Axial
@AxialXYZ
Followers
6,682
Following
10
Media
294
Statuses
1,745
Axial - agency for great inventors - info @axialvc .com
San Francisco, CA
Joined July 2019
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
ブロック
• 455277 Tweets
西田さん
• 288450 Tweets
Twitterくん
• 276603 Tweets
西田敏行さん
• 263545 Tweets
俳優さん
• 184519 Tweets
生成AI
• 148689 Tweets
Bluesky
• 131702 Tweets
AI学習
• 125948 Tweets
ブルスカ
• 118340 Tweets
ツイッター
• 117498 Tweets
Grok
• 105932 Tweets
スーパームーン
• 83798 Tweets
イーロン
• 77912 Tweets
インスタ
• 73277 Tweets
イラスト投稿
• 72798 Tweets
ぐりとぐら
• 65248 Tweets
pixiv
• 51775 Tweets
블루스카이
• 43324 Tweets
タイッツー
• 43058 Tweets
#INDvsNZ
• 37876 Tweets
Misskey
• 36073 Tweets
他のSNS
• 35863 Tweets
OUROAD UPCOMING PROJECT
• 32149 Tweets
池中玄太80キロ
• 30588 Tweets
ドクターX
• 25113 Tweets
無断転載
• 22324 Tweets
YIBO VOGUE FORCES OF FASHION
• 20877 Tweets
相互さん
• 15933 Tweets
絵師さん
• 12107 Tweets
New frontiers
#3
1. ADCs
2. Cultured meats
3. Phenotypic screening
4. Industrial enzymes
5. Chemokines
6. Building the US-version of WuXi
7. Infectious disease
8. Immunometabolism
9. Fast following in drug development
10. Single-cell sequencing
2
26
116
Substitutes and complements in life sciences
3
19
80
Gerty and Carl Cori won the Nobel Prize for discovering the lactic acid cycle, known as the Cori Cycle. They advanced how the body produces & stores energy forming the basis for current diabetes treatments. And showing the clarity of chemistry can be used to unveil opaque biology
3
18
85
In Vivo Cell Therapies
1
21
70
Congratulations to Aaron Ring
@aaronmring
on being named one of the top 20 translational researchers of 2020🎉He's just getting started. Founding
@simchatx
and
@Seranova
with more coming up, the Ring Lab will be a Golden Goose of great inventions & talent over the next decades
2
21
76
Prime Medicine $PRME just went public yesterday and is a fascinating case study given that the inventor, David Liu
@davidrliu
, is the largest shareholder at 24.79% before the offering. The company is pursuing a Moderna-like strategy to define & monopolize a new technology
2
11
66
The Superinvestors of Life Sciences
2
14
58
Atlas, Bruce Booth
@LifeSciVC
, and everyone who has built up the biotech industry deserve a lot more respect than they’re getting. A founder-led model is about building something different but everyone is still trying to solve the same problems - help patients and our environment
3
8
69
With
@MargauxPinney
, we discuss her journey to become a scientist & leader in her field and her work around enzyme evolution. By bringing quantitative, high-throughput assays to enzymes, the Pinney Lab investigates enzyme function at a scale beyond traditional biochemistry
3
10
60
Schrödinger sells physics-based software for drug discovery. With >$100M in annual revenue across >1K customers, the company is one of the most successful software companies in life sciences & used their own product to build a pipeline
3
8
62
Build with Axial.
