Diego Anazco, MD
@danazcomd
Followers
658
Following
607
Media
19
Statuses
376
PGY-1 @UTSWInternalMed | Former Research Fellow @MayoClinicGIHep | MD @USFQ_Ecuador 🇪🇨 | Aspiring GI | #COYG 🔴 | ⚽️ 🏓🧉🤿
Joined July 2012
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Pinned Tweet
Beyond thrilled to have matched at my dream program!
@UTSWInternalMed
@UTSWIMchief
Forever grateful for the support from my family, soon-to-be wife, friends, and exceptional mentors
@dr_aac
@Dr_RADillingham
@Pablo_delaC
@MDanielaHurtado
Dallas, here we go! 🚀
#Match2024
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Hi
#MedTwitter
!
I’m Diego Anazco, an Ecuadorian 🇪🇨
#IMG
and current research fellow
@MayoClinicGIHep
.
Thrilled to apply to
#InternalMedicine
for
#Match2024
.
I’m passionate about GI and obesity research, soccer ⚽️, and table tennis 🏓.
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29
158
Honored and humbled to share that I was awarded a Second Place Oral Presentation at the 2024
@MayoMrfa
Research Day!
Forever grateful with my mentors
@dr_aac
@MDanielaHurtado
and amazing team from the Precision Medicine for Obesity Program
@MayoClinicGIHep
6
2
73
Excited to be attending my first
#ObesityWeek
. Honored to be selected as a finalist for the 2023 Ethan Sims Young Investigator Award and to present our work in Dallas. Extremely grateful for my outstanding mentors
@dr_aac
@MDanielaHurtado
and team.
8
2
52
📢 Thrilled to deliver an oral presentation during
@DDWMeeting
.
⭐️ Proud of our lab’s effort that resulted in an AGA plenary session (
@FansaSima
), an oral presentation (
@AlisonMcRaeMS
) and 4 posters
#DDW2024
.
➡️ Beyond grateful for my amazing mentors
@dr_aac
@MDanielaHurtado
4
3
50
Humbled and honored for the opportunity to deliver 2 oral presentations showcasing our team’s work during my first
@ObesityWeek
@ObesitySociety
. I am extremely grateful for the continuing support from my exceptional mentors
@dr_aac
@MDanielaHurtado
and wonderful team.
7
5
49
Wrapping up
#DDW2024
with an oral presentation! Inspired by the brilliant sessions and happy to connect with amazing GI people!
Forever grateful with my mentor
@dr_aac
and wonderful team from the Precision Medicine for Obesity Program
@MayoClinicGIHep
@DDWMeeting
@MayoMrfa
4
2
49
I will be speaking at the
#ObesityWeek
@ObesitySociety
conference being held in Dallas, Texas from October 14 to 17. It's not to late to join! Register today
2
2
27
Our manuscript assessing type 2 diabetes remission rates after
#RYGB
in carriers of genetic variants in the leptin-melanocortin pathway has been selected as one of the best papers for
@JournalObesity
November Issue. Take a look at our work!
BEST PAPERS OBSU NOVEMBER ISSUE
"Type 2 Diabetes Remission in Patients with Heterozygous Variants in the Leptin-Melanocortin Pathway after Roux-en-Y Gastric Bypass: A Matched Case–Control Study"
DOI:
0
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2
5
26
🚨Check out our research letter
@AGA_CGH
on the incidence of pulmonary aspiration during upper endoscopy in patients prescribed a GLP-1 receptor agonist 💉
@dr_aac
@MayoClinicGIHep
@AGA_GIHN
@AmerGastroAssn
@ObesitySociety
@novonordisk
@AmDiabetesAssn
3
5
25
📢Take a look at our latest clinical review highlighting the evidence for the protective effects of weight loss interventions in cancer risk!
Grateful for my outstanding mentors!
@dr_aac
@MDanielaHurtado
@CathcartRake
@WorldObesity
@MayoClinicGIHep
1
4
22
The prevalence of obesity in patients with
#celiacdisease
is increasing. Take a look at our recently published manuscript evaluating the efficacy and safety of antiobesity medications 💊💉in patients with
#CeD
on a
#glutenfree
diet.
2
4
20
Excited to share our latest work assessing T2D remission rates in carriers of variants in the leptin-melanocortin pathway after
#RYGB
. Thankful for the unparalleled support and guidance!
@dr_aac
@MDanielaHurtado
1
3
19
🚨Take a look at our latest study
@eClinicalMed
@TheLancet
. Honored to have co-led this work with the one and only
@Wissam_Ghusn
⭐️
➡️The IMS score (surrogate for
#T2D
severity) could help predict weight loss outcomes for pts w/ T2D taking
#semaglutide
@dr_aac
@MayoClinicGIHep
Excited to share our study in
@eClinicalMed
!
