Muller Lab
@Muller_Lab
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Targeting tumors with 1p36 homozygous deletions since 2012. Cancer Genomics and Metabolism Lab. Tweets are my own opinion.
Houston, TX
Joined November 2019
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@PeterHotez
Did you predict that the emerging pandemic virus would differ from all other Sars-like viruses by the presence of a furin cleavage site at the S1/S2 locus?
The DARPA grant by Peter D "predicted" just that. Should we be praising
@EcoHealth
and Peter for their foresight?
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False, poorly informed and western-centered: the first scientists to propose, in writing, that COVID19 was introduced to the human population, through research activities, were in fact from China.
The 'lab leak theory' started with a 'brain fart' from that Trump. It was immediately seized on by people who hate science and rational enquiry. The COVID lab leak theory is dead. Here's how we know the virus came from a Wuhan market via
@ConversationEDU
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Peter Daszak — the Elizabeth Holmes of Pandemic Prevention? by Neil Harrison
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@jbloom_lab
@angie_rasmussen
@stuartjdneil
So we should trust the other statements put out by a regime that deletes sequencing data?
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@thenation
False - you are letting your readers down by allowing two opinion writers to pose as experts.
No discussion of the science - just citations to widely discredited articles relying on data relying on the good faith of the Chinese authorities.
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@c_drosten
What the data in the paper actually show: despite deep surveys of the SARS like CoV clade, not a single one has a functional human furin cleavage site, except SarsCov2.
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@Byron_Wan
@BillyBostickson
@gdemaneuf
@R_H_Ebright
@CharlesRixey
@franciscodeasis
@GMWatch
@MonaRahalkar
@quay_dr
@Daoyu15
@TheSeeker268
@Ayjchan
@mattwridley
@ianbirrell
@SharriMarkson
@Tantalite
@joshrogin
@keverington
Why did no medical personnel get infected?
A simple explanation: the Mojiang CoV did not have a fully functional Furin Cleavage Site, so only the miners exposed to the highest doses of virus actually became sick.
What evidence for this? Spelled out nicely in DARPA proposal.
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Remarkable study, showing that when tumors get big enough and have high enough glycolysis rates, they can consume so much glucose as to induce systemic hypoglycemia and extreme lactate elevations. Effect was accentuated by the drug, but present before.
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Simple, legitimate questions that many have raised, and been maligned by the virology establishment for doing so.
Troubling that it took "weaponized" FOIs to discover that leading virologists have had the same questions privately.
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@MichaelWorobey
At the least the Lancet study is cited - but the fact that it specifically notes that the earliest cases are not market tied is ignored.
And again, no mention of the public domain cases that pre-date the market.
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@Sri_Baqri
@CellCellPress
@stuartjdneil
What’s amazing to me is that
@CellCellPress
is actually accepting any manuscripts from this research group given their unwillingness to share critical data - a foundational principal of science.
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@natashaloder
@WashburneAlex
@mbalter
Except of course that it didn’t emerge anywhere near the market.
The earliest patient, Nov 17, had no connection to it.
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Why does chemotherapy kill cancerous but not normal cells? Most cancer biologists would answer this by stating that chemotherapy is selectively toxic to proliferating cells, and that cancer cell proliferate more than normal cells. Not exactly - there's a lot more to it.
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@lexfridman
@NIHDirector
@NIHDirector
keeps repeating that SarsCoV2 could not have been made from published CoVs like RaTG13.
How confident is he that the Wuhan Institute has published all the CoVs it has collected with
@NIAIDNews
funding? WiW took down a major database 22,000 paths they collected
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Happy to be corrected, but as far as I am aware, only three labs in the world had published on engineered Sars-like CoVs, prior to 2019.
UNC
UTMB
WIV
Hubris in Virology: Robert Garry explains why the presence of a virology lab in the city where SARS-CoV-2 emerged is unsurprising, justifies building BSL3/4 labs in big cities, and explains why BSL3/4 labs are needed (from TWIV ep. 762)
"Ignorance is hardly ever the best choice"
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@philipcball
Nice try….must be nice not to have to provide references and citations.
