Ross Wilson
@RossWilsonLab
Followers
903
Following
945
Statuses
425
CRISPR whisperer in perpetual training. We're working to enable safe & accessible delivery of genome editing therapeutics. @igisci @UCBerkeley https://t.co/89o53zRYUa
Joined December 2019
I’m excited to share our report - out now in @natBME - of a new approach to CRISPR delivery that is poised to transform the way engineered T cell therapies are manufactured. Visit for “how to” details. It’s threadin’ time! (1/11)
10
76
253
Credit goes to everyone who contributed: @srishtiupasana, @LorendelaOM, @BrunoSo42741366, and especially lead author Christy George, who worked tirelessly on this review.
0
0
0
@ProfluentBio This is incredibly important work. I've been hoping that a broader PAM "menu" would soon be available, since it can make a massive difference for the utility of base editors. It looks like you're moving the field in that direction, which is wonderful to see!
0
0
0
RT @gokul_ramadoss: CRISPR has the potential to cure many genetic diseases, but it’s notoriously hard to use in neurons. In this work we t…
0
87
0
@BrigetteManohar You're too kind. And the feeling is absolutely mutual - it's so great to work with you!
0
0
0
The Wilson lab has two new PhD candidates: 🍾 Congrats 🍾 to Brigette Manohar and Christy George on passing their @berkeleyMCB qualifying exams! They're both working to improve CRISPR delivery, potentially enabling new therapies for the central nervous system.
1
0
31
@DrTGPetersen @thisismadani @ProfluentBio People are already using CRISPR to tackle C9orf72 expansion, and this new developent could make those candidate therapies safer and/or more potent. Example:
1
0
1
@rammydev @thisismadani @ProfluentBio The field typically uses E. coli to "print" proteins, transforming them from genetic code to a physical enzyme (which we can purify). In the work reported here, they put the coding DNA into human cells and let them do the same thing. So they are reporting a real-world test!
0
0
0
RT @srishtiupasana: Here in this winter wonderland at Banff 🇨🇦 for the Keystone conference on Precision Genome Engineering #KSGenomeEng24 #…
0
1
0
@budcolincoln @davidrliu @Nature @DDunkelmann If the entire "dictionary" of life's biochemistry had been only ~20 words, this work expands the vocabulary substantially. More words = proteins w/ novel/diverse functions. The next step will be to find ways to put these words into widespread use, which has been tricky so far.
0
0
1
@Ella_Maru @davidrliu @NatureBiotech A great thing about prime editing is that it doesn't rely on double-stranded breaks in DNA, which can result in chromosomal rearrangements which - although not necessarily dangerous - would be nice to avoid. And it relies on 3 steps: more of a "filter" preventing off-target edits
0
0
2
@R_Schmidt_ @dlwagner13 @Nature @MarsonLab @carlcward Absolutely epic work - congrats and thank you for pushing things forward!
1
0
3
RT @R_Schmidt_: Excited to share a milestone in our forward genetics developments! Today in @Nature we report massive mutagenesis screening…
0
98
0
@Nicole_Paulk The terminology hills I'm ready to die on? CRISPR is not gene therapy - it's genetic therapy. Cutting w/ two gRNAs is not "dual guide" because that phrase = you used crRNA+tracrRNA (dgRNA). And it's technically CRISR-Cas9:
0
0
0
RT @BrigetteManohar: Happy Holidays from the Wilson Lab ❤️❄️ I wonder what Santa will be DELIVERing for us 🎅🏾🎄
0
3
0
@GeneInvesting @antonioregalado Yet... investments: 1. New editors 2. Different editors 3. Shinier editors 4. Delivery COI: am delivery guy🚛
1
0
1
@RTLeenay This is so great. Another thing in the "HEK" category is plasmid-driven delivery/expression (as opposed to something transient, like RNP).
0
0
1