Sally Church
@MaverickNY
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Scientist, cancer geek, journalist, Londoner, always curious, adventurer, explorer, immigrant, lover of curry, fine wine & football
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Joined February 2008
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Part 2 of our review of early stage onco developments from
#ESMO24
– reflections on standouts and wipeouts – some unexpectedly so!
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This is what happens when you have scientists as leaders... they understand numbers and facts...
It takes one minute listening to Merkel to understand why Germany has succeeded so far in controlling covid-19 where so many others failed
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Given the interest at
#ASH23
in a German study on CD19 CAR-T cells in autoimmune diseases such as systemic lupus erythematosus (SLE), a potentially life threatening condition – what can we learn from prior data? A short thread 🧵...
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There are no words to describe the sadness and utter desolation one feels when a dear friend of 30 years suddenly passes. Gone far too young, may he rest in peace. I shall miss his exuberant spirit greatly.
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I'm delighted to say we hit our 5-year anniversary this week for BSB as a specialist oncology paid subscription service... many thought we'd last 6 mon - here we still are, going from strength to strength! Thanks to all our supporters and fans.
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Ok here's my notes written during AACR predicting $BMY fail in CM026 1L NSCLC. Probably should have written it up
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Nice review from Jim Allison and colleagues on "Fundamental mechanisms of immune checkpoint blockade therapy" - explaining diffs in targeting PD-1 and CTLA4:
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There is a huge need to develop immunotherapies to enhance T cell responses against "immunologically 'cold' tumours" with low T cell infiltration and neoantigen burden. Despite numerous company efforts, there have been few successes to report...
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These pembro vs placebo curves in stage III melanoma from Prof Eggermont are a thing of beauty - great news for patients!
#aacr18
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Whoa 3 hours post vaccine waiting for the next
#aacr21
session and light headed with tingling hands, headache and chills. My T cells are busy doing their job! 🙏
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This has to be one of the most idiotic, rude, and ill advised tweets I’ve seen in 2020 given the sheer cultural diversity & productivity of cancer research labs in my stream every damn day...
Most third-world migrants can not assimilate into civil societies.
Prove me wrong.
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Hit a big milestone today - 10K steps and 4.5 miles - first tine since busting my knee 2 years ago!
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For those who wondered why IDO didn't work, check out this paper - MOA of unlocking 2 T cell brakes clearly did not address any of these key TME complications:
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Seriously, how on earth is slashing the NIH budget and reducing investment in science making America great again?
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Gosh just realised I signed up here in Feb 2008, can't believe that's 11 years of tweeting about science, cancer research, and occasionally biotech!
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One of my favourite memories of
@Becker_MichaelD
was a v spirited debate in we had in
#ASH10
poster hall on PI3K - whether or not Semafore's SF1126 was better than Calistoga's (idelalisib). At the end he was still gracious and smiling, always the gentleman. RIP Michael.
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After 5 years and 2 clinical trials, Patient
#1
stops cancer treatment of pembrolizumab - nice story!
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As someone who had a malignant cancer where docs wouldn't even talk of remission until 5 yrs... calling 6-mon data a 'cure' is cringeworthy
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Having experimented w/ a low carb diet for 6 weeks, I can say that there is noticeably less knee pain. Of course, it's anecdotal and correlation ≠ causation, but then saw this paper:
@DoctorTro
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Beautiful
#ASH23
plenary talk from NIBR's Pam Ting on the discovery of their molecular glue degraders dWIZ-1 and 2 targeting HbF in SCD. Great work from
@jaybradner
's team making the impossible possible!
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Who knew? Differences in anti-tumour efficacy of CAR-T cells among lymphoma patients w/ different clinical outcomes may be due to loss of CCR7 gene expression & other related factors:
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Vaccines/viruses are going to see a renaissance - not as monotherapies but in combo w: other inmunotherapies to boost responses
#Immunosym
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Interesting chat w/ anti-mask neighbour... asked how she would feel if we had seen 3 fatal jumbo jet crashes a day since March 1st? "That's a horrific thought!" Pointed out this is what total US deaths from Covid represents in the same time. "Oh no, it can't possibly be!"
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C’mon Georgia, c’mon! For the the scientists in my stream, DeKalb county is the home of the CDC - irony much?
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One for the scientists in my stream... beauty in action (starfirsh blastula)
Playing around with inverted color schemes to overlay confocal and transmitted images, seems to work ok!
#invertedLUT
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Tom Gajewski's new paper on microbiome & checkpoint blockade in melanoma pats is out and it's a good one!
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Hmm
@united
@USAnonymous
I do not think ‘volunteer’ means what you think it means. He was a paying customer entitled to respect not violence
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Have been practicing social distancing for the last month, my neighbours laughed at me for being paranoid. Now they’re all panicking and freaking out. No need to stress, stay calm and focused.
