Shahzeb Khan Profile
Shahzeb Khan

@ShahzebKhanMD

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@ShahzebKhanMD
Shahzeb Khan
1 year
📌 @ehj_ed Global Spotlight: Creation of next generation of diverse CV Physician-Scientists from Developing Countries: Insights from @R_C_O_P 📌A 📝 very close to my heart. Structured long term research mentorship is vital at every level- esp for med students (1/3)
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@ShahzebKhanMD
Shahzeb Khan
4 years
Incredibly excited and honored to match in Cardiology at @DukeHeartCenter . Extremely grateful to @JavedButler1 @SJGreene_md @FudimMarat @RichKrasuskiMD @ErinMichos @ambarish4786 @RamiDoukky and many others for all the great help during the application process.
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@ShahzebKhanMD
Shahzeb Khan
3 years
SGLT-2 inhibitors in Heart Failure with Preserved Ejection Fraction: Reasons for Optimism ‼️ ✅Targets multiple processes simulatenously which may be implicated in HFpEF ✅Placebo event rates in EMPA-REG Outcome similar to previous HFpEF trials
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@ShahzebKhanMD
Shahzeb Khan
4 years
Suggested approach of using SGLT-2 inhibitors or GLP-1 RA in different clinical scenarios from the state of the art review published in @CircAHA today
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@ShahzebKhanMD
Shahzeb Khan
1 year
Predicting and Preventing Heart Failure in Type 2 Diabetes 📝 in @TheLancetEndo @ambarish4786 @SubodhVermaMD @DLBHATTMD @kershawpatel
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@ShahzebKhanMD
Shahzeb Khan
4 years
Editorial in @JACCJournals with @JavedButler1 . Treatment is Good, Prevention is Better: Heart Failure Prevention for All
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@ShahzebKhanMD
Shahzeb Khan
3 years
Should etiology of heart failure be assessed more systematically in a standardized fashion in RCTs, or not at all, or what we have currently is good enough ?! Our editorial in @ESC_Journals discusses the assessment of etiology in HF. @JavedButler1
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@ShahzebKhanMD
Shahzeb Khan
3 years
Our 📑 in @ESC_Journals highlights 📌 ⬆️ Heterogeneity in reporting of kidney function and kidney outcomes in large RCTs 📌Need for stakeholders to draft a consensus solution 📌 Standardization of kidney outcomes, definitions and stats modelling, may help compare trial 📈
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@ShahzebKhanMD
Shahzeb Khan
3 years
Practical and Evidence-Based Approaches to In-Hospital Decongestion for Heart Failure:Are We There Yet Editorial comment in @JACCJournals on BLUSHED-AHF pilot trial Editorial: BLUSHED-AHF: Grateful to @SJGreene_md for opportunity
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@ShahzebKhanMD
Shahzeb Khan
2 years
Results from combined analysis of FAIR-HF and CONFIRM-HF 📌Pts receiving FCM had ⬆️⬆️ likelihood of >5,10 and 15 points improvement in KCCQ at week 12 📌These benefits persisted in >75% of the pts at week 24 🔑IV FCM improves QOL with sustained benefits
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@ShahzebKhanMD
Shahzeb Khan
2 years
Mechanisms of current therapeutic strategies for heart failure: more questions than answers ?
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@ShahzebKhanMD
Shahzeb Khan
4 years
New analysis of EMPEROR-Reduced in @ESC_Journals 🔑 Empagliflozin reduces CV death/HF hospitalization across spectrum of baseline health 🔑 Empagliflozin improves health status across various domains 🔑 Benefits sustained during long term f/up
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@ShahzebKhanMD
Shahzeb Khan
4 years
Results of EMPEROR-Reduced By Baseline Diabetes Status Published in @CircAHA today. Favorable heart failure and renal effects of empagliflozin were consistent in patients with and without T2DM, and across spectrum of A1C.
