A recent study showed that morning coffee drinkers had a 12% lower risk of all-cause mortality and a 31% lower risk of dying from cardiovascular disease over a 10-year period. This benefit was specific to morning coffee drinkers, as no similar protective effects were observed when coffee was consumed in the afternoon or evening. Moderate coffee consumption stood out as being most beneficial for reducing all-cause mortality among morning drinkers: - 1–2 cups per day was associated with a 16% lower risk - 2–3 cups per day was associated with a 28% lower risk - 3+ cups per day was associated with a 21% lower risk There were no additional benefits associated with "all-day" coffee drinking, which was defined as drinking coffee in the morning, afternoon, and evening. Even though morning intake was uniquely protective, higher coffee consumption—regardless of timing—was linked to a 14–19% lower all-cause mortality risk and an even greater 28–40% lower risk of dying from cardiovascular disease. While this study can't prove causation, there appears to be a health benefit associated with enjoying this beverage early in the day that might relate to the unique polyphenols, motivation to exercise, better sleep, or resetting circadian rhythms. Study PMID: 39776171

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In one year, I genetically engineered the boring Arabidopsis into a beautiful ornamental flower 🧬🌹 Here is how and why I gave this model organism a visual upgrade 🧵(1/7)

🇺🇸 STEVE JOBS: THE BEST MANAGERS ARE GREAT CONTRIBUTORS... WHO NEVER WANTED TO BE MANAGERS "At Apple, we thought hiring professional managers would make us a big company. It didn’t work—most were bozos who could manage but couldn’t do anything else. The best managers? Great individual contributors who never wanted the job but took it because they knew no one else could do it as well." Source: BusinessX on IG

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Eating more eggs could reduce your risk of developing Alzheimer's disease by nearly 50%. And for women, eggs may mitigate changes in cognitive function due to old age. That's what a pair of new studies suggests. In one study, a higher egg intake was associated with less of a decline in verbal fluency among women during a 4-year period, with those consuming 5 or more eggs per week experiencing the greatest benefit. However, no association between egg intake and cognitive function changes was observed in men. In the other study, eating 2 or more eggs per week was associated with a 47% reduction in Alzheimer's disease risk over a nearly 7-year follow-up period. But that's not all—an analysis of brain samples from participants who died during the study revealed that consuming 1 or more eggs per week reduced the odds of having a pathological diagnosis of Alzheimer’s disease by up to 49%—indicated by the presence of fewer plaques and neurofibrillary tangles. These effects are likely due to choline—an essential nutrient that serves as a precursor for methylation, affecting epigenetics globally, and plays a role in the production of the neurotransmitter acetylcholine. Choline is also converted into phosphatidylcholine, a crucial component of cell membranes that regulates intracellular transportation. Choline literally makes up the stuff of our brain and cells. 40% of the beneficial effects of eggs on Alzheimer's disease risk reduction were directly mediated by choline intake, highlighting the critical importance of this nutrient for brain health and reducing neurodegenerative disease burden. Not only are eggs rich in choline, but they're packed with omega-3 fatty acids and the carotenoids lutein and zeaxanthin, which have well-known benefits for the brain. I'm covering both of these studies and more on eggs and brain health in tomorrow's newsletter. Sign up here to receive it: Studies referenced - PMID:39203901 - PMID:38782209

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