Mina L Xu
@MinaXu7
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Physician, Professor of Pathology at Yale University School of Medicine, Director of Hematopathology, (tweets/retweets are not medical advice)
Yale University
Joined March 2016
So excited and grateful for this opportunity.
Congratulations to @MinaXu7 on being selected to serve on the prestigious @ASH_hematology Scientific Committee in #Hematopathology and Clinical Laboratory Hematology. Dr. Xu is Professor of #Pathology & Director of Hematopathology at @YaleMed
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External iliac lymph node of a 60 year old man with TdT immunostain in left lower corner. What's your differential?
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Unexpected finding on neuro frozen section (will follow with permanents):
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Adult patient with marked thrombocytopenia and splenomegaly. What do you see in this first set of images? Particularly for hematopathologists, try to look at this for a sweet moment before moving on to IHCs 🤨 and think of the first markers that you'd want.
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Our study just out showing real life experience obtaining clinically actionable results on liquid biopsy ctDNA for wide spectrum of heme malignancies - huge congrats @DouglasMataMD and team at Foundation #Hemepath.
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Excited to share our new paper in British J of Haematology showing the power of Hi-C genomic analysis in uncovering lymphoma biology. Hi-C allows for discovery of chromatin structure in addition to genomic sequences. 1/3.
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Some additional pictures of these crumpled tissue paper-like histiocytes on H&E and PAS, plus many plasma cells (CD138) which were clonal. Subset of Gaucher associated with monoclonal gammopathy and myeloma:
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Now that we have substantive followup, ready for discussion: 19 yo with large mediastinal mass.
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Archie hitting it out of the park with his talk on AITL, chosen for oral presentation at the 7th annual YCC Trainee Colloquium @archie_enninful @RongFan8 #hemepath
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After talking about it since 2004, finally made it to DC at the peak of cherry blossoms!
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Beyond my imagination that a tumor I diagnosed years ago (and have now looked at like, 84 times thru different lenses) is on the cover of Cell. Thank you for this opportunity @RongFan8 and @Zhiliang_Bai! @CellCellPress @yalepathology #hemepath @YaleCancer.
Our Patho-DBiT is featured on the Cover of @CellCellPress ! Thank you all for leading this amazing innovation @RongFan8 @MinaXu7 Dr. Jun Lu, @YiXing77 @DrMingyaoLi !.
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Archie presenting prelim data on our lymphoma spatial omics work at Yale Human & Translational Immunology Retreat @archie_enninful @RongFan8 #Hemepath #lymsm
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Congrats to our prior star resident (now assistant professor at UPMC) @NanaMatsumoto8 for putting together this beautiful review! And thank you @ljmedeirosMD Dr. Medeiros for your leadership on this special issue
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What joy to catch up with old friends, mentors and mentees and get encouraged by their passion for improving the lives of our patients #ASH24 #hemepath @sanamloghavi @YasoNatkunam
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@marklewismd Dear oncologist,.The best part of my day is seeing your optimistic reaction to some of the worst diagnoses we can pitch at you, as well as some uncertain ones. I know you share our sense of dread but project the strength and hope that your patients need. Huge pathology fan,.Mina.
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Happy birthday, Amer! Started as recruitment dinner but our beloved recruit had to leave early so this is just the oldies. @Dr_AmerZeidan @Dr_RoryShallis
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Some insanely large leaves are on the ground now…are these even maple?!
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Excited to share this labor of love from extraordinary Yale resident @LinaIrshaidMD and collaborators from Yuval Kluger's lab @JamesGarritano and @Dr_RoryShallis on machine learning in large cell transformation of follicular lymphoma #hemepath #lymsm .
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Excited to be part of this panel, happening now:.
We are very excited to host the 2nd International Workshop on Myelodysplastic Syndromes & Myeloproliferative Neoplasms which starts TOMORROW 🩸 📣 . This meeting will bring together top clinical and translational researchers who will discuss the latest advances in #MDS & #MPNs
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Dr. Pei Hui organizing a successful inaugural Yale CME at Yale Club in Manhattan and Dr. Guoping Cai presenting. @yalepathology @Hui2Pei @gcai1978
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My colleague and mentee Dr. Po-Han Chen giving a fantastic talk on “HGF/MET Signaling in Leukemias & Lymphomas” at today’s special seminar. Looking forward to getting this CAR to start! @yalepathology #hemepath @YaleCancer
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Congratulations to a rising star in hematopathology Dr. Jahg Wong with Yale coauthors Dr. Simon Roy and Dr. Jen McNiff on a derm-heme collab in AJSP. .@JahgWong @SimonRoyMD @JenniferMcniff #hemepath.