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@ShahzebKhanMD
Shahzeb Khan
3 years
You know you are at the best place for #cardiologyfellowship when incredible faculty @DukeHeartCenter take you to @dukebasketball matches on weekend after a great week of rounding on complex structural/congenital heart patients. Big shoutout to @RichKrasuskiMD for being the best
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@ShahzebKhanMD
Shahzeb Khan
4 years
State of the Art Review in @CircAHA regarding GLP-1 RA and Heart Failure. •No clear benefit on HF outcomes •Possible safety issues in HFrEF •May benefit HFpEF •Dedicated trials for HFrEF and HFpEF needed
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@ShahzebKhanMD
Shahzeb Khan
2 years
New 📝 in @JAMA_current where we propose 📌Reporting of stability of observed changes in PRO 📌Stability of response ➡️ how many who initially improved remained ⬆️ rather than reverting to neutral or ⬇️ 📌Comparing PRO over time can ✅ Rx benefits are robust @JavedButler1
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@ShahzebKhanMD
Shahzeb Khan
4 years
Comparison of Reverse Cardiac Remodeling Following Initiation of Sacubitril/Valsartan in HFrEF patients with and without T2DM. New data from PROVE-HF in @JACCJournals under the great mentorship of @JavedButler1 and @JJheart_doc
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@ShahzebKhanMD
Shahzeb Khan
6 months
📌 Our editorial in @JACCJournals regarding serial NT-proBNP measurements and implementation of GDMT. 📌 Potential use of NT-proBNP as a virtual physical exam Comment to the excellent 📝 by @MichaelFueryMD , @yaleHFdoc et al:
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@ShahzebKhanMD
Shahzeb Khan
2 years
Honored to present at #ADA on socio-economics of heart failure with this amazing group @drpmcampbell @HeartDocSadiya . Special thanks to @hvanspall and @kaulcsmc for the amazing opportunity @DukeHeartCenter
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@ShahzebKhanMD
Shahzeb Khan
5 years
Our comprehensive meta-analysis of 22 studies suggests imp diagnostic and prognostic value of LA function in HFpEF All measures of volumetric LA function ⬇️ in HFpEF ⬇️ LA reservoir strain ⬆️ risk of HFH/all cause mortality
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@ShahzebKhanMD
Shahzeb Khan
2 years
Minimal Clinically Important Difference for Six Minute Walk Test in Patients with HFrEF and Iron Deficiency: Pooled Analysis of FAIR-HF and CONFIRM-HF trials @JavedButler1 @JCardFail
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@ShahzebKhanMD
Shahzeb Khan
4 years
Baseline characteristics of the much awaited trial EMPEROR-Preserved are out now in @ESC_Journals @JavedButler1 @Filippatos @MarcoMetra
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@ShahzebKhanMD
Shahzeb Khan
5 years
Our fun paper “Kardashian Index of Cardiologists” published in @JACCJournals . K index is the correlation b/w the no of citations for a scientist and no of followers they have on twitter. Intermingling of academic research/social media
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@ShahzebKhanMD
Shahzeb Khan
2 years
📌 ⬆️⬆️⬆️ burden of HF related ☠️ in young adults 📌 Black adults have ~3 times ⬆️ rate 📌 Significant geographic variation in ☠️ 🎯Urgent action needed to address this concerning trend & ⬇️ disparities 🎯 Early Dx and implementation of GDMT 🔑 See
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@ShahzebKhanMD
Shahzeb Khan
3 years
Great study in @JACCJournals led by @MattSegar and @ambarish4786 regarding prevalence and implications of DM with cardiomyopathy in the community. Targeted prescription of effective Rx needed to ⬇️ risk of HF among such patients
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@ShahzebKhanMD
Shahzeb Khan
4 years
Conducting Clinical Trials During and After the COVID-19 Pandemic: An Expert Consensus Position Paper from the HFA of the @escardio @JavedButler1 @MarcoMetra @AdriaanVoors @jteerlinkmd @Filippatos @JBauersachsMD @BiykemB @texhern @ehj_ed
