UK Retrosynthesis Competition
@UKRetroComp
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The 11th UK National Retrosynthesis Competition starts off with a retrosynthesis of cinnamomol B. The final will be held on Fri 08 Mar 2024!
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Pinned Tweet
The molecule for the 11th SCI-RSC UK National Retrosynthesis Competition has been released! Please send in your retrosyntheses of cinnamomol B, according to the flyer linked here ⤵️
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It's what we've all been waiting for: the first round molecule is released.
Please visit the
@SCIUpdate
website to find out more - and get your entries in by Fri 10 Dec!
#UKRetroComp
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The Round 1 molecule is now released!
Enter the competition here, and remember for the first round we want to see your retrosynthesis only!
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The 7th UK Retrosynthesis Competition IS LIVE! The molecule has been released today, all info available at 😀
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The molecule will soon be released for the upcoming 11th UK National Retrosynthesis Competition (our pfp is still from last year, don't worry)!
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And first prize *drum roll*
Goes to the 'Flu Fighters' from
@GroupAggarwal
@BristolUni
! Many congratulations for an excellent synthesis and presentation.
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The 10th UK National Retrosynthesis Competition first round molecule is now released! We are excited to see all of your entries!
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Talaromynoid A is a complex, polycyclic, natural product with many points of oxidation. If you think your team can tackle it, please get your entries in by Fri 09 Dec!
#UKRetroComp
5
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The winners of the
#retrosynth2018
competition are "The Burton Boys" from
@OxfordSynthesis
! Congratulations guys! 🏆
#realtimechem
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10
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Announcing the 2020 SCI-RSC National Retrosynthesis Competition! The molecule will be released on 28th September 2020, and the final will be held on March 19th 2021 at
@SCIUpdate
HQ, London. Start forming your teams! 💪
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Top congratulations to our winning team, These Molecules Astatine To Get On My Nerves from
@SygnatureDiscov
! 🥇
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And this year’s
#retrosynth2020
winners are "Accident and Convergency" from
@chemleedsuni
! Well done guys – great effort!
#realtimechem
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@OxfordChemistry
@UniofOxford
@ASTRAZENECAUK
@AstraZeneca
And the much-awaited first prize goes to...
¿Hola, ketal? from
@Gaunt_Group
@ChemCambridge
@Cambridge_Uni
! Congratulations! 🎉🎉🎉
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RETRO COMP 2019 IS LIVE! The first-round molecule for
#UKRetroComp
2019 has been released today, all info available at 😀
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Announcing the 9th Annual UK Retrosynthesis Competition, hosted by
@RSC_HSG
,
@SciYoungChem
&
@SCIFineChem
@SCIupdate
- the final round, with a brand new molecule, due to be held on Friday 18th March 2022!
#UKRetroComp
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The 6th UK Retrosynthesis Competition is coming to you soon 😀 Stay tuned for more info
#RealTimeChem
@SCIupdate
@RoySocChem
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To celebrate the 10th UK National Retrosynthesis Competition
#UKRetroComp
, we are going back to the start, and looking through the 10 competitions in the 10 days leading up to this year's! 🙌
Here goes: 🧵
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Our second presenters (no particular order!) are ¿Hola, ketal? from Matthew Gaunt's group at
@ChemCambridge
@Cambridge_Uni
. They had an efficient, 19-LLS route to today's molecule with a high-pressure Diels-Alder
#UKRetroComp
1
5
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The chemists are piling into SCI, ready for the 11th UK National Retrosynthesis Competition! I'll be live-tweeting today's event
@UKRetroComp
all day!
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Registration is now open! Come and see our brilliant finalists in action
#UKRetroComp
📢 Registration is now open:
Sponsored by
@Evotec
,
@SygnatureDiscov
,
@AstraZeneca
and
@GSK
#SCIwebinars
#innovation
#conference
#chemistryconferences
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Drum roll.... We are delighted to announce the finalists for this year's
#RetroComp2019
😀 This year, the judges felt that there were 11 teams that deserve to go to the final, so without further ado....
