Michael Ison, MD MS
@MichaelGIsonMD
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#TxID MD and clinical respiratory virologist & Editor-in-Chief @TheTxIDjournal . All opinions and tweets are my own.
Rockville, MD
Joined June 2020
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🚨Big Personal News🚨
After 17 years at Northwestern, I will be leaving to take a new role at the NIH (Respiratory Disease Branch Chief).
As you can imagine, it was a difficult decision.
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We have our first COVID-19 breakthrough despite Evusheld. We definitely need approaches to collect this data in real time as it may inform efficacy of this new preventative therapy.
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Day 1 down - lots of new systems to learn but energized to be at NIH!
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Time to get my badge and start the next phase of my career.
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Today was my last clinic - for the last 17 years (nearly 900 clinics), I’ve had the honor of caring for countless patients - getting them ready for transplant and caring for them after.
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Look at hospitals - 100% mask mandate that is actually enforced. Also a place with many high risk patients and always indoor. No reports of outbreaks and data from ours and other hospitals suggest most cases in employees were of community origin.
Places around the world that used masks consistently have had half to two-thirds less Covid spread. Imagine how many deaths could have been prevented in the US if the federal government had focused on masks rather than hydroxychloroquine.
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Honored to be selected to be the next editor-in-chief of
@TheTxIDjournal
. So thankful to Bob Rubin, Hans Hirsch and
@FranciscoMarty_
for their incredible leadership to establish this critical journal for our community.
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This is a useful resource for finding locations that have Evusheld, Paxlovid and Molnupirivir. Can filter by state and drug to refine your information!
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So as we see more and more rebound after Paxlovid, some with documented transmissions after the rebound, and
@pfizer
reporting ~$22B in profit - what is being done to understand and correct the issue? How often does it happen? Do we need longer therapy or combos?
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My view for the last 17 years - coming to an end in 21 days!
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Such an AMAZING honor - thanks to all who got me to where I am!
@NM_Transplant
🎉Congratulations to
@AST_IDCOP
legend and leader
@MichaelGIsonMD
, who is the winner of the
@AST_info
Senior Achievement Award in Clinical Transplantation.
We are so thankful for your service and leadership in
#TxID
!!
#ATC2024Philly
🍾
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It was a huge honor to receive the Bob Rubin Award! You kind words as part of the nomination were so touching!
A very well deserved award to an exceptional mentor
@MichaelGIsonMD
No words can describe the dedication and support you gives to your mentees. You set an example of what mentorship and leadership.I am lucky to be handed my transplant ID certificate by a legend like you
#ATC2023
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Cleaning my office at Maria wanted to take a picture of all my saved lanyards!
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17+ years, countless trainees, thousands of patients cared for - it’s been an amazing time
@NM_Transplant
@NM_Lung
@NM_IDSteward
- thankful for a superstar last week of service with another dream team
@mahalamri
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I am at a loss for word - I have known
@FranciscoMarty_
since my
#TxId
in Boston. A kind, hardworking leader. Speaking with him just Friday he was excited to have some time off. The world and
#TxID
won’t be the same without him.
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An incredible day - RSV vaccine recommended by
#ACIP
for adults >60 and older should receive a single dose of one of the 2 approved vaccines!
It is thrilling to see the potential improvement in quality and quantity of life that these vaccines will provide!
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Understanding which agent to use against CREs in one slide - strong work
@StephaniePouch
!
@NM_Transplant
@NM_IDSteward
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Great summary of impact of various MAbs used in oncology and their infectious risks
@monicaslavin
#ECCMID2022
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Last night, my former colleague and
@AST_info
President
@JoshLevitskyMD
gave me the AST Senior Achievement Award in Clinical Transplantation - I have been incredibly luck to work w/ so many amazing individuals at AST,
@UNOSNews
,
@NM_Transplant
and
@TheTxIDjournal
over the yrs 1/X
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Congratulations to
@SajalTanna
for her promotion to Assistant Professor in Infectious Diseases
@NUFeinbergMed
@NM_IDSteward
!!!