E.g “most scientists believe…from a bat” - Philip, how exact;y do you know what most scientists believe?
can you point to a scientific survey that supports this statement?
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@profvrr
The echo chamber at full volume: those who are likely to disagree with this thread have already been blocked.
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@ggronvall
Can you point to an infected intermediate host and where/when was patient zero?
Until you can answer these questions in the affirmative the origins debate is wide open.
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The tweet-deleter’s judgment on journalism: those who uncritically repeat what I say are journalists- those who independently investigate, are conspiracy theorists.
Outrageous & totally unacceptable
@K_G_Andersen
calling serious journalists like
@KatherineEban
&
@zeynep
💩 conspiracy theorists when he himself has been so opaque & seemingly deceitful. Major scientists like
@jbloom_lab
also raising fundamental questions re
#COVID19
origins.
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@emilyakopp
@emilyakopp
: "Top virologists like Angela Rasmussen" is incorrect.
Dr. Rasmussen's academic record is mediocre at best - hardly any publications as either first or senior author.
More appropriate:
"virologists with active media engagement like AR.."
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@doctorsoumya
@Kempton
The
@WHO
has been consistently behind the curve on
#COVID19
(person-to-person transmission, aerosol, masks).
I'd trust
@CDUMerkel
's medical team more than the WHO, in their conclusion that mixing AZ and BioNT is safe and effective.
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A lawsuit against PD....does this mean his emails, sequencing data, etc of the EcoHealth Alliance are going to become public during the discovery process?
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@danengber
I feel most stupid about this whole thing.
My graduate students were like "this is totally from the lab" (in 2020)
My reaction: people who know sequence analysis would have looked into this and figured it out if it were....
I'm a "trust the system" kinda person..or used to be
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Regrettably,
@MichaelWorobey
did not take the opportunity given by his moment of fame to call out the Chinese authorities to release the samples, sequences and information on these early cases.
To be fair, neither did
@POTUS
when he met Winnie-the-pooh.
Apparently the WHO asked the Chinese government for data on 174 early cases, and the Chinese government refused.
Is that the same 174 limited info cases Worobey analysed?
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The wikipedia page of DRASTIC is locked -
@Wikipedia
: an editor needs to update to include DRASTIC's most revealing discovery so far, the DARPA grant proposal outlying how EcoHealth/WIV planned to insert FCS into Sars-like CoVs.
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Trust the experts; not common sense
A Sarbecovirus with an FCS showing up at the doorstep of the lab lab that both systematically collects and engineers such viruses (and which proposed adding an FCS to a Sarbecovirus) is pure coincidence for virologists such as
@florian_krammer
@harishseshadri2
@Muller_Lab
@florian_krammer
@WashburneAlex
@angoffinet
Matt Hancock: “just too much of a coincidence...denials are a bit like us claiming that a random virus just happened to break out near a little place called Porton Down [biolab], perhaps because of some badgers. It just doesn’t fly"
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@ProfPCDoherty
@ConversationEDU
Somebody of this stature, perpetrating, what can only be termed "disinformation" - but Sir Peter is in good company with other Nobel prize winners made equally poorly informed claims, be it about vitamin C or the cause of AIDS.
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@Ayjchan
It is very distressing that several of these "origins" papers gloss over the simple fact that the debate could be ended by a rigorous patient tracing study, for which the Chinese authorities have shown tragicomically little enthusiasm. This was even noted by WHO participants.
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@emilyakopp
It's my understanding that
@POTUS
has signed a law declassifying intelligence surrounding COVID19.
Are these redactions not violation of this law?
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@MJnanostretch
"horizontal gene transfer" - can occur in the wild (rarely) or can be induced in he lab artificially "transgenic".
In other words a nice code word for lab engineered virus leak.
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So many hours the TWIV podcast has spent discussing the supposed lack of evidence for the lab leak hypothesis....and so little time TWIV has spent on discussing the supposedly extensive evidence for natural origins.
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@Ayjchan
@ScienceMagazine
Question to Linfa: Were you aware that the rejected DARPA grant, on which you are listed co-investigator, proposed engineering a human FCS in SarsCoVs bat viruses and growing the chimeras in human cells? If yes, why not disclose it earlier.