🔶 The Individualized Metabolic Surgery Score helps predict weight loss outcomes of Semaglutide
🔶 The application of this score could permit a personalized weight loss approach and help define realistic weight loss goals
@dr_aac
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5
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2
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13
Congrats Wiss! You completely deserve it! Honored to be working with such a talented group! 👏🏼👏🏼👏🏼
Honored to be presenting our research work at
#DDW2023
:
✅ 1 Plenary Session
✅ 1 Oral Presentation
✅ 3 Poster Presentations
Beyond grateful to my colleagues and exceptional mentors
@dr_aac
@OMGhanemMD
and
@MDanielaHurtado
#GITwitter
@MayoClinicGIHep
@AmerGastroAssn
27
5
154
1
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Our article on preprints during the COVID-19 pandemic was published today on
@thePeerJ
. We hope you enjoy it.
#EvidenceBasedMedicine
#InfectiousDiseases
#PublicHealth
#ScienceandMedicalEducation
@e_teran_ec
@bryannicolalde1
0
3
9
Our article on publication rate of preprints released during the COVID-19 pandemic was one of the top 5 most viewed
#EvidenceBasedMedicine
and
#ScienceMedicalEducation
articles published in
@thePeerJ
in 2021!
@e_teran_ec
@bryannicolalde1
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Come to see your colleagues. Leave with greater possibilities. DDW is the premier digestive disease meeting. Be
#HereforDDW
and register today at .
#DDW2023
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Looking forward to connect with mentors and colleagues.
@IMG_Ecuador
@Inside_TheMatch
@projectimg
@storiesimg
@imgadvocate
0
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15/18
All patients receiving TNF-a inhibitors should be tested for LTBI. It can be assessed through tuberculin skin testing (TST) and Interferon-γ release assays (IGRAs). Repeated testing in 1-3 weeks could be considered if results are initially negative
1
3
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Muy feliz de poder aportar junto a nuestro equipo con un capítulo sobre opciones farmacológicas contra el COVID-19 en este gran proyecto
@e_teran_ec
@bryannicolalde1
Esta es la noticia que queríamos ver esta semana
al fin nuestro libro 📕 sobre
#COVID19
se publica 🤩
50 colaboradores
800 páginas
3 secciones
48 capítulos
35 tablas
115 figuras
1221 referencias
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201
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6/18
TNF-a is vital for acute and chronic inflammatory responses, such as chronic infections and autoimmunity. Signaling through TNFR1 results in a pro-inflammatory state, whereas signaling through TNFR2 causes immunomodulation and tissue regeneration.
1
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4
18/18
All patients treated with TNF-a inhibitors, with a positive LTBI screening and no evidence of active TB infection, should be treated accordingly. Recommended regimens to treat LTBI are described below.
0
1
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and outstanding team from the Precision Medicine for Obesity Lab
@MayoClinicGIHep
@LizCifuentesMD
@Wissam_Ghusn
@ACamposMD
@eliftama
@KhushbooSGala
@MayoMrfa
@IMG_Ecuador
@AGA_GIHN
@AmerGastroAssn
0
0
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13/18
Etanercept is a soluble fusion protein, not a monoclonal antibody. A reduced penetration into granulomas has been reported. As it binds less to membrane-bound TNF, TEMRA depletion might be less prominent. Differences could explain the lower TB rate.
1
0
3
10/18
Depletion of CD45RA+ effector memory T cells (TEMRA) has been proposed as a contributor to TB reactivation. TEMRA from patients with RA have high levels of membrane-bound TNF and could suffer complement-mediated lysis after exposure to infliximab.
1
1
2
5/18
TNF-a is mostly secreted by macrophages and monocytes. It is essential for innate and adaptive immunity, promoting the production of inflammatory cytokines and enhancing the adhesion and recruitment of immune cells. It may also induce cell apoptosis and necrosis.
1
0
2
11/18
Also, TNF-a inhibitors can interfere with phagolysosomal maturation, monocyte apoptosis, IFN secretion by memory T cells, and in the complement-mediated lysis of infected cells mediated by CD8 T cells, which are critical for TB containment.
1
0
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3/18
TNF-alpha inhibitors were initially developed for sepsis and underwent studies in animal models. After successful results in patients with rheumatoid arthritis, these agents have been widely evaluated in other chronic inflammatory diseases.
1
1
2
8/18
In TB, TNF-a is produced by epithelial airway cells, CD8 T cells, and activated macrophages. TNF-a stimulates the production of chemokines to attract immune cells to the site of infection, and increases the production of nitric oxide in macrophages.