We are excited to start a fellowship for 2022. If you're interested in building an enduring company, please apply here:
2
19
54
Vicki Sato
@VickiSato
is a biotech legend currently serving as the chairwoman of Vir
@Vir_Biotech
among other boards. She has had an incredible career in biotech serving as the CSO then President of Vertex
@VertexPharma
, VP of Research early on at Biogen, & a Professor at Harvard
4
7
54
Congratulations to Aaron Ring
@aaronmring
for being on this year's Endpoints
@endpts
20 Under 40 List. Axial
@axialxyz
is honored to partner with Aaron on
@SimchaTx
,
@Seranova
, Stipple Bio, & so much more
4
16
45
Each version of CRISPR builds upon the last. Work between 2012-2016 dealt with effector selection & corresponding PAM compatibility
CRISPR = Clustered Regularly Interspaced Short Palindromic Repeats is actually a defense system against bacteriophages
And has two major classes:
3
10
48
Bryan Dickinson
@chembioBryan
is a professor at UChicago building new chemical tools to control biology. In our podcast conversation, we discuss everything from directed evolution and drugging RNA to what it takes to start a lab
5
5
47
🤯the blueprint (mRNA) is larger than the object (protein) it encodes for
0
4
42
Oxford Nanopore
@nanopore
sequences DNA with a nanopore. Founded in 2005 out of Oxford, they productized decades of research & launched MinION in 2014/2015; I remember using it for an early-access program. Now they are moving into long-read & expanding surveillance applications
2
10
41
LatchBio
@LatchBio
has built one of the best software products in life sciences, providing infrastructure for scientists to store, process, and visualize their data. Founded in 2021 in by
@AlfredoAndere
,
@kylegiff
, and
@kenbwork
, Latch always ships product & talks to customers
1
9
38
Living Carbon
@living_carbon
founded in 2019 by Maddie Hall
@maddiehalla
engineers trees to enhance carbon capture & storage, designing trees and selling carbon credits. Over 1.5B trees are planted per year in the US & offer a clear way sequester gigatons of carbon
5
8
34
ChemoCentryx was acquired by Amgen for ~$3.8B in 2022. Founded in 1996, by Thomas Schall who discovered many of the 50 chemokines, the company was started to drug them, the trafficking control system for immune system & develop once-daily, orally-available drugs for autoimmunity
1
8
37
Biologics represent >$200B in annual sales. This has given space for unique business models that act as service providers to grow to billion-dollar companies from Abimab to AbCellera.
Now with >100 antibody discovery service companies out there the market is increasingly crowded
1
11
36
The Business of AI in Life Sciences -
1
12
34
Resilience
@IncResilience
is leading the way to onshore biomanufacturing to the US. Founded in 2020 by Bob Nelsen
@rtnarch
after frustrated with the COVID response & led by Rahul Singhvi
@rsinghvi
, Resilience with an end-to-end model, is reimagining how complex medicines are made
1
7
28
Adimab model for RNA
RNA therapeutics are beginning to have repeatable success in the clinic. With RNAi taking the lead in terms of approvals. However, IP for chemical modifications, delivery, formulation are becoming (temporary) barriers for new entrants.
1
11
31
Proteomics is filling out the picture of biology after ~2 decades of the genomic era
Moore’s-like law advances in LC/MS as well as single-cell proteomics is leading to a more biochemically sound understanding of proteins across all scales from organs/tissues to cells
1
5
33
Founder-led life sciences companies for the win🏆
Founder-led Stocks > Non Founder-led
Source: Bain & Company
44
285
1K
1
12
34
Genomics for target identification. Proteomics for target validation.
Until a dataset comparing protein expression/proteoforms in disease across enough people, using proteomics for drug development might be more impactful to selling the proteomics tool itself.
1
6
27
Axial is very excited to launch the BioBuilder Jobs Board -
Please RT to make sure as many founders and scientists see 🙌🎉
1
15
32
Really excited to put out a recent conversation with Hannes Stärk
@HannesStaerk
on the Axial podcast discussing his journey from Munich to MIT and research on graph machine learning for protein and small molecule design.
Find it on Anchor:
1
3
32
LanzaTech
@LanzaTech
is building a next-generation refinery to produce low carbon products. Founded in 2005 from a research paper found in a library, the company uses microbes to convert industrial gas into fuels & create a series of low-carbon products
3
5
32
Transferrin receptor (TfR) is currently the main shuttle for large molecules into the brain
With only ~0.1% of biologics crossing the BBB from blood. With ~2 decades of work on TfR delivery, why has Denali Therapeutics essentially leapfrogged everyone else?
1
7
32
Debut
@Debut_Biotech
uses cell-free biomanufacturing for ingredients, chemicals, and more. Founded in 2019, by Joshua Britton, Brady Beauchamp, and Greg Weiss, Debut focuses on using biotech to build brands. With a fully-integrated platform & various partnerships in health/food
1
6
24
Dyno
@Dyno_Tx
was founded by Eric Kelsic
@ekelsic
, Adrian Veres
@AdrianVeresBio
, Sam Sinai
@samsinai
, George Church
@geochurch
, & Alan Crane in 2018 to bring machine learning to AAV gene therapies. Doing an incredible job building their platform & getting partners on board
3
4
29
We see a need for patent management software designed for inventors and using LLMs to create better patents, automate lifecycle work, and overall, make patents less painful for inventors