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@R_H_Ebright
The timeline is early similar to 2 years ago - an exposure occurs in early November by a worker who fails to report it - the full impact in the community is only realized weeks later
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@PeaseRoland
@MichaelWorobey
@angie_rasmussen
@ggronvall
@PeterDaszak
@MarionKoopmans
@WildCRU_Ox
It is your privilege to select whomever you please to interview on your show - but it is disingenuous to portray to your listeners, that these individual's interpretations represent a unanimous scientific consensus on
#COVID19
origins.
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@SaskiaPopescu
@GCRInstitute
-Only 36/168 of the respondents were familiar with DEFUSE
-Only 98/168 of the respondents were familiar with the WHO study
Even accounts like
@past_is_future
would know these studies.
In other words - where did they find these people?
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@jimmy_wales
@crehage
It used to be a solid, neutral-point of view, source.
Not so anymore - case in point
#OriginsofCOVID
and any articles associated therewith (Wuhan Institute of Virology, Peter D, etc...).
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Just so that we are all on the same page:
@EcoHealthNYC
has subcontracts with various SE Asian countries to "arrange shipment of bats and other high-risk host...to Wuhan Institute of Virology"
That includes Vietnam.
Nguyen Huu Nam from Hanoi Agricultural University
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And these are the same authorities, that
@angie_rasmussen
,
@amymaxmen
and friends are asking us to trust when they assert that not a single worker at WIV ever tested positive for SarsCov2....
On Jan 1, 2020, 🇨🇳 state media reported 8 people in Wuhan were arrested and punished for spreading rumors of an unknown pneumonia. Dr Li Wenliang was one of the 8. That pneumonia snowballed into a global pandemic killing ~4M. Some scientists take the regime’s words at face value.
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@Laurie_Garrett
@janeqiuchina
It’s amazing that people with full access to information would actually believe that there is such a thing as “independent reporting” in China.
Perhaps Laurie also believes the disappearance of Peng Shuai was just a big misunderstanding.
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@UAWeapons
@CiroNappi6
The part I don't get is: heavy artillery, which is the main solider-killer in this war, is ok to supply to Ukraine - but modern battle tanks (more show than punch), are not?
@OlafScholz
- please do explain.
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Substantial segments of the international virology community have shown little interest in supporting
@WHO
's request for complete data release of early suspected cases and pretend that pre-market cases do not exists, despite peer-reviewed literature to the contrary.
The "I'm just following the data" copout. If the Chinese government gives you a truncated data sample, you should proceed to analyze the data at face value. That's just following the data!
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A widely held misconception is that peer-reviewers decide what gets published.
Not so - the decision is with the editor.
As such Holden - as editor in Chief of
@ScienceMagazine
- ultimately decides what does and does not get the official stamp of approval.
Let that sink in...
A new
#FOIA
release from NIH with records of communications between Dr. Fauci and Science magazine leadership:
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@Laurie_Garrett
An FOI email from
@PeterDaszak
on his earlier paused GOF grant make it clear that chimera experiments were to be done at WIV even though for grantsmanship purposes, the grant had stated UNC as the site of activity.
@Biorealism
- if you have it handy, please share with Laurie.
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The science-influencer Markolin forgets to mention that re-assembly of chimeric viruses from recombinant libraries is precisely what some observers have alleged as the lab synthesis of SarsCoV2.
What part did you find most convincing?
Was it the viral sex bit?
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The attacks by establishment scientists against junior researchers like
@Ayjchan
are much more problematic....
quick comment on Worobey's statement that "stooges will be stooges" is a childish insult:
Non-scientists trying to follow these complex and confusing discussions may not view "stooges will be stooges" as an insult, but rather as a clear and concise way to call bs.
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@gettylegion
This video should be playing in the background when Russian Ambassadors meet with Western leaders - just so that everyone is on the same page about what the horrors this war - of Russia's choosing - has unleashed on the Russian people.
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@c_drosten
Can you share the email from the editor showing no adequate reviewers could be found?
