Leena Ali Ibrahim
@LeenaAIbrahim
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🇵🇸 Neuroscientist | Assistant Professor @KAUST_News . Neural circuit development and learning. Layer 1 afficionado. Views are my own
Joined June 2018
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Very thrilled to announce that I will be joining
@KAUST
bioscience division as an assistant professor this summer. The Ibrahim lab will be focusing on development and plasticity of sensory learning, neuromodulation and neurodevelopmental disorders.
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Take a look at our recent work in Neuron
@NeuroCellPress
examining the contribution of early thalamic inputs onto L1 interneurons in the establishment of top-down connectivity in V1 cortex
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First Ibrahim lab outing! Very excited to be working with this amazing group of people!
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Thrilled and honored to be part of this amazing program.
Meet our 2022 cohort of Next Generation Leaders:
🧠
@Constantinatheo
🧠
@HeatherDSnell
🧠
@shekharlab
🧠
@KaueMCosta
🧠
@LeenaAIbrahim
🧠
@EissaTahra
Now in its ninth year, early-career scientists in this program help to advise our
#neuroscience
research.
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Our opinion article on Layer 1 interneuron function is out! Here we discuss recent articles highlighting the importance of L1 neurons in cortical circuits. I apologize in case we have missed anyone.
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Consider applying:
Hiring at all levels. Official job posts coming soon. We'll be using 2P imaging, electrophysiology, and high resolution structural imaging to address some of the questions.
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Super excited to be presenting at
#NEURO2022
alongside
@morishih
@HammJordan
, Songhai Shi and Etsuko Tarusawa
Stop by our Symposia on Local & Long-range Cortical Circuit Maturation
#NEURO2022
@jnsorg
(4:10PM- Japan Time today 6/30)!
Excited to present in person together with outstanding colleagues across the globe including Song-Hai Shi, Etsuko Tarusawa,
@LeenaAIbrahim
&
@HammJordan
!
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Hiring at all levels. Official job posts coming soon. We'll be using 2P imaging, electrophysiology, and high resolution structural imaging to address some of the questions.
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Congratulations
@GordFishell
,
@HongkuiZeng
and all the other newly elected members!
We are thrilled to announce the election of 120 members and 23 international members to the National Academy of Sciences in recognition of their distinguished and continued achievements in original research.
Congratulations to our new
#NASmembers
!
#NAS160
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I am very excited to be moving closer to my family, after having spent almost 13 years in the US.
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I guess I @ the wrong account. It's
@KAUST_News
. King Abdullah university of science and technology in Saudi Arabia. So much for regular tweeting.
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I am very grateful to my mentors, lab mates and friends over the years. Special thanks to my postdoc advisor
@GordFishell
, the most supportive mentor one could have; and my grad school advisors (Huizhong Tao and Li Zhang, not on twitter) for all their support.
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@Ben_S_Huang
Thank you so much for giving me the opportunity. It was really a humbling experience talking about both my scientific and personal journeys, and more importantly being given the platform to talk about the injustices faced by Palestinians on a daily basis.
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@neubadah
@KAUST_News
@KAUST_NewsAR
It was great to have you here and get to know more about the incredible work you are doing.
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Missing fall in Boston!!!
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@CSHL
@GPouchelon
Congratulations Gabrielle. Can't wait for all the great things that will come out of the Pouchelon lab. 🎉
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7. Conclusion: Proper establishment of top-down connectivity in the visual cortex depends critically on bottom-up inputs from the thalamus during postnatal development.
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1. Work from many labs have suggested that activity in the early postnatal cortex is initially dominated by bottom-up signals. The cortex only later develops recurrent activity following the establishment of functional connectivity between primary and associative cortical areas.
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@GordFishell
@KAUST
Thank you
@GordFishell
and
@GPouchelon
:)
Minor correction which I also keep messing up, it's
@KAUST_News
.
