TAGHIVscience
@TAGHIVscience
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Twitter for TAG's Basic Science, Vaccines & Cure Project, by Richard Jefferys. Primary Treatment Action Group twitter is @TAGTeam_Tweets 🏳️⚧️
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Pinned Tweet
Thanks to
@hancprograms
for generating this important resource: Directory for
#HIV
Research Community Advisory Boards & Community Working Groups (please share with anyone who might be interested in joining a CAB)
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@GeoffRBennett
@johnkruzel
Not just 17th, but the 19th and 20th also. The last of which is dubbed the "million militia march," with the stated of aim of preventing Joe Biden becoming president.
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295
@SteveFDA
A relative risk reduction with a very wide CI, cherry-picked at 7 days instead of 30, from a relatively small retrospective subgroup analysis (total n=1076) that compared mortality outcomes among recipients of arbitrarily defined "high" or "low" antibody plasma.
1
33
254
@ErinInTheMorn
@Esqueer_
This is appalling
@TwitterSupport
@TwitterSafety
@Twitter
and it's far from the first time, you need to fix now
1
20
209
@lisaannkerr
@washingtonpost
Grim to consider what possible "community standards and wishes" the author of that sentence was thinking about
4
4
107
@nicoleperlroth
@julianbarnes
@SangerNYT
"Officials say Russia’s ability to change vote tallies nationwide is limited."
I'm not finding a whole lot of reassurance in the word "limited."
3
23
112
The case of Marc aka the Düsseldorf patient, the third case of
#HIV
cure achieved by stem cell transplantation from a CCR5Δ32/Δ32 donor, now published
0
30
70
@ddiamond
Would be great if your headline writers could figure out a way of presenting this as what it is (a public health issue), rather than as a political problem for Joe Biden
2
4
63
Sorry that this is a little off topic for this twitter account, but it's so shocking. From Sunday, the day after the Barrett conflab. Note that Pence, currently objecting to safety measures for the VP debate, is right there in the front row.
More pics from the White House Flickr page....you can see Chad Wolfe is there from DHS. Has anyone asked him about his status?
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2K
6K
0
32
54
SARS CoV-2 mRNA vaccination exposes latent
#HIV
to Nef-specific CD8+ T-cells (open access)
@AwesomeJonesLab
1
35
49
@IAmKrishanPatel
@Redistrict
I'd guess they had more granular data on exactly where the outstanding ballots were going to be coming from.
0
1
47
@Laurie_Garrett
"Importantly, however, all the pangolin coronaviruses identified to date lack the insertion of a polybasic (furin-like) S1/S2 cleavage site in the spike protein that distinguishes human SARS-CoV-2 from related betacoronaviruses"
1
3
47
@thegarance
@mollycrabapple
And the conversion loophole that has allowed landlords to dodge rent regulation by combining apartments (there are now two duplexes in my LES tenement building).
0
8
41
#HIV
cure: The daunting scale of the problem (open access perspective article)
@ScienceMagazine
1
18
41
CRISPR-Cas attack of
#HIV
-1 proviral DNA can cause unintended deletion of surrounding cellular DNA (subscription req)
2
11
35
@DemocracyDocket
In retrospect it's obvious that this was the entire purpose of the avalanche of doomed lawsuits.
1
4
33
@washingtonpost
This piece makes claims that are absolutely false and should be retracted. Shame on
@washingtonpost
for publishing it.
2
13
33
IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in
#HIV
-1 elite controllers (open access)
@YuLabAtRagon
0
8
33
@NovelSci
@JenniferNuzzo
@SaskiaPopescu
There are rumblings suggesting maybe there are results imminent from the Oxford trial in the UK, and FDA will grant an EUA based on that. Nothing confirmed. Sadly the concern here doesn't seem likely to be the health of HCW, but the health of Trump's reelection campaign.