#RealTimeChem
@SCIUpdate
@RoySocChem
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Thanks all for your
#UKRetroComp
entries! We are excited to read through all your brilliant ideas. 🌟
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The third prize goes to SynCity 2000 from
@OxfordChemistry
@UniofOxford
. Congratulations, team for your excellent work!
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3rd place goes to 'Ion the Prize' from Imperial College London
@impchemistry
! Congratulations for an outstanding synthesis!
#UKRetroComp
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@CRiverLabs
Imperial College London
@impchemistry
@imperialcollege
has a team entirely composed of first year undergraduates 🤯 An Adler-Becker dearomatization was followed by several reductions to produce multiple stereocentres in a convergent synthesis
#UKRetroComp
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We're (or at least most of us are) on our way to London for the 9th UK National Retrosynthesis Competition
#UKRetroComp
tomorrow! Very excited to hear from our teams 👨🔬👩🔬
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Here are the winners!
Firstly, our audience prize voted for by those in the room went to Friday Serenade, the first year undergraduate team from
@impchemistry
@imperialcollege
! Very well deserved prize! 🏆
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Congratulations 'We Found Grubbs in a Hyp(atulone)less Place
@GSK
@UniStrathclyde
for winning the audience prize at the 2021 UK Retrosynthesis competition!
#UKRetroComp
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The 5th UK Retrosynthesis Competition is coming to you soon - stay tuned for more info 😀
#RealTimeChem
0
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In second place in the
#retrosynth2018
competition, we have the "The AZ Team" from
@ASTRAZENECAUK
! Congratulations! 🏆
#realtimechem
0
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In 2012, after the first ever Competition, we were congratulating a team from
@DonohoeGroup
@OxfordChemistry
on their winning route to pyrrolidinoindoline alkaloid (+)-alsmaphorazine E.
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The waiting is over – the first-round molecule for
#UKRetroComp
has been released! All info available at 😀
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@UofGChem
@UofGlasgow
@pharmaron
Last but not least, "A Payne in the Rearrangement" (personally that's gotta be my fave team name) from
@GSK
@strathChem
@UniStrathclyde
#UKRetroComp
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In third place in the
#retrosynth2018
competition, we have the "The atoms Family" from
@ASTRAZENECAUK
! Congratulations! 🏆
#realtimechem
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Many thanks to our sponsors:
@thermofisher
,
@SygnatureDiscov
,
@SyngentaCropsUK
,
@CRiverLabs
,
@ConceptLSGroup
,
@HeptaresTL
,
@ASTRAZENECAUK
,
@EvotecAG
,
@RedBMolecular
,
@drreddys
,
@KeyOrganics
,
@ucb_news
,
@BayerPharma
,
@VertexPharma
,
@SCIupdate
,
@RoySocChem
👍
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Save the date: the 7th UK Retrosynthesis Competition Final will be held on Fri 13 March 2020 - put it in your diary now! Molecule release date is Mon 30 Sept 2019, so start organising your teams now 😀
@RoySocChem
@SCIupdate
#realtimechem
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Thanks to team 'We Found Grubbs in a Hyp(atulone)-less Place', who picked a transannular cyclization across a 10-membered ring onto an epoxide, before finding the Grubbs of their life for an RCM.
#UKRetroComp
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In second place, we have the Dysfunctional Group from
@ADS_StAndrews
@CRITICAT_CDT
! Congratulations!
#ukretrocomp
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And of course the acclaimed audience prize - which goes to Philicity Actually, also from
@SygnatureDiscov
#UKRetroComp
🏅
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In second place in the
#retrosynth2020
competition, we have the “Carbene There, Done That” team from
@GSK
#realtimechem
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And this year’s
#retrosynth2019
winners are "Flower Power" from
@SyngentaUK
! 🏆 Well done guys – great effort!
