Amr Sawalha, MD
@asawalha
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Professor and Director, Division of Rheumatology, UPMC Children’s Hospital of Pittsburgh, Director, Lupus Center of Excellence, University of Pittsburgh
Pittsburgh, PA
Joined May 2009
Our latest publication on the genetics of Takayasu arteritis! We reveal new functional genetic insights, genetic risk score calculations, and a practical approach to communicating genetic risk to patients. @PittRheum @UPMCPhysicianEd @VasculitisFound
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Our rheumatology fellow @HocaogluMd first-author publication in A&R showing ANA production is primarily determined by non-genetic factors independent of lupus genetic risk @PittRheum @PittPediatrics @PittDeptofMed @UPMCPhysicianEd @ACR_Journals
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Our recent paper unravels the impact of hydroxychloroquine at a single-cell level in vitro and in #lupus. Enhancing CD8+ T cytotoxicity might underlie its protective effect against viral infections in #lupus @PittPediatrics @UPMCPhysicianEd @PittRheum
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Our latest publication showing that inducible deletion of epigenetic regulator Ezh2 in CD4+ T cells prevents interstitial nephritis in lupus models iScience @UPMCPhysicianEd @ChildrensPgh @PittRheum @PittPediatrics
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📝@ACR_Journals are dedicated to fair representation and respect. Our guidelines emphasize accurate reporting and thoughtful terminology. Let’s ensure our research is inclusive and unbiased, with clear, precise language that honors all individuals. 🌍🔬
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RT @UMIntMed: A new study led by Dr. Ajay Tambralli, in collaboration with colleagues from @umichmedicine and @PittTweet, shows the promise…
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🔬Pediatric #lupus in Western PA, US 🇺🇸and Turkey 🇹🇷! Turkish patients have earlier onset and more renal involvement. Damage Index scores are similar across cohorts. Global findings for better #SLE care! 🌍@UPMCPhysicianEd @PittPediatrics @PittRheum
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🔬🧬 New study of a rare #lupus case in Turner syndrome suggests a link between X-chromosome dosage and lupus #epigenetics. Could this explain sex-bias in lupus and the low lupus incidence in Turner syndrome?🤔@UPMCPhysicianEd @PittRheum @PittPediatrics
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🔍 Our analysis highlights a gap in preprint adoption within #rheumatology. Embracing high quality preprints could accelerate knowledge sharing, boost early career visibility, and enhance research collaborations. 🌟🔬#ResearchInnovation
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Just published: The first genome‐wide association study in primary antiphospholipid syndrome. New pathogenic insights revealed through genetics @UPMCPhysicianEd @PittPediatrics @PittRheum
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Very innovative and paradigm shifting work in APS. Thrilled to be part of this great effort by Dr. Tambralli, led by his outstanding mentor @jasonsknight
〽️🧐 Ajay Tambralli wrote about neutrophil metabolism as a potential treatment target in thromboinflammatory diseases like APS @jclinicalinvest @LyssiotisLab @asawalha @UMIntMed Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome
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Thrilled to be part of this genomic effort! Linking a genetic effect on chr21q22 to ETS2 as a casual gene unveiling new therapeutic targets for autoimmunity A disease-associated gene desert directs macrophage inflammation through ETS2 | Nature @UPMCPhysicianEd @PittRheum
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Excited to be part of this functional genomic effort unveiling new therapeutic targets for Takayasu arteritis! #vasculitis @ChildrensPgh @UPMCPhysicianEd @PittPediatrics @UPMC @PittRheum Bowel disease breakthrough as researchers make ‘holy grail’ discovery
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Just published: our work showing that intestinal permeability #leakygut correlates with disease activity in #lupus and changes DNA methylation in neutrophils. Leaky gut now linked to epigenetic dysregulation in lupus. @PittPediatrics @UPMCPhysicianEd
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Nice review! We are finalizing a small paper shedding mechanistic light to explain how #hydroxychloroquine might reduce risk of viral infections in #lupus stay tuned
✅ Recheck the MANY benefits 👌 and few (and well known) risks of #Hydroxychloroquine in #Lupus We have published a very detailed review ⬇️ about it:
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Our most recent preprint demonstrating a role for T cell EZH2 expression in tubulointerstitial nephritis, a strong predictor for end-stage renal disease in #lupus nephritis. We need a clinical trial for repurposing Tazemetostat in lupus @IpsenUS @UPMCPhysicianEd @PittRheum
Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/lpr ... #biorxiv_immuno
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See our newest preprint reporting the results of the first genome-wide association study in primary antiphospholipid syndrome and providing new insights into this rare disease @PittRheum @UPMCPhysicianEd @PittPediatrics
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RT @Kahlenberglab: #5 for @umichmedicine rheumatology in the past 11 years! Congratulations Jason! 💪🏻👨⚕️👨🔬
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