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The data is clear - there is generally no need to treat asymptomatic bacteriuria.
In this single centre RCT from Mexico (n=80), treatment of asymptomatic bacteriuria in the first 2 months post-kidney transplant did not reduce the incidence of UTI or graft pyelonephritis
#TxID
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Absolutely incredible news! RSV has been a significant cause of hospitalization and death in older adults, very young and immunocompromised. The first approved vaccine with 94% efficacy against RSV-related lower respiratory tract disease.
@GSK
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Proud of the
@NorthwesternMed
Lung Transplant team - gave a life saving lung transplant to a patient with end stage COVID lung damage.
@DonateLife
@NM_IDSteward
@AST_IDCOP
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Honor to speak as part of the press conference with
@AnkitBharatMD
and the rest of the
@NorthwesternMed
Lung Transplant Team about our first transplant in a COVID-19 patient
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Tocilizumab - another drug used extensively off label and was “the answer” has been shown not to reduce mortality, ordinal scale at week 4, or reduce ventilator days. Opinion and anecdotes shouldn’t be what drives care, even in pandemic.
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Excited to announce a new section for
@TheTxIDjournal
- entitled “Transplant ID Office Hours” - this section is going to transform some discussions by
@TxID_Fellows
into a permanent set of advice for fellows and jr faculty. Focusing on the next generation of TID!
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Honored to present about antiviral therapy for respiratory infections at the
@fredhutch
#IDSymp23
- for those who want the slides, they are available here.
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It was a huge honor to work on this important study - the RSV vaccine adds to our armamentarium to keep our older adults safe from the scourge of this important pathogen. Thanks to the dedicated
@NM_Transplant
research team for their support.
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After 26 months - my first international trip - looking forward to
#ECCMID2022
and then on to
#ISHLT2022
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Thanks to the scientists, study teams and subjects for making this happen! Thanks to
@US_FDA
and
@CDCgov
for following the regs to ensure safety and effectiveness. Thanks to the hidden teams locally for making this happen seamlessly
@NUFeinbergMed
#IGotTheShot
@NUCATSInstitute
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We’ve heard from several patients and confirmed with our social workers -
@cvspharmacy
and
@Walgreens
not have a process yet to give 4th doses to our transplant patients.
This is totally unacceptable as the guidance has been in place for over a month and patients are coming due!
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True highlight of my career - receiving the Bob Rubin award thanks to my amazing fellows for their kind words - it’s been such an honor to work with you and see you grow to become leaders in the field
@mahalamri
@MadyHeldman
@HannahNamMD
@rebecca_kumar
@CA_Boutin
@SajalTanna
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I am excited to announce that we have been approved for a Transplant ID Fellowship
@NM_IDSteward
! More details will be coming soon.
We already have the position filled for 2021-2022.
@TStosor
@mangarone23
@SajalTanna
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Looks like we are going to need a doubling of dose for Evusheld for all new patients and those who previously got it will need to be redosed.
Thanks
@dan_dkauld
for flagging this!
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I'm excited by the data supporting the FDA approve of letermovir.
The real challenge is going to be the HUGE cost difference between valGCV and letermovir. Per GoodRx, generic valGCV is $155-$998 per month while letermovir is $6700 - $7700 per month.
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As we finish packing the car and reflect on lots of goodbyes with friends and colleagues, I am thankful for for all of the love and well wishes. It makes me realize how lucky I am to have been surrounded by amazing people in every aspect of my life. Now on to the next adventure!
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Absolutely amazing! For the first time ever, we have transplanted 40,000 patients - that is an incredible number! More lives saved, more lives improved - all during an incredibly challenging time!