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@ShahzebKhanMD
Shahzeb Khan
4 years
Joint Position Paper of Heart Failure Association of the @escardio and Chinese HF Association regarding management of heart failure patients with COVID-19. An excellent overview based on available data /personal experiences led by @MarcoMetra 🔥:
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@ShahzebKhanMD
Shahzeb Khan
4 years
Rigorous, systematic and standardized framework needed for adequate comorbidity reporting and ⬆️ recruitment of multi-morbid HF pts. Many thanks to @Ayman__Tahhan @mvaduganathan @JavedButler1 for letting me contribute in this imp paper
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@ShahzebKhanMD
Shahzeb Khan
4 years
Our new meta analysis regarding FCM for the treatment of iron deficient heart failure patients published in @ESC_Journals @HFA_President No benefit on all-cause or CV mortality but reduces HF/CV hospitalizations
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@ShahzebKhanMD
Shahzeb Khan
4 years
Our latest perspective in @CircOutcomes on orphan drug development using examples of tafamidis and evolocumab. Current pathways ⬇️ evidentiary bar and generally priced ⬆️⬆️ due to marketing incentives. Pricing of orphan drugs needs regular re-evaluation
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@ShahzebKhanMD
Shahzeb Khan
5 years
Low Na diet is a common order that we put in. Does it really improve pt outcomes ? Our editorial “Salt, no salt or less salt for HF pts” discusses pros and cons. More research needed for optimum🧂intake. @JavedButler1 @amjmed
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@ShahzebKhanMD
Shahzeb Khan
8 months
📌Kidney Involvement in Transthyretin Cardiac Amyloidosis ✅Role of UACR and Need for Further Evidence Generation Editorial: Original Article:
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@ShahzebKhanMD
Shahzeb Khan
4 years
Natriuretic Peptide Levels and Risk of Cardiovascular Versus Non-Cardiovascular Events in HFrEF-Insights from the PARADIGM-HF and ATMOSPHERE Trials
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@ShahzebKhanMD
Shahzeb Khan
1 year
Extremely well deserved- UTSW is lucky to have you. You will be a ⭐️ there.
@ShariqUsmanMD
Muhammad Shariq Usman
1 year
Thrilled to match at my #1 choice: The UT Southwestern Internal Medicine-Cardiology PSTP track! Wouldn't have been possible without my mentors @ShahzebKhanMD and @JavedButler1 Excited to join the @UTSWInternalMed family!! @UTSW_IMResRsrch @utswheart @UTSWNews #Match2023
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@ShahzebKhanMD
Shahzeb Khan
1 year
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@ShahzebKhanMD
Shahzeb Khan
5 years
PROGRESS-HF Phase 2 Trial out now in @JCardFail . The trial evaluated the effects of elamipretide, a novel mitochondrial modulating agent, on LV function in HFrEF patients. Special thanks to @JavedButler1 and @Filippatos . See results below
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@ShahzebKhanMD
Shahzeb Khan
5 years
Excited to get the award at the @SCMRorg conference in Orlando for paper published in @journalofCMR . Special thx to Dr Manning and @khosafaisal . #SCMR2020 #whyCMR #cvImaging
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@ShahzebKhanMD
Shahzeb Khan
1 year
📌 Rx of iron deficient HFrEF with IV iron ⬇️ HF 🏥 and CV ☠️ 📌95% CI crossed upper limit of 1 in the Bayesian Prediction Model ➡️ some uncertainty 📌Nominally consistent across subgroups 📌 📝 HEART-FID and FAIR-HF2 awaited
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@ShahzebKhanMD
Shahzeb Khan
2 years
📝 in @ESC_Journals from EMP-Reduced 📌 Benefits of empa consistent across all BMI groups 📌 Weight loss led to ⬆️ all cause mortality in both groups 📌Distinction b/w intentional vs unintentional weight loss is imp.
