Isabel Saur
@IzzySaur
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Molecular Plant Microbe Interactions @ University of Cologne. Immunity, AVR, receptors, mildews, cereals .....
Cologne, Germany
Joined November 2009
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We have a Postdoc or PhD position available in the field of Plant-Microbe-Interactions from early/ mid next year on
@UniCologne
. If you are interested 𝐚𝐧𝐝 𝐡𝐚𝐯𝐞 𝐞𝐱𝐩𝐞𝐫𝐢𝐞𝐧𝐜𝐞 𝐢𝐧 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬, pls get in contact.
Pls share. Ta!
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First major paper accepted from the saur lab: We demonstrate atypical AVR effector function: inhibition of the barley MLA13 NLR by the AVRa13-V2 variant. Thx to the editor and reviewers for their suggestions.
With
@MerleBS4
&
@Emma_Crean_
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And once more in Englisch:
We have a fully funded PhD position
@UniCologne
(Molecular Plant-Microbe Interactions). More information about the position and about us at:
Please apply via the job portal!
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Many recent advances and an EXCITING TIME in (plant) NLR IMMUNITY. You can read up on this in our very up-to-date REVIEW from
@mpipz_cologne
PSL,
@RWTH
Ralph Panstruga and I.
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In our manuscript we show that a variant of a Bgh AVR effector can act as an inhibitor of MLA cell death and this is associated with 'enhanced' effector-receptor interaction.
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Look at those guys! Today at group meeting I really was so proud of what we have already managed! 1y ago, I have started
@unicologne
and first was all lost. (1/4)
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At
@mpipz_cologne
, we have extensively used barley protoplasts for testing AVR - NLR pairs. Here we show that the protocol can also be applied to wheat. Great to see that MLA also recognises AVRas in wheat & in turn, Sr50 detects the matching AVR in barley. Enjoy protoplasting!
A cell death assay in barley and wheat protoplasts for identification and validation of matching pathogen AVR effector and plant NLR immune receptors
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Oh and thanks to the reviewer's suggestion, we also provide a video that shows epidermal peeling. Check out how I failed in the first try :-)
#demo_effect
At
@mpipz_cologne
, we have extensively used barley protoplasts for testing AVR - NLR pairs. Here we show that the protocol can also be applied to wheat. Great to see that MLA also recognises AVRas in wheat & in turn, Sr50 detects the matching AVR in barley. Enjoy protoplasting!
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Humboldt Review from
@HuckelhovenR
and me. Enjoy!Recognition and defence of plant-infecting fungal pathogens
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Pls retweet:
Ich habe eine voll finanzierte Doktorandenstelle (65%)
@UniCologne
(Molecular Plant-Microbe Interactions). Mehr Infos über die Stelle und über uns unter:
Bewerbungen bitte über das Jobportal!
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Wei's
@cauwhiskypaper
from his Postdoc in
@gun_doelab
also with
@JohanaMisasis
now published in JXbot …(previously found on biorxiv 10.1101/2022.12.19.521009). No MS data generated here without S. Stolze &
@Grandpa_Hiro
of course :-)
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Thought I am a grown up at some point, but even after half my life spend in the lab...........there is just NOTHING like the feeling when your western blot works first try (after using a new protein / extraction protocol).
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Our new ‘Bgh infection tower’ finally arrived :-D inaugurated immediately with Em
@Emma_Crean_
!
@StefanEngelhar3
@HuckelhovenR
seems familiar?
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Today at the Uni Köln, Plant Sciences Institute day: Dorit
from
@FoodSecurityUoC
@FoodSecurityUoC
@ceplas_1
about the biggest (food security) challenges these days
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I am apparently now (after 6ish years) finally re-intregraded to Germany (after spending year in Australia) : An undergrad student replied to my email without salutations and I found this to be very rude!
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Als voll-berufstätige Frau kann ich nur sagen:
‚menoring4women’ und andere Leadership Kurse sind sicher nützlich…aber in erster Linie benötige ich eine anständige Kinderbetreuung
#womeninscience
#frauenquote
#kitaplatz
2/2
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Starting of AG Döhlemann
@JohanaMisas
@gun_doe
annual retreat that we are invited to joint this year. Lovely location at the Rhein in St Goar. Thanks for organising Looking forward to the fun and the science! Whopwhop!!
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Amongst others,(
#PhD
)Students may be scared of loosing time during
#homeoffice
to
#FlattenTheCurve
...maybe because funding is limited.If this is the case,but u feel uncomfy to go to work,then DON't do it!!! You'll be able to finish your degree!!Staying home now wont stop u! (1/2)
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Currently I am really a worthless fellow, but hey at least one with style. Nerdy goody from
@RensingStefan
group made my day!
