Tiffany Cheing Ho, Ph.D.
@TiffanyCheingHo
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Assistant Prof @UCLA Psychology studying adolescent brain development, depression, stress 🧠
SF 🌁✈️ LA☀️
Joined August 2016
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Pinned Tweet
Inspired by other faculty throughout the country who are offering their mentorship to black scientists, I’ve created a Google spreadsheet with a list of folks so far I’ve seen on Twitter.
I hope this will be a useful resource for
#blackinSTEM
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💙💛In Nov, I will be joining the Clinical Area of the Psychology Dept at
@UCLA
💛💙
If you are interested in studying stress, depression, & 🧠 dev in teens, please reach out!
I will be admitting 2 PhD students for Fall 2023 + hiring a lab manager, RAs, & postdocs Jan 2023!
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I just submitted my first R01 focused on examining the confluence of inflammation, glutamate, and social stress in depressed adolescents! 3 months of writing but 3 years of planning and piloting. Poured my ♥️ into this and hoping we get a chance to do this project🤞
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Another day, another grant rejection...anyone have tips on staying resilient in a soft $ gig? 🥺
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Our review on psychobiological risk factors for suicidal thoughts and behaviors in the context of pubertal development is now out in Molecular Psychiatry! Huge thanks to
@gifuni
&
@GotlibLab
for working patiently with me on this🙏🏻
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So my R21 that is supposed to be reviewed in less than 2 weeks was WITHDRAWN due to the inclusion of hyperlinks in my Biosketch and RS (including linking to GitHub and bioRxiv preprints). Looks like I can either appeal and/or resubmit the app June 16. Advice?
#academicnightmare
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I am so proud of this new review on early adversity, 🧠, and depression risk with
@lucysking
! Online now at Translational Psychiatry
@nresearchnews
:
“Mechanisms of neuroplasticity linking early adversity to depression: developmental considerations”
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🚨JOB ALERT🚨
Looking to hire✌🏻Study Coordinators to manage data collection for a new study on how stress affects🩸 and 🧠 in depressed teens! Ideal start date Jan 2023. Great opp for aspiring clinical psychologists or neuroscientists!
Please RT!!!
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This is why women leave science (and why I would have also if my partner was not in tech). We must do better.
Did you know:
UCSF daycare is $2800/mo for infants? 😳😳😳
A UCSF 2bedroom is $2779/mo
$5579/mo in just rent and daycare 🤯
To afford rent, daycare, and everything else, I have a 2x90min commute and live 30miles away from campus.
It is very difficult.
@UAW5810
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I am stoked to be joining the editorial board of BP:CNNI 🎉 🎈 🎊
@SOBP
♥️🧠
Citations for our journal reached an all time high this year with 50,155 📈Thanks to all of our contributors for doing such impactful (no pun intended) work 🤗
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🚨 JOB ALERT 🚨
Looking for full-time coordinators to work on multimodal neuroimaging projects related to adolescent stress and depression! 🧠 🩸
Start date: Anytime between Jan 2024 to June 2024
Must be willing to 🚗 (in LA traffic 🥲)
E-mail me with CV + 3 refs!
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Now out in
@TheJCPP
!
BWAS-y ML approach to predicting depression Sx in the ABCD study (test N=2k). We confirm what Marek et al. have been reporting: rsfMRI FC is consistently a stronger predictor of Sx than structural MRI but associations are small…
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Starting off the year of the 🐮 right!
Thrilled to share our preprint where we used machine learning techniques to predict CBCL depression scores from clinical, sociodemographic, and MRI-based features from
#ABCD
at baseline and one-year followup!
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This cycle is the first time I received formal rejections from all the TT positions I applied for. I hadn’t realized how much more respected I feel as a result, despite the disappointing outcome. Hoping more depts/SCs spend the time to write/send these—it makes a difference!
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Being a successful researcher doesn’t make you a good researcher.
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We are so excited to welcome Shiba this fall! 💙💛💙💛
Beyond thrilled to announce that I will be starting my PhD in Clinical Psychology this fall
@UCLA
under the mentorship of
@TiffanyCheingHo
! Can’t properly put into words how excited I am to join such an incredible lab and department.
#AcademicTwitter
#psychtwitter
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I am so proud to be a part of this society that values innovative brain science and diversity, equity, and inclusion! I pledge to use my invitation to further the mission - if you are an URM ECR interested in attending
@ACNPorg
in the future, please reach out to me!!!