#realtimechem
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We'll be live-tweeting from
#retrosynth2019
throughout the day tomorrow to keep you all updated, so follow us NOW if you haven't already! Good luck to all finalist teams 🍀
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The 2nd prize winners of
#UKRetroComp
2021 are 'Ready, Stetter, Go!' from
@VertexPharma
- congratulations, team!
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Those teams come from all over the UK -
@Pfizer_UK
,
@SygnatureDiscov
,
@AstraZenecaUK
,
@OxfordChemistry
,
@RedxPharma
,
@NewsFrom_MP
,
@ChemistryUoN
,
@BristolChem
,
@impchemistry
, and
@MSDintheUK
! We will live-tweet from Burlington House all day to share everybody's valiant efforts.
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And finally, in first place, we have Totally Disconnected with Base, from St Andrews! Very well done - super route & great presentation :-)
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Welcome to
#UKRetroComp
! Our first team to present is Trost Me, It Works from
@Pfizer_UK
! They featured a key Diels-Alder and their namesake Tsuji-Trost allylation, to give a total synthesis with 19 LLS sequence. Well done Pfizer! 🙌
#UKRetroComp
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"In Tsuji We Trost" from
@EvotecAG
, "Flower Power" from
@SyngentaUK
, "Shawshank Reduction" from
@OxfordChemistry
, "Totally Disconnected" from
@StrathChem
, "Reflux and Chill?" from
@OxfordSynthesis
and "The Tryptophantastic Four" from
@BristolUni
👏👍😀
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Next team "Nickel My Fancy" has some clever base metal-mediated cross-coupling reactions used to build up their main fragments
@UofGChem
@UofGlasgow
#UKRetroComp
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Huge thanks to our judges Gail Wrigley from
@ASTRAZENECAUK
, Richard Horan from
@GSK
, Mike Greaney from
@UoMChemistry
and Ed Anderson from
@OxfordChemistry
@OxfordSynthesis
for their efforts - we are super grateful!
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Back to it with
@ASTRAZENECAUK
's team AZomethine Assemblers, and a neat concomitant deprotection and double bond reduction to set their last stereogenic centre
#UKretrocomp
#AZchemistry
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Excited yet?! The
@UKRetroComp
first round molecule will be released on Mon! More info @ , sort your teams out now 😀
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We wanted some nitrogen back in the game, so we asked for syntheses of the polycyclic cage molecule phlegmadine A, with a large-ring tertiary amine.
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The audience prize has been awarded to "In Tsuji We Trost" from
@EvotecAG
- congratulations! 👍
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The moment you've been waiting for has *nearly* arrived:
#retrosynth2018
final is tomorrow! Many thanks for
@SCIupdate
for secretariat/sponsorship and to
@RoySocChem
for sponsorship through the Organic Division 😀
0
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In third place in the
#retrosynth2020
competition, we have the “The Frustrated Lewis Pair” team from
@OxfordSynthesis
and
@ucb
#realtimechem
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Audience registration (free!) is now open for the
#retrosynth2019
final! Go to and press the "Join This Event" button at the top of the page to register. Looking forward to seeing you all there 😀
@SCIupdate
@RoySocChem
0
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Without further ado, the audience prize goes to "With Pauson We Khand" from
@EvotecAG
#realtimechem
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How are everyone's first round routes going? There's still over a month to submit your retrosynthesis!
#UKRetroComp
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That's a wrap! Last but not least: team 'You'd Stetter Believe It' with a great Fries rearrangement of dihydrocoumarin, diastereoselective Stetter reaction and a bioinspired radical cascade
#UKRetroComp
0
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In no particular order, this year's finalists include: "Hold Me Closer Vinyl Dancer" from
@ChemCambridge
, "The Bloomsbury Group" from
@ucl
, "SygTeamTwo" from
@SygnatureDiscov
, "Live and Let Diene" from
@ConceptLSGroup
, "Total Synthesisers" from
@UoMChemistry
...
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How are we getting on teams?! Looking forward to receiving your entries in Dec, and hoping you are enjoying the challenge!
