Kevin A. Scott
@Sculpturatus
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🇩🇪🇺🇸 New York City, NY Chemistry | Immunology | AI | Saving the world, one molecule at a time
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Joined December 2020
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folding proteins on the train - what a time to be alive
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I always thought 2D nmr spectra looked cool, so I printed the first ones ever collected in our lab on canvas and hung them above the chemistry hoods.
#dataart
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Congrats to Chris and Ryan in Jon Njardarsons lab (my PhD lab) for continuing their amazing work on disseminating the top 200 FDA approved drugs by sales in 2022. Always great to see these.
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Are you a chemist who has just made a molecule that has never been made before? Curious where in chemical space it occurs compared to FDA approved drugs? I made a Colab where you can plot a PCA of FDA approved drugs along with your own molecule (see the red dot) RT! 1/2
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The Top 200 Drugs of 2021 poster from the Njardarson Group at my alma mater is out! Download it for free at the group website.
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I’ve heard of DMSO nmr samples freezing when walking between buildings in a cold climate but this is the first time I’ve experienced it.
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My graduate advisor, Jon Njardarson, has always been an inspiration to me both in the lab and in the classroom. Last semester he set out to modify the organic chemistry curriculum to make it accessible to blind and visually impaired students.
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Small molecules made up 60% of 2021 drugs by sales (40% biologics). Check out the new posted by my PhD lab (Njardarson) on Top 200 Small Molecule Drugs of 2021.
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Irises are my favorite flowers, and they're toxic to dogs! Here are some of the steroids responsible for the toxicity.
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Found on Williamsburg Bridge. Should I add stereochemistry?
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Thanks for an amazing two years
@katenokv
- I hope we cross paths again soon. I'll cherish these memories.
#chembio
#proteomics
#DrugDiscovery
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Vivideon's first molecule, KEAP1 activator VVD-037, is in the clinic
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Last week we saw the new poster of the Top 200 FDA Approved drugs of 2022 - excited to see more and more biologics being approved. For the chemists, here are the Top 200 Small Molecule Drugs of 2022 (by sales) from my colleagues in the Njardarson Lab.
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@MaximZiatdinov
I didn't come from a famous lab AND I didn't mention what i've accomplished. Beat that.
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My last week of postdoc at
@RockefellerUniv
. Two years in an amazing, nurturing environment. I love the people I've met and worked with, I've grown as a scientist and a person. Excited for a new opportunity. There are so many things I want to say, but for now it's just "thanks"!
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Every time I give a talk about covalent electrophiles I get the question about GSH reacting with the probes. Here's a nice half-life approximation for some representative electrophiles in this great review by Hillebrand et al.
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This paper highlights the impressive power of stereochemical diversity in library generation for chemical proteomics (or other drug discovery approaches).
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Here is the Colab notebook
Here is a GitHub link with a .csv file containing FDA approved drugs from 1951-2021 (needed for code)
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While I don't regret naming my dog Entropie, entropy was definitely higher when I came home from lab today.
#deltaS
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New: Plot your molecules in 2D or interactive 3D chemical space with FDA-Approved Drugs.
2D
Interactive 3D
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@KatrinaVelle
On a side note, Fisher's search function has to be the worst creation in the history of anything that has every existed. You can search for the exact name of your item and it'll be search result
#354
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@ItaiYanai
It's interesting that movies that win oscars and songs that win grammys don't get retracted at a higher rate.
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I support this. Academics spend a lot of time writing and we rarely have formal instruction on the topic. I teamed up with a linguist and wrote a J Chem Ed piece on this during my
PhD
As we step into 2024, let’s focus on a key academic resolution: enhancing our students’ writing skills.
