JASN_News
@JASN_News
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This account will no longer actively post. Follow @asnpublications for the latest from ASN publications, including JASN, CJASN, Kidney360, and Kidney News.
Washington, DC
Joined January 2015
We are no longer posting on this account. Follow us on @asnpublications for the latest from ASN publications, including JASN, CJASN, Kidney360, and Kidney News.
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We’d like to announce that Katalin Susztak is joining the JASN Editorial team as an Associate Editor. Welcome aboard, @KSusztak!
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ASN welcomes the new JASN Editor in Chief and Senior Editor in Chief for the ASN Journal Portfolio, Rajnish Mehrotra MD, MS, FASN. @rajmehrotra1122 aims to "develop a shared vision for advancing kidney disease care."
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IgA nephropathy is the most prevalent primary glomerulonephritis worldwide. This Review proposes a comprehensive approach that tackles the different targets in the pathophysiology of IgA nephropathy according to their relevance in the individual patient
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SGLT2 inhibitors and GLP1-RA slow the worsening of kidney disease and improve cardiovascular outcomes in patients with CKD. A study shows that among patients with CKD, these agents are frequently discontinued, and discontinuation is associated with hospitalization, race,
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The effects of SGLT2 inhibitors on regional tubular sodium handling is poorly understood in humans. This study shows empagliflozin caused substantial redistribution of intra-renal sodium delivery and reabsorption @dhekidney @fperrywilson
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IgA nephropathy is the most prevalent primary GN worldwide. This Review proposes a comprehensive approach that tackles the different targets in the pathophysiology of IgA nephropathy according to their relevance in the individual patient @fervenzafernan1
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JASN is pleased to announce the incoming Editorial Team, under the direction of EIC @rajmehrotra1122, effective January 1, 2024 @MagdalenaMadero @girish_nadkarni @SannaCherchiLab @Sheena_Singh15 @sydney_tang @edgarvlermamd @Nephro_Sparks
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IgA nephropathy is the most prevalent primary GN worldwide. This Review proposes a comprehensive approach that tackles the different targets in the pathophysiology of IgA nephropathy according to their relevance in the individual patient @fervenzafernan1
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Age-associated changes to podocytes adversely affect kidney health. This Review discusses the molecular and cellular mechanisms underlying podocyte aging and approaches to mitigate progressive damage to podocytes
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The complement system plays a central role in the pathogenesis of IgA nephropathy. This study found that an early, sustained, and clinically meaningful reduction in proteinuria and trend toward stabilization of eGFR were observed with ravulizumab versus placebo.
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SPRINT showed that intensive lowering of systolic BP increased the risk of incident CKD and episodes of AKI. A study looked at legacy effect of intensive vs. standard systolic BP lowering on longer-term incidence of kidney failure. Rates of dialysis or transplantation were higher
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A randomized trial found adding the SGLT2 inhibitor empagliflozin to standard fluid restriction to treat patients with the syndrome of inappropriate antidiuresis resulted in a significant increase in #plasma sodium compared with #placebo @UniSpitalBasel
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The interaction between the kidney & coagulation system affects each other because of vessel distribution & blood perfusion in the kidney. This Review discusses the progression of research on the crosstalk between the coagulation system & kidney diseases
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Hemodialysis (HD) induces left ventricular transient myocardial dysfunction. This study found intradialytic exercise applied acutely during HD improves regional myocardial mechanics & may warrant consideration in the therapeutic approach for patients on HD
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This study finds that patients on hemodialysis with atrial fibrillation experienced decreased cardiovascular events and major bleeding complications with direct oral anticoagulants compared with vitamin K antagonists
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Kidney survival is poor in patients with circulating anti–GBM antibodies & severe kidney injury. This study found that single dose of imlifidase led to kidney survival without major safety issues in 10 of 15 patients with anti-GBM disease & poor prognosis
