Veena Padmanaban
@VeenaPadmanaban
Followers
185
Following
133
Media
8
Statuses
31
Hope Funds Fellow #TavazoieLab @RockefellerUniv | PhD #EwaldLab @HopkinsMedicine | Scientist by day, mom by night (&day) | Decoding breast cancer metastasis |
New York, NY
Joined December 2012
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
Oprah
• 389348 Tweets
JIN AT MILAN FASHION WEEK
• 232655 Tweets
FACE OF GUCCI JIN
• 219299 Tweets
FAYEYOKO X SRICHAND LIVE
• 139927 Tweets
XIAO ZHAN REPRESENTS THE HEART
• 76298 Tweets
TRUEDTAC5G X FB
• 66445 Tweets
GULF BA GUCCI IN MFW
• 56032 Tweets
GUCCI PRINCESS HANNI
• 55197 Tweets
大本丸博
• 36038 Tweets
#lovefighters
• 33399 Tweets
真島吾朗
• 31664 Tweets
アニポケ
• 29522 Tweets
ロバート秋山
• 22551 Tweets
Majima
• 19330 Tweets
#獅子堂あかり3D
• 18066 Tweets
貴景勝引退
• 15728 Tweets
転売ヤー
• 13237 Tweets
レイエス
• 11761 Tweets
オースティン
• 11341 Tweets
ビーズリー
• 10219 Tweets
Pinned Tweet
🚨❗️🚨 New Paper Alert
My postdoctoral work now out in
@Nature
. We find that sensory neurons drive breast cancer metastasis via an activity-dependent paracrine signalling mechanism mediated by substance-P, extracellular ssRNA & TLR7 receptor. (1/11)
$
🧵👇🏾
18
62
443
Original link broken. Find the paper here:
1
1
13
What causes metastatic tumors to be more innervated? We discovered an unexpected role for the tumor endothelium: SLIT2, an axon guidance cue released by endothelial cells of metastatic tumors drives innervation. Builds nicely off previous work from our lab (Nature, 2020). (3/11)
1
0
12
Breast tumors don’t show evidence of perineural invasion, a prognostic factor in other cancers. Yet mammary glands are very innervated. We find breast tumors are frequently innervated by sensory neurons and extent of tumor innervation correlates with metastatic capacity (2/11)
1
0
10
Excitingly, this neuro-cancer axis is targetable! An approved anti-nausea drug, aprepitant is a TACR1 antagonist that significantly impairs tumor growth and metastasis across models. Prospective studies are required to test its clinical efficacy as an anti-metastatic drug (8/11)
2
2
9
Cancer cells hyper-activate neurons to promote release of substance-P (SP) and drive metastasis. Loss of host-derived SP significantly inhibits metastasis. (5/11)
1
0
8
In 3D organotypic co-cultures, sensory neurons drive tumor growth, invasion, and colony formation. For the first time, we also show a requirement for sensory innervation in breast cancer metastasis in vivo. (4/11)
1
0
8
Very grateful to
@SohailTavazoie
for his great mentorship & support in letting me pursue this new line of work, fantastic students
@IsabelKel
and
@ESeltzr
,
@benostendorf
for computational expertise,
@theNCI
&
@HopeFunds1
for their generous support (10/11)
1
0
8
Hope to share more exciting discoveries in the
#cancerneuroscience
space soon in the “Padmanaban Lab” 🤞🏽 stay tuned! (11/11)
1
0
8
Cancer cell derived ssRNAs then activate tumoral TLR7 receptors in a non-canonical, MyD88-independent, immune-independent, PI3K-dependent manner to drive breast cancer metastasis. This TLR7 gene signature associates with poor survival in breast cancer patients. (7/11)
1
0
7
An unexpected twist: SP promotes release of ssRNAs from cancer cells and promote metastasis in an RNA-dependent manner. This RNA is coming from a small fraction of apoptotic cells that overexpress SP’s receptor, TACR1. A case of altruistic suicide! (6/11)
1
0
6
This work complements findings from
from Brian Davis,
@UdeMTalbotlab
, Moran Amit,
@MadeleineOudin
and others revealing how sensory innervation can regulate tumor progression across multiple peripheral cancers through cancer cell-autonomous or non-autonomous effects. (9/11)
1
0
5
@Ella_Maru
@Nature
Thank you! This could be worth exploring in tumors innervated by sensory nerves (seen in PDAC, head and neck, colon, and several more).
1
0
2
@sid_ereal
@Nature
Great point, thanks. We have not yet looked into what causes apoptosis downstream of TACR1 overexpression..
0
0
1
0
0
1