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THESE CANNOT BE REAL OMG
The real reason they discourage MRIs during pregnancy is because then people would realise they’re incubating nightmare demons and would be rightfully terrified
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@DeniseLit4Kids
You are her greatest joy and we can all see why. I lost my grandmother last week and was fortunate to be there to hold her, have her kiss my hand, and call me her treasure on her last lucid day. She too called for her own mother before passing. I pray for a peaceful transition.
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As a parent of a 3 yo and 6 month old, I am overjoyed. I never thought this day would come!
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Thank you
@washingtonpost
for highlighting our study in BP:GOS where we found more internalizing Sx, larger amygdalar & hippocampal volumes, thinner cortex, & older brainAGE in peri-pandemic v. pre-pandemic youth.
Check out
@GotlibLab
’s comments here:
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@MarcusCrede
Assuming two effects are different because one is “significant” and one is not without directly testing the difference
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2 grant rejections (5 total in the past 2 weeks) and an editorial rejection for the first paper from my K study. When it rains it pours!
#academicchatter
#newpislack
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Straight up cried reading this. To all the new faculty who are also new parents…I see you.
For the new faculty out there, here is a brief summary of my first 18 months as a professor, 16 years ago, as I remember it today. This came up on Facebook:
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Now out in DCN: a cross-species systematic review examining associations between puberty—defined based on staging and/or hormones—and adolescent white matter!
This pre-COVID project was a labor of love for David Piekarski,
@natalie_colich
, and myself 💓
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Thrilled that our protocol paper for my K01 study “Teen Inflammation, Glutamate, & Emotion Research” is now out!
We lay out the scientific motivation for examining peripheral inflammation, glutamate in the ACC, & neurophenotypes in depressed teens...
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Who are the 30%?!?!?!
In a poll of 1,122 US faculty members almost 70% said they felt stressed in 2020, more than double the number in 2019 (32%)
Work time has increased due to the extra time required to teach online, even as many people have far less child care and support.
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Taking in this view before our grantwriting workshop! Excited to be speaking with
@darbysaxbe
, Kate McLaughlin,
@salovphd
, &
@Divyanganar
!
#Flux2022
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Congratulations to everyone who has been awarded a Ford or NSF! Based on my Twitter feed you’d really think the vast majority of applicants receive these awards when it’s really the opposite. For those who didn’t get it this year, submitting is a huge accomplishment already!
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🚨🚨🚨JOB ALERT🚨🚨🚨
I am looking to hire an SRA to help with NIH-funded multimodal neuroimaging 🧠 projects in depressed pt! Experience working with this population and with statistical software is strongly preferred! Please apply by March 1! 👇🏻
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Can’t wait to be speaking on “Markers and Mediators of Brain Maturation and Psychiatric Risk in Adolescence: A Cross-Species Perspective” with
@cfloreslab
@AshCParr
@K_dele
@bealuna55
at
@ACNPorg
at the end of the year! 💃🏻 ☀️ 🧠
#acnp2023
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“We recommend candidates submit the research they are most proud of, regardless of journal or publication status.”
This is so refreshing to see 😍 Three openings at Vanderbilt’s Dept of Psychology and Human Dev!!!
We're hiring!!
Cluster hire of 3 assistant prof of psychology
We seek candidates who will increase the department’s commitment to diversity, equity, and inclusion through their research, teaching, mentoring and/or lived experience.
More details at & ⬇️
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Check out commentary in
@BiologicalPsyc1
discussing studies that predict youth depression from a large array of variables!
Results from consortia such as IMAGEN, ABCD, &
@enigmabrains
narrow the parameter space & guide the design of smaller n studies 💫
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Truly outstanding talk by
@MJalbrzikowski
on using MR-based risk scores for youth at risk for psychosis and working toward a *scalable* and *portable* measure of this by leveraging low-field MRI!
#ACNP2023
@ACNPorg
Check out her recent paper:
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Incredible longitudinal study by
@LaraWierenga
showing greater variability in the developing male brain (see also her 2018 cross-sectional paper in Cerebral Cortex and
@StuartJRitchie
’s 2018 cross-sectional paper on adults from UK BioBank also in Cerebral Cortex)!
New work from our lab: where we tested if sex differences in school performance are related to sex differences in brain maturation
With
@MariekegnBos
@FabiennevanRossenberg
, and
@EACrone
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New preprint from
@GotlibLab
! Perceived severity of early life stress is associated with social anxiety, and flexibility of the autonomic nervous system mediated this association in female adolescents!
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Stress is a key nongenomic factor that contributes to nearly all aspects of depression—onset, maintenance, and outcome—and is a driver of neuroplasticity. Honored to comment on this topic with a recent paper from the ADEPT study published in
@SOBP
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Reunited and it feels so good!
