Alex S. Aguirre, MD
@asaguirremd
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Following
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PGY-1 LEAD Child Neuro via @TheBCRP ( @The_BMC / @BostonChildrens )| Passionate about Global Health Equity, Advocacy, Med Ed | @USFQ_Ecuador |🎾🗻🧠🧸🧬🇪🇨
Boston, MA
Joined September 2010
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37
19
1K
Your bow tie guy is going to
#Boston
!Extremely happy and honored to join my top choice (
@BostonChildrens
/
@The_BMC
) to continue my work on
#ChildNeurology
,
#HealthEquity
, and
#Advocacy
!
#Pediatrics
#Neurology
#Match2024
@USFQ_Ecuador
@NMatch2024
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22
991
Hello there!
#Match2024
season is here! I'm Alex S Aguirre, an 🇪🇨 Ecuadorian
#IMG
applying to
#ChildNeuro
🧠. I'm passionate about
#NeuromuscularDisorders
and
#Epilepsy
. I'm enthusiastic about
#GlobalHealth
and
#Education
!
Looking forward to connect with you all!
#MedTwitter
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@luiscarl
@luisevivanco
"CUIDAR mi propia salud, bienestar y capacidades para prestar atención médica del más alto nivel".
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My first
@AmEpilepsySoc
meeting! One of many in the future!
#AES2023
#Neurology
#ChildNeurology
#Epilepsy
3
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Hey
#MedTwitter
! Happy to share my last publication hot off press
@FrontNeurol
!
Honored and grateful to work with an outstanding doctor, mentor, and friend
@AlcyTorresMD
!
#ChildNeurology
#Neurology
#Neurotwitter
#TBI
#War
#Pediatric
#Trauma
#Injury
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I was definitely worried about not finding a "bowties are cool" ribbon
@AmEpilepsySoc
meeting
#AES2023
!
#bowtie
#neurology
#epilepsy
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Check out our latest publication related to the role of
#Neuroimaging
in the Rare
#SleepDisorder
of Kleine Levin Syndrome
@MDPIOpenAccess
#Neurology
#ChildNeurology
#MedEd
#MedTwitter
#NeuroTwitter
#NeuroRad
#Neuro
#RareDisease
@KLS_Foundation
1
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Hey
#MedTwitter
!
I'm starting a podcast. The Child Neuro Podcast.
If you're interested in
#childneurology
check it out on Spotify or Apple Podcast.
I'll be discussing neuro topics for parents and people preparing for the
#USMLE
steps. Links are in the tweet below.
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8
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What an honor to have an accepted abstract for the
@AmEpilepsySoc
!
#Neurology
#Neurotwitter
#Epilepsy
#EpilepsyAwareness
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I am honored and excited to be part of the
#ANA2022
meeting! I'll be presenting a poster and giving an oral presentation.
I am looking forward to growing and learning from this magnificent event!
#Neuro
#Neurology
#neurotwitter
@TheNewANA1
4
1
27
Today I'm presenting my poster at the
#ANA2022
about Kleine-Levin Syndrome. Check it out at M298.
Honored to share the room with amazing colleagues.
#ChildNeuro
#Neurology
#KLS
#RareDisease
@KLS_Foundation
@TheNewANA1
0
1
23
Learned a new word today at the
#ANA2022
Fact: Parkinson's Disease is preventable.
Thank you Dr.
@RayDorseyNeuro
for such a wonderful and an eye opener presentation!
@TheNewANA1
#Neurology
#Parkinsonsdisease
0
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Hey
#MedTwitter
! If you're into
#Epilepsy
check our latest publication about
#PCDH19
. A great review to understand it!
#ChildNeurology
#Neurology
#NeuroTwitter
#Pediatrics
#RareDisease
#MedEd
#EpilepsyAwareness
@PCDH19Alliance
@pcdh19
2
9
14
Hey
#MedTwitter
! Here you have an excellent applicant for this
#Match2024
! Estelle is truly a great leader and friend. She will definitely be an amazing
#pediatrician
! Best of luck to our
@FuturePedsRes
co-director!
Hi
#MedTwitter
&
#PedsTwitter
! I am Estelle and I am applying into
#Pediatrics
this
#Match2024
cycle. I am passionate about medical education, health equity, advocacy, & homeless health. I love to crochet, train dogs & drink lattes. I look forward to connecting!
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@UjuMomah
I'm Alex, last year med school in Ecuador. Interested in
#Neurology
.
