Renegade Research -- #TheNicotineTest
@TheNicotineTest
Followers
5,007
Following
575
Media
93
Statuses
2,361
A Patient-Led, @RemissionBiome , @RenegadeRes Project. Nicotine Patch data collection/sharing for #LongCovid , #MECFS /post-viral disease. Admin: @Canal1point5
The world
Joined May 2023
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Pinned Tweet
Don't Rush into Low-dose transdermal nicotine!
1. Watch our YouTube videos
2. Join the private FaceBook group for support
3. Go slow and low...
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Hello
#TheNicotineTest
#LongCovid
#MECFS
Tribes!
Safety Guidelines (3.0) are published!
🥳
And FAQs are updated
🤔
And a Handy Linktree Page
🔗
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#TheNicotineTest
Links!
Survey!
Protocol 2.0
Step by Step Dose
Objectives & Doubts
Hypothesis 1.0
Dr
@LeitzkeMarco
's Hypothesis
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#TheNicotineTest
Survey update... So far, we have n=127 responses on the survey 1.0.
I have done an extensive review of the data (37 pages) and a short (9-page) summary... but now.... I have to wait to share the data because it may be published, which is good news!
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#TheNicotineTest
Protocol 2.0 in graphic format.
Video for Easier Viewing.
For
#LongCovidAwareness
day!😍
@LeitzkeMarco
@petri_pellinen
@TheNicotineTest
#LongCovid
#TreatLongCovid
#longhaulers
#POTS
#PEM
#brainfog
#pwLC
:
#vaccineinjuries
#MECFS
#millionsmissing
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#TheNicotineTest
basic flowchart of the safety guidelines protocol 3.0 has been added to our linktree.
😃
Feel free to share across social media with your
#LongCovid
#MECFS
and
#Fibromyalgia
groups.
🤗
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More good news with nicotine patches! After decades!
Persistence pays off!
#LongCovid
#MECFS
#success
😍😍😍
We are 💪 together!
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#TheNicotinePatch
#Success
#LongCovid
#MECFS
come in many forms. Even professional athletes. A good endorsement of taking a break to see if you are doing even better!
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Anyone have contacts in the
#pharmacy
industry that can help?
We need to find a manufacturer who can make patches that are easier to adjust/taper the dose.
#NicotinePatches
with gradual dose changes
of 1, 1.5 or 2 mg.🦥
The would improve outcomes!
thenicotinetest
@gmail
.com
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#TheNicotineTest
The first Survey review (n=110) will be released in the coming days.
The first version (with graphs is 40 pages long!).
We will try to do a condensed, easy-to-understand summary.
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"pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2."
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"We found that nicotine exposure delays and dramatically attenuates CNS inflammation and autoimmune responsiveness to myelin Ags, suggesting several novel mechanisms of neuroimmune interaction."
#TheNicotineTest
#research
#LongCovid
#MECFS
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#TheNicotineTest
#research
"nicotine exposure increases autophagy activation in human fibroblast cells 31, human cancer colon cells 32, and bronchial epithelial cells 13. These findings suggest that nicotine is one of the key activators of autophagy."
.
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@PutrinoLab
A doctor asked me if "Long Covid" meant that I was contagious... to see if he should put on a mask... in 2023! Ignorance abounds.
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A Good summary from
@ahandvanish
.
Low-dose nicotine patches are not a magic pill, but many people increase their baselines and improve their quality of life. Every little bit helps.
For some, it is that missing piece of the puzzle to heal.
#LongCovid
#MECFS
I've been doing
#TheNicotineTest
(via 7mg patches) for a month now & it has greatly improved my quality of life.
Major caveat: I'm on ivabradine. The nicotine increases heart rate, & I wouldn't recommend to anyone w POTS who isn't on beta-blockers or ivabradine.
#LongCovid
1/
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It is odd...but many report feeling fantastic after vomiting 🤮...when they overdo the dose of Nicotine Patches.