I never heard of something like this
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Superb job by Chinese virologists and CCP-authorities in tracing the zoonotic injection of a novel RNA virus.
And yet somehow, these highly surveillance-proficient Authorities are unable to trace the zoonosis of SarsCoV2....
In this report, investigators in China identified a new henipavirus associated with a febrile human illness. This virus was also found in shrews.
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@shellenberger
@shellenberger
: can you ask your contacts in intel who gave you the name "Ben Hu" - whether they can leak a PDF of this grant by Ben?
Might be DEFUSE 2.0?
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@RNCResearch
Just as reminder - the latest Fauci email dump make it very clear THAT RESEARCHERS IN CHINA were suspecting a lab origin and communicated that to their western counterparts prior to the Feb 1 phone call.
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Stuart Neil is actually accepting that the WiV Sep 12 2019 database take down is relevant....
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@stgoldst
Can you clarify whether you were aware that only a single read in that critical sample mapped to SarsCoV2?
If so - did you share that qualifier with
@KatherineJWu
?
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@carlzimmer
@carlzimmer
’s latest article nicely exemplifies why both scientists and the general public have lost trust in mainstream media science reporting
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@TheSeeker268
Not enough attention to the confirmed lab leak in Taiwan, at BSL3 - should be a wake up call to the virology community
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@EcoHealthNYC
@jack
How is it that
@Ayjchan
can't get a blue check mark, but
@EcoHealthNYC
- which can't get their story straight?
Given their contradicting story, should one report
@EcoHealthNYC
for spreading
#covidorigins
disinformation?
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@PeterHotez
@shasha55
The only thing "we" (the scientific community - for which Dr. Hotez does not speak - his opinion are his own) has reached a consensus on is that the distant ancestor of SarsCoV2 came from bats in and around the border area of Yunnan/Vietnam/Laos.
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Edward Holmes, Andrew Rambaut, and Kristian Andersen said, “Making promises about disease prevention and control that cannot be kept will only further undermine trust.” They described assumptions that such virus hunting projects could succeed as “misguided” and “arrogant.”
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@profvrr
believes that RaTG13 is ancestral to SarsCoV2?
"Recombination analysis demonstrated that the SARS-CoV-2 genome is a mosaic of at least five different genomes, including BANAL-52, -103, and -236, and the previously published ...N06, and RaTG13.."
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@ScienceMagazine
I believe the error in code was pointed out first here on Twitter.
@nizzaneela
?
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@PeterHotez
Not so, Peter.
More supervision and scrutiny of research involving genetic enhancements of pathogens is no threat to biomedical research in general.
As
@R_H_Ebright
explained, little translational value, but is easy to publish and boost careers.
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Note the date: this is again the same Linfa who didn't think it pertinent to share his knowledge on FCS engineering of the DEFUSE proposal by
@EcoHealthNYC
- until documentary evidence was presented.
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At BSL3 with a fully vaccinated worker with a known highly transmissible human virus - I am waiting for
@ggronvall
to tell us that this has no bearing whatsoever for the possibility of SarsCo2 ancestor having leaked from WiV by pretty much the same route.
"Taiwan's Central Epidemic Command Center (CECC) concluded..Saturday..that a..researcher was infected with the Delta variant of COVID while experimenting on the virus in a high safety laboratory."
Taiwan confirms researcher infected with COVID in lab
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@MichaelWorobey
@jeffykao
@KatherineEban
@SenatorBurr
@jeffykao
and
@katherineEban
please note that what Michael refers to as “earliest” cases are those in the China-WHO join study. Cases provided by the Chinese authorities, not independently verified.
Numerous mistakes in that report have been noted, eg WaPo
@evadou
article.
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@Bryce_Nickels
@PeterHotez
unscientifically disparages
@Ayjchan
who by objective metrics - has shown herself a better scientist than Dr. Hotez
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@TheSeeker268
The chimp/human 96% analogy is disingenuous: the mutation rate is way lower than in CoVs....not sure how this got through review.
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Should trust the transparency of the WiV scientists on revealing what viruses they constructed?