@NM_Transplant
@UNOSNews
@AST_IDCOP
@TheTxIDjournal
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The highlight of meetings is the
#TIDSupperClub
- connecting with fellow
#TxID
colleagues to discuss work and life is key! Thanks Nicole Theodoropoulos for organizing
@EmilyBlumbergMD
@ArunaSubraman12
@PCH_SF
@jschaenman
@jobadd
@maricar_malinis
@amezochow
@SajalTanna
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A detailed story of
@AnkitBharatMD
and the
@NorthwesternMed
Lung Transplant team’s first lung transplant for COVID-19.
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Last - I’ll provide clinical recommendations based on summarized data from COVID-19 and placing in context with other vaccines
@ATCMeeting
@AST_IDCOP
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Its a huge honor, along with
@NUCATSInstitute
members Kenzie Cameron, Rich D’Aquila, and
@WeinbergCollege
Bryna Kra for the 2022 Provost Award for Exemplary Faculty Service.
@NU_IntMed
@NM_IDSteward
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“Individual antibody levels, as measured by myriad commercial assays, do not offer a useful indicator as to whether a booster dose is needed; their use outside of clinical research should be discouraged.”
Couldn’t agree more.
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Excited to start digging into the work in my new role!
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So proud of my incredible research team - we have enrolled our 100th COVID-19 recovered patient today! We will be able to better understand immune responses to infections and how long they last with this study. We have several special populations - first report under review!
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A discovery that has totally transformed our approach to vaccines and allowed us to emerge quickly from the COVID-19 pandemic - can’t think of a more deserving award!
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I encourage all in
#TxID
to mark their calendars and save the date for our First
@TheTxIDjournal
and TID Section of
@ttsorg
Clincaopathologic Conference. See if you can help the team figure out how to diagnose and manage a brain lesion in a transplant patient!
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COVID is being compared to Influenza again - To date, there are as many COVID-19 related deaths as nearly 5 years of influenza - and its only been 7 months with the disease.
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At the
#NTM
Research Consortium meeting - great update on antimicrobial susceptibility (rapid growers: ; slow growers: ).
Excited too by emerging therapies with data coming soon.
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This is great news - we are going to be introducing new initiatives to facilitate people getting their papers published with
@TheTxIDjournal
- still without publication fees.
@AST_IDCOP
@TxID_Fellow
@PergamIC
@DocSaimaAslam
@jaguadog1
@RazonableMD
@MaddalenaPeghin
@monicaslavin
@TheTxIDjournal
is pleased to announce that we are now accepting papers rejected from other journals with expedited review.
As opposed to some journals that charge over $3000/article, there is no publication fee
@TheTxIDjournal
.
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Excited to see our 1st
@TheTxIDjournal
Special Edition focused on Antimicrobial Stewardship. Great work by
@Gnfidz
and
@shahidh80523771
who are the guest editors.
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As I reflect back on an amazing
@IDWeek2022
, I’m exceptionally thankful for 3 things:
1. The amazing advances (including COVID vaccine that allowed the meeting to happen) in science that have given us the promise of new RSV vaccines and new drugs to treat a range of infxns.
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Fun things you find when you are starting to clean out your office - my first poster from fellowship (lots of what not to do) and my TID Fellowship Certificate!
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My last
@NorthwesternMed
#FluSelfie
! If you haven’t gotten yours, with cases expanding rapidly, nows the time to get it!
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#FluShotSelfie
- Thanks to the
@NIHClinicalCntr
Team for coming to vaccinate our office. It’s a good reminder - everyone should:
✅ Get your Flu Shot
✅ Get your 2023-2024 COVID-19 Shot
✅ Get your RSV vaccine if over 60 years of age
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Finished my last Transplant Nurse Educational session - these nurses are nothing short of amazing - always positive, always putting patients first!
@NM_Transplant
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excited to see
@EmilyBlumbergMD
,
@IDSAInfo
Finland Lecturer for 2023, shining a light on
#TxID
- highlighting about our key role in expanding the donor pool. Given all that Emily has done & how many stars she’s trained - I cannot think of a more deserving awardee!