What could be the exact mechanism? 🤔
#LongCovid
#MECFS
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More
#success
from
#TheNicotineTest
.😍
Don't give up hope!
....
We are stronger 💪 together!
#LongCovid
#MECFS
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"...
#Nicotine
could inhibit glucose hypermetabolism...which in turn helped to ameliorate cellular energy metabolism disorders."
#TheNicotineTest
#research
#LongCovid
#MECFS
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@pamelarbishop
There is a recent study where they tested for "3 boring metabolites" related to lactate, glucose and insulin and found a higher correlation with dementia than amyloid beta. It was found by an algorithm. Researchers admitted never thinking of looking at those.
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#TheNicotineTest
#success
Not a magic pill or cure... But it is helping so many people 😍
Keep going!
Keep testing!
Keep sharing and helping others!
Together we are stronger 💪
#LongCovid
#MECFS
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#TheNicotineTest
#success
story from our private Facebook group.
If you see benefits, don't give up! Keep going! There is hope!
#LongCovid
#pwLC
#SARSCoV2
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#TheNicotineTest
#research
has made a huge leap with the brilliant, detailed hypothesis from
@CiaraGlenville
👏👏👏
TLDR:
DMN... Is similar to "fight or flight" mode.
Nicotine turns it off... Or resets it. ⤵️👀
A unifying *hypothesis* to explain the seemingly miraculous response to
#TheNicotineTest
and how it might prevent PEM in
#LongCovid
#vaccineinjured
#mecfs
- a root cause approach to PEM by modulation of the Default Mode Network in the brain. Very long thread incoming!🧵
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Here is a little update from
#TheNicotineTest
survey with n=62.
We will publish a complete summary when we get to 100.
🧵
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There will be new safety guidelines (v3.0)... with small changes to hopefully reduce the chances of some people finishing with a lower baseline and to increase the gains of others. There will be a new survey soon (v2.0) to better inform future safety guidelines.
🙏😀
3/3
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#TheNicotineTest
#LongCovid
#MECFS
The Survey,
all documentation, protocols, instructions available in this pinned thread!
Only 5 minutes!
🧵
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More details from this fantastic success story. Only 3 rounds...and it has been 6 months.
😍🥳🤩
Another example of great success with
#TheNicotineTest
For
#LongCovid
and
#MECFS
.
Not a miracle drug, but it is helping many people!
We are stronger together 💪!
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#TheNicotineTest
Survey
"Live update"... still early days, but there are already some clear trends.
Main Side effects are:
Nausea, Herx and Sleep disturbances.
I reduced food intake to minimize side effects. But I seem to be alone...
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Who thinks that the
@NIH
should add a sudy on nicotine patches for
#LongCovid
?
1⃣
#NIH
will open 4 new
#LongCOVID
clinical trials to study sleep disturbances, exercise intolerance and malaise following minimal exertion.
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#TheNicotineTest
Rule number one with personal experiments= Be safe!
Speak with your doctor(s).
Listen to your bodies.
Just because something works for some people, it might make other people worse.
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Mainstream media is hearing about
#TheNicotineTest
. But they don't even get the basics correct in their coverage.
I do agree that each person needs to weigh the risk/benefits of any n=1 test, but doing nothing is more dangerous when people are left to suffer and die.
Have you seen this,
@TheNicotineTest
?
It's good to see some coverage in MSM. I just wish
@naomibargh
had used better judgment when choosing "experts" & papers to cite.
That said, it's not horrible.
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From a tester😍
"My wins are vast, and include improvement in energy, lifting of brain fog and huge reduction in allergic symptoms. I've suffered CFS mutiple allergic issues for over 20 years. My family and friends are astonished, I couldn't be more happy with the improvement"
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#TheNicotineTest
is not a miracle cure, but it is helping many people. Me included!
Sharing my story to get the word out about low-dose nicotine patches.