This week I wrote my first tweetorial about ALS .
Why are UMN and LMN damaged in Amyotrophic Lateral Sclerosis?
#EndNeurophobia
#MedTweetorial
#MedStudentTwitter
#MedEd
#Neurology
#Neuro
#ALS
@alsassociation
1
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Why are UMN and LMN damaged in Amyotrophic Lateral Sclerosis?
#EndNeurophobia
#MedTweetorial
#MedStudentTwitter
#MedEd
#Neurology
#Neuro
#ALS
@alsassociation
1
8
12
Today I listened Dr. Patapoutian
@ardemp
and his great love for
#Science
. What an honor to receive a talk from a
#NobelPrize
winner! Thank you for motivating all of us to keep looking for answers in the simple things.
@USFQ_Ecuador
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Hey
#NeuroTwitter
! Check out our latest publication related to the role of
#Riluzole
in the treatment of Hereditary
#Ataxias
@MDPIOpenAccess
#Neurology
#ChildNeurology
#MedEd
#MedTwitter
#NeuroScience
#NeuroRad
#Neuro
@Friedreichsatax
@CureFA_org
0
3
9
Meet Kass, a true force of inspiration
@FuturePedsRes
! Her dedication, creativity, and kindness are boundless. You'll be an excellent pediatrician! Best of luck!
#Match2024
#Pediatrics
#IMG
I guess it's time to reintroduce myself! I'm Kass an IMG from 🇲🇽 applying to the best field of all👶🧸I am passionate about community health and those who know me in helping others in and outside of medicine! I am excited to meet more amazing people along this journey! ❤️
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"Everything we hear is an opinion, not a fact. Everything we see is a perspective, not the truth."
~Marcus Aurelius
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"All great changes are preceded by chaos" ~ Deepak Chopra
0
1
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Hey
#MedTwitter
! We just published a new paper! If you are interested in muscular diseases and radiology, check it out!
#Neurology
#ChildNeuro
#NeuroTwitter
#Juvenile
#Parkinsonism
#Dopamine
#Dystonia
#Radiology
#Fluorodopa
#PET
#Scan
0
2
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Starting the 2nd day of
#ANA2022
meeting! Excited to learn from outstanding neurologists!
@TheNewANA1
#Neurology
0
1
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Listen to my
#podcast
! This week I discuss about
#TikTok
Tics! Available in
#ApplePodcast
and
#Spotify
.
#Neurology
#ChildNeurology
1
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"Do not look for a sanctuary in anyone except your self." ~Gautama Buddha
0
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You can't miss this if you are applying to
#Pediatrics
this
#Match2024
!
Join us tomorrow for our South Atlantic Part 1 Webinar! Check out the all the amazing programs that will be there 🤩 Make sure to stick around for the resident panel afterwards!
@APPDconnect
@COMSEPediatrics
#PedsMatch2024
#Match2024
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Join us tonight!
#PedsMatch2024
🌊🩺🤩Did someone say West Coast, Best Coast? Catch us tomorrow August 3, for our Pacific West Webinar, at 5 PM PT, 8 PM ET. Featuring programs from California, Oregon, and Washington!!
#PedsMatch2024
#Match2024
@COMSEPediatrics
@APPDconnect
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"No man is crushed by misfortune unless he has first been deceived by prosperity." ~ Seneca
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13/
Final Points
-ALS has a clinical presentation with UMN and LMN dysfunctions
-Glutamate excitotoxicity is a possible initiator of the pathogenic mechanism of this disease
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Glutamate excitotoxicity is a main pathophysiologic pathway of neuron damage in ALS, which final step is neuronal death. Its etiology resides in glial cells (e.g. Astrocytes and Microglial cells) surrounding the MNs of the spinal cord.
1
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@danazcomd
@MayoClinicGIHep
Best of luck
@danazcomd
! You are one of the best applicants for this season! Any program would be fortunate to have you!
1
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See you tonight!
#Match2024
#Pediatrics
🤩🏔️See everyone tonight, August 8th at 7 PM CT for our West North Central and Mountain West Webinar! Here are the Break Out rooms for tonight! Link in bio 🥳🤩🥾⛰️🏔️
#pedsmatch2024
#match2024
@COMSEPediatrics
@APPDconnect
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@jess_talltree
@BostonChildrens
@The_BMC
@USFQ_Ecuador
@NMatch2024
Congrats to you too, Jess! See you soon! 🎉👏🏾🧠
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More info about riluzole
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@jsvivanco1
@NeurosurgeryCNS
@CerebrovascLab
@cvsection
@svinsociety
@SNISinfo
@CNS_Update
Congrats! 🧠
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A clinical presentation of a patient with asymmetric limb weakness, dysphagia, fasciculations, and clonus should immediately make us think of ALS. A fatal disease characterized by both Upper and Lower Motor Neurons alteration.