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@archie_enninful presenting our work using multiple modalities at the Yale pathology research retreat @RongFan8 @yalepathology
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And he does it again…Best Poster this time! We need a best smile category for him as well @archie_enninful
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Thanks to USCAP, finally met our collaborator from Qatar in person, the amazing Dr. Dina Soliman @dshalash2006
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Excited to work with Rob, Sanam and John on this #hemepath:.
If you are interested in #MDS Morphology, you'll want to check out this virtual session with @sanamloghavi, John Bennett, Robert Hasserjian & @MinaXu7 . Register to attend here 💻. #MDSsm #MDSF @LLSusa @MDSFoundation
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Join me & my @YalePathology colleagues at the Diagnostic Pathology CME Annual Review Sept. 17-18 at @YaleClubNYC, where I will discuss “Diagnosing Lymphoma on Ever Smaller Needle Biopsies.” @YaleCancer. Info: Register:
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@sanamloghavi @MDAndersonNews What an amazing opportunity to see this great institution and learn more from these brilliant hematopathologists:
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Mina L Xu, Yale Hemepath (and I am really not familiar with Twitter just so you know) #HemepathJC.
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IHC for IRF8 showed high sensitivity and specificity in relation to aspirate blast count. Controls included reactive monocytosis, other AMLs, CMMLs at various blast counts. There is more to be done but I am hopeful that we are finally on our way to getting a reliable marker.
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Inspired by first-author scientist @Zhiliang_Bai whose talent and work ethic are out of this world. Congratulations, team! Excited to keep working toward making this a clinical reality one day. #hemepath @YaleCancer @yalepathology
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@ashrafelfiky1 @shafinyc On the differential for sure but projections were not circumferential (more like Mohawk)! The infiltrate was nodular on bone marrow with some intrasinusoidal activity. Neg for cyclind1, cd25, cd123, cd103, cd11c and had del 7q so great for splenic marginal zone lymphoma.
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@frances13690 @bruno_sedassari Coccidioides bc of spherules w multiple endospores. Can be confused w blasto if no spherules.
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Very cool work from @JeffTownsend and his lab that was wonderful to be a part of #hemepath.
Sequence analyses of pediatric acute lymphoblastic leukemia (ALL) have identified somatic genetic mutations as therapeutic targets. Typically, they've been prioritized by mutation prevalence. Much better: prioritize by cancer effect!.
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@sanamloghavi Thank you Sanam! I’m a little chagrined by this. The more honest ad would be: I optimistically agreed to take on some more unpaid work, lol.
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Agree with Danielle, total tumor cells. However, because it has been thought that there's some off-target activity, questions have been raised as to whether we should report %of tumor cells as well as %of non-tumor cells (a bit like some other companion diagnostics) #HemepathJC.
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@IHC_guy @ISIMMweb @AimmJournal @hemepathguy @KMirza @lbsmithmd @evemariecrane @FlaviaRosadoMD @KirillLyapichev @MattGosseMD Optimizing Ecad is totally worth the investment even if you have CD71. While there's now WHO/ICC debate re: PEL/AEL, the disease entity is still striking on morphologic and IHC grounds. Older study that convinced me to use Ecad:
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@Dr_AmerZeidan @YaleCancer @YaleHematology @Yale @YaleMed You are an inspiration to us all @Dr_AmerZeidan regardless of specialty! Of course, pathologists must do the cutting honors.
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Congratulations @Ramikomrokji, @Dr_AmerZeidan and all coauthors; thank you for leading us in this important effort.
Data-driven, harmonised classification system for MDS It took a global effort for this project using largest MDS cohort to date from Moffitt and Genomed datasets. Thx to all my dear coauthors @MoffittNews @Dr_AmerZeidan @drsomedeb @genomed4all @ic_MDS.
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Pathologists: how do you haul your slides from office & back? We use beer coolers and mine was on its last Velcro strap so I used a rubber band to remedy for a month. But it completely collapsed last wk (too many cases)! And yes, my shoes match the bag at heels. #hemepath
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Proud of 2nd year Yale medical student Dan McQuaid for spearheading this followup story on our new biomarker: .@PanseGauri @hemepath.