Linfa Wang - who isn't even from the WiV - wouldn't tell on the DEFUSE proposal until confronted by a leak.
Do we really expect more transparency from the other co-authors?
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@BenFPiercePhD
@COVIDSelect
As a former
@NIH
grantee:
Getting progress reports in on time was incredibly stressful on the whole lab since it was understood that missing the deadline would result in grant termination.
I find it very irritating that Peter flaunted this requirement and keeps getting funded.
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The Origins of SARS-CoV-2: A Critical Review
"Despite extensive contact tracing of early cases during the COVID-19 pandemic.."
@arambaut
Difficult to take this sentence seriously given that
@Peterfoodsafety
et al were denied tracing data.
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I wonder whether the recent DRASTIC leaked DARPA application will be entered into evidence in this lawsuit against Peter D.
I would love to see how a jury will evaluate the competing claims.
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@janeqiuchina
@Ayjchan
These types of bland statements don’t carry any weight, especially not from a “reporter” based in Beijing who has strong incentives to tow the part line.
That said, I am eager to hear detailed critiques, supported with evidence and citations.
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@ggronvall
Let's try the rational scientific approach.
Can you name a therapeutic benefit to humanity that resulted from the genetic enhancement of viruses with pandemic potential?
Ralph Baric couldn't give an example when pressed - and neither could Ben.
Let's hear it from this account.
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The DEFUSE proposal also explains why the FCS doesn't correspond with the best humans could design.
DEFUSE didn't set out to make the most infectious virus possible - small modifications, one at a time, to see how evolution might allow a Bat Virus to jump the species barrier.
Importantly, even if SARS2 was genetically modified, it doesn’t mean that it was a bioweapon or intended as dual-use.
My reading of the Defuse proposal is that the scientists were genuinely curious and wanted to study rare cleavage sites in SARSrCoVs.
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@cremieuxrecueil
Let's see whether "epigenetic age" accurately predicts mortality doubling time (demographic aging) in a prospective trial.
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@WashburneAlex
Fauci and Collins have experience with FOI's so their choice of language is likely reflected by the knowledge that their comms might become public - if
@HouseGOP
are serious about their investigation, they would subpoena personal e-mails, phone and texts from public officials.
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@MichaelWorobey
@ScienceMagazine
MW's Zenodo paper turned out to be "unpublishable".
Only with extensive revisions, expressing caveats and disclaimers did it finally make it through at
@ScienceMagazine
- a publication whose Edt-in-Chf is unreceptive to any non-natural origin hypotheses.
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@robertson_lab
"....scientific credentials to bolster false claims that... ultimately, damage health. "
Scientific credentials were wielded by Peter D against
@Ayjchan
's questions. And leading virologists continue to use credentialism when the data doesn't support their narrative.
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@natashaloder
@MarionKoopmans
@PeterDaszak
@PNASNews
Funny that Marburg, a virus named for the city in which it first escaped from a research facility, is labeled as zoonotic
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@MichaelWorobey
@jeffykao
@KatherineEban
@SenatorBurr
@evadou
He neglects to mention that Open sources identified multiple pre-December cases.
"can be traced back to November 17, according to government data seen by the South China Morning Post."
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@Illegalemigran1
What I can say from personal communications with other scientists is that her book is drawing researchers into the discussion which were previously sitting on the sidelines.
If AR hadn’t blocked me, I would say this to her: Angela, write your own book and stop being jealous.
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Disagreement on definitions seem like a key issue in the SarsCoV2 origins debates.
Previously it was "GOF" - now it is "Launched"
Just like Fauci's definition of "GOF", which is rather NIH-specific.
I've read your entire thread and explained why I think it's accurate to describe the GVP as stalled. As for the definition of "launched," we have different opinions.
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the same Linfa who knew about the FCS and said nothing until documentary evidence was produced….
Let’s clarify: does not have to be a permanent breeding colony. The question to pose to Shi is: did you bring field collected Rhinolophus to WIV?
Clearly, researchers have kept Rhinolophus in captivity, albeit none of these as far as I can tell are breeding colonies and the largest has 32 animals. I will return to Linfa Fang, who is not on Twitter, for his thoughts.