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@ShahzebKhanMD
Shahzeb Khan
5 years
@CircAHA GFRW 2020 •All fields except orthopedics had higher proportion of women trainees than ❤️ •Only 21% of general ❤️ trainees were women •Even ⬇️ in IC and EP •PCCM & ❤️ the most male dominated IM spec •Peds ❤️trainees were 50% women
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@ShahzebKhanMD
Shahzeb Khan
5 years
In this article published today in JAMA open, we discuss spin (manipulation of language) in CV RCTs @drjohnm @RamiDoukky @TariqJamalSidd1 @safinmc @RichKrasuskiMD
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@ShahzebKhanMD
Shahzeb Khan
3 years
Empagliflozin for the treatment of HFpEF: Prophecy fulfilled Great for patients with HFpEF to finally have a tx which improves outcomes. Eagerly await EMPEROR-PRESERVED at ESC Kudos to the leadership @JavedButler1 @Filippatos @FaiezZANNAD #StefanAnker
@ShahzebKhanMD
Shahzeb Khan
3 years
SGLT-2 inhibitors in Heart Failure with Preserved Ejection Fraction: Reasons for Optimism ‼️ ✅Targets multiple processes simulatenously which may be implicated in HFpEF ✅Placebo event rates in EMPA-REG Outcome similar to previous HFpEF trials
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@ShahzebKhanMD
Shahzeb Khan
3 years
Really looking forward to this session at #CVCT2021 on cheaper, faster and more efficient trials: is pragmatic the solution. Tune in at #CVCT2021 to hear more: @hvanspall @CVCTForum @FaiezZANNAD @JavedButler1 @docbhardwaj
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@ShahzebKhanMD
Shahzeb Khan
2 years
Insights from VITALITY-HFpEF 📌8.3 points represents MCID for improvement for KCCQ-Physical Limitation Score✅✅ 📌Any degree of worsening in KCCQ-PLS from baseline is imp‼️ 📌These threshols from pre-specified/blinded analysis have 🔑 implications for future HFpEF Rx trials
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@ShahzebKhanMD
Shahzeb Khan
4 years
From the FAIR-HF trial: The minimal clinically important difference (MCID) for KCCQ score was ⬇️ than 5-point change for weeks 4 and 24 in HFrEF pts. Imp implications for clinical interpretation of patient reported outcomes and endpoint selection.
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@ShahzebKhanMD
Shahzeb Khan
5 years
🔥article regarding threshold of statistical significance in HF trials and how to interpret/communicate uncertainty within trial results. Published in @ESC_Journals @ESCardioNews @safinmc @mvaduganathan @MRMehraMD @drjohnm @MarcoMetra
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@ShahzebKhanMD
Shahzeb Khan
1 year
📌 Imp to teach research skills, both theoretical and practical, at grass root level so today’s students can be tomorrows scientist in the developing 🌎 📌Since @R_C_O_P , we have taught >3500 students (>70% women and ⬆️ from rural areas), of whom many are now published 📝 (2/3)
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@ShahzebKhanMD
Shahzeb Khan
1 year
Ejection Fraction, Biomarkers, and Outcomes and Impact of Vericiguat Across EF in Victoria Trial @JavedButler1 @texhern @JACCJournals @lamcardio @DukeHeartCenter @AdriaanVoors @coconnormd @JustinEzekowitz
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@ShahzebKhanMD
Shahzeb Khan
5 years
With 🌍of HF trials, geographical differences in resp to rx are imp. Placebo effect is well knwn-here we show there are country level variation in placebo effect. Need more data for replication-imp aspect for future 🌎 HF trials. Mentored by @JavedButler1
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@ShahzebKhanMD
Shahzeb Khan
3 years
The pathophysiological link between CKD and CVD is fascinating. Looking forward to this important session at @CVCTForum on the rapidly changing landscape of cardiokidney trials. Will be an interesting discussion with the leaders in this space Register at
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@ShahzebKhanMD
Shahzeb Khan
1 year
📌Such models should be considered in other developing 🌎 to overcome shortage of physcian scientists. 📌Special thanks to @FrancescoPaneni for letting us contribute in @ehj_ed on this imp topic. @AnkurKalraMD @JTLLERGO @ValleAlfonso @vbluml
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@ShahzebKhanMD
Shahzeb Khan
6 months
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@ShahzebKhanMD
Shahzeb Khan
3 years
• Carillon Device Vs GDMT in Patients with Secondary MR and Severe LV Enlargement • Carillon Device improved MV function, LV morphology, functional outcomes and HFH • Pre-operative LV dimension should not be a limiting factor for eligibility
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@ShahzebKhanMD
Shahzeb Khan
4 years
PROGRESS-HF Trial Published in the May Issue of @JCardFail . Elamipretide did not improve LVESV at 4 weeks in HFrEF patients. @JavedButler1 @gcfmd @Filippatos @AdriaanVoors @SJGreene_md @HFSA @coconnormd @UMMC_Heart @UMMCnews
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@ShahzebKhanMD
Shahzeb Khan
2 years
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@ShahzebKhanMD
Shahzeb Khan
4 years
Many thanks Dr Michos @ErinMichos for your amazing help and support throughout. Has been such a pleasure collaborating with you.