Writing is first and foremost about organizing your thoughts and ideas, not just facing a blank page and hoping for inspiration. A thread🧵
#academicwriting
#Resolutions
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A big congratulations to Katya and her amazing team. The project was a ton of fun to work on, exciting to see it out! In short: state dependent targeting of splicing in T cells leads to ITK degradation/activation suppression through SF3B1 inhibition 1/2
Very excited to share our new
@biorxivpreprint
! Big thanks to all the co-authors who contributed to this story on Covalent targeting of splicing in T cells!
@Sculpturatus
, Hiro, Nathalie,
@chardw98
@teezhangg
@xzhang85
Read more below!
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this is the coolest thing i've see in a long time
just for the pleasure of it, the fine choreography of epithelial cell migration with a PI3K mutation. This is the complex behavior we have to drug to treat cancer ... Movie from
@lhinderling
. Switch sound on.
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Are you a chemist who is having a baby?! Here are some nice
#chemtwitter
names for your child!
nBuLi
DMAP
BArF
(Het)Ar
DMSO-d6
Hartree-Fock
Bürgi-Dunitz
6π-electrocyclization
Turbo Grignard
Are you a chemical biologist who is having a baby?! Here are some nice
#chembiol
names for your child!
Maldi
Protac
Azide
Ester
Phage
MOFO
Bruker
Glicknack
Edman
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Holy shit best going away present ever! Combines my love for plants and passion for chemistry. I've always loved
@Phil_Knutson
art, i'm a big fan. Now it's going on my wall. Thanks
@teezhangg
super thoughtful 🥰
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My dog loves the bathtub. Just because. I always find her there.
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Chugai's LUNA18 is one of my favorite recently disclosed structures - so unnaturally natural.
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alright the cicadas are buzzing now so it's officially summer. here's my photogenic dog
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i've always made a hobby out of going to botanic gardens everywhere i travel. berlin's is among the most impressive i've seen.
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#ChemTwitter
where do you get quality, low cost lab clamps from? Clamps from fisher are like $80 and the $30 ones break upon use. Does anyone have a tip for a good clamp source?
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I’ve been to a lot of botanic gardens and the one in Denver is one of my favorites.
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Well, Entropie jumped into the pond. First swim. This is now my favorite picture of her.
#NYC
#CentralPark
#deltaS
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When I was an undergrad I did some work in aerospace. One of the projects I worked on was the Mars InSight lander that just discovered water on Mars - :p cool
Mars water: Reservoir found deep in Martian rocks
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@ChrissyStachl
If the assessments are rarely in sync with what students are learning then the assessments should be reassessed 👀
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My umbrella got destroyed in the hurricane and now it kind of looks like a phage.
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In celebration of
#InternationalCoffeeDay
here are some of the non-caffeine natural products found in Coffee arabica.
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These hothouses in Göttingen were built in the 1850s. At this time there were botanic gardens in Europe that were several hundred years old, built in part to propagate medicinal plants that were otherwise only found in the tropics. This was important for early medicine.
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Nobel Prize winning aussies - Entropie meets Charlie Rice's dogs Lilly and Bruno
#NobelPrize
#RockefellerUniv
#deltaS
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Alright last tweet for today - the next version will allow for multiple datasets, like veterinary drugs and natural products. I'll probably have that up by this weekend. Cool that people are interested.
Are you a chemist who has just made a molecule that has never been made before? Curious where in chemical space it occurs compared to FDA approved drugs? I made a Colab where you can plot a PCA of FDA approved drugs along with your own molecule (see the red dot) RT! 1/2
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I've been writing code that takes a structure and uses a model trained on FDA-approved drugs to iteratively change the input so it's more drug-like. So far it consistently makes the input less drug-like. If you need to make your compounds less drug-like hit me up 😂
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@JavierDomingoB
No, I'm actually just using an algorithm called AlphaFold2 to predict the structures of several hundred proteins at a time from their sequences.
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Do all viruses that infect eukaryotes require host splicing factors to infect and replicate?
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One of the things I love best about
@SouthwestAir
is that they're always prepared. Today we're bringing a spare door with us.
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