@GotlibLab
members past and present (and honorary member
@ArielleKeller
)! So proud of you all! ❤️❤️❤️
#flux2023
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🚨JOB ALERT🚨
Looking for a master’s level RA to assist with building lab infrastructure and preprocessing multimodal MRI data related to adolescent 🧠 development and depression in sunny Los Angeles 😎. Ideal start date Jan 2023.
Please RT!!!
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I am so unbelievably grateful for this talented and hardworking group! 🥹 And so proud of Abby for getting into one of her top Clinical Psychology programs already! Go CANDY Lab! 🍭 🧠
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If the amazing science isn’t enough to convince you to attend
#sobp2023
then perhaps this paella is!
#twittersupperclub
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Overjoyed to share our latest work published in BBI showing that lower FA in the corpus callosum genu may be a preferential target of inflammatory signaling in adolescents!
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The one and only
@bealuna55
the Huttenlocher award winner! The roasts—I mean, intros—were so touching ❤️Congratulations!!!
#flux2023
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Preprint of our harmonized meta-analytical investigation on subcortical shape differences in depression from the
@enigmabrains
MDD working group led by
@lianne_schmaal
is live:
Thrilled to have worked w/ Boris Gutman & researchers from around the world!
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@ryanlei_psych
@Sakiera_Hudson
They’re expected to have publications to be competitive for the GRFP *before* they even get into grad school. And people be complaining about the GRE…
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I am legit obsessed with this paper! One of the best examples of applying ML methods to passive sensing data to predict mood states in adolescents. Check it out!!! 👇🏻👇🏻👇🏻
🚨Now out in Psych Med. Can we predict when teens are in a state of high negative affect based solely on passive smartphone sensor data (e.g., accelerometer, GPS, device state)? New paper (led by Boyu Ren) from our lab focuses on this question. 1/n
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Please RT!!! And if you would like to be added onto this list please fill out this form:
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I am obsessed with this paper - what an incredibly sophisticated set of analyses but used in a way that elegantly furthers our conceptual understanding of how the timing of adversity impacts white matter development! Go
@lucinda_sisk
,
@dylanggee
, and team!!! 🌟
‼️Excited to share a new preprint! Using a novel measure of adversity exposure (the DISTAL), we characterized links between the developmental timing of adversity, integrity of brain-wide white matter tracts, and mental health symptoms (1/8)
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How much of your startup (assuming no expiration) should you spend by year 1, year 5, etc?
Every single aspect of research becomes more expensive every year so I also want to make sure I am saving enough to support trainees (& for rainy days)…
#newPI
#AcademicTwitter
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@DrNadiaChaudhri
For you to find a way to lift others up during such a difficult and distressing time is beyond inspiring. Thank you for what you have done for your field and also for junior scientists everywhere.
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PIs: if you are funded by NIH you likely can apply for admin supplements to support URM at the level of research assistants, grad students, & postdocs. URM is defined not only as race/ethnicity but also disabilities. Happy to share funded examples - DM or email me!
#BlackInSTEM
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UPDATE: I received a thoughtful and sympathetic response from CSR but my appeal was declined due to the links in the RS which was seen as a way of adding more info than allowed. NIH also has specific concerns about reviewer confidentiality/tracking with GitHub.
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I swear, 90% of the new papers I read/skim come specifically from
@JamieLarsH
’s tweets. No need for Google Scholar alerts!
The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback
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Check out our latest paper from the TIGER 🐯 study! Consistent with animal models of inflammation-induced glutamatergic excitotoxcity, we are finding that ⬆️ levels of peripheral cytokines are associated w ⬆️ glutamate in the dorsal ACC in depressed teens
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Surely they meant “25.2 hours” and not minutes?
Americans lost an average 25.20 minutes of sleep on election night: analysis
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Lost 5% of my weight since working on my R01. Trying this tonight as grantwriting fuel.
#AcademicTwitter
#AcademicChatter
#istudystress
#theirony
#fundmesoicanfeedme
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New preprint from
@natalie_colich
and
@GotlibLab
! We found that sex moderates associations between longitudinal changes in testosterone and longitudinal changes in fractional anisotropy in several major white matter tracts in teens. Feedback welcome!
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“The amygdala is not a fear circuit but instead a defensive survival circuit.” Brilliant piece by
@theamygdaloid
. This and work by Miller et al. inspires me to think of the neural circuits I study in teens from an approach-avoidance perspective:
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Anhedonia is a multifaceted construct that can be expressed across different domains of functioning (social, physical). If you’ve been wondering how anhedonia contributes to suicidal thoughts and behaviors, read this amazing review by
@Auerbach_Lab_CU
!