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Congrats to
@maricar_malinis
who is going to take over as the lead of the
@TheTxIDjournal
/
@ttsorg
TID Section CPCs.
Moving forward,
@wan_clemente
&
@StephaniePouch
will continue to work with Malinis on the CPC. A new member will be selected to help this superstars team soon.
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The
@AST_IDCOP
Virtual Meeting started with a reflection on Francisco Marty’s contribution to the field.
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This is one of the most educational and thought provoking podcasts I’ve listened to. Amazing review of molecular diagnostics and discussion of challenges in their use and application
@febrilepodcast
@micro_rp
@AST_IDCOP
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Looking for an excellent review on infectious complications of kidney transplants? It was great working with
@NU_Nephrology
Abby Agrawal and
@ldanzigerisakov
on this review.
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What can beat a true
@NM_IDSteward
dream team on my second to last week on
@NM_Transplant
TID Service (superstars: TID Fellow
@mahalamri
, TID PharmD
@moore_wjustin
and Chief Fellow
@beckyosbornmd
? A delicious cake 🎂 at the end of rounds!
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As we get more and more data on COVID Vax responses, we get a clearer picture of extent of protection. After 2 doses 87% of heart and 93% of liver recipients had humoral and/or cellular responses.
@EmilyBlumbergMD
@NATBASH15
@camwolfe
@nikkitheomd
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Transplant Nurses are the core of organ transplantation - they are central to the success of every program and every patients. Thank you for all you do!
Transplant Nurses are a driving force in our collective mission to save and heal lives. Join us this
#TransplantNursesWeek
as we celebrate and honor their incredible work!
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Great session by Jay Fishman
@mgh_id
@mgh_transplant
talking about the value of TID, why transplant-specific ID expertise is essential and the need to keep
#TxID
a core part of all Tx programs.
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Tasty food, great conversation- this is what I’ve missed during the pandemic! Such a treat to catch up with
@StephaniePouch
and plot our the next steps for the
@AST_IDCOP
Controversy Conference!
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Looking forward to a great 2 day Update on Infections in the immunocompromised Host
@IchsGlobal
@ESCMID
@esgrev_escmid
Full Schedule and registration details at:
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A sign of both an amazing session and the popularity of
#TxID
- a packed room learning about Oncology/HSCT ID
#ECCMID2022
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Unsure of what to do about the SARS-CoV-2 vaccine for transplant patients? The
@ttsorg
TID section has updated guidelines for COVID-19 in this population!
@wan_clemente
@jobadd
@FranciscoMarty_
@maricar_malinis
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Such a treat to get one last dinner with
@mahalamri
before she returns to Saudi Arabia - looking forward to a bright future of TxID after a super successful 2 years training at
@NM_Transplant
@NM_IDSteward
!
@SajalTanna
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15 years of tireless leadership to establish and run the gold standard organ vigilance system -
@UNOSNews
DTAC and it’s leaders have accomplished so much. Thanks to
@AST_info
and
@RicardoLaHozMD
for organizing this reunion
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and to have the opportunity to train the future experts in our field.
Overall, Ken and I are very much looking forward to our move to (and our new life together in) DC! Full details will follow soon.
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Celebrating a successful first day of presentations by our amazing
@NM_IDSteward
team!
@mangarone23
@beckyosbornmd
@KKruegerMD
@mahalamri
@moore_wjustin
@TheNachDoc
@NM_Transplant
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Thanks - honored to take on this new leadership role - hope to make clinical research easier for all of us at
@NorthwesternU
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The excitement is almost too much to handle for tomorrow’s
@fredhutch
4th Symposium on ID in ICH - already ran into
@NATBASH15
,
@ldanzigerisakov
,
@MadyHeldman
,
@AjitLimaye2
and Michael Boeckh!
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Great NTM session by
@van_jakko
and Claire Andrejak - best proof we need better drugs and trials in humans to inform therapy. Our current therapies have significant challenges.
