Andrew Beggs
@adbeggs
Followers
5K
Following
6K
Statuses
6K
Prof Cancer Genetics & Surgery @unibirmingham, Colorectal Surgeon @uhbtrust, Scientist as well as surgeon. MRC Senior Fellow. Cancer/Surgery/Genomics.
Birmingham/Leamington Spa
Joined January 2010
This is really interesting… I hadn’t realised that indirect costs for US gov grants are 60% (!!) in the UK it is more like 20% of which we get 80% of - so 16%. Almost the same as the US are complaining about being lowered to!
1
0
4
Really delighted to show our first attempts in @beggs_lab at growing Wilms Tumour organoids (left) and the kidney (right) from paediatric patients by @maxj_p, Zeynep Kaya and Kaitlin Marley. Funding from @LPTrustUK made this possible! Project here:
1
5
23
Trying to improve somatic cancer genomic testing in the NHS at the moment feels like an Esherian/Penrose staircase. Always falling. Immensely painful. It is almost as if we want to go backwards as a healthcare system.
0
0
4
RT @ShivanSivakumar: Ecstatic to see this out! Important implications for immune targeting in pancreatic cancer. Has been a labour of love!…
0
7
0
RT @PeterPrinsley: With universities unable to afford them, clinical academics across the country are being offered redundancy. These are…
0
123
0
Reading this article is depressing. Not because of the conclusions but because of the fact our genomic medicine services are falling so behind our Eur/US peers. Everyone in UK should have large panel NGS on their tumour at least, even better an exome But most are lucky to get a single gene hotspot currently. And this is in the country that developed Solexa & Nanopore sequencing as well as the 100KG project. We have lost our way.
Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid Tumors:
0
2
13
The question is now, why the hell would you want an oesophagogastrectomy if you are dMMR? >60% chance of no surgery The role of IO in the primary treatment of multiple dMMR malignancies seems to being ignored at the moment… frustrating
Clinical significance of baseline reflex dMMR testing in oesophagogastric adenocarcinoma in the context of IO availability - Tremelimumab and durvalumab as neoadjuvant or non-operative management...
1
3
10
Thanks to @JenSeligmann @FoxtrotStudy and many others for involving us in this important study
0
0
2
RT @CholestasisDoc: New from us: our trial protocol for faecal microbiota transplantation to treat people living with PSC and IBD. Active…
0
6
0
RT @EdinUni_IGC: Read this paper by @CGATist and @AvaKhamseh: High order expression dependencies finely resolve cryptic states and subtypes…
0
4
0
RT @Neil_J_Smart: Interesting from today's Sunday Times, but something that many of us within healthcare have known about for well over a d…
0
10
0
What he really needs is to go to the National Polyposis service in the UK run as part of the NHS Rare diseases Collaborative Networks - @Mcfark runs the branch in Devon and Cornwall 👉 Specialist FAP care 👉 National MDT 👉 high volume services
This is a 70M with a history of gastrectomy and subtotal colectomy for familial adenomatous polyposis (FAP) who had multiple adenomas within their neo-terminal ileum, as evidenced by the small bowel villi. Shared #WithConsent. There are several noticeable differences from Lynch syndrome, another hereditary autosomal dominant condition associated with colon cancer 👇 Patients with classical FAP (📸 below) tend to have thousands / tens of thousands of adenomas with cancer at a young age. Development in later life as in this patient with fewer polyps are known as attenuated FAP. This patient will be discussed at an MDT to consider appropriateness of further polypectomy and to consider aspirin chemoprevention (already on clopidogrel for coronary stents). 📸:
2
0
6
@iskander @cityofhope But 14 had no ctDNA detected but imaging positive - my point is more that liquid biopsy assays need to be multimodal. Although high sensitivity detection is great, in the era of neoadjuvant and adjuvant therapy the cancer will evolve its way out of these
2
0
6