@ErinMichos
Erin D. Michos, M.D.
4 years
Wow @DukeHeartCenter @manesh_patelMD chose very well! 👏👏👏 The extraordinary @ShahzebKhanMD is going to be a cardiology fellow with @DukeCardFellows . It has been a great honor to be one of his collaborators in his journey. Take good care of him @DukeHFDoc @robmentz @SvatiShah !
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@ShahzebKhanMD
Shahzeb Khan
1 year
@SeguraCardio
Diego Segura-Rodríguez
1 year
📌Effect of #SGLT2 Inhibitors on Cardiovascular Outcomes Across Various 👥 Population #CardioTwitter #CardioEd #SGLT2i
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@ShahzebKhanMD
Shahzeb Khan
5 years
🔥in @CircOutcomes regarding Fragility Index in CV Trials. Statistical sig can change based on few events.Brilliant accompanying editorial by @ProfDFrancis .
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@ShahzebKhanMD
Shahzeb Khan
4 years
Excellent paper in @AnnalsofIM regarding dual versus triple therapy for Afib after PCI led by @safinmc . Accompanying editorial discusses the difference between our and the recent @ESC_Journals @ehj_ed meta analysis. @ErinMichos @mmamas1973
@safinmc
Safi U. Khan, MD, MS
4 years
Dual Versus Triple Therapy for Atrial Fibrillation | Ann Intern Med | ACP | our latest SRMA in Annals of IM @ErinMichos @ShahzebKhanMD @Osmancardio @mmamas1973 @RaniKHasan @DiZhao16
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@ShahzebKhanMD
Shahzeb Khan
4 years
@ErinMichos Thank you so much Dr Michos for all your help and support. Really means a lot !!
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@ShahzebKhanMD
Shahzeb Khan
4 years
Suggested approach of using SGLT-2 inhibitors or GLP-1 RA in different clinical scenarios
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@ShahzebKhanMD
Shahzeb Khan
5 years
Our latest meta-analysis published in @asaiojournal regarding obesity and LVAD outcomes. @ShariqUsman2 @Mustafa_memon2 @CookCtyHealth @DemmerRyan
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@ShahzebKhanMD
Shahzeb Khan
4 years
In response to an excellent article by @rudolf_deboer et al in JACC showing that CV risk factors are strongly and similarly associated with incident HF in both sexes @MichaelJBlaha @JJheart_doc @JenHoCardiology
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@ShahzebKhanMD
Shahzeb Khan
5 years
How many CV RCTs adhere to CONSORT Abstract guidelines. Check our latest paper in @CircOutcomes . @safinmc @RamiDoukky @AsimShaikh99 @rohan_ochani
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@ShahzebKhanMD
Shahzeb Khan
5 years
Excellent accompanying editorial by Drs. Reddy and Borlaug @MayoClinicCV . Steps needed to standardize and use these important data.