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C3 glomerulopathy is a rare disease resulting from an overactivation of the complement alternative pathway. This study found intra-renal terminal pathway activation was associated with specific histological phenotype & disease prognosis in this population
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AKI affects approximately 13.3 million people around the world each year. This Review explores the mechanisms and detection of AKI in tissue culture, with an emphasis on bioengineered approaches such as human kidney organoid models
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The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. This study shows the SGLT2 inhibitor empagliflozin is a promising new treatment for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function
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The pivotal event in the pathophysiology of IgAN is the binding of circulating IgA-containing immune complexes to mesangial cells This Review proposes an approach that tackles the different targets in the pathophysiology of IgAN @fervenzafernan1
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SGLT2 inhibitors & MRAs reduce the urinary albumin-to-creatinine ratio and confer kidney and cardiovascular protection in patients with CKD. This study assessed efficacy and safety of the SGLT2 inhibitor dapagliflozin & MRA eplerenone in patients with CKD
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SGLT2 inhibitors & MRAs reduce the urinary albumin-to-creatinine ratio and confer kidney & cardiovascular protection in patients with CKD. This study assessed efficacy of a SGLT2 inhibitor & a MRA in patients with CKD @jlgorriz @chuspuchades
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Patients requiring hemodialysis have a higher risk of cardiovascular morbidity & mortality. This Review examines the pathophysiology of hemodialysis-related vascular injury & consider a range of therapeutic approaches to improving outcomes
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Eculizumab therapy for pediatric patients with Shiga toxin–related hemolytic uremic syndrome does not appear to be associated with improved renal outcomes during the acute phase of the disease, a randomized trial with 100 patients shows
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Autoantibodies against the M-type phospholipase A2 receptor (PLA2R-AB) appear & increase rapidly in patients later diagnosed w primary MN before the earliest preclinical evidence of disease, including non-nephrotic-range proteinuria
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Among patients on hemodialysis, hypertension is common, often treated, but remains poorly controlled. This Review covers the epidemiology, diagnosis and management of resistant hypertension among patients on dialysis
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During a rapidly developing #COVID-19 epidemic at a large #dialysis center, rapid implementation of control measures-universal protective equipment, a regular screening process, and case isolation-appeared to help protect pts from infection. @NeillDuncan3.
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Please join us in welcoming the 2022-2024 class of JASN Editorial Fellows! In the JASN Editorial Fellowship Program, these fellows will be introduced to the editorial processes, while also bringing their own valuable expertise to our team @agkattah
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SGLT2 inhibitors and MRAs confer kidney and cardiovascular protection in patients with CKD. This study found that combined SGLT2 inhibitor and mineralocorticoid receptor antagonist treatment lowered albuminuria by more than half in patients with CKD
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Review: CKD: A Call for an Age-Adapted Definition.with two #openaccess Perspectives-Does eGFR by Any Number Mean the Same? & Modification of eGFR-Based CKD Definitions: Perfect, or Enemy of the Good?
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The effect of SGLT2 inhibitors on regional tubular sodium handling is poorly understood in humans. This study found empagliflozin caused substantial redistribution of intrarenal sodium delivery and reabsorption @fperrywilson @dhekidney
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ASN Journal Portfolio is pleased to welcome incoming editors, effective 1/1:. JASN EIC: @rajmehrotra1122.CJASN EIC: @ConnieMRhee.Kidney360 EIC: @MikeAllonK360.Statistical Editor: Patrick James Heagerty.Visual Abstract Editor: @edgarvlermamd.Communications Editor: @Nephro_Sparks
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Findings of the PEXIVAS trial challenge the role of PLEX in ANCA-associated vasculitides. This study shows that a score incorporating kidney biopsy findings identifies patients with AAV who may benefit from PLEX, findings that need independent validation
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Long-term outcomes of rituximab-treated adult patients with podocytopathies are largely unknown. This study found that rituximab facilitated achievement of initial and long-term response in a majority of adult patients with difficult-to-treat podocytopathies.
