Crystian Massengill
@Oliver_Snacks
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Neuroscience PhD student @Pin_Harvard, Andermann Lab | Solving consciousness via neuromodulators | formerly Mao/Zhong labs @ Vollum Institute
Boston, MA
Joined March 2017
Nearly all neuromodulators & neuropeptides are integrated through GPCRs to converge onto the cAMP pathway. However, in vivo imaging of cAMP remains challenging. We develop new sensors and demonstrate compartmental cAMP dynamics in neurons during behavior:
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The only person I know to have written an entire review before finishing their qualifying exams: the indominable @GizemTerzioglu_
In my first, first-author publication, @YoungPearseLab and I review what’s known about the role of inflammation in AD, contributions of the NLRP3 inflammasome to microglial inflammatory response and the known intracellular functions of SHIP1 in myeloid cells.
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Congrats soon-to-be Dr. Terzioğlu!
I passed my qualifying exam today! I am a whole PhD candidate now!
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Fantastic work from @Jonna_Singh_ & @andrewlutas! Critical push forward in our understanding of how intracellular signaling can translate fast neurotransmission into other timescales.
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@HainingZhong @Nature @mmuunniiaakk @BJunDing @VollumInstitute @OHSUNews So happy to see this out, congrats!
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@trose_neuro As I said, surgery without has brain popping out, surgery with dex 2 hour prior doesn’t, so yes it does help, at least in the cases I described.
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@trose_neuro Dex does help for intra-operative brain swelling in mice. Don’t think it’s needed for medial regions or large >3mm windows, but I’ve definitely had brain tissue popping out when drilling small (2-3 mm) craniotomy in far lateral regions, and dex 2 hours before fully prevents this.
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@trose_neuro As a further extreme. I’ve heard from a lab who swears by daily dexamethasone for a week prior to craniotomies.
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RT @NatureBiotech: An optimized cAMP sensor enables live-monitoring of physiological signaling dynamics in mouse neurons in vivo. #NBThighl…
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RT @naturemethods: cAMPFIREs: Improved genetically encoded sensors for in vivo subcellular imaging of cAMP. @Oliver_Snacks @BaylessLandon…
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cAMPFIREs are available on Addgene: Many thanks to my PIs @HainingZhong and Tianyi Mao, and coauthors @BaylessLandon @byneuron @ElizabethCebul, Cesar Ceballos, Maozhen Qin, Evan Wilson, Matt Whorton, Isabelle Baconguis, James Cahill, & Arpita Bharadwaj,
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