Joanna Kovalski
@ScientistJoanna
Followers
73
Following
56
Statuses
31
Postdoc @ UCSF in Ruggero lab | PhD Cancer Bio Stanford University🦀 | Cancer biologist with a love for RNA.
Joined August 2014
We are excited to share our new work out today in @NatureCellBio uncovering a new Achilles heel of pancreatic cancer. Myc is a key driver of PDAC and predicts poor survival. Thus, we asked the question of how Myc protein levels are regulated in PDAC. 👉 🎉
3
10
39
Thank you, @RuggeroDavide for his fearless leadership and the rest of the fabulous co-authors. Thank you also to @ACS_Research for critical fellowship support and providing supportive research community as well as @UCSF @UCSFCancer #UCSFPancreasCenter #UCPancreasConsortium
0
0
4
This study highlights the importance of taking a new perspective on the control of oncogene expression in cancer. We are excited to take the next steps to translate these findings into novel therapies for patients.
0
0
0
Critically, as part of a fantastic collaborative effort with @rushika_perera’s group, we show that RBM42 is required for PDAC tumorigenesis through its regulation of Myc, which is also supported by studies in human PDAC tissues.
1
0
1
Using a new translational reporter system combined with CRISPRi, we identify a rich translational regulatory network for MYC. RBM42, an RNA binding protein, jumped out to us as an exciting new target that we found regulates Myc mRNA translation and is necessary for PDAC growth.
1
0
1
We are so pleased to share our new work looking at the selective production of the oncogene Myc in PDAC. Moving one step closer to novel ways to target a deadly cancer driver. Thank you to @RuggeroDavide @RNACanadaC2R2
Davide Ruggero characterized the structure of Myv 5’UTR and a key RNA binding protein that regulates its translation level by interacting with specific structural motifs. Cool work
0
0
11
RT @RNACanadaC2R2: Davide Ruggero characterized the structure of Myv 5’UTR and a key RNA binding protein that regulates its translation lev…
0
3
0
Lots of interest and excitement about our forthcoming research looking at how PDAC regulates Myc protein levels. So glad I could share this story with the translational control community. #cshltranscon
0
1
9
Absolutely beautiful day for exciting findings in translational control here at CSHL. We cannot wait to share our interesting new work on translational control in cancer! @RuggeroDavide @DuyguKuzuoglu
0
0
8
RT @RuggeroDavide: I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting a…
0
73
0
@Now_UALCAN Can you provide information on the statistical tests used in your extremely helpful Cancer "omics" tools?
0
0
0
RT @DuyguKuzuoglu: Dear friends and colleagues, Turkey, my home country, was hit by two back-to-back earthquakes with magnitude 7.8 and 7.5…
0
9
0
RT @lwelmore0320: Hot off the press: big enhancements to @ACS_Research postdoctoral fellowships. More $, expanded eligibility, and no citiz…
0
45
0
@RuggeroDavide @Forester_lab @sohitmiglani @mbarnalab Congratulations @Forester_lab !! Fantastic work!
0
0
4
RT @RuggeroDavide: Another beautiful study of how ribosomal heterogeneity at the atomic level shapes tissue organogenesis and specialized t…
0
10
0
RT @RuggeroDavide: Fascinating work by @Megan_L_Norris! Uncoupling mRNA localization from translation but not protein activity in cytoplasm…
0
4
0