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@vaskannan Great question! We thought it was just a nice Castleman at first, but flow found a small population of double pos (CD4/CD8) T cells and there is that expanded rim of lymphocytes in the periphery. This led us down the TdT, CD1a staining pathway.
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One of the smartest and kindest human beings that I know is looking for a postdoc. He's been a long-term collaborator and friend. Can vouch for his strong mentorship skills. Will be posting his ad below with his contact info. Serious applicants only, please:.
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She helped us scoured the literature on gene expression profiles of monoblasts and came up with several potential targets. I used my hard-earned experience in antibody validation and here we have it. We scored 90 cases of acute monocytic/monoblastic leukemia.
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From a superstar Yale resident and our future hemepath fellow.
Thrilled to share our work where we characterized HHV8-negative effusion-based large B-cell lymphomas. I am grateful to be able to work with such brilliant colleagues and mentors, specifically @ZenggangPan and @MinaXu7.
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@KMirza @yalepathology Kamran, thank you for being such a light in this world; a mentor and role model for so many budding hematopathologists!.
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@SanjayPatelMD @RongFan8 @yalepathology @YaleCancer Thank you so much for visiting us and for the inspiring talk @SanjayPatelMD ! Really thought-provoking findings. Look forward to the MDS story.
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@DitaGratzinger Thank you Dita; it would mean a lot to me to hear your thoughts on the paper. Yes I believe it does pick up on promonos. The few discrepancies were primarily in over-count rather than under. Would be interested in multi-inst validation for sure!.
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Fast forward to 2 years ago when I found a great research assistant in Susmitha (who happened to have a lot of time on her hands before her next job). I gave her our pie-in-the-sky dream of discovering a monoblast marker that tracks with leukemic burden.
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@kitagawa_yukiko We did do them all and they were negative. Infiltrate was not diffuse but predominating nodular. Had del7q!.
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@meryemkubrat We weren’t sure either. But “EBV+ large B cell lymphoma” seemed true to the tissue with a comment that it appeared morphologically (and clinically) like PMBL. After discussion they treated w PMBL regimen and pt has done very well.
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@Dr_AmerZeidan Ichigo Daifuku (strawberry mochi). The layer in between is red bean paste. Outer layer is soft room temp mochi. The strawberry that they use for this super sweet. The best I've had was in Tokyo but Hachiroku in New Haven does a great version too!
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@AadilAhmedMD Good case in point: recent consult case with focal interfollicular involvement of lymph node by ALCL (which on outside prior lymph node of same site was only reactive with variable CD30 staining).
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@kalishahillmd @KAMitchellR Amazing presentations, @KAMitchellR! I learned a lot. Thank you for putting together such a well-organized and meaningful panel.
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@MaracajaDLV @YuriFedoriw Thank you Danielle! Here’s a group pic afterwards for your collection
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Look forward to discussing this clinically relevant project we did with scientist @_AnthonySchmitt.
Another great webinar coming your way! On October 8th, join our talk with Dr. @MinaXu7 from @YaleMed. Discover how #3Dgenomics revealed a mystery rearrangement in a lymphoma case that was missed by RNA-seq and FISH. Register 👇 #CancerResearch.
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@TashakoriM @BloodJournal @MDAndersonNews Really awesome work! Congrats to you and @sanamloghavi @kanagalshamanna @JoeKhouryMD I just forwarded to our whole Hemepath team. Btw, have you been reporting it manually on current cases?.
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@AadilAhmedMD @JLHornick @Sara_Jiang @rovingatuscap @JMGardnerMD @smlungpathguy @CArnold_GI @KMirza @PathDocBoston @drmehrarohit @RaulSGonzalezMD @AkgulMd @AGMSKCC If there’s no oil on that Prussian blue, someone is slacking off on the hunt for rings!.
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@AadilAhmedMD @MaracajaDLV @ChrisTormey3 Upon last review for a different study, CD30 semi-quantification by IHC is standard. Flow showed lower sensitivity (some attribute to the larger tumor cells not getting analyzed). CD30 mRNA quant was more sensitive but not really clinical test.
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@lbsmithmd THIS. I’ve had complicated marrow consults for MDS w about a brick of paperwork detailing the molecular genetics performed and the many nonspecific findings. And after hunting high and low, have uncovered normal cbc! Biopsy initially done for lymphoma staging.
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