WallStPirate
@WallStPirate
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My posts are my thoughts and are not to be considered to be investment advice do your own due diligence.
Boston, Cape Cod
Joined February 2014
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$NWBO fantastic read about SOC changing of endpoints and OS with links to FDA showing new guidelines and other info from smith on stocks. Full disclosure I am long with 10k shares at .7 cost
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$ARWR Medicine Co purchased for 10b only owned 80% of a drug and no other meaningful ip. DRNA sold for over 3B. ALNY upgraded to 27b market cap and hemorrhaging cash. These are facts, so its easy to see how undervalued we are on a long term basis. No one thinks long term now.
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$ARWR B.Riley Financial analyst Mayank Mamtani reiterates buy rating on Arrowhead setting a price target of $106
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$ARWR Regarding HIF2, they have a10 fold increase in potency with redesigned construct and seen an 85% KD. Utilizing this strategy, we demonstrated that silencing of HIF2α mRNA (85% KD) resulted in tumor growth inhibition in the A498 xenograft model.
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$ARWR Landmark study presents evidence Alzheimer’s disease begins in the liver (Toxic proteins)
By Rich Haridy September 15, 2021
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$ARWR Its easy to get excited on up days. But once in a while you need a visual reminder of what you own. Looking at the pipeline page and seeing the lines move closer to P3 reaffirms that everything is moving along fine and no AES. We just need time.
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$ARWR ALNY announced good results for their ATTR amyloidosis this morning. This is great for all RNAi co's as word spreads about safety, efficacy and high success rate from preclinical to P3 of over 50% while small molecule is at 5% success.
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$ARWR New SeekingAlpha article about Takeda and has a lot of good information about ARO-AAT (TAK-999)
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$ARWR Coming up on month 6 for the first patient dosed for HIF2. No safety issues announced, lets hope these patients are still living as they were all late stage 3 & 4 RCC. Remember the mice that were dosed all lived and tumors shrunk non dosed mice died.
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$ARWR Can RNAi reverse aging?
The protein hasn’t previously been implicated in aging. The researchers show that the amount of the protein, called 15-PGDH, is elevated in old muscle and is widely expressed in other old tissues.
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$ARWR
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$ARWR regarding the lack of pr's and trying to find the good, look at it this way, no AE's or deaths. So sometimes no news is good news.
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$ARWR From Tad on YMB:
Ted Tenthoff after he & CA's discussion on apoc3 & ang3
Ted Tenhoff: I agree & I believe the market validated that value with Novartis 13B dollar acquisition of Medicine company just for inclisiran you know you could have two drugs like that on your own
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$ARWR Fantastic article about FCS. ARWR corporate tweeted about this earlier this week. ARO-APOC
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$ARWR From Puts and Calls on ST, Citi raises price target to $110.
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$ARWR
#RNAi
#RNAIREVOLUTION
RNAi is moving into neuroscience, UMASS announced last year patients being dosed RNAi for ALS. Let the RNAi revolution begin.
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$ARWR RE: APOC3 price for volanesorsen 11k Euro weekly for patients with FCS familial chylomicronemia syndrome. The FDA failed the drug based on safety issues of thrombocytopaenia and risks of bleeding. Euro approved based upon pressure. APOC3 will own this space. 5k patients
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$ARWR Great article about xenograft models for ccRCC and how they have vastly improved in helping extend the lives of ccRCC patients. So the 85% KD we see with RNAi with htis model is an excellent indicator.
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$ARWR has orphan status for AAT they will therefore have a 7 year exclusive. DRNA and all the other me too's can just wait in line.
Wait besides DRNA etal, Vertex could roll out another new and super improved small molecule drug that Mani can get behind.
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$ARWR In yesterdays presentation they mention Soliris as current SOC. Soliris has very nasty side effects and costs $678,000 per year.
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$RILY
This is huge news. Thanks to
@shotoneshot
$RILY would have had to file an 8-K within four days if Marcum had told them there was an error that required a restatement. Item 4.02.
So that means no errors or restatement required
Short thesis is totally dead now.
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$ARWR $PRQR $XAIR $XFOR
@elonmusk
Can someone explain how to remove all these dammm disord monopoly adds and other spam. Elon FYI, Twitter has become a cesspool of spam. We should have a SQL like simple filter not in " " . I can help you. Thanks
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$ARWR The article about FCS got me thinking about APOC3 and totally forgot that the FDA has granted orphan drug designation to ARO-APOC3 for the treatment of familial chylomicronemia syndrome (FCS).
