Castello Lab
@castello_lab
Followers
1K
Following
719
Statuses
338
RNA-binding proteins in virus infection
MRC UoG CVR, Glasgow
Joined January 2019
We are very proud of our new preprint revealing #alphaviruses induces cellular #RNA #degradation via XRN1 and the decapping complex to feed viral #replication with nucleotides. Thanks to the whole team and collaborators for the fantastic work.
0
5
21
Our lab group is thrilled to have won with our "Do-Re-Mi" costume from The Sound of Music for the "music" themed Christmas party! It was a fantastic team effort and a great way to bond. Thanks to everyone who voted for us! Happy holidays from our lab to yours!
Really important achievement.. Price to the most original lab costume for the @castello_lab in the @CVRinfo Christmas party. Inspired by the notes of the "Sound of Music"😁. 🍾🥂🏆
0
0
5
RT @esagredo: It was amazing to share and listen to @Alf_Castello at the @scilifelab Spotlight seminar series yesterday. Very inspiring, en…
0
4
0
Attention UK students! The James McCune Smith PhD Scholarships at the @UofGlasgow offer opportunities for underrepresented black students in the UK. Benefits include mentorship, leadership training, and 6-month placements. If you are interested in applying contact us!
0
1
1
We are delighted to share one of our exceptional MSc student has been awarded with MSc in Infection Biology Best MSc Project Award (2023/2024) for her research, “Towards Elucidating the Complexes Formed by SARS-CoV-2 Proteins.” #SARSCoV2 #RNAbiology #InfectionBiology
0
2
36
RT @MolecularCell: Large-scale map of RNA-binding protein interactomes across the mRNA life cycle
0
50
0
RT @Alf_Castello: Proud of our contribution to the Focus on RNA Biology issue in @MolecularCell. We discuss the new approaches to uncover t…
0
14
0
@JamesLPurr @MolecularCell “A virus is bad news wrapped in protein,” said Sir Peter Medawar. While much research has explored the interactions of viral proteins, we still still have a very fragmentary understanding of the cellular factors that engage with the viral RNA—the “bad news” itself.
0
0
0
Proud of our recent work uncovering the RNA binding mechanism of TRIM25. We combine biophysics with molecular and cellular biology to map the amino acids in TRIM25 involved in the interaction with RNA and show that they are critical for its antiviral role. #RNA, #virus
We are excited to share our latest research, a joint effort between the Hennig group at @EMBLHeidelberg and the @castello_lab at @CVRinfo . We’ve uncovered the key residues for the RNA binding of TRIM25, which plays a key role in its antiviral activity. 🔗
2
7
18
Very proud of our contribution to the @MolecularCell issue with "Focus on RNA biology". Our review focuses on the interactions that viral RNA establishes with the host cell and the emergence of new approaches to profile them systematically. #virus, #RNA
1/4 🧬 In this study, we delve into innovative methods to explore the viral RNA interactome. Our approach allows for step-dependent analysis of viral infection and provides resolution at the level of specific viral RNA species.
0
0
6
Saying the hardest goodbye to an amazing postdoc of our lab Azman Embarc. His dedication, hard work, and positive spirit has made a lasting impact on all of us. Wishing you all the best in your future endeavours! You’ll be missed!
We bid a fond farewell to Azman Embarc, our brilliant postdoc researcher, as he embarks on a new journey. Your contributions to the @castello_lab have been invaluable, and you will be greatly missed wishing you the best in your future endeavours, Azman!!! 🍻🎉🎉
0
1
14
Excited to share our latest bioRxiv paper, in collaboration with @FranklinSystems (@RosFrankInst ), which explores virus permissive, intermediate, and hostile intracellular environments using multiple Omic platforms. Grateful for the amazing teamwork!
0
4
13
RT @Alf_Castello: So proud of @LouieIselin, who defended her thesis successfully. She joined the @castello_lab before the pandemic and went…
0
2
0
Thrilled to announce Vincenzo Ruscica delivered an outstanding talk at the #RNASociety meeting 2024, Edinburgh! His exciting research on RNA decay and virus infection sparked exciting discussions. We are incredibly proud of his contributions to advancing #RNA biology research.
1
2
33
RT @CVRinfo: 📢 DEADLINE EXTENSION #GlasgowVirologyWorksop Deadline for abstract submission and registration are now next week! 📆 Wednesd…
0
9
0
Congratulations @Wilsonasaur !!! 🥳🥳🥳 We wish you all the best in your next stage in Brno. We are sure you will shine 🥹
Very proud to say that I’ve passed my viva (with minor corrections)! I couldn’t have done this without my amazing supervisors @bbrennan83, @Alf_Castello and the @brennanlab and @castello_lab 🔬Special thank you to my examiners @bjwillett @pylozach #PhDone
0
0
2