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6 Years ago yesterday we launched the BSB subscription service - can't believe it has done so well with people still subbed since that very first month! Really appreciate all the feedback, comments, and interactions we've had with all our readers.
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Every now and then a momentous ODAC comes along where we remember where we were and how exciting it was - a historic day for CAR-T cell Tx!
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Always good to see a presentation on pediatric neuroblastoma - I'm one of the 30 year survivors!
#sitc2014
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For all the scientists and data geeks in my stream... this narrated coronavirus post is an excellent read - v sobering - reminds me of how much we can learn from self isolation like my buddy in HK
@Sports_bios
:
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Irony of this is that at ECCO15 a lot of KOLs HATED the idea of IO + chemo... really hated it to the point many thought it was a truly bad idea. They wanted IO-IO combos. Now they hate the tox with IO-IO. Funny how things turn out sometimes.
So far only 3 MoA have succeeded in I/O combo Ph3 trials:
- Chemo combo in NSCLC/SCLC/TNBC
- TKI or VEGF combo in RCC
- CTLA4 combo in melanoma and RCC
All proven MoA as
@DewDiligence
noted...
My bet is on T-Vec being the 4th.
@robertcoffin3
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2 yrs ago we said that bispecifics were an emerging area in oncology R&D... people scoffed. Now next gen T cell bispecifics might seriously challenge CAR T cell therapies, here's why:
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<Cough>
Vladimir Putin said today about Hillary and Dems: "In my opinion, it is humiliating. One must be able to lose with dignity." So true!
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$MSFT can't solve the blue screen of death so why on earth would we believe this grandiose statement?!
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New CAR-T cell paper implicates cellular elements other than T cells, suggests novel links betw syst inflammation & characteristic neurotox symptoms via MSK:
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Conference organisers keep sending me surveys about attending their meeting live. No! Not for a while and here's why - risk of Covid-19 transmission remains, as this JAMA study clearly illustrates:
1/n
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Hmmm $KITE meh it's not no. of CRs, it's how durable they are. Too many relapsing by 3 months. Come final data set that could be worse
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Have been catching up on my longish reading pile over the holidays after the 4Q conference hurly burly, so here's a science thread on oncology R&D for those interested... 1/n
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This is an excellent and v educational thread - read it and understand why social distancing is more impt vs. coronavirus than herd immunity...
There is a lot of talk about
#herdimmunity
. Vaccination is the only safe way to achieve it. In the absence of vaccine, we need to practice
#SocialDistancing
.
@BioRender
made this amazing infographic to explain how a hypothetical virus spreads through the population. (1/n)
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This promises to be a really good read ahead of
#AACR18
- The Immune Landscape of Cancer - from
@DrChoueiri
@DrNDisis
and colleagues:
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Happy New Year to all my BioTwitter buddies from London! May 2016 be a great one
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Intriguing paper here which may expand our ability to hit a wider array of targets - T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome:
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Why can't Trump administration grasp that it's not process that slows down progress but biology? Reduce Defense $ and divert to NIH grants!
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Neoantigen quality not quantity - nice opinion piece based on TRACERx data from
@NickyMcGranahan
@CharlesSwanton
- confirms Ton Schumacher’s assertion a couple of years ago:
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We complain about high drug prices but not so much the broken hospital system or their exorbitant fees... this tweet nails it :(
“So, you’re telling me that you can reprogram T cells to find & kill cancer cells, but it took 4 months to get my mother an appointment w/ a neurologist; she spent 2 hours in the waiting room; & then she got an exorbitant bill that read, ‘This is not a bill’?”
Painfully true 🤦🏻♂️
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If you're 3rd or later to market in a cancer niche then you'd better show up with better OS, much improved safety profile, or risk smaller revenues 'cos mkt leaders will already have formularies wrapped up and you will have less MD loyalty baked in. That is all.
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Lovely character piece from Adam about a well loved biotech analyst many of us will miss. Will never forget Mark rescuing me from a company briefing when they tried to throw me out, "Don't worry, she's with me!" RIP Mark
My remembrance --> Mark Schoenebaum was the best biotech analyst ever. Better still, he was a great person
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@daphnezohar
Agreed. I’d argue from my recent experiences of US healthcare that maybe
@ewarren
and others should direct some well deserved ire at hospitals and their gross overcharging, which is far more grievous
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We need to look at learnings from our antibody experiences with immune agonists & checkpoints. Here's an interview with
@DanChenMDPhD
, who does a superb job explaining why things didn't always work out as expected:
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Science can be beautiful...
I borrowed this video of T cells killing cancer cells.
Really stunning!
The "burst" of calcium that happens with apoptosis onset is cool.
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For the γδ T cells fans out there – a new review article on their origin and fate, subsets, diseases, and immunotherapy:
Check it out here:
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Can't believe I'm celebrating 10 years of blogging about science and cancer research but whoa! The time flew by!