#LongCovid
#MECFS
My interview with Raelen Agle where I talk about my journey,
@TheNicotineTest
, my n=1
@remissionbiome
expereince, my HSP hypothesis, how brain training is mismarketed and how "mental pacing" helped me get back to 90%.
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Another example of great success with
#TheNicotineTest
For
#LongCovid
and
#MECFS
.
Not a miracle drug, but it is helping many people!
We are stronger together 💪!
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Yeah! 🙌
So nice to hear great news like this! More proof that it takes time and adjustments /experimentation.
#LongCovid
#MECFS
#SARSCoV2
#success
#TheNikotineTest
I'm on week 4 of
#thenicotinetest
for my long COVID symptoms. And let me just say... Hooooly shit I think I might actually be able to get a good chunk of my life back after this. Details below 👇
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@tessfalor
@remissionbiome
@theacidtesters
So far, with n=35, more than 60%
#TheNicotineTest
had significant improvements (10% to 50% improvements in their baselines!).
Great considering most did a small dose for a week!
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"Nicotine treatment decreases the intracellular copper concentration ... These data suggest that the effect of nicotine on reducing beta-amyloidosis is partly mediated by regulating metal homeostasis."
#TheNicotineTest
#Research
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... but that might slow the release of some of the information that is being reviewed. The main point is that most see benefits from the NP, a small group see no change and about 10% get worse.
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@PutrinoLab
Any thoughts on why nicotine patches seem to help avoid and recover from PEM?
Maybe something to do with the energy transfer of mitochondria in skeletal muscle?
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#TheNicotineTest
For any of the new nicotine testers out there. Be safe! Here is a set of instructions on regulating the dose of your patch without cutting it!
#LongCovid
#MECFS
#Fibromyalgia
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#TheNicotineTest
#research
How many other diseases might have nicotinic receptor abnormalities in parts of the brain or body that could be helped by use of the nicotine patch?
A small case study on 4 patients:
#LongCovid
#MECFS
.
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#TheNicotineTest
early adopters leading the way!
These great outcomes are helping future testers learn, test more safely and improve chances of good outcomes.
Both
#LongCovid
and
#MECFS
seeing light at the end of this long tunnel! 😀😀😀
@simuellers
@TheNicotineTest
@LeitzkeMarco
I first started it in May. This week I was able to work 70+ hours in 7 days, including one day stuck outside in the heat.
No PEM or brain fog. 🤯
I am basically in full remission. Not everyone has this much improvement, though.
Ask me any questions, if you want to!
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Very grateful that many who try nicotine patches find relief.
Hopefully, more will try it before spending tons of money on other experiments.
#TheNicotineTest
#success
#LongCovid
#MECFS
Not a cure, but it helps many people improve QOL.
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While we work on our data for publishing...
You can see the data on Nicotine Patches on the HealthRising website. This kind of response should help you decide on the risk-reward calculations.
#LongCovid
#MECFS
Im Artikel über Nikotin-Pflaster als Massnahme bei
#LongCovid
ist eine Umfrage eingebaut: mehr als 80% der Patienten hat es geholfen, 30% bezeichnen es als Gamechanger, was ich auch angekreuzt habe.
Zum Artikel mit umfangreichen Infos:
#TheNicotineTest
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#TheNicotineTest
Protocol 2.0!
🤑It is free to Retweet and Share!
🌐Easy to follow graphic version coming next!
🙏🫂 Special thanks to all the input from
@LeitzkeMarco
,
@remissionbiome
and fellow testers sharing their wisdom!
@patientled
@tessfalor
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#TheNicotineTest
#research
Nicotine patches are also prophylaxis against damage from acute
#SARSCoV2
infections.
It does not avoid acute infections, but it reduces the long-term effects that lead to
#LongCovid
#MECFS
.
*Nicotine patches, not smoking!
This may explain the neuroprotective benefits of nicotine. It also connects to the the myelin damage that leads to
#MECFS
and
#LongCovidKongress
And it may explain why some people need extended rounds of nicotine patches to see the benefits.