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This study found that in patients with unexplained acquired hypomagnesemia, pathogenic claudin-16 autoantibodies may be an autoimmune cause of specific renal tubular transport disturbances and tubulointerstitial nephropathy @LucileFigueres
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The goal of therapy in lupus nephritis is remission of disease activity to improve long-term outcomes. This Perspective describes how to balance between disease activity control and adverse effects to safely withdraw immunosuppressants @hjanders_hans
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Testing for SARS-CoV-2 antibodies in 356 adult UK patients with ESKD receiving in-center #hemodialysis found a seroprevalence rate of 36% and revealed that 40% of patients with antibodies had either asymptomatic infection or undetected disease by PCR alone
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An atlas of kidney single-cell gene expression changes in 18 mouse kidney disease models shows limited overlap between models as well as between a diabetic kidney disease (DKD) mouse model vs human DKD, but also reveals consistent pathway-level changes
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JASN proudly celebrates @JosiePBriggs for her amazing leadership as the first female Editor-in-Chief of an ASN journal in honor of yesterday’s National Women Physicians Day. @womeninnephro
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SGLT2 inhibitors have become an integral part of management of patients at risk of cardiovascular disease both with and without diabetes mellitus. This Editorial discusses a study on tubular handling of Na+ after the administration of SGLT2 inhibitors
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Methotrexate can lead to kidney injury at high doses for cancer and is contraindicated in advanced CKD. This study shows that low-dose methotrexate does not harm the kidneys of patients with normal kidney function or with mild-to-moderate CKD
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The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. This study found the SGLT2 inhibitor empagliflozin is a new treatment option for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function
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Burton “Bud” Rose, a brilliant educator, entrepreneur, and nephrologist, died on April 24, 2020 from Alzheimer disease complicated by coronavirus disease 2019 at age 77.
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Membranous nephropathy is a common cause of proteinuria in syphilis. This study shows that neuron-derived neurotrophic factor is a novel target antigen for proteinuria in patients who have syphilis with membranous nephropathy @SethiRenalPath
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New research has found that a subset of adults and children with minimal change disease have circulating autoantibodies that target nephrin, a slit diaphragm component essential to integrity of the glomerular filtration barrier @BWHPath
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Ultrafiltration is essential in peritoneal dialysis for maintenance of euvolemia, making ultrafiltration failure an important complication. This Review argues that reduction of peritoneal glucose exposure is essential for high-quality long-term PD
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Primary membranous nephropathy (MN) is caused by circulating autoantibodies binding to antigens on the podocyte surface. This study shows that Netrin G1 is a podocyte membrane protein that circulating autoantibodies target, causing some cases of MN
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JASN mourns the loss of Dr. Robert Schrier, a towering figure and leader in nephrology. "Dr. Robert W. Schrier was not only a giant in medicine, he was an extraordinary person who looked for the best in others and gave the best he had." -Dr. Tomas Berl
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Kidney transplant recipients with BK virus infection are at risk of developing BK virus–associated nephropathy. This study found posoleucel was generally safe and linked to a larger reduction of BK viremia @TransplantPulse @D_M_Dadhania @Dr_Faravardeh
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Molecular matching for the HLA-DQ loci of prospective donor-recipient pairs for kidney #transplant may be more helpful than antigen matching for HLA-A, HLA-B, & HLA-DR to minimize formation of donor-specific antibodies & to improve outcome after transplant
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December Highlights: Effect of SGLT2 Inhibitors on Discontinuation of Renin–angiotensin System Blockade. This study found in patients with albuminuric CKD with and without type 2 diabetes, SGLT2 inhibitors facilitate the use of RAS blockade
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SGLT2 inhibitors and MRAs reduce the urinary albumin-to-creatinine ratio & confer kidney and cardiovascular protection in patients with CKD. This study supports systematic rotation of the SGLT2 inhibitor dapagliflozin & MRA eplerenone to optimize treatment
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Kidney fibrosis is a common manifestation of all CKD and progression toward kidney failure, regardless of the disease etiology. This article describes recent progress behind the discovery and development of a new potential therapy for kidney fibrosis
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The complement system is increasingly recognized as a key component in several pathways leading to allograft injury. This Review describes the role of complement pathway activation at different stages after kidney transplantation @julienzuber
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The @ASNKidney Journal Portfolio board, including the Editors-in-Chiefs and Deputy Editors of JASN, @CJASN, and @ASNKidney360, met today to collaborate on the future direction of the Journal Portfolio