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@ShahzebKhanMD
Shahzeb Khan
4 years
@DLBHATTMD Thank you @DLBHATTMD for all the support and guidance. Honored to co-author this important paper with you.
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@ShahzebKhanMD
Shahzeb Khan
5 years
Great talk by @ErinMichos on acc primary prevention guidelines at @CVCTForum
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@ShahzebKhanMD
Shahzeb Khan
5 years
@hmkyale
Harlan Krumholz
5 years
Why you need to critically review studies, not just read abstract conclusion. "This study suggests reports of CVD RCTs w/statistically nonsig 1° outcomes, investigators often manipulate language to detract from neutral primary outcomes. @JAMANetworkOpen
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@ShahzebKhanMD
Shahzeb Khan
4 years
CHART study led by @JavedButler1 published in the May Issue of the @JCardFail . In HIV pts, diastolic dysfunction associated with ⬇️QOL and multiple alterations in cardiac structure/function @SJGreene_md @HFSA @SvatiShah @HFpEF @texhern @UMMCnews
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@ShahzebKhanMD
Shahzeb Khan
7 months
Excellent initiative by @BalimSenmanMD
@CCCEnthusiasts
CCCEnthusiasts
7 months
🚀 Calling all #CCCEnthusiasts ! 🚀 Are you passionate about CCC and eager to connect with others? 🤔Or a trainee trying to navigate training and the world of CCC, we've got the perfect space for you! 🌐 🌟 Introducing – Your One-Stop Shop for CCC! 🌟
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@ShahzebKhanMD
Shahzeb Khan
5 years
Our study published in @JAMANetworkOpen discusses level and prevalence of “spin” in CV RCTs with non-sig primary outcomes. @HarisRiazMD @TariqJamalSidd1 @safinmc @RamiDoukky @drjohnm
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@ShahzebKhanMD
Shahzeb Khan
6 years
Our letter in jacc regarding gender equity trends in academic cardiology @TariqJamalSidd1 @ShariqUsman2 @JACCJournals @Cardiotweets83
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@ShahzebKhanMD
Shahzeb Khan
6 years
Our meta-analysis of mendelian randomization studies (first ever) in almost 1 million patients shows that obesity likely has a causal association with coronary artery disease !! @haithamahmedmd @HarisRi50354107 @TariqJamalSidd1
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@ShahzebKhanMD
Shahzeb Khan
5 years
@EuroInterventio
EuroIntervention
5 years
"Performance of Current Risk Models in Predicting Short-Term Mortality After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis" by @ShariqUsman2 @TariqJamalSidd1 @ShahzebKhanMD et al. #EAPCI
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@ShahzebKhanMD
Shahzeb Khan
5 years
In >30% of HF pts, RAASi is stopped/not optimized due to fear of hyperK. In this viewpoint published in EJHF, we discuss the role of novel K binders as enabling therapy in HF patients and point out examples of enabling therapies in medicine @JavedButler1
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@ShahzebKhanMD
Shahzeb Khan
5 years
@djc795 @bnallamo @CircOutcomes @venkmurthy @SVRaoMD @DrNancySweitzer @ProfDFrancis Absolutely. I think its virtually impossible to fit in all the important elements within 200-250 words. Effect of hardwiring abstract reporting elements (like @AnnalsofIM ) will be interesting as pointed in our discussion. @safinmc @RichKrasuskiMD
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@ShahzebKhanMD
Shahzeb Khan
6 years
In this editorial for AJM, @HarisRiazMD and I discuss the impact of documenatation on modern medicine
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@ShahzebKhanMD
Shahzeb Khan
5 years
@drjohnm @ADAlthousePhD @WFMMD Agree. Also FI obv does not solve the larger stats issues like frequentist vs bayesian, using statistical sig threshold or not. However if we c/w using frequentist+statistical sig, I dont see an issue with FI telling us numerically when results can jump
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@ShahzebKhanMD
Shahzeb Khan
4 years
@khurramn1 Many thanks @khurramn1 . Look forward to continuing our collaboration
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