More time sick = longer treatment.
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"RCT's testing nicotine ... for CVD patients, case control studies, long term longitudinal studies, and meta-analysis have found no increased risk of serious CV events in patients given nicotine medication,"
#research
#TheNicotineTest
.
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When will mass media start speaking with us?
Instead of speaking to some random doctor who is unfamiliar with the research?
Nicotine Patches made it to the news... No mention of our research or results.
Only some doctor saying..
"wait a few years"
Waiting is unethical and not practical.
@TheNicotineTest
#TheNicotineTest
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We show that nicotine, operating via nicotinic receptors, does protect these neurons against endoplasmic reticulum stress.
#TheNicotineTest
#research
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"Collectively, these findings provide evidence for a mechanism by which low-dose nicotine can activate NAD+ salvage pathways and improve age-related symptoms."
#TheNicotineTest
#research
@TheNicotineTest
Here is a newer study-
#nicotine
possesses multiple functions in NAD+ homeostasis to regulate signaling pathways and metabolism involved in senescence cells- I believe dosage varies by weight or metabolism but safe at 7mg-10mg daily to increase NAD+
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#TheNicotineTest
#research
#LongCovid
#MECFS
"The ‘nicotinic anti-inflammatory pathway’. The
#vagusnerve
can regulate inflammation through an α7 nAChR-mediated physiological pathway."
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@NickChambers2
How are you feeling now?
Remember to pace for a few weeks after...even if you feel well.
The nicotine patch during infection is clearly beneficial. Nobody has reported otherwise...yet.
IMO, it is the reduction in neuroinflammation that comes from a tampered immune response.
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#TheNicotineTest
Another success story.
Luckily, these are more common than "bad" outcomes. However, even if the risk is only 10%? ...that is a risk we all take each time we start a new med, sup, test etc.
#thenicotinetest
#LongCovid
Another great improvement, but this time with long Covid.
Thank you
@lornaweavesoak
& congratulations 👏🏼❤️
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1/4
"Mean power output ...no effect of nicotine was observed ... [but](20%) were unable to complete their 30°C nicotine trials .. These results demonstrate that nicotine use increases thermal strain and risk of exertional heat exhaustion by reducing SkBF."
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I have heard this many times.
Smoking is clearly bad for health, but many are probably self-medicating with Nicotine.
Nicotine from a patch is 7000 times safer and should be considered for long-term harm reduction.
Stop smoking, start patching!
#LongCovid
#MECFS
@SamRoseAuthor
@TMaritanoAquino
@ThePOTSPostman
@TheNicotineTest
This is fascinating to me (no LC, but POTS & ME/CFS) as my health declined *dramatically* when I quit smoking cigarettes in 2016. Brain fog-friendly reading material?
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#TheNicotineTest
#Success
Don't give up hope!
Some parents of
#LongCovidKids
Are seeing benefits as well.
#LongCovid
#MECFS
We are stronger together 💪
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#TheNicotineTest
#success
story
Few see such a quick change! But it is amazing seeing these stories!
Keep sharing!
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#TheNicotineTest
Survey
So far n=56 of a total of n=140 have returned to the survey to answer the new set of questions we need to complete analysis.
If you filled out the survey, please take a few minutes to come back and fill out the new questions🙏
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#TheNicotineTest
1. This treatment for neurological issues is not new.
2. When nicotine is truly understood to be different than smoking, then the benefits will be much clearer.
3. It will take time for science to separate fact from fiction.
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I wish that everyone who used Nicotine Patches responded well, but 2 out of 3 ain't so bad.
Hopefully we will find something that also helps the other 1/3rd benefit 🙏.
#LongCovid
@LeitzkeMarco
@TheNicotineTest
Day 13b
#TheNicotineTest
#Covid
#LongCovid
No real tachycardia (under 120)
No SOB,
No joint pain,
No fatigue,
Some gritty dry eyes,
No PEM,
Little brain fog.
