Today in @NatureBiotech we report on the use of base and prime editing for high throughput interrogation of genetic variants in cancer. Excellent work by first authors @olivier_belli & @k_karava. 🧵👇 @ETH_en @ETH_BSSE

Understanding how a single cell develops into an entire body is one of biology’s biggest mysteries. Today we celebrate @Merlin_Lange + @loicaroyer & the team at #CZBiohubSF for publishing Zebrahub, a resource that gets us closer to solving this puzzle 🎉

🚨Big news! Five years in the making, our Zebrahub paper is now published in #Cell 🎉. We’ve built a timecourse atlas of zebrafish embryonic development, combining #scRNAseq data and #lightsheet live imaging, and delved deep into the dynamics of key progenitors. Explore the datasets here: Led by @Merlin_Lange with key contributions by @ale_agranados, @Shruthi94Vijay, @jobragantini, @Sarah_E_Ancheta and @yangjoonkim #zebrahub #devbio #cell #Biology #imaging @CellCellPress @czbbiohub #CZBiohubS

📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish development. Integrating scATAC-seq and scRNA-seq from 94,000+ cells, we map gene regulatory networks across six key stages of embryogenesis (10 to 24 hpf). A major accomplishment by @yangjoonkim co-led by @Merlin_Lange with experiments by @Shruthi94Vijay #Zebrahub-Multiome is a sequel to our transcriptomic and imaging atlas of zebrafish development. #zebrafish #development #ATACseq #cell #biology #sequencing @czbiohub #CZBiohubSF @cziscience Note: We sent two preprints simultaneously yesterday, and this is the first one to come out... I will append to this thread when the second one is out...