2
7
29
5 unsolved mysteries of the brain 🧠
1. What is the brain made of?
2. How does the brain change in disease?
3. How do neurons talk to each other?
4. How does the brain compute?
5. What will it mean to understand our brains?
1
7
29
There’s a large opportunity to transform linker design from trial-and-error to a rational process. First starting with PROTACs (with
@ArvinasInc
as the 1st mover) then expanding to ADCs, bispecifics, and bridging any molecule
1
8
29
Arbor Biosciences
@ArborBio
is commercializing the myTXTL cell-free expression kit. Founded in 2006 out of the University of Michigan by Erdogan Gulari & Jean-Marie Rouillard to serve their scientific peers with new reagents. Growing from sequencing panels to protein expression
1
5
25
Abcam
@abcam
was founded in 1998 by Jonathan Milner with Tony Kouzarides & David Cleevely to build a marketplace for antibodies. Milner was a postdoctoral fellow in the Kouzarides Lab at Cambridge where his project was slowed down by the lack of high-quality antibody reagents
3
3
18
Nimbus
@NimbusTx
:
- Founded in 2009 by Atlas & Schrödinger
- Combining computational chemistry with a capital efficient business model
- Selling a NASH asset to Gilead in 2016 for ~$400M
- Selling a TYK2 inhibitor to Takeda in 2022 for ~$4B
- Still controlling their own destiny
0
5
26
Bicycle Therapeutics
@Bicycle_tx
develops bicyclic peptides into drugs. Founded in 2009 by Gregory Winter, who invented phage display, the company has brought this new modality ('bicycles') in the clinic to treat cancer.
1
4
27
CambridgeSoft commercialized ChemDraw
@ChemDraw
& revolutionized how chemistry is communicated. Before ChemDraw, every chemist needed a drafting board. Now used by >1M people, ChemDraw was invented by Sally Evans after hours of frustration drawing chemical structures by hand
1
8
26
Crossing the BBB (blood-brain barrier)
Development of therapies to treat CNS diseases, especially large molecules like antibodies, is limited by the BBB. As the gatekeeper for the brain, the BBB separates the brain from circulating blood
1
7
25
Cryoport
@cryoport
is the leading biotech logistics company for cell therapies to immunotherapies & embryos. Founded in 1999, the company started off to replace dry ice shipping with a cryogenic flask. Now Cryoport generates >$200M in annual sales across 1000s of clients
1
5
25
Glycobiology in the clinic
Glycans decorate every cell in the body. As well as most proteins and most recently found on RNA. Advances in glycoproteomics/chemical biology has led to several drug candidates in the clinic targeting glycosylation.
1
7
25
Funding models in life sciences -
1
9
25
PacBio
@PacBio
is the market leader for long-read sequencing. Founded in 2004, spun out of Cornell from research in the late 90s & incubated by Kleiner Perkins, PacBio (was Nanofluidics) increased the accuracy of sequencing a single molecule of DNA with their SMRT technology
1
6
24
RNA modifications have been historically considered to be relatively static fine-tuners of the RNA structure and function. However, it has become evident that the epitranscriptomic layer is not only dynamic and reversible - catalyzed by RNA modification “erasers” -
1
3
19
Drugs that are their own pipelines
3
8
24
Illumina sales Illumina sales
in year one: today:
$474,000 $474,000 per hour
0
4
23
Epigenetic theory of aging
0
8
23
Denali
@Denalitx
:
- Founded in 2013 & led by Ryan Watts, former head of neuroscience at Genentech
- Getting started with the largest biotech Series A at the time, >$200M
- Drugging TREM2 for AD, RIPK1 from an M&A & building a unified neuro platform with their TfR delivery tech
0
3
18
EnginZyme
@EnginZyme
uses cell-free to produce chemicals without living cells. Founded in 2014 out of Sweden by Karim Engelmark Cassimjee, Robin Chatterjee, & Samuel Hargestam, the company creates new catalysts to convert renewable feedstocks into high-value chemicals & materials
1
6
21
Element Biosciences
@ElemBio
decentralizes sequencing. Founded in 2017 by Molly He
@MollyminHe
, Matt Kellinger, & Michael Previte after working together at Illumina, Element built a benchtop sequencer from the ground up centered around new chemistry to reduce reagent use by ~100x
1
7
21
DNA-encoded libraries (DEL) promised to bring a rational process to small molecule discovery. There have been many struggles over the last 2 decades with so much work left to be done. Time to get back to the lab.