The 7th UK Retrosynthesis Competition IS LIVE! The molecule has been released today, all info available at 😀
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Good job team "Reflux And Chill?"! Rubottom oxidation, Wittig, relay RCM, transannular Diels-Alder, reduction with Vaska's complex to set up a Mannich reaction are key steps. 16 steps in longest linear sequence, 8% overall yield.
2
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And this year’s
#ukretrocomp
winners are the SnAZzy synthesisers from
@ASTRAZENECAUK
! Well done guys – great effort!
#realtimechem
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Tell your network you're taking part or attending
#UKRetroComp
this year by joining our LinkedIn networking group!
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The final three teams are "Mannich Black" from
@SygnatureDiscov
, "Flower Power" from
@SyngentaCropsUK
and "The Radical Strikes Back" from
@ConceptLSGroup
. Very well done to all teams - we look forward to seeing you at the final 😀
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Just over three days to go until
@RetroComp
entries are due! Hope you are all ready, as the judges are looking forward to receiving their work 😃 The top ten teams will be selected to present their forward synthesis at the final
@RoySocChem
@SCIupdate
#realtimechem
0
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Taking part in this year's National Retrosynthesis Competition?
Tune in and get inspired by 3 of last year's winning teams, in our
#SCIwebinar
at 15:00 BST tomorrow!
Don’t forget to dial into tomorrow's Special SCI Webinar Session at 15:00 on Tuesday 21th July. We’ll be Showcasing the Winners of the 2020 National Retrosynthesis Competition from
@UniversityLeeds
@GSK
and
@Evotec
#SCIWebinar
#retrosynthesis
#organicsynthesis
#organicchemistry
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0
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Many thanks to our sponsors:
@thermofisher
,
@SygnatureDiscov
,
@SyngentaCropsUK
,
@CRiverLabs
,
@ConceptLSGroup
,
@HeptaresTL
,
@ASTRAZENECAUK
,
@EvotecAG
,
@RedBMolecular
,
@drreddys
,
@KeyOrganics
, ,
@ucb_news
,
@BayerPharma
,
@VertexPharma
,
@SCIupdate
,
@RoySocChem
0
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In second place in the
#retrosynth2019
competition, we have the “Shawshank Reduction” team from
@OxfordSynthesis
🏆
1
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Thank you to team 'Cyclopropane and Suffering' from
@UoMChemistry
- strain-release-assisted cyclopropane opening followed by a Diels-Alder and late Dieckmann condensation!
#UKRetroComp
0
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We are super grateful to
@SygnatureDiscov
for sponsoring this year's
#retrosynth2018
😀 Looking forward to the final on 16th March!
0
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The final team of the morning's session was SynCity 2000 from
@OxfordChemistry
@UniofOxford
They proposed a multiply oxidative cascade to form much of the core of cinnamomol B
#UKRetroComp
1
3
9
Many thanks to
@SygnatureDiscov
for their generous gold sponsorship of this year's
@UKRetroComp
- we are really grateful for your support!
Would YOU like to sponsor us too?! Opportunities still available, contact info at: 😃
0
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And that's a wrap on this year's competition! Congratulations to all winners and finalists. And well done Trost Me It Works from
@Pfizer_UK
!
#UKRetroComp
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Good job team "Hold Me Closer Vinyl Dancer"! Key steps include Cu-catalysed enantioselective 1,4-addition, Robinson annelation, Shi epoxidation, intramolecular Tsuji-Trost, photocat oxidative vinylogous Mannich reaction; 23 steps and 1.2% yield
0
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This molecule has since been made 'in real life' by Hanfeng Ding & coworkers. I wonder what similarities there are between the two routes!
#UKRetroComp
1
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Thanks to all teams for submitting your retrosyntheses on Friday 👍 They are now being processed then will go to the judges for their consideration - good luck to all teams!
#RetroComp2019
@RoySocChem
@SCIupdate
0
5
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Taking part in the 2021 National Retrosynthesis Competition?