A bit bloated but been fasting.
Symprove probiotics today for 4mths after 3mths placebo trial/study
Still on H1&H2
🤞🙏
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Another reason to protect the Brain with nicotine patches.
#LongCovid
#MECFS
Research shows that even mild COVID-19 can lead to the equivalent of seven years of brain aging
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Hopefully, more people will try nicotine patches at the beginning of
#LongCovid
where good results are more likely.
Don't forget to rest and pace😊
I am updating about my post covid syndrome/long covid on instagram pretty much daily. I have started
#TheNicotineTest
run by
@TheNicotineTest
and all the info is also on my instagram where I am updating my symptoms and how the test works and is working.
#Longcovid
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"Nicotine, a neuronal nicotinic acetylcholine receptor (nAChR) agonist, promotes M2 microglia polarization via activation of STAT3 pathway."
#TheNicotineTest
Reduces neuroinflammation.
#LongCovid
#MECFS
#research
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#TheNicotineTest
Here is the new graphic version of the Safety Guidelines Protocol (v3.0).
🤫🤫🤫
#LongCovid
#MECFS
Use the "Pause" button to stop and read longer slides.
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This drug, like nicotine, also affects acetylcholine in the nerves of the muscles.
@LeitzkeMarco
Might Amifampridine be a complement to nicotine patches or possibly an alternative for NP non-responders who present with muscle pain?
#LongCovid
#MECFS
Case report (5 cases)
3,4-diaminopyridine (Amifampridine) may reduce fatigue in
#LongCovid
:
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@ChrisPalmerMD
More good reasons for people with
#LongCovid
and
#MECFS
.... And possibly other diseases to try
#TheNicotineTest
😁
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Great to see this making it to Bloomberg. The author's advice is good as well. Research first, then go Slow and be safe.
She is pacing and appears to be a responder. Good luck!😀🤞
#LongCovid
#MECFS
"Some
#LongCovid
sufferers, like me, are taking the experiment into their own hands..
On the first day (of the nicotine patch), I felt like I had enough energy to go for a run after work for the first time since developing long Covid."
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New study.
Mito issues in the muscles can be caused by signals from the CNS.
IL-6 is the key messenger to the muscles. Low-dose nicotine happens to reduce IL-6 in the gut and brain.
Which might not be true at higher doses.
#LongCovid
#MECFS
#TheNicotineTest
"Infection and chronic disease therefore activate a systemic brain-muscle signaling axis in which CNS-derived cytokines bypass the connectome and directly regulate muscle physiology, highlighting IL-6 as a therapeutic target to treat disease-associated muscle dysfunction."
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Nicotine helps reduce mania in Bipolar Disorder (BD), probably by stimulating the cholinergic system.
"Nicotine may therefore play a role in the management and prevention of manic symptoms."
This explains the benefits in reduction of ForF
#LongCovid
#MECFS
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Lots of good results and helpful tribe over in Facebook.
Just one of many stories so far.
#TheNicotineTest
#success
#LongCovid
#MECFS
#pwLC
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@LeitzkeMarco
#TheNicotineTest
Safe Patch Dosing instructions video:
#TheNicotineTest
#LongCovid
#MECFS
New Video to explain the
"Step by Step"
Dose adjustment instructions.
How I safely get a 5.3 mg dose
...from 21 mg patch
...Without cutting the patch
Link to written instructions here:
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#TheNicotineTest
#research
#LongCovid
#MECFS
Here is a quick overview of a new article on Nicotine!
You can download a highlighted version here:
@LeitzkeMarco
@remissionbiome
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Check out
@spoonless_me
's thread on feeling much better after nicotine and then adding in Choline and Thiamin based on DNA testing.
#TheNicotineTest
NP is not a cure, but it is helping many people!
Don't give up!