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A beautiful story for everyone in oncology R&D; what does a CR really mean for a man with refractory melanoma and the oncologist treating him? Last 10 secs from Dr Diab are the kicker:
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In mice... humans have different immune systems so cannot extrapolate easily from murine models to patients!
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Opening up America while coronavirus is still rampant is a recipe for disaster. Look at what happened in Singapore & Hokkaido where they flattened considerably, opened up now have a 2nd cluster surge! What could possibly go wrong in US? 😱
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We’re off! Season 3
@TargetsPodcast
is live: interviews with
@jasonlukemd
@gulleyj1
@DanChenMDPhD
Check it out!
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One of the fun aspects of the
#ASH23
meeting is people watching...
It's not as strange as it might seem.
Unlike other major cancer conferences, you soon learn ASH has an entirely different flow and vibe to its poster sessions. A 🧵
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So much better than the scissor analogy many peeps use...
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Interesting that two of the most dynamic speakers in cancer research are women (Drs Belcher & Bissell)
#aacr17
we need more like this!
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Topline NSCLC thoughts from am press briefing
- pembro 1L; solid
- pembro + CT 1L; promising
- atezo 2L; v good
#esmo16
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Many are familiar with bispecifics and T cell engagers, so how about a bispecific dendritic T cell engager (BiCE) to potentiate anti-tumour immunity?
This one comes from Israel where researchers have created a dual molecule to target CLEC9A and PD-1:
Why do this this?
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A new cell therapy engineered to produce two immunostimulatory cytokines, IL-12 and FLT3L - Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy:
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Been waiting to see something like this: Neoadjuvant oncolytic virus pre-surgery sensitizes TNBC to checkpoint tx
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FDA now doing a call on CAR-T cell therapy at 12.30pm... last time I remember them doing this in oncology was for Gleevec
#historicmoments
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Skipped the big session at
#ASH19
this afternoon to hear my long time BioTwitter buddy
@PDRennert
present on overcoming CD19 CAR relapse. Go Paul!
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Words for the wise...
Note: Do not engage in a discussion someone who has already decided he will not change his mind as a result of said discussion.
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A very good point...
During WWII, Churchill was asked to cut funding for the arts.
He replied "Then what are we fighting for?"
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In mice... not humans, to be more precise:
Researchers have developed a treatment that can get the body's immune cells to gobble up tumor cells (via
@BostonGlobe
)
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Just in time for the East Coast evening commute - interested in STING and TLR agonists and what they can do? Check out the latest podcast episode...
On Episode 24, hear leading
#ImmunoOnc
experts talks about how to make the immune system dance by stimulating innate immunity.
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A lovely tweet to make everyone's day - a decade ago this was unimaginable...
I am approaching six years as a stage 4 NSCLC patient, thanks to targeted therapy!
#lungcancerchat
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Woke up this am to learn that I won my fantasy football league, which was a rather nice end to year! Shout out to
@mcbio316
for his excellent draft tips, which made a huge difference.
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@LizzieCoker
@NaturePortfolio
@NatureBiotech
It's a really great example of the GIGO (garbage in-garbage out) which plagues ML based on a training an inherent bias in the rules, sigh
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Up at stupid o'clock for a cancer conference somewhere in the world. The new normality resumes...
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Have been wondering how long epidemics have lasted historically - looking at the data tells us a few intriguing facts... (1/n)
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The numbers from Spain this morning... oh my, my heart goes out to all those people right now, especially the doctors & nurses in the frontline dealing with the case surge.
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So many excellent papers to read lately, my plane stack for
#AACR18
is now v long indeed!
Review on "Regulation and Function of the PD-L1 Checkpoint" from Chong Sun, Riccardo Mezzadra, & Ton Schumacher | Part of special collection on immunity in the tumor microenvironment
#immunotherapy
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We’re merely 7 days behind NYC in Miami with an incompetent, unprepared Governor who allowed all those Spring Breakers to run loose and is now dodging questions, sigh
.GovRonDeSantis decided to violate the state's public meeting laws and chose to exclude the
@MiamiHerald
and
@TB_Times
from a media briefing at the Capitol. He was so determined to keep us out, he had an FDLE vehicle pick up TV reporter Mike Vasilinda to give him back door access
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@adamfeuerstein
They lost all credibility after the Wakefield debacle so now we have a sorta tabloid for science with buzzfeed-like headlines and teases. Sigh.
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Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer (mCRPC):
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Gotta love that grouchy old Brit Churchill - words for the wise through the ages
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After 20 years here I finally said math instead of maths (sigh) my mother would be appalled.
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Oh this is cool - took a photo of bioRxiv link on slide by a presenter. iPhone automagically asked if I wanted to open QR code to paper! Oh yes, please...
#cimt2019
B cells predict response to ICB:
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