1
1
30
Bispecific antibodies promote natural killer cell-mediated elimination of
#HIV
-1 reservoir cells (open access)
@NatImmunol
1
20
33
@marceelias
Trying to improve the conditions for an authoritarian coup, having failed at the first attempt.
0
6
29
The impact of antiretroviral therapy duration and intensification on isolated semen
#HIV
-1 RNA shedding
http://t.co/2MHaeQbN
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7
@EricSchultz
@AdamParkhomenko
Sad to say that, in its current form, this article represents a false smear. Biden is not "flouting" anything, he's following the CDC guidance - the piece links to the guidance, but fails to explicitly quote the salient part defining "close contact."
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3
26
Lymph node dendritic cells harbor inducible replication-competent
#HIV
despite years of suppressive ART (open access)
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12
29
@bobvonscio
@selva_obscura
@thebadstats
No they're not, you've fallen for Peter Duesberg's disinformation tactics just like the author of the book you read.
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0
28
@JimJones2020
@mkraju
Meadows is still claiming there might be another four years of this maladministration, not just another eight weeks.
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1
27
"This is actually a really unique moment in time": Navigating Long-Acting
#HIV
Treatment and HIV Cure Research with Analytical Treatment Interruptions - A Qualitative Interview Study in the United States (subscription req)
1
8
27
@whereismygarden
@AliNouriPhD
No, unusually for RNA viruses they have a proofreading mechanism which greatly lessens mutation rate compare to others like flu or HIV. Reason immunity to seasonal cold-causing coronaviruses is short-lived appears unclear and not related to mutation AFAIK.
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SARS-CoV-2 spike protein is readily vulnerable to neutralizing antibodies thankfully. But HIV Env protein has a protective cloak of sugar molecules, and mostly only weird-shaped antibodies produced by rare B cells can penetrate the cloak and neutralize HIV.
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7
27
@lrozen
@AshaRangappa_
Giuliani delusionally said it was because state legislators were on the verge of somehow withdrawing their certified Electoral College votes: "it would give us the opportunity to get the legislators who are very, very close to pulling their vote"
1
7
26
Research Toward an
#HIV
Cure Clinical Trials & Observational Studies - February 16, 2024 update
1
11
24
@GreenesLlama
@kaitlancollins
@jabinbotsford
Unfortunately, I don't think the reality of what's possible is the concern here - it's what Trump might delusionally imagine is possible. The election results couldn't be overturned on Jan 6, but his fantasy that they could caused at least seven deaths and many more injuries.
2
0
22
A Conversation with Adam Castillejo (
@londonpatient
), the second person cured of
#HIV
-
@LGBTCenterNYC
, Thursday October 20, 6:30-8pm
@HIVpxresearch
@REACHforthecure
@DAREtoCureHIV
@HOPEforHIVCure
2
16
26
Adeno-associated virus-vectored delivery of
#HIV
biologics: the promise of a “single-shot” functional cure for HIV infection (open access review)
@viruseradicate
0
15
25
Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes
#HIV
-1 latently infected cells and delays rebound in humanized mice
1
7
24
I think the confusion arose due to plans for future work with
@moderna_tx
to use mRNA to deliver this & other proteins. This is good news - hopefully will accelerate efforts to push B cells to take the remaining steps toward generating effective antibodies
1
4
25
Mosaic vaccine-induced antibody-dependent cellular phagocytosis associated with delayed
#HIV
-1 viral load rebound post treatment interruption (open access)
@CellReports
@MHRPInfo
0
9
25
"Even if the cost of treatment could be radically reduced, it would remain impractical in much of the developing world. Anti-HIV drugs need to be administered with a precision that rudimentary health infrastructures cannot aspire to."
@washingtonpost
, 1/6/2000
1
9
25
The latent
#HIV
reservoir: current advances in genetic sequencing approaches (open access review)
@mbiojournal
@ndhlovulab
@HOPEforHIVCure
0
13
24
Recent advances in CD8+ T cell-based immune therapies for
#HIV
cure (open access review)
@HeliyonJournal
0
13
23
@annamerlan
Thanks for covering this dismal development. Rogan had Duesberg on his show in the past. The AIDS denialist writer Celia Farber who RFK Jr thanks for help with his book once sued me for libel for calling her & Duesberg liars & frauds, case was dismissed (x3 - 2 appeals).
