@Hemepathguy
@hemepathguy
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The real, former @DennisOMalleyMD . Opinions are NOW my own. Hematopathologist, #lymphoma , #heme , #spleen , guitar
Joined May 2020
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Peripheral blood smear! Oh my! What could they be? Relax - they are endothelial cells...
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Signet ring change in lymphocytes of follicular lymphoma. don't be fooled - all that is signet ring is NOT carcinoma.
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#hemepath
#bonemarrow
Another rare thing in the bone marrow. Oxalosis! Also from the Diane Farhi slide collection!
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Burkitt lymphoma. CD20 (upper), LEF1 (lower). Just a reminder, Burkitt is LEF1 positive.
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#bonemarrow
After 20 years, this is the first Charcot-Leyden crystal I have seen. From a case of PMF
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#hemepath
#bonemarrow
Not something you see every day - bone marrow involvement by cystinosis. From the Diane Farhi slide collection.
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Challenge case for the day. Bone marrow shows complete replacement. Older male. Guesses?
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The big 6: plasmablastic morphology
✅PBL
PEL
HHV8
ALK+
LBCL in multicentric Castleman
DLBCL with immunoblastic look (CD20-, CD138+)
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Granulomas surrounding follicles in IgG4 RD adenopathy. Fairly sensitive for this diagnosis.
#hemepath
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Goose blood - as you probably know - avian blood (as well as other species) are nucleated
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#pathology
twitter I am excited to share a new project with you. TheHematopathologyFoundation a non-profit organization that will be providing online education and research content.
@roche
@BDandCo
@MorphleDigiPath
@MoticEurope
@bioimager
@HamamatsuPhoton
@zeiss_micro
@NikonUSA
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#hemepath
Public Service Announcement. Pembrolizumab (Keytruda) may case significant eosinophilia. In this case 22 K eosinophils!
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#hemepath
Marginal zone lymphoma with extensive plasma cell differentiation. This is follicular colonization by the neoplastic plasma cell component
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Back in the day, they thought this was a specific entity - this is a "hand mirror" cell in B-ALL
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#HemePath
Have a medical student visiting so have been reviewing red blood cell abnormalities. "Washington monument" crystals = hemoglobin CC
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#hemepath
. I've had Hodgkin lymphoma on my mind. Here are a few pics of CLL with Hodgkin like cells
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Peritoneal effusion. HIV+ patient. Primary effusion lymphoma
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#hemepath
Did you know...that Burkitt lymphoma is typically positive for FOXP1 and LEF1 and negative for GCET1 and LMO2. This can help if you have a challenging case like the consult I just signed.
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#hemepath
A little case of mycosis fungoides (MF). Note lymphocytes in epithelium. CD3 (LL), CD4 (UR) and CD7 (partial loss, LR)
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hemaophagocytic lymphohistiocytosis. Macrophages gone mad!
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#hemepath
- so here's the thing. Sometimes my job can be annoying. Then, I get a case like this - ATLL!
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#hemepath
L - CD21, normal follicles; R - CD21 with marginal zone lymphoma and follicular colonization
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#hemepath
OK. Here is a nearly impossible case. Give it a try. Enlarged inguinal LN, 30 yo male 1/
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REtweet Kikuchi-Fujimoto disease. Necrosis without neutrophils, increased plasmacytoid dendritic cells, CD123 positive
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Type AB thymoma - classic board question. Upper right - CD20. Lower right PAX5. Remember thymoma epithelial cells can stain for CD20
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#Hemepath
It's new book season in my office! Ioachim a gift from LJ Medeiros! Author copy of survival guide. contributor copy of Dabbs!
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#hemepath
hepatosplenic T cell lymphoma in bone marrow. IHC are CD3 and TCR delta. Note sinusoidal involvement
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I just realized. Every hemepath lecture that will be given in 2023 (and beyond) is going to be about comparing differences in WHO 22 and ICC-CAC classifications. UGH
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#hemepath
Since I posted a recent pic of this in bone marrow I thought I'd show you the LN version of Niemann-Pick (from Peter Banks, my mentor)
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#hemepath
@MGBayerl_MD
Increased mast cells in lymphoplasmacytic lymphoma as illustrated by Giemsa stain
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#hemepath
this is a photo of acute panmyelosis with myelofibrosis (APMF) which according to the new WHO and ICC doesn't exist. So, if you see a case, look the other way.
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#hemepath
No-see-um diagnosis. Hepatosplenic T cell lymphoma in bone marrow. IHC are TCR delta (lower) and CD3 (upper)
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#lymphnode
#hemepath
spindle cell lesion in LN. Kaposi sarcoma. Thanks to Jason Hornick for slide!
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#hemepath
. Key features of this disease - follicular hyperplasia, eosinophilia, polykaryocytes. Also, I forgot I knew this - increased IgG4! Kimura disease
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#hemepath
Starry sky pattern in LN. Not always Burkitt. In this case it is acute EBV/infectious mono!!!!
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Classic paratrabecular bone marrow lymphoid aggregate in follicular lymphoma
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