In the past few weeks, I've experienced significant improvements in my health in the areas of small fiber sensory and autonomic neuropathy, cognitive dysfunction, fatigue, and rapid muscle fatigue. It feels like I'm finally unraveling the mystery of my own broken body. 🥹🧵
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Thanks for sharing your experience!
Good luck!
I'm on day 4 of using nicotine patches for long COVID. The best part so far? I haven't woken up with brain fog, like, at all this week! I wake up feeling pretty normal in the brain for an hour or two, absolutely amazing. It eventually comes back, but not for an hour or so...
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@Canal1point5
Each time a researcher comes out with this kind of information... then says, "don't try this at home"...that is irresponsible (in my opinion). There should be clear safety information (risks, dosages they will test, etc) because
#pwLC
are not going to wait.
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"The findings support the safety of long-term use [52 weeks] of nicotine patch treatment, although they do not support efficacy [to quit] beyond 24 weeks of treatment in a broad group of smokers."
#TheNicotineTest
#Research
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#TheNicotineTest
#research
"Vagally secreted acetylcholine binds to α7 nicotinic acetylcholine receptors (α7nAchRs) at the cell surface and blocks NF-κB action, thereby controlling virus replication, cytokine release, and the synthesis of procoagulant/anti-fibrinolytic factors."
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Most people who try the
#TheNicotineTest
benefit.
Please share with any French-speaking
#LongCovid
#MECFS
More info in our
@apresj20
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Facebook Poll results on
#TheNicotineTest
Patch irritation. (n=227)
16% suffered enough irritation to stop or change brands.
Name brands were 3X more likely to cause irritation!
Nicotinell, NiQuitin, NicoDerm.
Generic Brands = cheaper and less chance of issues.
#LongCovid
1/3🕺
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This is my life now.
Even after months,
I feel immensely grateful 🥹 🤩!
Watching people improve their quality of life.
Will you be number 5000 in our 🥸🔖🫂?
Some of
#TheNicotineTest
wins from the Facebook today!
@TheNicotineTest
is not a cure! But it is helping 2/3rds feel much better. And for some, it is the missing piece of the healing puzzle for both
#LongCovid
and
#MECFS
.
A🦋🧵full of joy 😍😍😍!
@NickChambers2
@LeitzkeMarco
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#TheNikotineTest
#research
".... nicotine, at certain doses, improved sociability and reduced repetitive behaviors in a mouse model of autism, implicating the potential therapeutic values of a pharmacological intervention targeting nicotinic receptors for autism therapy."
@TheNicotineTest
The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model
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Nicotine patches are immune modulators. Despite the many downsides of smoking. They still have lower IgG levels due to immune modulation.
#LongCovid
#MECFS
#research
#TheNicotineTest
"... smoking, which is also associated with low IgG levels, as shown here and in previous studies"
Smoking is clearly bad, but nicotine patches are not. Lower IgG levels, despite the many downsides of smoking, is another reason to try
#TheNicotineTest
#LongCovid
#MECFS
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#TheNicotineTest
Nice to see that Dr Newhouse (with decades of research) will be doing
#research
on nicotine for
#LongCovid
as well.
The more, the better!
How can we help?
@Filtermag_org
@aftariak
Ping
@TheNicotineTest
- "His latest research project will investigate the use of nicotine to treat long COVID."
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Many people with
#LongCovid
and
#MECFS
might not know the "Cholinergic system"... but they will probably be very familiar with the Parasympathetic system, vagus nerve, etc.
#TheNicotineTest
#FAQ
@mrartimisfoley
@TheNicotineTest
@Really_Richelle
@tessfalor
@cobba27
@simuellers
Cholinergic neurotransmission is describable as the effectiveness of energy transmission within your body. It regulates the energy consumption of each cell of you body. If cholinergic neurotransmission is blocked, even partly, (nAChRs), effectiveness breaks down.
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#TheNicotineTest
#research
Nicotine causes mostly vasoconstriction... but not in all the body.