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In ANCA-associated vasculitis (AAV), there is a lack of biomarkers for predicting renal relapse. This study found urinary CD4+ T cell counts could identify AAV patients at a substantial risk of renal relapse within six months
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"Phosphate restriction. may provide a novel therapeutic approach to address a critical aspect of AKI pathophysiology and potentially improve patient outcomes." This Editorial discusses a recent study on mitigating AKI-associated complications
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Reliable prediction tools are needed to personalize treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. This study shows the updated score optimizes clinicopathologic prognostication for clinical practice and trials
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CNIs are used after transplantation, but are linked to reduced graft survival. This study shows that belatacept is a safe & effective alternative to calcineurin inhibitors in immunosuppression following renal transplant @rohiniprashar @StefanPBerger
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Membranous nephropathy (MN) is a common cause of proteinuria in patients receiving a hematopoietic stem cell transplant (HSCT). This study found that a novel protein, protocadherin FAT1, is the target of antibodies in HSCT-associated MN @basmeomeo
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Inhibitors of the renin-angiotensin system (RAS), SGLT-2, and the mineralocorticoid receptor (MR) were superior to dual RAS/SGLT2 blockade in attenuating CKD progression in a mouse model of Alport syndrome @hjanders_hans @RosKaroAT @cirluigi @LaBOORatory
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A Perspective describes how to find the balance between disease activity control and treatment-related adverse effects to safely withdraw immunosuppressants in patients with lupus nephritis in remission. @hjanders_hans .@BradRovin .@AKronbichler
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The impact of SGLT2 inhibitors is advancing rapidly. The benefits, risks, mechanisms of action, and clinical applications of SGLT2 inhibitors are discussed in this collection of articles published across ASN journals
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CKD is associated with fluid excess. This study found in patients with CKD, empagliflozin resulted in a sustained reduction in a bioimpedance-derived estimate of fluid overload, with no significant effect on fat mass @MartinLandray @Oxford_NDPH
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Data from the PEXIVAS trial challenged the role of PLEX in ANCA-associated vasculitides. This study found that PLEX was not linked with a better primary outcome in the whole study population, but identified a subset of patients who could benefit from PLEX
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"Peer review provides an opportunity to stay on top of the cutting-edge research in nephrology while striving to maintain the high standards and scientific integrity of JASN." Thank you for your contributions to peer review, Dr @LeslieGewin!. @WUNephrology
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This study found hospitalized patients with acute coronary syndrome are less likely to receive clinically indicated invasive cardiac care such as angiography if they have chronic kidney disease. Not receiving such care is linked to higher 6-month mortality
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African American pts with #COVID-19 who have certain high-risk variants in the gene encoding apo L1 are at increased risk for experiencing an aggressive form of #kidneydisease associated with high rates of #kidney failure @VelezNephHepato @renalpathdoc .
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Kidney scarring or fibrosis occurs as a consequence of all CKD, but there is no specific treatment for kidney fibrosis. This article describes recent progress behind the discovery and development of a new potential therapy for kidney fibrosis
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Testing for 385 genes among 1623 CKD patients identified variants in 20.8%, half of whom had new or changed diagnosis, 90.7% change in management, and 32.9% change in treatment @ndahl48 @HilaMilo @fouadchebib @MayoClinicNeph @ColumbiaKidney
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January Highlights: Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis. This study found that empagliflozin is a promising new treatment option for chronic SIAD-induced hyponatremia
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Reliable prediction tools are needed to personalize treatment in ANCA-associated GN. This study shows the updated ANCA kidney risk score optimizes clinicopathologic prognostication for clinical practice and trials
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Adequate dietary potassium intake may be renoprotective, but what are the effects of increasing dietary potassium and the risk of hyperkalemia? A new study shows that most CKD patients do not become hyperkalemic when given a potatssium supplement of 40 mEq
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Kidney transplant recipients with BK virus infection are at risk of developing nephropathy, allograft rejection, and graft loss. This study found posoleucel was generally safe, well tolerated, and associated with a larger reduction of BK viremia
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Editors' Choice: Effects of Empagliflozin on Fluid Overload, Weight, and Blood Pressure in CKD. This study found empagliflozin resulted in a reduction in a bioimpedance-derived estimate of fluid overload in patients with CKD @MartinLandray @Oxford_NDPH
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Rituximab is the standard therapy for childhood-onset complicated frequently-relapsing or steroid-dependent nephrotic syndrome. This study shows that administration of MMF after rituximab may prevent the development of treatment failure
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Special Article: .Mechanisms of Metabolic Acidosis–Induced Kidney Injury in Chronic Kidney Disease.
