newest class of Guggenheim Fellows! These 184 individuals represent the best of their respective fields, ranging from applied mathematics and political science to choreography and translation. Check out the full announcement here:
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Happy to share the discovery of labile Cu(II) in cells using a sensor with metal and oxidation state selectivity led by Aidan/Carson with @bradylabupenn @TimothyASu @UCB_Chemistry @berkeleyMCB @PNASNews 1/n
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Awesome to have @cathleencrudden as our Muetterties lecturer @UCB_Chemistry this past week, great science from @cmc_lab and always fun company! @MChangGroup @Toste_Group
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“People are more important than papers”. nice to see a healthy perspective from a scientist’s scientist
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Pure joy to see this! Congrats for @CarolynBertozzi, Sharpless, and Meldal for changing chemistry and biology for the better for us all! @UCB_Chemistry @Stanford_ChEMH @HHMINEWS @ACSCentSci #glycotime #chemistry.
BREAKING NEWS: .The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Excited to share this community perspective on copper and cancer co-led by our postdoc Eva @evajge @UCB_Chemistry @berkeleyMCB and @bradylabupenn where we show a roadmap on how to leverage copper as a cancer vulnerability 1/n
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Congrats to our former grad student Eva on her new faculty position @UBCChem ! #proudofalumni @UCB_Chemistry.
The Department of Chemistry is pleased to announce the appointment of Dr. Eva Nichols in the area of #InorganicChemistry starting this August. To learn more about her research at UBC, visit our website: #UBCChem #UBC
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First flight in 18 months, found a familiar masked friend at SFO! @DanNomura @UCB_Chemistry @berkeleyMCB
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Montreal. Smoked meat. Happy Chris. @SchwartzsDeli @MChangGroup @CIFAR_News @UCB_Chemistry @berkeleyMCB
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Congrats to Michelle on winning the 2022 Centenary Prize! @MChangGroup @UCB_Chemistry @berkeleyMCB @BerkeleyLab @UCBerkeley #RSCPrizes
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Happy to share work co-led by @enicholschem @InorgChemJeff in @J_A_C_S on molecular templating of bicarbonate to augment CO2 reduction with @sep_funnel @AilaRothweiler @mhg_group @UCB_Chemistry 1/n
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Berkeley Chem Bio get-together at the #bioorganicGRC! @SavageCatsOnly @DanNomura @GroupFrancis @UCB_Chemistry @berkeleyMCB
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With all the hurt and outrage on the #Hudlicky @angew_chem fiasco, myself included, we can use this anger to improve peer review. One actionable idea is to require authors suggest reviewers with gender and international diversity, etc. @ACSPublications @WileyVCH @RSCPublishing.
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Voluntary shutdown of lab starting now, notified the group this morning. We can all do our part! @UCB_Chemistry @berkeleyMCB @UCBerkeley.
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BREAKING NEWS: .The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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First prospective grad visit of the year @UCB_Chemistry in the books, look forward to welcoming back new recruits in the fall! @DKBediako @Toste_Group @GroupFrancis @HartwigGroup
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Native biosynthetic pathways to #bioorthogonal chemistry by the M. Chang lab @UCB_Chemistry, congrats to Jorge and Monica!.
A biosynthetic pathway that makes amino acids containing terminal alkynes. Because such functional groups are rare in natural products, they provide a handle for chemistry that’s not generally found in biological organisms. Via @nature
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Epic dinner at Masa with @chefmasanyc to celebrate @dmac68 @NobelPrize @LongLabCal @emrabinow #sohappy
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Holiday get-together with @UCB_Chemistry faculty and families, fun for all ages! @MChangGroup @DKBediako @MillerChemBio #eatallthebrisket
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Excited to see our Bay Area Chem Bio community come together at @QBI_UCSF, metals take center stage in the first session! @MChangGroup @adamrenslo @lmkdassama Michael Marletta @UCB_Chemistry @berkeleyMCB @realJimWells
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Latest review from the lab on history and principles of activity-based sensing, lots of new opportunities for synthesis to enable biological studies. Nice job Kevin and Steven! @chembiokevin @SWM_Crossley @UCB_Chemistry @berkeleyMCB.