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@WashburneAlex
@amymaxmen
also seems unaware or purposefully ignores the impact NextGen sequencing has had on virology.
If there was a natural reservoir and CCP wanted to find it, with current technology (sequencing + mas surveillance), it would have been located by now.
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How about
@NIAIDNews
redirects the funds used in the genetic engineering of viruses to basic chemistry research of anti-microbials and anti-virals?
Problem solved. The next
@NIH
director should commit himself to this in the next hearings.
It's going to be weird to watch Democrats die on the hill of unregulated gain-of-function virology.
I have a bad feeling that doesn't play as well with voters as it does with Twitter famous virologists.
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Is someone going to add the
@FBI
to the list?
Supporting lab leak conspiracy and all.
On the 52 American doctors who propagated Covid misinformation throughout the pandemic regarding vaccines, masks, promoting treatments without evidence, and conspiracy theories
@JAMANetworkOpen
by
@Sahanasule
and colleagues
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@SaskiaPopescu
@GCRInstitute
Only 22% of responding "experts" were familiar with DEFUSE
Enough said
"**Annex Table F3. Familiarity with COVID-19 Studies and Reports, by Expertise** "
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@SamRamani2
Since Russia has no issues revoking international treaties, maybe
@Denmark_UN
should consider revoking the Copenhagen convention of 1857 and start charging transit fees to Russia bound cargo ships
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They keep repeating “most virologists say….wild animal” without scientific survey data.
I just don’t see how the benefits of gain-of-function research can ever justify its pandemic risks. The risky GoF research by EcoHealth and WIV — creating new SARS-like CoVs or supercharging MERS — has yielded zero benefit in preventing the SARS2 pandemic.
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@emilyakopp
It's interesting that this rightfully exasperated virologist (someone is making money off of his work) has to make a statement of faith ("I believe it came from an animal") at the end of the e-mail.
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@TheSeeker268
@vattay
It's easy to find what you want in seq datasets at low coverage (see
@c_drosten
FCS artefact). But this study looks credible and suggests a systemic investigation of all NGS projects on Illumina from 2019-early 2020, looking for SarsCoV2 reads.
@illumina
- what do you think?
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@harishseshadri2
Two possibilities:
1) Dr. Morens is really unaware of the DEFUSE proposal - which would nice illustrate the "Head in the sand" approach of the zoonosis side - an utter unwillingness to examine the evidence for the lab leak hypothesis objectively
2) Dr. Morens lied under oath.
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@Ayjchan
@USRightToKnow
Sadly, a significant fraction of the Virology and the Science Writing community (though not the scientific community as a whole) will see these FOIAs as "victimizing"
@EcoHealthNYC
rather than being stunned by the idea of withholding critical data in the midst of a pandemic
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@MarionKoopmans
Can you ask
@EcoHealthNYC
what samples were sent from Vietnam to WiV?
FOI documents show a funded collaboration with a Vietnamese University. We'd love to know what was actually sent to the Wuhan Institute.
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@VBruttel
@ch_zimmer
@CD57227
@SteveBigpond
@Rebecca21951651
@AdrianJ44426152
@ColinDavdButler
@hoojeenix
@R_H_Ebright
@Biorealism
@zasdak
@ianbirrell
@emilyakopp
@bell00david
@stevenemassey
@VillanuevaPM
@BillyBostickson
@CharlesRixey
Virology expert
@_b_meyer
insists that Marburg Virus's introduction to the human population wasn't a lab leak...
Given that the lay public can easily see that this is false - what should the LP make of his other "trust-the-expert" declarations?
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@GYamey
@natashaloder
@emilyakopp
Can you clarify how this affects the original documents obtained through an FOI - that are open and plain for anyone to read?
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@Ayjchan
I'd read his comment rather differently:
What Fauci says
"Almost certainly not"
but what this really means is
"I cannot rule out"
I.e. Fauci cannot rule out that a
@NIAIDFunding
was in fact used to produce SarsCoV2.
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@gorskon
Even fierce opponents of lab leak have voiced concern that people with relevant content information did not speak up until FOI documents came to light.
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