Eric Taylor
@Mitoverse
Followers
554
Following
1K
Statuses
281
Professor and Principal Investigator, Molecular Physiology and Biophysics | Faculty Director, Metabolomics Core. Carver College of Medicine, U of Iowa.
Iowa City, IA
Joined May 2017
1/n. Final version now online @MolMetab! Especially for labs newer to metabolomics, we hope this clarifies the need to freeze tissues immediately after loss of perfusion to preserve the in vivo metabolism.
Ever wondered how quickly mouse tissues need to be frozen to preserve the in vivo metabolome? Immediately after disrupted perfusion. We show here that this applies to the broad metabolome, between-genotype differences, and 13C-isotopologue distributions.
3
15
52
RT @HSingh_OSU: Thanks to @nih_nhlbi for the direct support for the project and highlighting the publication. Read behind the paper story a…
0
8
0
RT @fujiryosan: Building upon our previous study published in Cell Rep (10.1016/j.celrep.2023.112289), which identified large Mafs as essen…
0
12
0
Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact? We did! Published Online today ( and led by first-author @adam_rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone acetoacetate, and leucine in several mouse models of disrupted hepatic mitochondrial and cytosolic acetyl-CoA generating pathways. Surprisingly, deleting the mitochondria citrate carrier (CiC) increased DNL from both exogeneous and leucine-generated acetoacetate. Overall, our findings delineate a mitochondrial-cytosolic DNL substrate supply network that may guide more accurate therapeutic development for MASLD and T2D. Many thanks to our expert collaborators: No X Ryan Sheldon, now leading metabolomics at the @VAInstitute, who helped start the project and develop the necessary mass spec methods with @adam_rauckhorst; for @StanislawDeja and @Isotopomer for deuterium tracing by NMR and careful contibutions to quantitatively framing our mass spec data; and Tom Vallim of @TarlingVallim for guidance with in vivo gene deletion by AAV CRISPRs. Please also see the exciting co-published manuscript from @WellenLab and Christian Metallo Labs ( showing that bempadoic acid does more than just inhibit ACLY! @FOEDRC, @UIowaResearch, @UIMolecPhysBio
4
31
99
The truly immersive John Luther Adam’s Inuksuit! Performed by 100+ percussionists at Iowa City’s City Park, with Hancher Auditorium. @HancherUI @CityOfIowaCity @IowaCityofLit
0
0
3
G3 storm arriving with lights likely most visible Saturday. #aurora #northernlights #spaceweather #iowa
The northern lights could be seen as far south as Iowa, Oregon and Pennsylvania, according to the Space Weather Prediction Center.
0
1
5
RT @sawernimont: So grateful for support of @RsdpScholars @umnmedschool and many mentors and colleagues who helped get this far! I’m exc…
0
3
0
RT @ThePlanetaryGuy: Open this image up fully. Look to the top right. That's Phobos, one of the moons of Mars. And that bright point of…
0
7K
0
@Isotopomer @StanislawDeja @Cell_Metabolism @AmberMuellerPhD Congrats Shawn and Stan! Interesting connection with amino acid metabolism!
0
0
2
RT @Isotopomer: Excited to share our recent work on the surprising effects caused by loss of malonyl-CoA synthesis in liver. Outstanding wo…
0
22
0
RT @WallaceUcsf: Metabolism is really just a list of compounds that Chuck Norris allows to cross the mitochondrial inner membrane https://t…
0
3
0