1
0
2
2/18
Which of the following agents is not a TNF-alpha inhibitor?
Adalimumab
1
Infliximab
1
Etanercept
6
Secukinumab
22
1
0
2
4/18
A meta-analysis showed that the use of TNF-alpha inhibitors was associated to an increased risk of tuberculosis (OR: 1.94; P=0.02), especially in patients receiving treatment for rheumatoid arthritis
1
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7/18
Cell-mediated immunity is essential for controlling TB. CD8 T cells limit TB growth by destroying infected cells and secreting cytokines to activate macrophages. CD8 T cells are crucial for the chronic containment of TB, avoiding reactivation of LTBI.
1
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@Wissam_Ghusn
@MayoClinicGIHep
Thank you so much Wiss! Would love to work with you again!!! 🙌🏼👑
0
0
1
9/18
TNF-a is critical for the formation and maintenance of granulomas to contain TB. Activated macrophages within the granuloma secrete IL-6 and TNF-a, which favor inflammation, and IL-10, which modulates inflammatory responses
1
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0
0
2
@Wissam_Ghusn
@SigmaXiSociety
@MayoClinicGIHep
@BMCimRES
@MayoMrfa
Congratulations Wiss! Completely deserved! 🙌🏼🙌🏼🙌🏼
0
0
2
12/18
Which of the following TNF-alpha inhibitors is less frequently associated with TB reactivation?
Infliximab
0
Etanercept
8
Adalimumab
2
1
0
2
@xHarsh_Agarwal
Thank you Harsh!! Congratulations as well! Can’t wait to meet you in person!
Great Spanish 🙌🏼
1
0
1
17/18
Interferon-γ release assays (IGRAs) assess in vitro T cell response against specific M tuberculosis antigens. It is more specific as antigens are not found in BGC or other non-TB mycobacteria. IGRAs are more expensive and less accessible.
1
0
2
Amazing work from the Precision Medicine for Obesity Program
@MayoClinicGIHep
. Thankful for the support from my mentors
@dr_aac
@MDanielaHurtado
!
@ObesitySociety
@WorldObesity
#obesity
#semaglutide
#ozempic
#wegovy
2
0
1
16/18
TST consists of injecting TB purified protein derivatives in the forearm. In exposed individuals, a type IV hypersensitivity reaction produces skin induration that is measured 24-72 hours later. It is less specific, as other mycobacteria (BCG) might cause false positives
1
0
2
@KarlHageMD
@MayoClinic
@Inside_TheMatch
@StoriesImg
@IMG_Advocate
@IMG_MATCH
@ImgJourney
@OMGhanemMD
@MayoClinicSurg
@MayoSurgery
@MayoMrfa
Best of luck Karl! You will do amazing my friend!! 🙌🏼👑
1
0
2
@LizCifuentesMD
@AmerGastroAssn
@dr_aac
@MayoClinicGIHep
@PittGIM
@PittDeptofMed
@PittGILiverNutr
@MDanielaHurtado
@Wissam_Ghusn
Congrats Liz, you are outstanding! 👑⭐️ Always representing 🇪🇨 in the best possible way! 🙌🏼
0
0
2
@asaguirremd
@BostonChildrens
@The_BMC
@USFQ_Ecuador
@NMatch2024
Congratulations my dear friend, you completely deserve it, Boston is lucky to have you! 🙌🏼⭐️
1
0
1
@Kamalabimosleh
@MayoClinic
@OMGhanemMD
@Inside_TheMatch
@FutureGenSurg
@IMG_MATCH
@IMG_Advocate
Best of luck my friend 🙌🏼🙌🏼🙌🏼
0
0
1
@Halrcomentarios
Bolivia y Perú se unieron en una confederación, pero esta fue derrotada por la alianza entre Chile y Argentina.
0
0
1
@Wissam_Ghusn
@dr_aac
@MDanielaHurtado
@FansaSima
@LizCifuentesMD
@ACamposMD
@AlisonMcRaeMS
Thank you so much Wiss for all your support! ⭐️🙌🏼
0
0
1
🇪🇨
La Comisión de Apelación de la FIFA adopta una decisión sobre la convocatoria del jugador Byron David Castillo Segura
▶️
186
738
2K
0
0
1
@Halrcomentarios
El heredero de Hidalgo fue el también sacerdote José María Morelos, quien reclamaba la República del Anahuac.
