Excited to share our recent publication in @Nature! We mapped single-cell phylogenies in mouse models of intestinal tumorigenesis, revealing a polyclonal origin for colorectal precancerous lesions. Check it out here:

@sciqst @Nature scRNA sequencing uncovered widespread intercellular interactions in polyclonal lesions, which significantly decreased as the lesions transitioned to a monoclonal state. Inhibiting this transition might offer a strategy to disrupt tumor formation and progression.

@AsAshraf123321 @Nature Thanks Ashraf!

@exosome @Nature Thanks Dr. Thomas Ichim!

@gofinditwhy @Nature Thanks Dr. Seeker!

RT @huzheng1: Thrilled to share our paper published in @Nature, where we uncover a new process of tumor initiation through a polyclonal-to-…

RT @EricTopol: A huge day for spatial omics of cancer, tracing the precise origin and evolution of 20 types of cancer, many in 3D, in ~2,0…

Thanks @huzheng1 , Prof. Xionglei He, Prof. Zhen He, Shanlan Mo, @DuoXie1907, Xiangwei Zhai, and Shanjun Deng, collaborators/friends.

RT @KenLauLab: Excited to share our latest work published in @Nature, by grad student @mirazul302, currently on the job market. We uncovere…

RT @MattG_Jones: I'm thrilled to share our new study of the spatial evolution of Kras;p53-driven mouse lung adenocarcinoma! It's been fanta…

RT @ZLinSLU: I am so saddened to hear that Dr. Masatoshi Nei has died at 92. Dr. Nei was one of the most eminent figures in the field of ev…

@YuZhan54402885 Congrats！

RT @ZLinSLU: My lab is recruiting a PhD student in fall 2023! If you’re interested in studying eukaryotic gene regulation and/or genomics u…

RT @ZLinSLU: Very happy to share that our new paper on an R package we developed for analyses of TSS sequencing data has just published in…

@BagginsBorikens @ZLinSLU @SLUResearch @SLUBiology Thanks, Letty

RT @ZLinSLU: Excited to see our paper on evolution of transcription initiation as the cover story on Genome Research this month ( https://t.…

RT @ZLinSLU: Our RNA Biology paper is now online. We found that nucleosome sliding and histone modifications play distinct roles in control…

RT @evol_genomics: The origin and evolution of a distinct mechanism of transcription initiation in yeasts @genomer…

RT @ZLinSLU: Our new paper in Genome Research is now online. This study unravels the origin of the “scanning model” of transcription initia…