5
3
20
Addgene is one of the most widely used products for scientists. Serving >100K scientists. Generating >$23M in annual sales. With their collection of ~131.8K plasmids from around 5K research labs. Along with their expanded product offering of AAVs, CRISPR reagents, and antibodies
1
4
21
Seagen
@SeagenGlobal
(started as Seattle Genetics) pioneered antibody-drug conjugates. Founded in 1997 to cure cancer with a large dose of skepticism, the company started work on CD30 that led to Adcetris for lymphomas, their 1st blockbuster & sparked 3 more approved medicines
1
3
20
The central dogma of molecular biology describes the flow of genetic information within biological systems. It was first formulated by Francis Crick in 1958 and later clarified in 1970. The dogma states that information flows from DNA to RNA to protein
1
7
21
Kymab was acquired by Sanofi for >$1B in 2021. It is a case study of developing drugs with high conviction despite patent challenges, competition in the clinic, & trailblazing a new MoA. Founded in 2010 out of Cambridge, UK, Kymab is also an example for every British biotech
1
5
17
Microscopy has been a driving force for breakthrough discoveries in biology from how cells divide to how proteins interact with each other. And it has historically attracted unique characters over the centuries like Antonie Van Leeuwenhoek, the Janssens, and Douglas Prasher
1
2
18
BioRender
@BioRender
, founded in 2017 & led by Shiz Aoki
@ShizAoki
, has grown into a market-leader for scientific illustrations. Improving scientific communication. Used seemingly by every immunologist & microbiologist, BioRender is a under-the-radar success story in biotech SaaS
1
5
21
Evotec
@Evotec
is a drug development partnering company, built mainly through trial-and-error. Evotec was founded in 1993 in Germany by Nobel Laureate Manfred Eigen (measuring chemical reactions), Charles Weissmann (cloning interferon) and a set of German entrepreneurs
3
4
19
Looking at clinical phase transitions from 2011-2020, it becomes abundantly clear that monoclonal antibodies (and maybe biologics in general) have a huge advantage over other drug modalities
1
5
21
10X
@10xGenomics
created the single-cell sequencing market & enables the next century of discoveries in biology. Founded in 2012 by Serge Saxonov
@saxonov
, Ben Hindson, & Kevin Ness
@kevin_dean_ness
, were all at QuantaLife, 10X builds tools to measure biology at high resolution
1
5
20
Affinivax was acquired by
@GSK
in 2022 for $2.1B. Founded in 2014 out of Boston Children’s Hospital, Affinivax develops vaccines without adjuvants. The company was acquired mainly for its 24-valent pneumococcal vaccine in late-stage trials to go heads up against Pfizer/Prevnar
1
5
20
Fabric Genomics
@FabricGenomics
is a computational genomics company that provides end-to-end genomic data analysis, annotation, curation, classification, and reporting solutions. To clinical/hospital labs and life science companies.
2
5
18
Frontier Medicines. “I think 50–100 years from now, there will be no protein that is undruggable. Everything will be druggable."
- Daniel Nomura, Co-Founder
Frontier was founded in 2018 by Chris Varma, who was an EIR at MPM Capital, and Zoncu and Nomura
1
6
19
Aethon Therapeutics
@AethonTx
develops antibodies to help the immune system to find and kill persistent cancer cells. Founded in 2022, based on work from NYU Langone, the company's HapImmune platform uses covalent inhibitors to generate haptens targetable by antibodies.
1
4
20
Sano Genetics
@sanogenetics
is a data-sharing platform that enables its users to participate in research studies. Founded in 2017 to connect consumers and researchers to precision medicine research.
1
4
19
Tierra
@tierrabio
prints custom proteins using cell-free. Founded in 2015 by Zach Sun, the company unlocks new proteins for their users & lowers barriers for protein synthesis. As a platform for protein engineers, users can send up to 10K protein sequences & get custom proteins
1
8
20
Hexagon Bio
@hexagonbio
mines the global metagenome for new medicines. With one of the best engineering teams in biotech, Hexagon combines data science + genomics + synbio to scale & automate the discovery of natural products to drug the "undruggable" genome
3
3
19
Morphic
@MorphicTx
is a clinical-stage company developing small molecules to replace the multi-$B market of integrin targeting biologics. Founded in 2014 by
@timothyspringer
(discovered integrins), Morphic is taking on the daunting task of drugging specific states with oral drugs
1
4
19
Royalty Pharma $RPRX is the largest buyer of drug royalties in the world. Founded in 1996 by Pablo Legorreta
@plegorreta
, the company has deployed over $20B for >50 royalties on marketed medicines like Xtandi & Imbruvica. Generating over $2B in annual revenue
3
5
17
Eight Lessons from Alejandro Zaffaroni, a biotechnology pioneer. Initially working at Syntex, he founded a wide-range of companies: Alza in particular, which brought over 20 medicines to market and created an entire new category centered around drug delivery
Thread below👇
1
9
19
Axial is excited to announce the first company in the Axial 22 class: Circos Health led by Stan Kwang. The company is building a precision medicine platform to scalably profile immune repertoires for monitoring and treatment of immune-related disease.