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@jfais20
Regarding the Takeda deal, I think going it alone on AAT would have dangerous regardless of how strong the data is. No one in $ARWR has the level of experience to bring a drug to market fast and this is a way to eliminate risk and assure a fast launch to market
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$ARWR Best news of the day was when Chris said they can get through the mucus.
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$ARWR Wow the latest updates of increase in shares.
JPM increased by 934,000 shares ++++
Cetera Investments 97,000 shares ++++
Jane Street Group 134,000 ++++
and many more, look the through the list, link below.
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$ARWR Perceptive Advisors recently opened a new position in ARWR starting with 1.07 million shares after selling out all their shares last year. Guess after listening to Obiwan Anzalone they feel the force is strong with this one.
Whalewisdom link:
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$ARWR position for a tax planner / strategist. Management is already beginning the next steps to advance from a discovery development bio to a real revenue producing pharma. My post on ST confirm mngt is truly top notch with "ObiWan Anzalone" at the helm.
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@jfais20
Jonathon, we all know DIRK is game playing, but thanks for your post, you are known for being honest and having integrity unlike Dirk who went to the dark side when he sold $ARWR for under $6.00 and now has his hidden agenda,
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$RILY
So no resignation from Marcum
No sec investigation
No loan called from Nomura
Insiders still buying
Selling an asset on books for 35m for almost 1/2 billion
No people jumping out of Riley's HQ windows
Whats left besides a possible MOASS
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$ARWR
From
@BikeReider
open position post, "Principal Scientist/Group Leader, Pre-clinical Respiratory Virology"
I see the word franchise.
"Provide strategic and operational leadership for the development of a respiratory virology franchise within Arrowhead"
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$ARWR $FULC nearly doubled and has major upgrades on their DUX data and has no KD effect like we see referenced in today pr. It will only get better when in humans as again ZERO safety issues.
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$ARWR Join the 2nd RNAi Based Therapeutic Summit 2021
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$RILY Fascinating. A post from Stocktwits showing an email exchange between Marc Cohodes and a Fortune Mag. financial news reporter. News independence is out the window.
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$ARWR
New open position from Western Financial Corp. starting with 820,340 shares
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$RILY
From Gr8Tyme on Stocktwits.
$RILY Guess what yall, Marcum’s most recent Form 3 was filed today listing the clients they no longer the audit & guess who is NOT listed?
"RILEY"
This means they haven’t walked off the job like Chodes etal have been hinting at.
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$ARWR Both Twitter and TMB are talking about rumors of deal with VRTX. Does anyone have info of origin of rumor? NZ is tiny so maybe news of children recently dosed are showing great early results?
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$ARWR From Coldlander on YMB:
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ARO-ENaC updated on . Enrollment increased from 54 to 92. Primary completion extended from August to December 2021. Study completion extended from November 2021 to March 2022.
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$ARWR
@JMaraganore
$ANLY Five delicious ways to reinvent your stale potato chips. I am sure Chris Anzalone has a few other ways to make them delicous as well.
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$ARWR Why are people are talking as if ENAC or HIF2 will fail. Mouse data showed solid tumor destruction and up to an 85% knockdown. Chris states we can increase dosage as no AE's /anemia. All ARO mice lived /all placebo mice died. All 1st cohort patients had a biopsy so living.
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$ARWR Chris used the term "next generation" in this April 2020 interview article. This reads like TRIM to me.
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@BikeRieder
An absolute amazing number of items to pick from and all are serious game changers and huge addressable markets so I will take anyone but deep down want HIF2 POC data or announcement regarding trial.
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$KALA Wife put on eyvusiv today. Doc in Wakefield Ma and knows about it and prescribes it. Doc works on a chain which means a lot of potential patients. I posted the discount card she was given on stocktwits.
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$EGLX A fantastic research paper loaded with stats and info about eSports and digital advertising.
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$RILY No SEC announcements YET
PLUG offering about 50m
APLD paid back 50m
CORZ loan paid back but equity up almost 500% thats over 200m
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$ARWR Today is International NASH day, hopefully Chris will give us some additional info about HSD.
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$ARWR We went green for a moment I was getting worried that hell just froze over. Now red so all is fine in hell.
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$TGTX Great video about B from Dr. Larry Fienman from Stanford.
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$ARWR Just a note AMC has a market cap of 32 billion. We need to get into the bankrupt movie business. So looking at Game Stop and Cathie and her crack team and SPACs and this market is pretty messed up Just venting, sorry. Back to coding now.