Chang (@christhechang, @UCBerkeley), Bruemmer (@chembiokevin), and Crossley (@SWM_Crossley) give an overview of #ActivityBasedProbes for the highly selective detection of small molecules and metals in biological systems #MolecularImaging
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Happy to see our first histidine #bioconjugation study appear in @J_A_C_S with helpful peer review after the first version was posted on @ChemRxiv.
New paper from @christhechang lab! Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation - Journal of the American Chemical Society (ACS Publications)
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We are proud to announce that Dr Jun Ohata of @OhataLab will join our faculty later this year as an Assistant Professor! Jun’s research is at the chemistry-biology interface with a focus on carrying out chemistry on proteins.
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Metalloantibiotics! Fascinating study by @BoLiunc lab and @rdavbritt on metals at the host-pathogen interface
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Excited to be back the #bioorganicGRS and #bioorganicGRC! A welcome surprise gift from @chembioBryan with a little chemistry that will be enjoyed this week ☺️
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Excited about this work led by @audreyglynn @puroAGV @UCB_Chemistry with @Toste_Group and @NovartisScience where we develop a methionine-directed covalent fragment library and identify a CDK4 inhibitor by targeting a new redox/phosphorylation crosstalk pathway.
Interesting @ChemRxiv preprint by the groups of @christhechang and @Toste_Group. Profiling of methionines with gel-based ABPP identifies a methionine-directed CDK4 inhibitor. An impressive library of oxaziridine-based methionine ligands. @christhechang
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Super excited about this work! We show that the bioinspired design concept of exchange coupling can enable CO2 reduction in water and improve overpotentials by over half a volt compared to using redox-active ligands alone without this redox balancing @mhg_group @LongLabCal 1/n.
Metal–Ligand Exchange Coupling Promotes Iron-Catalyzed Electrochemical CO2 Reduction at Low Overpotentials by Christopher Chang & co-workers.
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My job for the group cleanup today, sorting through the synthetic compound cabinets from past group alumni #memorylane #theygrowupsofast
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Nice to see @CHADNANO @NUChemistry twice in a week, this time locally as our Lewis Lecturer @UCB_Chemistry! Fun dinner with #omarnotontwitter
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Fantastic Braisted lecture today from JoAnne Stubbe @ChemistryMIT, fun dinner with @MChangGroup and @UCB_Chemistry @berkeleyMCB and @UCSF colleagues @realJimWells @kevansf
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Beer o’clock on a Friday at @UCB_Chemistry before the Latimer shutdown with #maimonenotontwitter flashing the Blue Steel look @DKBediako @RittleLab
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First preprint from the lab! @ChemRxiv.
Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation by Shang Jia & Christopher Chang (@christhechang). #biochempreprints
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Synthetic chemistry with @MChangGroup today for our daughter’s 5th birthday, who chose the color scheme #RealTimeChem
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Happy to welcome back @ChanLabUIUC to @UCB_Chemistry for a great seminar and dinner! @MillerChemBio @DanNomura @AlannaSchepartz @MChangGroup
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Excited to be back in Korea for a KCS editor’s symposium with some familiar faces! @Toste_Group @LongLabCal @haw_lab @UCB_Chemistry @PrincetonChem
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Virtual viewing of the Kentucky “Turtle” Derby in our finest hats, turtle racing is definitely the slowest two minutes in all of sports! @LongLabCal @dmac68 @chemandwine #mccuskernotontwitter
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Congrats to our group member Angel Gonzalez-Valero on being awarded an NSF graduate fellowship! @UCB_Chemistry @NSFGRFP.
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#FluorescenceFriday comes out a day early! Nice work by @mo_hannes @michelb247 @jonah_jurss @SamirRezgui_ @UCB_Chemistry @berkeleyMCB on activity-based sensing of CO with fundamental organometallic chemistry.
A Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes that Enable Endogenous Carbon Monoxide Detection by Christopher Chang & co-workers.
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Happy to share this study led our postdoc Mina @MinaRaafat87 where we decipher charge and hydrogen-bond effects on second-sphere enhancement of CO2 reduction @UCB_Chemistry @BerkeleyLab @CIFAR_News.
Multifunctional imidazolium pendants in the second sphere enhance electrochemical #CarbonDioxide reduction catalysis by charge and hydrogen-bond effects @christhechang @minaraafat87 @UCB_Chemistry @BerkeleyLab
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Excited about this new direction in metal-based therapeutics started by the hard work of @TimothyASu and @marieheffern.
New from @christhechang and coworkers: A Targeted Ionophore-Based Metal Supplementation (TIMS) strategy for treatment of localized metal deficiency #bioinorganic #copper
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Excited about this #bioinorganic finding! #RealTimeChem
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Excited to post new work led by Joel and @SWM_Crossley that deciphers how RNA N-demethylation is an endogenous source of fast or slow formaldehyde release depending on the non-heme iron demethylase @UCB_Chemistry @berkeleyMCB @chembiokevin @evajge.
Distinct RNA N-Demethylation Pathways Catalyzed by Non-Heme Iron ALKBH5 and FTO Enzymes Enable Regulation of Formaldehyde Release Rates by Christopher Chang & co-workers.
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Officially a scientific grandfather! @UCB_Chemistry graduation yesterday with @evan_w_miller and his first class of PhDs #proudofalumni #theygrowupsofast
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Please spread the word, we have multiple open positions @UCB_Chemistry this cycle!.
The Department of Chemistry, at the University of California, Berkeley, invites applications for two faculty positions at the assistant professor level. For more info see
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Extended #changstas lab reunion at the #BioorganicGRC #proudofalumni @MillerChemBio @chembioBryan @ChanLabUIUC @lippertlab and #alumniofalumni @BRaliski @StevenC_Boggess @xiaop14 @sim_rauch @huiqing_zhou @HaileyJKnox @Weiwei_An_ @LukeRya21072197 @mo_hannes !
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Latest @ChemRxiv preprint from the lab @UCB_Chemistry on a bioinspired dual electron-proton mediator approach to enhancing CO2 reduction catalysis, with synthetic NADH analogs as second-sphere additives. Nice work Peter and Sophia!
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Awesome study on a new platform for metal-metabolite identification by @Pdorrestein1 lab led by our former @UCB_Chemistry grad student @AllegraAron @NatureChemistry #proudofalumni
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Happy to welcome back @CHEMilyQue back to @UCB_Chemistry for a seminar today! #proudofalumni #firstyearclass
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Congrats to our group member Paty on being awarded an NSF Graduate fellowship! @UCB_Chemistry @NSFGRFP.
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Excited to share this new study on methionine oxidation driving pancreatic cancer, led by our postdoc @dan_he_chembio @UCB_Chemistry @berkeleyMCB and @Chiolaboratory @ColumbiaGenDev @columbiacancer 1/n
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Congrats to Evan @MillerChemBio and all the rest of the awardees! @UCB_Chemistry @berkeleyMCB
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Another @ChemRxiv preprint this week! Really excited about this new activity-based sensing platform with @UCB_Chemistry @berkeleyMCB collaborators @MillerChemBio and @Toste_Group.
An Activity-Based Methionine Bioconjugation Approach to Developing Proximity-Activated Imaging Reporters by Chris Chang (@christhechang) & co-workers.
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With prospective visits moving online, please take a virtual tour of our lab @UCB_Chemistry @berkeleyMCB !
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First #bioRxiv from the lab, fun collaboration with @bradylabupenn! We usually post @ChemRxiv but decided to give @biorxivpreprint a try for this one #copper #glutathione #chembio.
Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism #bioRxiv.
