Michael J. Lee
@TheLeeLab
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A Laboratory of Systems Pharmacology
UMass Med School
Joined September 2013
@DrTonyLetai I don’t think it has another name (not well studied… just a couple papers). I’ll contact you about it as we move forward! We definitely want to explore how MOMP activation works in this context but the first paper is just focused on the existence of this pathway.
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@DrTonyLetai Thanks Tony! PTBP1 doesn't have a BH3 domain and as far as we can tell, it doesn't interact directly with any BCL2 family protein. We identify 1 BCL2-family/BH3- protein as being required for apoptosis in this context and it's BCL2L12... relationship between these is TBD.
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I don't post in this space much anymore... I can be found on other platforms using the same handle.
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It's challenging to uncouple Pol II expression from Pol II activity (Pol II activity creates Pol II expression) but we managed! We did many things, but the most notable is that we suppressed lethality caused by loss of Pol II by giving cells a non-functional form of Pol II! (4/n)
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RT @UWPharmacology: Please RT! We are officially accepting applications to the @UW Pharmacology PhD program! Are you excited about doing a…
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The SACB Abstract deadline is this Friday. This is an awesome community and always a very engaging meeting. Join us in Colorado this February!
Abstracts are due this Friday for #SACB2025! A great meeting for those who are employing systems approaches in cancer. We have an incredible array of speakers and a fantastic new location near Denver, Colorado.
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RT @CancerSysBio: Systems approaches to cancer biology meeting (SACB2025) is coming up! The abstract deadline and application to be part o…
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RT @mbyaffe: Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - The whol…
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RT @NobelPrize: Congratulations to our 2024 medicine laureate Victor Ambros ✨ This morning he celebrated the news of his prize with his co…
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RT @UMassChan: Victor R. Ambros, PhD, @UMassChan's Silverman Chair in Natural Sciences and professor of molecular medicine, has won a Nobel…
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RT @ZheWang_NCB: 1/ 📢 Our special issue on #celldeath is now live @NatureCellBio, which features Editorial, Reviews, Perspective, Comment,…
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Bonsai Bar event at @RR_BrewingCo last night to celebrate @meganhoneywell and her amazing career in the Lee Lab @UMassChan @UMassChanGSBS. before & after pics of my bonsai included. no idea what i'm doing, but the folks at Bonsai Bar did their best with my lack of ability.
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RT @CancerSysBio: After many successful meetings at Woods Hole, MA the Systems Approaches to Cancer Biology meeting has finally joined the…
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