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Many of these links were in my R01 application submitted last fall which didn’t cause any problems. But given the tweets I’ve seen on this topic I should have even more careful. FML. Hope this helps anyone working on NIH grants right now...
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It blows my mind that Ruby Bridges is only 10 years older than Kamala Harris. The wounds of racial injustice are still very fresh in our young country. May the Biden-Harris administration be the beginning of a journey toward healing and unity.
Ruby Bridges, age 6, being escorted into school by U.S. marshals, when she became the first Black student to integrate an elementary school in the South, by Norman Rockwell.
Madam Vice-President-elect Kamala Harris & the silhouette of Ruby Bridges. By Bria Goeller
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Ordering takeout for just myself and getting three sets of utensils
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“Neurodevelopment is not merely a process of brain maturation, but an adaptation to constraints unique to each individual and to the environments we co-create.” 🔥
Understanding divergence: Placing developmental neuroscience in its dynamic context
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#ACNP2023
was truly memorable - thanks to
@cfloreslab
and
@bealuna55
for bringing us together and thank you to all who stayed through W and attended our session!
(I have also never had so much 🍷 in my life…Bea studies approach behaviors for a reason 😆)
@K_dele
@Sarabellum128
@BeaLuna
We had an amazing panel at
@ACNPorg
with
@AshCParr
,
@TiffanyCheingHo
,
@Sarabellum128
, and
@bealuna55
. We missed you
@K_dele
. But getting ready for the next one!!!
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One of the most brilliant pieces I’ve read on outcomes in depression research.
“It could be argued that the goodness of any marker in medicine is judged against its ability to predict not just a narrow trial target, but outcomes that really matter to the individual and society.”
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Inspired by and indebted to you both in so many ways…love hearing about your exciting research and the meteoric growth
@lucinda_sisk
and
@aojha7
! How far we have all come from our
@GotlibLab
days 🥰
#Flux2022
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Check out our latest review on why graph theoretical metrics may be helpful for understanding the effects of stress on the developing adolescent brain and where we can go from here! Special thanks to Emily Dennis,
@PTenigma
, and Ian Gotlib!
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Ecstatic to chair a symposium at
@SRCDtweets
on intrinsic network connectivity patterns associated with suicidal & NSSI in adolescents w/
@a_wiglesworth
, along w/ talks from
@Jackie_Kirsh
&
@dr_mindyws
!
There will be big data, 🧠 connectomics, & machine learning - can’t wait!!!
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Humbled to have our study examining sex diff in sensitivity to ELS (perceived severity accounting for objective severity) as a mediator of ANS functioning following a social stress challenge -> soc anx in 163 adolescents in this SI honoring
@GunnarMegan
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Incredible talk by Dr. Nim Tottenham, inaugural awardee of the Linda Spear Award
@Flux_Congress
@FluxSociety
#flux2022
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@DiegoPizzagalli
@MaryPhillips23
@LeonardoTozzi1
& Lisa McTeague bringing in the crowds at
#SOBP2023
! The Taylor Swifts of clinical neuroscience!
@SOBP
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Anyone else crying from hearing Amanda Gorman recite her poetry? My heart swells at the idea that we can be allowed to hope again.
#InaugurationDay
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Excited to share our new 🐯 paper now out in
@npp_journal
:
We combined quantitative + diffusion MRI to estimate R1 (1/T1) signal in major WM tracts in depressed & non-depressed adolescents & found higher R1 in uncinate & callosal tracts in the MDD group
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Great q by
@DPagliaccio
at the dev cohort study discussion on how the landscape of big data has shifted the expectations of reviewers which disadvantages jr scientists. Deanna Barch responds with a call to arms for reviewers to dev more appropriate expectations 👏🏻
#acnp2022
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Extremely proud of our latest TIGER study in Trans Psych:
We compared depressed teens w and wo Hx of self-harm w CTL on rsfMRI networks. Lower coherence of ventral DMN is associated w SI while lower coherence in insular-somatosensory SN is associated NSSI
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Although my experience in going on the job market and negotiating an offer is strictly limited to the UCs, please reach out if you’d like to see my materials and hear my observations! I want to pay it forward best I can✨
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This study found that Dutch male & female profs don’t differ in their external service but do in their internal service (75% women, 25% men)!
Several male profs also said they “actively didn’t respond to emails, or acted in an exaggerated disorganised manner” to avoid service.
