Guo-Liang "Chewie" Chew
@chewomics
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Using all the '-omics to understand cancer, human diseases, and fundamental biology.
Singapore
Joined February 2020
@ribonucleicacid The paucity of As and Ts in the first exon is likely due to the depletion of start (ATG) and stop (TAA, TAG, TGA), all of which are AT rich. This general depletion of uORFs is observed quite generally.
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@eugenevalkov Isn't this similar to the (formerly Ambion) Bright star BioDetect system? I've previously used this to detect 30nt RNA footprints
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@johnprensner @StevenSalzberg1 @carninci I discussed this in the last chapter of my thesis some time ago:
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RT @s_batzoglou: LLMs are ideal models for molecular biology. Here is my new essay reviewing some recent advances and looking to the future…
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RT @locus_lukas: Welcome to the primate genome bonanza! Check out our studies on the whole genomes of 233 primate species that shed light o…
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RT @Alex_Aravanis: Introducing PrimateAI-3D, a significant step forward in our use of deep learning to identify genetic mutations most like…
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RT @SashaGusevPosts: Interesting study of UK Biobank exomes for common traits. In aggregate, rare variants still explain much less variance…
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RT @PauliGroup: A unique opportunity for bioinformaticians to join our labs @IMPvienna as embedded computational biologist to work on excit…
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@ShechnerLab I got Psoralen-biotin (Ambion BrightStar) to work during my grad school days, both for small (~30nt) and large mRNAs. Caveat: probe was to EF1A, so a very abundant mRNA. Could work for your case though...
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@Ruchi_P_Jain @shifengxue @ZebrafishRock I agree, I believe the Sive lab had a technique for brain ventricle injections (PMC2791086)
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RT @acapellascience: LEUKOCYTE: a complete musical overview of the human immune system hope @bts_bighit don't mind :)
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RT @Alex_Aravanis: Groundbreaking research by Mo Ameen and Laksshman Sundaram in @Cell highlighting AI to diagnose non-coding de novo mutat…
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@aspens_grove Also depends on where the conference is, and the field in general. CSHL / Gordon conferences in the basic sciences are chill (I've attended them in shorts, even as a postdoc), but the more "medical" and "European" a conference is, the better people tend to be dressed.
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