@ESCMID
Global.
Current
@NIAIDFunding
NOSI around this issue:
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Congratulations to all members and collaborators of the
@UNOSNews
/OPTN Disease Transmission Advisory Committee in being honored for our contributions with the
@AST_info
Innovation Award!
@EmilyBlumbergMD
@camwolfe
@ldanzigerisakov
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Excited to announce the launch of our registry of Lung Transplants for COVID-19. This is a team effort from Rade Tomic and
@MichaelGIsonMD
from
@NM_Lung
@NM_IDSteward
,
@DocSaimaAslam
and Max Weder
@uvatransplant
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Congratulations
@DocSaimaAslam
- newly elected member of the
@ISHLT
Board! So excited to see another superstar
#TxID
on the board!
@AST_IDCOP
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As a journal editor, it is increasingly challenging to get people to agree to review papers. Today, I caught up on a dozen reviews I accepted to do. If you have papers you want reviewed, agree to be a reviewer.
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I want to send a big thanks to our
@TheTxIDjournal
Deputy Editors -
@jaguadog1
, Andreas Groll, Monica Slavin,
@PergamIC
,
@RazonableMD
and
@nikkitheomd
. Our turn-around-times for decisions are AMAZING. Average turn around time to first decision sent to authors is 13 days!
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Congratulations to
@CA_Boutin
who got a travel award to
@fredhutch
#IDSymp23
to present our
#NNITS
(Nitazoxanide for Norovirus in Transplant Study) - transient symptomatic improvement but no change in other markers and doesn’t lead to cure.
@NM_Transplant
@nutorc
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Congratulations to Daniela Ladner
@nutorc
,
@NUFeinbergMed
@Northwestern_Tx
! Through her hard work, she was awarded at T35 grant to support our incredibly successful NUCTORC Summer Research Program for Medical Students with the T35 program starting in 2022!!!
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There is a real problem with how Evusheld is being distributed. We’ve become aware that a private group (iCare Mobile) is offering the MAb to the public. Meanwhile, some large centers with huge populations of eligible patients still have not drug -
@MoffittNews
@UMiamiHealth
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Our opinion piece highlights the overuse of antibiotics and underutilization of antivirals (that reduce need for antibiotics) in patients with flu.
@jeffreylinder
@NM_IDSteward
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So excited to see the
@TheTxIDjournal
to have crossed the 4000 followers! Such amazing accomplishment in a little over a year! Strong work
@PergamIC
in leading our Twitter presence.
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@GermHunterMD
@AST_info
holds its annual Fellow’s meeting in Texas - definitely time to rethink this longstanding tradition!
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Excited to see the results of the SOLSTICE Maribavir trial published - this will help us as we begin to use this newly FDA-approved drug!
@RobinRavery4
@BarbAlexanderMD
@EmilyBlumbergMD
@ChemalyRoy
@dktransplant
@KamarNassim
@dfflorescu
@GenPapaMD
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Excited to see this important data out. Adjuvanted RSV vaccine found to have efficacy over 2 seasons of 1 RSVPreF3 OA dose was 67.2% (97.5% CI: 48.2-80.0) against RSV-LRTD and 78.8% (95% CI: 52.6-92.0) against severe RSV-LRTD.
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Despite the know limitation of many fungal markers, they are frequently ordered (often repeatedly) in lung transplant recipients.
@CA_Boutin
reviewed the experience
@NM_Lung
@NM_Transplant
found limited utility of addition of BD glucan.
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What I currently hate about my life - the insane amount of time I'm on Zoom, Skype, WebEx and Teams meetings. My day started at 6am and the last call ended at 6pm. I had only about 1 hour spread throughout the day that was not on a virtual meeting.
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What started as a small group of experts, has grown into the best organ vigilance program in the world! Review of data from its first 10 years is out!
@camwolfe
@EmilyBlumbergMD
@mg_michaels
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