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Exciting work from @MChangGroup @UCB_Chemistry @berkeleyMCB and @pauldauenhauer on sustainable synthesis of petroleum precursors from bio-renewable sugars! @NatureChemistry.
Feed bacteria a little glucose and, with the right genetic tweaks, they can produce hydrocarbons - sustainably - that replace those from fossil fuels @UCBerkeley @UCB_Chemistry @UMN_CSP.
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And I’m thankful for the community we have @UCB_Chemistry, @berkeleyMCB, and @UCBerkeleyNeuro here in @UCBerkeley to make science happen, particularly our students! #GoBears.
For #ThankAScientist week we want to say thanks to Prof. Chris Chang! Follow @christhechang and learn about his research in bioinorganic chemistry, chemical biology, inorganic & organic chemistry . @UCBerkeley #BerkeleyChemistry
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Thanks to all past and present members of the group for their creativity and hard work!
American Academy of Arts & Sciences elects 11 Berkeley faculty as members @americanacad #highered #gobears
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Great to welcome @songlin_chem back to @UCB_Chemistry for a seminar yesterday, exciting to hear about the latest electrocatalysis work from @SongLinLab! #proudofalumni.
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Congrats to our grad student Angel @puroAGV! Proud to mentor him @UCB_Chemistry @berkeleyMCB with generous support from @HHMINEWS #GilliamFellows.
Today HHMI announces our largest group of new #GilliamFellows as part of our commitment to advance diversity and inclusion in science. Learn more and meet the Fellows:
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Tuning Second Coordination Sphere Interactions in Polypyridyl–Iron Complexes to Achieve Selective Electrocatalytic Reduction of Carbon Dioxide to Carbon Monoxide by David Zee, Michael Nippe, Amanda King, Christopher Chang (@christhechang) & Jeffrey Long.
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Ending our @ACS_NCW #MarvelousMetals week @UCB_Chemistry with a great visit from @DeyIACS and fun dinner with @RittleLab @HartwigGroup #metaltime #bioinorganic
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Congrats to all the new #PackardFellows, including @UCB_Chemistry PhD alums Amy Weeks @scientistamy and Mark Levin @LevinChem! @MChangGroup @Toste_Group @PackardFdn.
Meet the 2021 class of #PackardFellows! These 20 extraordinary scientists & engineers will each receive $875K to explore new frontiers. See how their research will improve people’s lives & enhance our understanding of the universe.
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Existential Saturday question - is chow mein wrapped in a bun a sandwich?
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Our small contribution in @ChemElectroChem led by Peter In the lab in honor of Jean-Michel Saveant, who taught us and many others the wonders of electrochemistry @UCB_Chemistry @BerkeleyLab @ProfKimoonKim #saveant.
Porous porphyrin cages enable electrochemical hydrogen evolution in water by @christhechang @UCB_Chemistry @BerkeleyLab @ProfKimoonKim #saveant
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Many congrats to my colleague @SarpongGroup @UCB_Chemistry and all the other deserving newly elected members!.
Congratulations to the newly elected members of the American Academy of Arts & Sciences! Today we are honored to welcome 276 scholars, leaders, artists, and innovators into the Academy.
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Arts and crafts inspired by family movie night, daughter says “Sporky” is a more accurate name for the Toy Story character #forky
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Well, fell off the wagon quickly on that healthy eating train.
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Congrats to all the awardees, especially our former postdoc Song @songlin_chem @SongLinLab and colleague Markita @Landry_Lab @UCB_Chemistry! #proudofalumni.
The Dreyfus Foundation announces the selection of 16 Camille Dreyfus Teacher-Scholars for 2021. These young faculty have each created an outstanding independent body of scholarship, and are deeply committed to education. For details on the awardees, see
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Picked up a friend on the next stop of a fun @RoySocChem tour @Toste_Group @UCB_Chemistry #realtimechem
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Powering up on #dumplings for #ACSKCS joint symposium with @CarolynBertozzi @ACSCentSci #RealTimeChem
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