0
0
1
@FansaSima
@ObesityWeek
@ObesitySociety
@dr_aac
@MDanielaHurtado
@LizCifuentesMD
@Wissam_Ghusn
@ACamposMD
@AlisonMcRaeMS
Thank you for your support Sima! You did amazing as well, proud of you!! 🙌🏼⭐️
0
0
0
@Wissam_Ghusn
@BMCimRES
@AUB_Lebanon
Congrats Wiss! Completely deserved! Best of luck in Boston!! 🍾🎉💪🏼
1
0
1
@Wissam_Ghusn
@dr_aac
@MDanielaHurtado
@OMGhanemMD
@MayoClinicGIHep
@LizCifuentesMD
@FansaSima
@AlisonMcRaeMS
@KhushbooSGala
@Ellehkolkin
The absolute best 🙌🏼🙌🏼🙌🏼
0
0
1
@KarimAlAnnan
@lebamericanuni
@LAUMCRH
@MayoClinicGIHep
@Inside_TheMatch
@StoriesImg
@IMG_Advocate
@IMG_MATCH
@ImgJourney
@MayoMrfa
@AdvancedEndoLab
@MayoClinic
@babudayyeh
Best of luck habibi! You will do amazing! 🙌🏼🙌🏼🙌🏼
1
0
1
@camiesquetini
@dr_aac
@MDanielaHurtado
@Wissam_Ghusn
@FansaSima
@LizCifuentesMD
@ACamposMD
@AlisonMcRaeMS
Gracias Cami! 🇪🇨
0
0
1
@LizCifuentesMD
@ObesityWeek
@ObesitySociety
@dr_aac
@MDanielaHurtado
@Wissam_Ghusn
@FansaSima
@ACamposMD
@AlisonMcRaeMS
Thank you so much for all your support Liz! It truly means a lot! 🙌🏼🇪🇨
0
0
1
0
0
1
@AndreeFrans
@UTSWInternalMed
@UTSWIMchief
@dr_aac
@Dr_RADillingham
@Pablo_delaC
@MDanielaHurtado
@JimenaBelenGim1
The best co-intern I could have asked for! Excited for our time in Dallas! Vamos Ecuador!! 🇪🇨🇪🇨🇪🇨
0
0
1
@Wissam_Ghusn
@AGA_CGH
@dr_aac
@MDanielaHurtado
@FansaSima
@MayoClinicGIHep
Thank you so much Wiss! Learned from the best 🙌🏼
0
0
1
@LizCifuentesMD
@dr_aac
@AlisonMcRaeMS
@JessicaAtieh
@PittGIM
@PittGILiverNutr
@MayoClinicGIHep
@Wissam_Ghusn
@Ellehkolkin
@DDWMeeting
Congrats Liz! You are the best! ⭐️
0
0
1
@Halrcomentarios
La segunda revolución industrial en Europa fue uno de los factores principales que contribuyeron a la inmigración hacia AL.
0
0
1
@asaguirremd
Thank you my friend! We did it!! Excited to see which program will be lucky enough to have you!
0
0
1
@Wissam_Ghusn
@ObesityWeek
@ObesitySociety
@dr_aac
@MDanielaHurtado
@LizCifuentesMD
@FansaSima
@ACamposMD
@AlisonMcRaeMS
Thank you so much Wiss! Learning from the best 🙌🏼
0
0
1
1
0
1
0
0
1
@LizCifuentesMD
@AmerGastroAssn
@dr_aac
@PittGIM
@PittDeptofMed
@PittGILiverNutr
Felicitaciones Liz!! 🙌🏼 Siempre dejando a 🇪🇨 en alto!👏🏼
0
0
1
@asaguirremd
@ObesityWeek
@ObesitySociety
@dr_aac
@MDanielaHurtado
@LizCifuentesMD
@Wissam_Ghusn
@FansaSima
@ACamposMD
@AlisonMcRaeMS
Thank you so much my friend! 🙌🏼🇪🇨💪🏼
0
0
1
0
0
1
@LizCifuentesMD
@AmCollegeGastro
@PittGIM
@PittGILiverNutr
@PittDeptofMed
@PittIMChiefs
Congrats Liz! The absolute best! 🙌🏼🇪🇨
0
0
1
@AnthonyFadelMD
@AUBMC_Official
@MayoUrology
@Uro_Res
Best of luck my friend! Excited to see which lucky program recruits you! 🙌🏼🙌🏼
0
0
1
@Wissam_Ghusn
@KarimAlAnnan
@DDWMeeting
@MayoClinicGIHep
@AdvancedEndoLab
@AmerGastroAssn
@SSATNews
@RudyMradMD
@razanaburummann
@babudayyeh
Congrats Karim! 🙌🏼
1
0
1
@asaguirremd
Thank you so much my friend, congrats to you as well!! You completely deserve it! 🙌🏼🙌🏼🙌🏼
0
0
1