Brandon Logeman
@brandon_logeman
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BRAIN Initiative K99/R00 Awardee || Studying hormonal control of neuronal circuits at the single cell level || 🐷 former pig farmer 🐷 #FirstGenCollege
Harvard University
Joined April 2010
@LaramieDuncan @PGCgenetics @SashaGusevPosts @dgmacarthur @tuuliel @hailianghuang Thanks @LaramieDuncan , I'll look up those works. BTW I'm very excited to dig into your recent paper on cell-type associations in complex brain phenotypes...its next on my list!
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@doctorveera @sanogenetics Gotcha, thanks @doctorveera for the explanation that what is being observed is more statistical, rather than biological, in nature.
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@SashaGusevPosts @PGCgenetics @dgmacarthur @tuuliel “…apparent cross-population differences in genetic effects may be largely explained by differences in allele frequencies or linkage disequilibrium with “tagging” variants rather than differences in the underlying effect sizes.” Thanks for the great write up @SashaGusevPosts
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RT @Fusion_Conf: A big congratulations to our #GWAS24 Poster Winners, Luis Eichelmann (@LuisEichelmann) from @UniLuebeck & Brandon Logeman…
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@TonyZador Others have discussed grant funding as a weighted lottery (i.e. better study section score gives you more ping pong balls in the ticket tumbler)....could something similar happen for publications?
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@GeneticsMike7 @BritMartinez Dependent on one's definition of beauty, pretty sure Alaska can give Hawaii a run for its money
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@OstuniLab @MolecularCell @pioneerfactors Thanks for highlighting this discussion which has a core topic (advantages / disadvantages of in vitro / in vivo studies) that is relevant beyond pioneer factors and permeates much of biology. Well written on both sides.
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@GeneticsMike7 @doctorveera @Nature @mnelsonxy @NatureGenet Conceptually the important genes = low effect sizes seems measurable. Practically I'm not sure how it would be done; perhaps some kind of meta study across multiple traits comparing effect size with PhyloP scores or dN/dS...something like that. Anyone tried this?
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New GWAS study examines when a baby takes their first steps 🧬 ➡️ 🚼 ➡️ 🚶♀️ SNP based heritability, a lower bound of heritability calculated using only common variants, shows up at ~25%, much higher than I would have guessed. Work led by @annagui86
This recent GWAS preprint is the first to explore genetic influences on the age at onset of walking 🚶♀️🚶, a milestone that may indicate broader (neuro)developmental delays. Find out more⤵️
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@doctorveera @Nature @mnelsonxy @NatureGenet I’m sure folks smarter than me have pondered over this before, if anyone has any thoughts please share; would love to learn more
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