Zaret Lab
@pioneerfactors
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We are a biomedical research lab at the Univ. of Pennsylvania, Dept. of Cell and Developmental Biology, Inst. for Regenerative Medicine, and Epigenetics Inst.
Philadelphia
Joined June 2020
Pioneer transcription factors are a subset of gene regulatory proteins that can target a partial DNA sequence on a nucleosome and thereby initiate gene expression changes in embryonic development, human disease, and cell reprogramming.
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@TheMilnerInst @TzelepisLab @TKLABUK @storm_tx @sangerinstitute @GurdonInstitute Big congratulations, starting with a general interest in a new topic, RNA modification, and getting to the clinic so soon! I will hoist one for you tonight
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RT @PennMedEVDCSO: Congratulations to @Marisa_S_B & Celeste Simon on their recent election to @theNASciences! 🥳🎉 @PennCDB @PennEpiInst @Pen…
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RT @PennEpiInst: A huge congratulations to our own @Marisa_S_B for her election to @theNASciences! We are so proud of her scientific achiev…
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We haven't tweeted for a while but we're coming with great news! Congratulations to Ken, just elected at the American Academy of Arts & Sciences !
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New paper from the lab in @ScienceAdvances ! Hsieh et al. show how hemizygous loss of MYBBP1A promotes tumorigenesis in PDAC cells, and how PARP1 inhibition by small molecules evicts MYBBP1A from chromatin and impairs cell growth. doi: 10.1126/sciadv.abc4517
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While waiting for America to finish counting all the votes, please read our latest review on Pioneer factors for @AnnualReviews of Genetics !
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RT @epigenetics_pod: In this episode, we caught up with @pioneerfactors from @Penn, to talk about his work on Pioneer Transcription Factors…
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RT @kelsey_kaeding: Checkout my poster number 216 at #cshlepich20 to learn about KRAB-ZFP mediated heterochromatin regulation during fibrob…
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We are @cshlmeetings #cshlepich20. Check out our posters #208 about heterochromatin and gene/repetitive elements repression, #131 about chromatin opening by pioneer factors, #182 about chromatin scanning in live cells and #216 about heterochromatin & Zn fingers proteins
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Our latest Molecular Cell paper is freely accessible for 50 days, enjoy the read!
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Thanks for the shout out @KamalaHarris ! 😜
First on CNN: Kamala Harris chooses "Pioneer" as her Secret Service code name
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RT @MolecularCell: Online Now: The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors
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@AlexandreMayran @RalfBlossey Thank you, I thought I had attached a link. Still new to Twitter here
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Must read: R. Grosschedl lab shows that EBF1 binding to chromatin is succeeded later, not immediately, by generating accessible chromatin.
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Must read: Structural study by the P. Cramer lab showing how Sox pioneer factors bind nucleosomes, in one mode leading to a change in the histone H4 tail that would affect access to the acidic patch on the nucleosome.
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