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$ARWR Start on page 4 for great ENaC overview of "in the Era of CFTR Modulators"
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$ARWR How does the reduced ALT impact Nash and what other diseases could benefit from these early KD #'s. I thought Nash was fatty liver and we needed to reduce fat %. FYI: NASH is new to me just reading up on it. Thanks
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$HYZN Iceberg wanted a response, so the board gave him a huge response of 5M right up his ass. Now they say cover bitch! Love mngt.
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$ARWR This was another of Cathie's picks. She also said oil would never hit $70.
Cathie you have some splaining to do!
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$RILY So another weekend passes and Rily is not kaput
So what to do, just spew even more nonsense.
Even if I had no shares this is fun to watch the shorts come unhinged.
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$ARWR Easy to understand overview of C3 complement and testing. Some links to other info included.
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$ARWR For newbies. I am posting this article because of the decent overview for APOC3 (FCS) etal, not the price target or anything else. Good overview, graphics and competition ( Well there isn't any but worth the read )
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$ARWR Considering Ionis #'s. so depressed enac expression leads to better mucus clearance which leads to a better enac exp reduction. So is it safe to say the longer the treatment the more the drug gets through the mucus resulting in more reduction, etc etc.
contd.
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@TheSliv
@FTS_consult
@RNAiAnalyst
Absolutely correct and yet all we hear is how cheap they are blah blah. Buy the best and sit back and watch.
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$rily. Reddit article excellent. Looks like Reddit WSB is going long.
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@BikeRieder
In their previous filing dated 2/4/2020, BlackRock Inc. had reported owning 12,360,958 shares, indicating an increase of 1.64 %.
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$RILY At a recent presentaiton Riley said
they have over 50 suitors for Sylvan. Shorts said
it was worthless and nodoby would want it.
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@pt117cool
I went back and read the R & D 2019 presentation for HIF2 and just think the data will be amazing. AAT data points the way.
Link to presentation is below.
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$RILY
So here we are shorts and another weekend with no news of an SEC investigation but you all had a great time here as I see the Twitter feed littered with hundreds of useless circle jerk posts from all of you. Bill Abbate & Mis Robie looks like they pulled some all niters!
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$RILY To the Riley shorts cover now keep a little money and you can still have your wife or girlfriend otherwise. Ruhro!
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$ARWR Thanks to
@semodough
for his post below.
I remember Perceptive stated they closed their positon last year. link below.
Now they hold over 1 million shares. Anyone know when they went back into ARWR. Thanks
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$RILY
@WSB
@WALLSTBETS
94% owned by insiders and tutes. How can shorts cover safely. Answer -- they cannot. Time to show these #'s to the Reddit WSB crowd and let them slice and dice the short cabal and move the share price to $100
@WallStPirate
@KacKaczz
Terrible optics. I think the company is a 0 but if it doesn't make at least a new low soon, shorts are in a very crowded situation at 70% with only 16 million in the float. Insiders do own a ton as well $RILY
% Held by Insiders 45.72%
% Held by Institutions 48.65%
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ARWR GSK will assume rights and obligations of the existing license agreement between Janssen and Arrowhead, including all remaining financial obligations owed to Arrowhead for JNJ-3989 under the original agreement. GSK will be responsible for upfront and potential milestone.
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$ARWR SVB Leerink ( Mani ) maintains a $250 price on Vertex. I think there may be a little bias.
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$ARWR Us laughing at shorts all fleeing to cover. Ending of this video is perfect.
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$RILY Ask yourself shorts, do you feel lucky. Someone is covering heavy while others are buying long. The Friendly Bear fables are just that fables story is detroyed.
Who will be left holding the short stick??
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$RILY The shorts huffed and puffed and blew their brains out!!
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$CSPI Even at $100 CSPI is still under a $500 million ev.
They have two divisions, the MSP division is worth approx 200m +.
They have 25.5 m cash and no debt
Patents & contracts both regular and SaaS & reseller partnerships. Lots of leads & proof of concepts being tested now.
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$RILY Is cohodes covering to get out and let his minions roast?
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$RILY Well the shorts have one last prayer left which is they do not file. Well now that Marcum is still onboard they will file. Also may have news of Great American selling for $500 million, shorts die and Riley jumps to $40.
@WallStPirate
If $RILY can't file by March 15, then they'll be late even after the extension. If it squeezes past that date, coudl they issue stock then? Seems like a dangerous situation for both longs and shorts. Options degens could have some fun with this one.