1
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@RobynCohenMD
@BostonChildrens
@The_BMC
@USFQ_Ecuador
@NMatch2024
@AlcyTorresMD
He's the best mentor 🧠❤️
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"He who laughs at himself never runs out of things to laugh at" ~ Epictetus
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MNs are the largest neurons in the human body. The specific reason why MNs are targeted in ALS remains unknown. The capacity to breathe, speak, and move deteriorates from the start, but the visual, sexual, and sphincter functions remain normal throughout the disease length.
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Don’t miss today’s webinar! Dr. Yano will discuss some ways
#research
data on molecular mechanisms of neurogenetic disease can assist the clinician's judgment during diagnosis, prognostication, and treatment.
Register here ➡️
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"Never let the future disturb you. You will meet it, if you have to, with the same weapons of reason which today arm you against the present."
~Marcus Aurelius
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"Wealth consists not in having great possessions, but in having few wants."
~Epictetus
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@JennyWpedsneuro
Dr. Wilson, we can definitely help to get the word out
@FuturePedsRes
!
Other options would be
@Inside_TheMatch
and
@NMatch2024
!
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@eddy_saad
@USJLiban
@UWorldMedical
@ambossmed
@StoriesImg
@IMG_Advocate
@ImgJourney
Congratulations 🎉
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"Do not seek for things to happen the way you want them to; rather, wish that what happens happen the way it happens: then you will be happy."
~Epictetus
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Reduced expression of those proteins in spinal cord MNs, and the presence of other proteins (e.g. Semaphorin A3, Dynein), increase the number of glutamate receptors (e.g. AMPA, NMDA) in this specific location.
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@hamhatch
@BostonChildrens
@The_BMC
@USFQ_Ecuador
@NMatch2024
Congrats to you too!! Same! See you soon!!
0
0
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@danazcomd
@ObesityWeek
@ObesitySociety
@dr_aac
@MDanielaHurtado
@LizCifuentesMD
@Wissam_Ghusn
@FansaSima
@ACamposMD
@AlisonMcRaeMS
Amazing job! Congrats! 🎉
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11/
Dysfunction in the astroglial glutamate transporter (EAAT2) seems to be responsible for the mismanagement of this NT. In consequence, an excessive glutamate uptake by the enhanced receptors in the spinal cord initiates abnormal Ca2+ signaling which ends in cell death.
1
0
1
@danazcomd
@UTSWInternalMed
@UTSWIMchief
@dr_aac
@Dr_RADillingham
@Pablo_delaC
@MDanielaHurtado
@JimenaBelenGim1
Congrats!! 🎉 Best of luck!! You deserve this!!
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@EstelleAGreen
Thank you so much, Estelle!
You are an incredible leader! Any program would be lucky to have you! You'll be an amazing pediatrician! 🧸
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4/
Which factors protect those MNs in the spared functions?
Specific proteins
0
Location
0
Glial Cells
0
All of the above
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8/
Also related to the variation in those specific proteins, the spinal cord has a lower number of calcium buffers compared to other MNs. Ca2+ buffers are important in the maintenance of a friendly environment against free radicals which may damage neurons.
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The main difference may be in characteristics of susceptibility present in the spinal cord motor neurons, and the discrepancy with features of the oculomotor neurons and Onuf’s nuclei motor neurons, which control visual, and sexual-sphincter functions, respectively.
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Finally, cell death amplifies excitotoxicity by releasing more glutamate from dead neurons, thus, killing more susceptible neurons. Riluzole, approved in 1995, inhibits glutamate release from neurons and inactivates certain channels protecting neurons from damage.
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I registered for 2021 Neurocritical Care Conference . Check it out here
0
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14/
Final Points
-There are intrinsic susceptibility factors for neuronal damage such as specific proteins subdivided by location
-Riluzole is one of the only two drugs approved to treat ALS, and it is the only one to target glutamate excitotoxicity directly.
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"There is no easy way from the Earth to the stars" ~ Seneca
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