1
4
16
@MyoKardia
is one of the largest & rare success stories in cardiovascular drug development. Founded in 2012 & acquired by BMS in 2020 for >$13B, the company led by
@tgianakakos
pioneered a precision medicine approach in heart disease with a 2022 approval of mavacamten in HCM
5
5
19
Axial is building a new company in kidney disease. If you want to get involved to transform the lives of patients, apply here:
1
7
19
Elektrofi
@elektrofi
, founded in 2016, is an odd biotech company with the ability to build a profitable & efficient business. Focused on drug formulation & delivery, Elektrofi enables subcutaneous delivery of mAbs and other large molecule drugs
4
3
19
Forge Biologics
@ForgeBio
is a gene therapy manufacturing, and therapeutics company based in Columbus, Ohio. Founded in 2020 & led by Tim Miller, Forge has built one of the largest AAV manufacturing facilities, with end-to-end production from 50L to 5K liters right in the Midwest
1
6
17
Antibody therapeutics have become a major class of biologics used to treat a wide range of diseases, particularly cancer:
1. Innovation in antibody formats and engineering is enabling improved efficacy and safety
1
4
18
Seven Powers in Life Sciences
1. Scale: lowering unit costs
2. Network: increased value per user
3. Counter-Positioning: new business model
4. Switching: product moat
5. Branding: product's history
6. Cornered Resources: scarce resource
7. Process Power: institutional knowledge
3
4
18
Codexis
@CodexisInc
uses directed evolution to design enzymes & improve sustainability. Founded in 2002 as a spinoff from Maxygen, Codexis makes enzymes for partners like Merck, Novartis & GSK. Getting to >$100M in sales, showing a path for other enzyme companies
0
4
16
Beautiful work 👏👏👏
@josephmreplogle
@JswLab
I'm thrilled to share our latest work performing genome-scale Perturb-seq screens to explore a remarkable breadth of questions in genetics and cell biology (thread below). Congrats to Reuben Saunders, Tom Norman, and
@JSWlab
for co-leading this work.
11
162
519
1
8
17
Tu Youyou is a chemist who won the Nobel Prize in 2015 for the discovery of artemisinin
A medicine that has saved millions of lives for the treatment of malaria. All starting from ancient Chinese texts to screen >2K traditional recipes & ~380 extracts
1
3
16
Merck is one of the greatest drug companies ever. With one of the best selling medicines in the world the company can trace its roots to a small German pharmacy centuries ago. Roughly the Merck story can be divided into 6 major events/parts:
2
5
18
Benchling
@benchling
is leading the digitization of biotech. Founded & led by Sajith Wickramasekara
@sajithw
, the company started as a better plasmid editor & has grown into a unified R&D cloud for life sciences. Used by >200K scientists & 1000s of biotech companies/institutions
1
6
18
How successful drug companies closed their first deal? -
0
4
18
BioNTech
@BioNTech_Group
:
- Founded in 2008 out of Germany by Uğur Şahin, Özlem Türeci & Christoph Huber
- Starting off with €150M in capital to develop mRNA-based individualized cancer immunotherapy
- Shifting to COVID vaccines during the pandemic
- Now going back to cancer/IO
1
3
15
Where can marketplaces succeed in biotech?
For startups, it’s only really scaled in biologics with Abcam & now BenchSci. With high market concentration plus regulatory hurdles, biotech-specific marketplaces have been hard to build
1
5
15
Ultima Genomics
@UltimaGenomics
delivers the $100 genome. Founded in 2016 by Gilad Almogy & Mark Pratt
@markrpratt
, the company combines chemistry, ML, & fluidics to “drive down the cost of genomic information until it is routinely used in every part of the healthcare system”
1
5
17
There are 14 new job postings from really exciting companies like
@GlyphicBio
to
@InscriptaInc
and
@Novozymes
on the BioBuilder Jobs Board -
Please RT to make sure as many founders and scientists see so they can post and see new job opportunities 🙏
2
10
18
Solugen
@solugen
is working to become the Standard Oil of biology & help decarbonize the world along the way. Founded in 2016 by
@GaurabC
&
@TungstenSeanide
, the company sold hydrogen peroxide for hot tubs and even wipies before finding PMF for wastewater treatment
3
3
18