"Nicotine has been shown to induce neurogenic vascular relaxation in multiple vascular beds..."
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Call to all doctors/clinicians. If your patients are using nicotine patches for
#LongCovid
#MECFS
join our study to increase data/knowledge.
#MedTwitter
#research
@TheNicotineTest
@Pandore_Clavis
My doctor is prescribing to other patients following my results
Thanks to you I owe you this one not my doctor 😉
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Hello Testers! If you have filled out the survey... please take a minute to come back and answer are few more questions.🙏
We need some more data... so we can do proper data analysis and possibly publish some data in a scientific journal 🤯🤞
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The record for the slowest taper down. We need better patches that make it easy to adjust the dose.
Just finished another round of
#TheNicotineTest
7 days at 3.5mg and then a verrry slow wean down to avoid symptoms of restless leg and insomnia from withdrawal. Finished today, feel like the wean-down worked, still sleeping well: schedule below in case anyone wants to know ⬇️
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#TheNicotineTest
#LongCovid
#MECFS
NEW FAQ
(Answers to all the most frequent questions)
has been published!
👏👏👏
*Based on tweets from
@LeitzkeMarco
, research, the survey and n=1 annecdotes!
Will be updated as we get more data and more questions!
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#TheNicotineTest
is going international tomorrow for
#LongCovidAwareness
day!
Plus a graphic version of the protocol and a Facebook page!
Have your retweet thumb warmed up!
Patient-led! Together we are stronger!
#LongCovid
NICOTINE PATCHES OFFER PROMISING TREATMENT OPTION FOR
#LongCovid
#LongCovidAwareness
day June 15th
tweets with this picture in full size will be launched
with 🧵of
-78 success stories
-QUICK START graphics
Share those to Fb groups
by "copy link to Tweet"
@TheNicotineTest
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Have you listened yet? Hear about Nicotine Patches from the expert who wrote the original hypothesis.
I spoke with
@LeitzkeMarco
about use of nicotine patches in
#longcovidrecovery
- this was a really interesting conversation!
**Full episodes wherever you get your podcasts or at **
Direct link to this episode & transcript:
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"Infection and chronic disease therefore activate a systemic brain-muscle signaling axis in which CNS-derived cytokines bypass the connectome and directly regulate muscle physiology, highlighting IL-6 as a therapeutic target to treat disease-associated muscle dysfunction."
📝Animal model disease cascade in COVID & other illnesses causing extreme fatigue & muscle pain
🧠NeuroInflammation (ROS)
⏫ IL-6
Activated JAK-STAT pathway in muscle
🟰 Mitochondrial dysfunction
🟰Impaired motor function
Therapeutic target possible
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Hey
#LongCovid
peeps! Just wanted to post an awesome update. I did
#TheNicotineTest
this Spring (stopped early June). I had been couch bound. Sunday I did a short *strenuous* hike. I was fine the next day. Still fine 2 days later!! 🎉🥳🎈
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#research
#TheNicotineTest
"Neurotoxic effect of LPS-activated microglia due to inflammatory cytokines was also attenuated by pre-treatment of microglia with nicotine."
#LongCovid
#MECFS
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#TheNicotineTest
A new way of doing research, but not new for the known benefits in many diseases.
@kiddr_7
@henrygoldstein
Are there any health benefits from nicotine?
Decades of research, often using nicotine patches, show there are. Old-school tobacco control "experts" are VERY uncomfortable with this evendence, so never talk about it.
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@StevePhillipsMD
We have been researching and collecting patient stories since May.
So far
@TheNicotineTest
survey (n=160+) is showing very positive results.
And we are planning a formal trial.
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#TheNicotineTest
Most benefit from the patches, but even those that do not learn something.
And with patient-led research, even data from "failure" is useful for the tribe as a whole.
Each time we fail with an experiment, that failure is a useful data point.
That data point will bring us forward in our healing journey.
Go forth and fail, fail, fail.
Until you succeed.
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