💊 Investigators presented a multifunctional #nanotherapeutic platform designed to combine cytokine-sensitized mild photothermal therapy, immune checkpoint blockade (ICB), thereby improving the efficacy of ICB therapy in #TNBC. 📑 @ACS_AMI |

💊 The authors emphasized the significant clinical potential of DT as an innovative carrier-free #nanomedicine and provided profound insights into the design of nanomedicines for #cancer therapy. @PNASNews |

💊 Researchers at @BristolUni showed that RASAL2 was enriched following neoadjuvant chemotherapy in #TNBC patients. This enrichment was specific to the tumor compartment compared to adjacent normal tissues. 📑 @oncogenejournal |

🔎 The authors at @UniCalPortale provide an overview of the molecular mechanisms driving #BreastCancer chemoresistance, focusing on the role of ω-3 PUFAs in recognized cellular paths. Check it out! 📑

🧬 Scientists at @Inserm investigated the sensitivity of BRCA1-deficient #TNBC models to the frequently used replication chain terminator gemcitabine, which does not directly induce #DNA breaks. 👉 @CR_AACR |

📈 Researchers revealed that the upregulation of LINC00626 in #BreastCancer was associated with poor overall survival in patients. 🛡️ They support the role of LINC00626 as a potential therapeutic target for combating tamoxifen resistance. @SciReports |

🧬 Scientists used primary BMECs as a model and utilized overexpression and knockdown techniques for the PI4K2A gene to investigate the specific mechanisms by which it regulated lipid #metabolism in BMECs. @SciReports |

🚭 .@UCSanDiego investigators showed that S100A8/A9 innate immune signaling was a molecular mechanism that identified smoking-related #BreastCancers and underlined their enhanced malignancy. 📖 @oncogenejournal |

🐭 Dr. Jackson Liang and the team at @genentech studied the impact of ERα antagonist/degraders against Esr1 mutations expressed in mouse #mammary glands. 🧬 @NatureCancer |

🦊 Scientists screened for phase-separated proteins in #BreastTumor cells and identified forkhead box protein M1 (FOXM1) as the most prominent candidate. 🔓 @Nature |

💬 Researchers identified a previously unidentified mechanism by which the unfolded protein response pathway dictates cross-talk between cancer cells and #immune cells, providing important #anticancer therapeutic opportunities. 📖 @ScienceAdvances |

💡 Dr. Mehrnaz Safaee Talkhoncheh and @lunduniversity researchers uncover a population of TAMs that are effector targets for adjuvant anti-angiogenic immunotherapy in mouse models of metastatic #BreastCancer. 🔓 @jclinicalinvest |

📊 Drs. @annemariamay, Aniek Schouten, and @UMCUtrecht scientists evaluated the cost-utility of a 9-month supervised exercise program for patients with metastatic #BreastCancer. 👉 @JCO_ASCO |

💊 Dr. Qianying Zuo and the team at @UofIllinois investigated how a ketogenic diet enhances estrogen receptor-positive liver metastatic #BreastCancer’s response to Fulvestrant treatment. 🔗

🩺 This Phase II, single-arm, prospective study led by Drs. Zhi-Ming Shao, Jun-Jie Li, and Li Chen aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2- #BreastCancer patients. Check it out! 📑

🔬 Scientists demonstrated a novel regulatory role of golgin-97 in ERK/MAPK signaling and the #tumor microenvironment, possibly providing new insights for anti-breast #cancer drug development. 🔗

🧬 Drs. Ciara Metcalfe, Jackson Liang, and team members at @genentech studied the impact of ERα antagonist/degraders against Esr1 #mutations expressed in mouse #mammary glands. 📑 @NatureCancer |

🩺 This trial demonstrated improvements in progression-free and overall survival with first-line metronomic capecitabine plus aromatase inhibitor (AI) compared with AI alone in hormone receptor-positive+/HER2-negative metastatic #BreastCancer. 🔓 @JCO_ASCO |

🧫 Drs. Hyung Bum Kim and Lee Kraus at @UTSWMedCenter observed that MCF-7 cells treated acutely with 17β-estradiol retain a substantial amount of the #hormone even upon removal of the hormone from the culture medium. 🔗 @MCR_AACR |

🔬 Researchers at @MonashUni explored the potential of #TNBC-targeting aptamer-decorated porous silicon nanoparticles as targeted nanocarriers for TNBC. @ACS_AMI |