1
3
23
Implications of the accumulation of CXCR5+ NK cells in lymph nodes of HIV-1+ patients (open access)
@EBioMedicine
0
5
23
@vivaledemps
@KevinMKruse
They know this, but assume that a swathe of their audience doesn't - it's cynical propaganda.
1
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This "variant" has been around since the 1990s and, as you find out in the 9th para of this piece, "Its circulation has been declining since around 2010." I fear that those facts won't stop this irresponsible headline being widely shared and misunderstood on social media.
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6
23
@paulkrugman
The poll Politico posted yesterday counted the answer "somewhat agree" (that the response is OK) as approval - that seems potentially misleading to me. I can see people picking that answer because they don't want to be negative but actually don't think everything's OK.
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An additional error in the viral tweets circulating about this study is the statement that 97% of recipients developed antibodies against
#HIV
- *this wasn't measured.* Rather, it was the proportion of people in whom a certain type of B cell was detectable (see this fig from R4P)
0
8
23
@CarlosdelRio7
@NEJM
It'd be helpful to know if any of the 26 women who were asymptomatic at discharge developed symptoms later. Perhaps the reader is supposed to infer that they didn't, but it doesn't seem to be specifically stated.
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@sciencecohen
From the RECOVERY results: "there was no evidence that dexamethasone provided any benefit among patients who were not receiving respiratory support at randomization, and the results were consistent with possible harm in this subgroup."
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4
21
The hypoxia-regulated ectonucleotidase CD73 is a host determinant of
#HIV
latency (open access)
@CellReports
0
10
23
New
@TAGTeam_Tweets
#HIV
Cure Research Media Monitor entry: HIV “completely eliminated” from cells in a laboratory dish with CRISPR technology
1
11
21
Potent Dual Block to
#HIV
-1 Infection using Lentiviral Vectors Expressing Fusion Inhibitor Peptide mC46 and Vif-Resistant APOBEC3G (open access)
@MolTherapy
0
7
22
The combination of venetoclax and ixazomib selectively and efficiently kills
#HIV
infected cell lines, but has unacceptable toxicity in primary cell models (subscription req)
0
10
20
Viral reservoirs in elite controllers of
#HIV
-1 infection: Implications for HIV cure strategies (open access)
@EBioMedicine
@BezaWoldemeskel
0
9
21
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques (subscription req)
@ImmunityCP
0
6
22
Mild
#HIV
-specific selective forces overlaying natural CD4+ T cell dynamics explain the clonality and decay dynamics of HIV reservoir cells (open access preprint)
@medrxivpreprint
0
5
17
The latent reservoir of inducible, infectious
#HIV
-1 does not decrease despite decades of antiretroviral therapy (open access)
@jclinicalinvest
1
12
20
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with
#HIV
-1: a phase 1b/2a, randomized trial (open access)
1
12
22
Participant experiences in
#HIV
cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States (open access)
@BeatHivCAB
@MontanerLab
0
6
21
Research Toward an
#HIV
Cure Clinical Trials & Observational Studies - January 16, 2024 update
1
7
21
Vaccine induction of heterologous
#HIV
-1-neutralizing antibody B cell lineages in humans (open access)
@CellCellPress
@HelpEndHIV
0
8
19
Viral and Host Mediators of Non-Suppressible
#HIV
-1 Viremia (preprint of study presented at
#CROI2023
)
@medrxivpreprint
1
9
20
Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against
#HIV
-1: a phase 1 clinical trial (open access)
@NatureMedicine
@ragoninstitute
1
13
19
#HIV
-1–infected T cell clones are shared across cerebrospinal fluid and blood during ART (open access)
@JCI_insight
0
5
19
Depletion of
#HIV
reservoir by activation of ISR signaling in the resting CD4+ T cells (open access)
@iScience_CP
0
5
20
.