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The Chairman, National Center for Science Communicators (NCSC): Change the state of Indian SciComm - Sign the Petition! via
@Change
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@polybiotique
Academia's loss for sure! But also, you're going to do great wherever you land. All the best with your new and exciting adventure.
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Moreover, sensory deprivation or selective removal of dLGN inputs to L1 INs prevented the strengthening of ACC projections, but not those from the RSP.
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If you are at
#FENS2022
do not miss this important discussion!
#FENS2022
Join ALBA,
@FensKavliNet
& Young IBRO today @ 7pm in Hall E for an engaging panel discussion on how we can collectively translate awareness to action to ensure
#inclusivity
and
#equal
#opportunity
for
#neuroscientists
from all backgrounds. 👉
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5. Using optogenetics and patch clamp recording from L1 IN subtypes in brain slices, we found that ACC projections strengthen across development, whereas bottom-up inputs get slightly weakened.
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Rafiq is on to great things. Go work with him!!!
Excited to welcome Huda lab's first graduate student
@TheREALSamGritz
! Sam will be spearheading our alcohol work, looking at the role of the PFC in modulating the relationship between autonomic arousal and drinking. We are recruiting postdocs for his project - come work with us!
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6. Conversely, premature chemogenetic activation of ACC caused strengthening of these top-down inputs onto L1 NGF cells, and this was dependent on activity from the thalamus.
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@takaki_komiyama
Do a trial run before hand to make sure things are running smoothly. And use the pointer function, the mouse pointer doesn't usually work.
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The question we wanted to address was whether there is a link between early bottom-up activity and the later establishment of top-down connectivity.
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2. To investigate this, we focused on L1 interneurons (INs) in V1, since most cortico-cortical projections primarily terminate in this layer.
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This work would not have been possible without the invaluable contribution of all co-authors
@Su_hang_
@marianf_otero
@SpurtiV
@GPouchelon
@RudyNeuroLab
@GordFishell
and Twitterless Mia, Yanjie, Qing and Rob.
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4. We found that projections from the dLGN preferentially target Neurogliaform cells (NGF) in L1 and a fraction of the projections to L1 are shared with those in L4.
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3. Using monosynaptic rabies tracing from NDNF INs, we found that early in development, dLGN inputs are predominant, whereas inputs from the ACC and RSP are comparatively weaker. This trend shifts in the adult.
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@tararaam_
Power to the women and youth of Iran. Wishing you all strength and patience in these trying times. We're not giving up on you!
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Rafiq is great!!!
Looking for a postdoc in a supportive environment with fun toys (2p, opto, ephys)? Want to work together to decode the secret language of striatal astrocyte signaling in movement, learning, and decision making? Apply here or DM to setup informal meeting
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@emiliafavuzzi
@CellCellPress
@stevens1lab
@Datta_Lab
@RichBonneauNYU
@harvardmed
@broadinstitute
Congratulations 👏
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@miguel_turrero
@manuel_baizabal
@neurodev_lab
@YajunXie
@6degreesofManni
@englishlauren2
@Chris_M_Reid
@Harwell_Lab
Congratulations 👏
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@kallaway14
@Nature
@MGabitto
@RichBonneauNYU
@GordFishell
@harvardmed
@StanleyCenter
@SimonsFdn
Congratulations Kate. Great to see this out awesome job!!
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@arisbenjamin
@ShelbyMWhite1
@neuroepicurean
@NunezKant
@tatianalau
@esmaeilpour_znb
@hayley_drozd
@Asiminas_Ant
@gabigabbahey
Thanks for being an amazing TA.
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The least we can do!
How neuroscience labs can limit their environmental impact
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@6degreesofManni
Haha it wasn't on the rig, but also didn't do anything. Sigh!! What about you?
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@rmassonix
@mabdelhack
@Mohamed_Nabil95
Are you interested in coming to KAUST in Saudi Arabia? We have great infrastructure and a great PhD program. Let me know if you want to learn more about the place 🙂
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Yup. Leaving academia doesn't mean you're a failure!!
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