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Biomarker studies in the setting of CKD have increased considerably within the past 15 years, but vary significantly. This Systematic Review and Meta-Analysis summarizes the prognostic value of preclinical plasma and urine biomarkers for CKD outcome
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Does it seem like every day there’s new information published about SGLT-2 Inhibitors? Stay informed with ASN Publications’ SGLT-2 Collection. This series, featuring articles from all ASN journals, showcases the latest updates on SGLT-2 inhibitors #jnlcoll
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The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations.
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Donor-specific HLA antibody in kidney transplant patients with biopsies classified as no-rejection was more common than thought and associated with increased risk of kidney failure within 3 years
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Perspective: Acute #kidney injury in #COVID-19: Emerging evidence of a distinct pathophysiology @Dan_Batlle @sundarswaminat4 @PepaSolerR @pawellingMD @asouth_neph @Nephro_Sparks @hswapnil #AKI #COVID19 #openaccess
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Thiazide diuretics are associated with glucose intolerance and new-onset diabetes mellitus. This study found thiazides attenuate insulin secretion via inhibition of the mitochondrial CA5b isoform in β cells of mice
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Platelets play essential roles in hemostasis. This Editorial discusses a recent study that examined a mouse model of antibody-mediated CKD induced using an antiserum against the glomerular basement membrane
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Patients requiring HD have a higher risk of cardiovascular morbidity and mortality. This Review examines the underlying pathophysiology of HD-related vascular injury and considers a range of therapeutic approach to improving outcomes set
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Kidney gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting. This study shows that CKD disrupts kidney gluconeogesis, with systemic decrease in glucose and increase in lactate levels, and is associated with worse prognosis
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Clinical trials have shown remarkable benefits of SGLT-2 inhibitors. This collection from JASN, @CJASN, & @ASNKidney360 highlights rapidly advancing knowledge of SGLT-2 inhibitor benefits, risks, mechanisms of action, & clinical application #jnlcoll
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Researchers have developed a method for selectively inducing human podocytes derived from human pluripotent stem cells. These human stem cell–derived podocytes are expected to serve as a valuable resource in kidney research.
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The complement system is increasingly recognized as a key component in several pathways leading to allograft injury. This Review describes the role of complement pathway activation at different stages after transplant @julienzuber
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Anemia is a common complication of CKD; it is mainly treated with erythropoiesis-stimulating agents (ESA) and iron. This Review examines HIF-prolyl-hydroxyl domain (PHD) inhibitors, a new class of oral drugs developed to treat anemia in CKD
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This study of patients with ANCA-associated vasculitis identified a specific subtype that includes the presence of renal parenchymal arteritis, has different presentations, and is associated with a poorer renal prognosis @BoudhabhayI @CanaudLab
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The classification of podocytopathies has been based on limited glomerular features. This study utilizes machine learning to identify prognostic features for MCD/FSGS biopsies, increasing granularity of podocytopathy classification @LauraMarianiMD
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ASN and NKF recommend adding the CKD-EPI creatinine equation without the race variable to estimate eGFR and adding cystatin C measurement
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In a subset of patients with membranous nephropathy, the finding of novel antigen PCDH7 in the glomerular basement membrane—as well as PCDH7 antibodies in serum and tissue—suggests that a distinct type of MN is linked to PCDH7 @SethiRenalPath @pi_ronco
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Presence of antibodies against factor B promotes complement activation in acute postinfectious GN in children and might help distinguish this disorder in its acute phase from C3 glomerulopathy @chauvet_sophie @VeroniqueBacchi
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Kidney transplant recipients are at high risk for death from cardiovascular disease, but are often excluded from studies on minimizing this risk. This Perspective calls for more research into the treatment of heart disease in this population @mannonmom
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New findings imply that in most cases, primary membranoproliferative GN is driven by autoimmunity—challenging the paradigm of complement gene mutations typically causing the disease. @dannygale_1 .
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Why are SGLT2 inhibitors underutilized in older patients? Data from large RCTs do not indicate higher rates of adverse outcomes with SGLT2i or attenuation of treatment efficacy in patients aged ≥70 years with CKD. Perspective argues that SGLT2i should be considered a therapeutic
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