A study on what many of us already know: over 75% of internal service work in academia is done by women. “We were surprised by how brazenly the male researchers described their priorities, for example that they actively didn’t respond to emails”
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IF can be gamed. I cite more papers from NPP than I probably do from Nature, Science, and Cell combined. Everyone I know in the field of biological psychiatry would be thrilled to publish in NPP. As a reviewer, I’ve loved seeing the rigorous science. Support society journals!!!
I feel that this is a damned if you do, damned if you don't post, but hey I'm having a crappy day anyway, so flame away. In the spirit of transparency and not being a hypocrite we wanted to announce that our impact factor for
@npp_journal
declined year over year to a 7.6
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Huge thanks to everyone who helped me navigate this 🤯 process! It is impossible for me to list everyone here but major shoutouts to
@FumikoHoeft
,
@LucinaUddin
,
@regilapate
,
@laurel_joy_gd
,
@JASilvers
,
@BridgetCallagh3
,
@K_L_Humphreys
,
@GotlibLab
,
@knutson_brain
,
@serences
💛
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Celebrating a successful
@NIMHgov
CREST visit! We prepared for months for this but are genuinely thankful for the support by this program in executing our mechanistic R01 based on good clinical practice 🫡
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Very appreciative of the advice by
@russpoldrack
in running a lab! He recommends aiming for inbox zero and even spending a few minutes a day cleaning your desk. Messiness and disorganization can and often represent a point of friction that prevents workflow optimization…
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So it turns out I’ve been mispronouncing both “Likert” and “PNAS”
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My decade in emojis!
2010: 👫🏻 🇹🇼
2011: 💔👴🏻
2012:👩🏻🎓👩🏻💻 🌉 🇹🇼🇭🇰🇯🇵
2013: 👰🏻🤵🏻 🇹🇼
2014: 🇹🇼🇹🇭🇱🇦
2015: 🏡 🐱 🇹🇼
2016: 👩🏻💻 🇳🇱🇫🇷🇭🇷
2017: 🏃🏻♀️💔👵🏻🇹🇼🇹🇭🇻🇳🇲🇽
2018: 🤰🏻🇲🇽
2019: 👶🏻👩🏻🏫
Wishing everyone a happy and healthy 2020 and beyond!
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Check out this incredible piece by
@SomersJenn
, one of the most thoughtful scientists I’ve ever worked with:
Integrating Biobehavioral and Environmental Components of Developmental Psychopathology via Interpersonal Dynamics: An RDoC-Advancing Model
Excited to emerge from the hurricane & share one of my favorite papers yet! We argue biobehavioral and environmental processes in the etiology of psychopathology can be integrated via interpersonal dynamics; this is a much-needed way to bring the environment into the
#RDoC
matrix
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It’s time to move away from
@the
reductionist idea that Amygdala =/= fear and Nacc =/= reward!
🚨 New Paper Alert 🚨
The final part of my PhD work is out in
@sfnjournals
with
@mahsamoaddab
&
@mikemcdannald
!
I recorded NAcc neurons during fear discrimination and found the NAcc to be a source of threat information and valence hub. Thread below 👇🏻
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Normalize eating half a tub of Red Vines when you have all the deadlines happening in the same week that democracy is crumbling
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Please check out our latest work in Psych Med and
@aojha7
’s comprehensive 🧵 on the findings 👇🏻
Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation
Thrilled to announce that our new paper (10.1017/S0033291722002239) is now out in Psychological Medicine! We investigated the extent to which social stressors, in particular, relate to neurodevelopment, and adolescent depression symptom severity over a 9-month period. A 🧵 1/n
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Going on the job market last year was one of the most rewarding yet challenging things I’ve had to do as an introverted and illness-prone academic. Remember that there are factors behind your control and to celebrate putting yourself out there—regardless of the outcome!
I’m on a search committee this year, and we just rejected some amazing candidates for our faculty position. Important PSA: it's not personal. A rejection is (truly!) not a referendum on you or your skills/qualifications. More often than not, the decision comes down to fit. 1/
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Thrilled that our replication study is now out in JAD (and free for 50 days):
More details in 🧵 below👇🏻
Check out our paper (now published!!) replicating results showing smaller dorsal striatal grey matter is associated with implicit suicidal ideation! 🧠
@TiffanyCheingHo
@GotlibLab
@aojha7
@Jackie_Kirsh
@WalkerJ_C_
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Relieved but not satisfied. Justice demands change. The outcome of a single trial is a step toward change, but it is not an upheaval of a system that needs to be dismantled.
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