@robertkennedyjr
promoting the shameful falsehoods of AIDS denialism.
@Dennis_Kucinich
Unearthed: RFK Jr. pushed HIV/AIDS denialism, attributing AIDS not to HIV, but to a “gay lifestyle” and recreational drugs:
“There were people that were part of a gay lifestyle, they were burning the candle at both ends, …there were poppers on sale everywhere at the gay bars.”
430
987
2K
3
10
19
Some background on the
@americangene
#HIV
gene therapy candidate that is due to enter clinical trials soon
0
10
20
@statnews
Desperate to blame someone else for his maladministration's incompetence, caring nothing about who gets hurt.
0
0
17
@RVAwonk
@NYGovCuomo
Needs to be careful with words like "strain" as they're ripe for misinterpretation. Genetic signatures that allow tracking don't necessarily equate to distinct strains as the word might generally be interpreted (e.g. viruses with different properties)
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Robert Kennedy Jr's presidential campaign makes him the most high profile political figure to promote AIDS denialism since Thabo Mbeki. I think journalists should mention this every time they cover him.
2
2
19
@ddale8
He directed his own VP to commit lawless actions, and called on the crowd to go after his VP to make it happen
0
3
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0
7
19
@HelenBranswell
@TheLancet
I'd guess the peer reviewers had some feedback about post hoc combining of data from two separate trials with different control arms, one of which involved a subgroup of people given a different dose by mistake
0
0
18
Estimating the contribution of CD4 T cell subset proliferation and differentiation to
#HIV
persistence (open access)
@NatureComms
2
8
19
The
#HIV
-1 proviral landscape reveals Nef contributes to HIV-1 persistence in effector memory CD4+ T-cells (open access)
@jclinicalinvest
0
6
16
Deadline for applications now extended to August 31st
@HIVpxresearch
Are you an
#HIV
advocate or peer educator interested in the field of HIV cure?
Do you work in a country with limited resources for HIV cure research?
Applications for the 2022 Advocacy-for-Cure Academy close on Sunday 21 August at 23:59 CET!
Apply here➡️
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0
8
19
Measuring the latent reservoir for
#HIV
-1: Quantification bias in near full-length genome sequencing methods (open access)
@PLOSPathogens
0
10
15
High monoclonal neutralization titers reduced breakthrough
#HIV
-1 viral loads in the Antibody Mediated Prevention trials (open access)
@NatureComms
@HelpEndHIV
1
6
19
Investigation of the Impact of Inducible, Replication-competent Latent
#HIV
-1 as an Impediment to HIV/AIDS Cure in the Context of Sustained Viral Suppression (new study opening at
@KEMRI_Kenya
)
0
7
16
Nice illustration of collaborative research plans for using mRNA to help work toward an efficacious
#HIV
vaccine. It's likely to be at least several years (at best) before it might be possible to traverse the last arrow, from human clinical trials to protective vaccine.
Dr. Schief of
@IAVI
describes a novel strategy to study HIV vaccine approaches.
#ModernaVaccinesDay
#mRNA
6
17
85
1
12
19
@LisaGrande13
@Com_Truz
@robertjdenault
You're correct. From a New Yorker profile last year: "In early 2018, he moved to Los Angeles."
0
1
17
CD4/CD8 ratio during
#HIV
treatment: time for routine monitoring? (subscription req)
@serranovillar
1
3
18
Small molecule inhibitors of transcriptional cyclin-dependent kinases impose
#HIV
-1 latency, presenting “block and lock” treatment strategies (open access)
0
10
17
Quantitative and Qualitative Distinctions between
#HIV
-1 and SIV Reservoirs: Implications for HIV-1 Cure-Related Studies (open access review)
@VirusesMDPI
0
9
19