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$RILY MWHAAAAA MHAWHAAAAA *
Battle stations
***Attn Minions this is not a drill!! This is the captain. Please start posting more nonsense and begin the circle jerk. This is not a drill. ******
MHAWHAAAA
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$RILY
They are talking about sponsorship for a golf game and rehashing a loan that was paid in full in January and Spicer. Nothing about Marcum still being the auditor or the fact that they can sell Great Amercian for a 10 to 13 x ebitda which is 350 to 500 million.
@WallStPirate
The shorts need to produce evidence to support their claim that Riley is Satan, soon. Or they might be done. $RILY
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$TGTX So no buyout coming short term with the sale of European rights. so of course panic sell and let shorts attack. Still a 3 to 5 bag over the next 2 years as sales ramp. Guess people all looking to get rich quick.
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@ozzy_jozzy
How many of DRNA's drugs are a me too of ARWR's?
Also did he forget about Medicine co?
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$RILY
@wallstbets5
@WSBetsOfficial
@WallStBets11
@wallstbetswsb
@WSBTradesAlerts
@WallStBetss
I think a Reddit nudge would squeeze this to $60.
Tell all your friends approx a 200% carry cost and stock up strong most shorts now underwater & feeling the heat. Squeeze MOASS
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@ozzy_jozzy
@Mcdivot06
@RNAiAnalyst
@cmac45068222
@Orangeman1992
@DavidNohejl
@alamentarius
1 billion dollars, 50/50 royalty US, 25% ROW. ARWR has never brought a drug to FDA approval, has no salesforce, no marketing guys in fact they know nothing about selling a drug. Takeda is paying them to apprentice and learn from one of the best.
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$RILY Is Cohodes covering? Someone should ask as he ha sme blocked.
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$TGTX Page 2, 10/1/23 United Health Cimmunity plan
B doesn't need any pre approval requirements now. They can switch at will move form O to B as prices are less.
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$RILY Did the minions know Riley did over 1 billion in deals for January 2024 alone. Over 1 billion hmmm.
This form a supposedly kaput company with employees hiding. ( More bs form the circle jerk crowd)
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@BioBoyScout
@ArrowheadPharma
@AlphaFriend
Hi, BBS. Do you know if this line in the pr means they had cirrhosis of the liver? If so, does this mean we could see great kd effect for cirrhosis / nash?
"The two patients who improved fibrosis stages during treatment were both deemed cirrhotic (F4) when the study began"
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$RILY How many of you minions thought you could actually cause a run on riley like a regular bank.
The best was when you guys stated they had questionable deposits.
Better start the circle jerk because no bank run or sec announcment coming. Keep paying that 85% ir.
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@chiragontwtr
@ArrowheadPharma
RNAi is a little different than CRSP. What this tells me is VRTX needs something as they know the AAT they have is junk and ARWR's science is working for ENAC and on all variants.
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$CSPI I strongly believe news soon.
Rockwell alone should make this a 400 to 500 m market cap stock without the MSP side of the house.
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$rily when the 10k is out then shorts are dead
They can scream and harass but it’s that simple
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I am sure both competitors and hedge funds have people all over NZ trying to dig up early info as this is a massive opportunity and threat.
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$RILY Look at this chart it seems lots of shorts entered in Nov when Rily was approx 18.50 on avg
Look at the massive multi million share increase in Nov, I think many are underwater and panicking. Isn't that when the Bill Abbates entered?
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$CSPI $NVDA $PANW
Remember the CSPI MSP aka High Performance division is worth more than the current market cap.
Right now you get Aria security, AZT Protect and its patents, contracts, leads, poc's, SaaS accounts, 25.5 million and much more for $0.
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$RILY looks like the shorts found some shares to short at a 135% borrow rate. OUCH!
Almost a million share already sold in an hour, its going to be wild for the rest of this week.
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$RILY Wait earnings announcement means the auditors signed off. Thats was the a huge premise shorts posted many times daily saying auditor left and may not sign off.
So shorts no whats the new story. I'll tell you its called.
MOASS Mother of all squeezes.
BOOM
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$RILY Rily shorts will need diapers to sleep tonite.
This is going to be a fun week.
MOASS on way. Riley may open $45.00 wowsa.
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$TGTX
Briumvi at home infusion. Not from the FB page but it was on Youtube. Anyone know about this and if so, thoughts, is this a game changer?
Wish this women nothing but the best.
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