Before the molecule is released on 28th September, tune into our webinar to see how some of last year's winning teams made their routes!
Don’t forget to dial into next weeks Special SCI Webinar Session at 15:00 on Tuesday 21th July. We’ll be Showcasing the Winners of the 2020 National Retrosynthesis Competition from
@UniversityLeeds
,
@GSK
and
@Evotec
#SCIWebinar
#retrosynthesis
#organicsynthesis
#organicchemistry
2
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0
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Thanks to everyone who attended the
#Ukretrocomp
final yesterday for making it such a great day - looking forward to next year already 😀
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@SCIupdate
@RSC_HSG
@SCIYoungChem
@SCI_FCG
First up, Team "Oops!... I Oxygenated Again" from
@AstraZenecaUK
Macclesfield showed their synthetic prowess including a series of early oxygenation steps and a Pauson-Khand
#UKRetroComp
1
2
9
Huge thanks also to our sponsors
@thermofisher
,
@SygnatureDiscov
,
@VertexPharma
,
@pharmaron
,
@SyngentaUK
,
@Bayer
,
@RoySocChem
,
@CRiverLabs
,
@ASTRAZENECAUK
,
@EvotecAG
,
@ConceptLSGroup
,
@KeyOrganics
,
@GSK
,
@SCIupdate
,
@RedBMolecular
👍👏
0
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Good job “If Pauson-Khand’t Do It…” from
@StAChemistry
! List enantioselective epoxidation, Peterson, Pauson-Khand, Corey-Chaykovsky, Appel, Rubottom,
@LeonoriLab
radical addition, 15 steps LLS, 17% predicted yield
0
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First team to kick off the competition is The Last Sakurai from
@pfizer
- they bravely chose to embed SELECT criteria & devise a scalable route to phlegmadine C!
#PfizerChemistry
#ukRetroComp
0
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Just over a month until the
#RetroComp2019
submission deadline - how are you all getting on teams?! All info available at , still time to get a team together if you haven't already 😀
@SCIupdate
0
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The
#retrosynth2018
audience prize also goes to "The Burton Boys" from
@OxfordSynthesis
! Fantastic synthetic route and presentation - well done! 🏆
#realtimechem
0
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Just under two weeks until the
#RetroComp2019
submission deadline - feeling the pressure yet??!! All info available at , judges are looking forward to receiving your entries 😀
@SCIupdate
0
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Next we hosted Team If You Like (Semi)Pinacol-Adas from
@CRUKresearch
- they show a neat route with biocatalysis right at the start and computational support for their decisions
#UKRetroComp
0
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Well done "Live And Let Diene"! Key steps: HWE, Diels-Alder, two Au-catalysed cyclisations, Robinson annulation, photoredox-catalysed Giese coupling and sp3-sp3 radical cross-coupling, Pd-catalysed thiol coupling. Longest linear sequence 22 steps, overall yield 1.5%
1
2
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Good job “The Frustrated Lewis Pair” from
@OxfordSynthesis
and
@ucb_uk
! Key steps include , hydroboration-Suzuki cascade, Sakurai allylation, RCM, Danheiser-Stork transposition, Co-catalysed hydroboration, Simmmons-Smith, with mix & match routes to the fragments also discussed!
0
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More information on the
#retrosynth2019
molecule can be found in the following paper: Org. Lett. 2018, 20, 816-819
@JOC_OL
0
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Sygnature Discovery's team "Diels-Alderley Park" showed a couple of choice cycloadditions in their synthesis
#UKRetroComp
1
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The moment you've been waiting for has *nearly* arrived:
#retrosynth2019
final is tomorrow! We have a full house and we're looking forward to welcoming you all to Belgrave Square - registration starts at 10.30 and the competition gets underway at 11.00 😀
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Great work again by team SynCity from
@OxfordChemistry
. They do a key photoredox cyclization with NHC catalysis late in their synthesis to tie the two halves of their molecule together into a central ring.
#UKRetroComp
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