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Powdery mildew AvrA effectors are RNAse like proteins - still 😊. But now we know for sure. But contrary to some previous thoughts the hypothesis is that they may have different virulence functions despite structural conservation. Let’s see if we can confirm this hypothesis.
Structural polymorphisms within a common powdery mildew effector scaffold as a driver of co-evolution with cereal immune receptors
#biorxiv_plants
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Für unseren 2.Sohn haben wir haben heute einen Kita betreuungsvertrag in der
@BundesstadtBonn
für 45 h im U2 Bereich unterschrieben. Furchtbar, dass sich das anfühlt als hätte man im lotto gewonnen und wir das mehr feiern als das Abitur oder den Studienabschluss 1/2
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@ghjkema
handing over the worldwide Zymoseptoria tritici collection to
@EvaStukenbrock
. Thanks to
@EvoMPMI
for inviting me here to the
@KielPlant
Center summer event
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@MCBotany
@StegmannMartin
@TrujilloLab
here a little lookback to the last Botanikertagung. The conference dinner will again be on a ship, this time on the Rhein. Let’s see how the food is this year….🤔
The „Botanik-Tagung“ (Aug 28 - Sept 01, 2022) of the
@PlantScienceDBG
taking place
@UniBonn
is now open for registration!
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@mpipz_cologne
PSL Departmental retreat
@SchlossRingenb
Tegernsee with
@ParkerLab_MPIPZ
@LuckyStrike1984
@hacquard_st
@laplap10
@TonniGrube
and many more members and guests. Great to be here and combine this view with talks, workshops & discussions.
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#ICMPMI2019
ppl may be interested in these two PhD positions with the new
@mpipz_cologne
group leader
@TonniGrube
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single nucleotide exon found in Arabidopsis....things getting more and more complex
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Grew some green beans and hope to collect some Erysiphe (powdery mildew). Got wilting instead 🤦♀️ verticillium maybe 🤔
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Vorlesung gestern Abend im Hörsaal 15 an der TU München bei
@HuckelhovenR
uns
@StefanEngelhar3
. Excellenter Stoff!
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And now with the support of all the colleagues at the plant science institute incl
@gun_doe
@MaekawaLab
@Team_Thomma
@Team_Zuccaro
@MeauxJuliette
@mb_bucherlab
as well as associations with
@ceplas_1
and
@sfb_1403
we are really set! (2/4)
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Winter wonderland here at
@mpipz_cologne
credit for snowman and snowman’s weird friend goes to
@ParkerLab_MPIPZ
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I think all of us had a really good and informative time at the
@ceplas_1
women in plant science event. Thanks a lot Claudia and team! We,
@MerxLaura
@PiaSaake
@JohanaMisas
& me, had a crazy trip back that involved a towed away car and being saved by
@FranziFichtner
🤷♀️.Thx a lot!
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Still a few open spots. Register until Friday. It is going to be agreat meeting again, I am sure
#MBP2024
📢Registration is open!
Conference Molecular Biology of Plants☘️
🗓️4. to 7. March 2024
📍Sportschule Hennef
Exciting science, fantastic keynotes
@ClaudiaKohler11
@pilarcubas
@PlantSciDBG_en
#ECRfriendly
#plantscience
#research
#networking
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Love it!
Battle field under the microscope: our favorite plant-fungus interaction works in a cell-autonomous manner. Highlighted in red: spores that weren’t allowed to enter, green: successful infection of barley epidermis cells.
SEM image by Krystina Opalski
#YoungSFB924
#phytopathology
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In this review, we give a general overview of plant recognition and defence of fungal parasites tracing back to the early 20th century with a special focus on Triticeae and on the (molecular) progress that was made in the last 30 years.
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The best project competition started at the
@mpipz_cologne
postdoc symposium
#mpipzPS
. Let’s see if we come up with the most original research project....I see plants drawn on each flip chart
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Or resistosome...no wait that is a pentamer
some good boys illustrating the molecular mechanisms of apoptosome formation
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#mbp2021
@ParkerLab_MPIPZ
gives a great overview of all the recent advances of (plant) NLR signalling
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Postdoc
@yarkhunova
today
@mpipz_cologne
annual science day. She studies flowing time among 360 (!!!) At acession. Spoiler: location may not associate with latitude...maybe altitude!?
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Guess I have to surrender. Day 1/7 my life in pictures.
Rules: no words, no people, nominate someone new each day. I was nominated by
@Bjoern_S
,
@fleissing
and
@Farid_El_Kasmi
and I nominate
@KatharinaMel1
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preprint from
@mpipz_cologne
Seq analyses of wild barley population: divergence of 2 subgroups of allelic MLA NLR distinctive by CC domain. Note: Only subgroup 1 confers powdery mildew resistance. So what (bastard) drives subgroup 2 diversification?
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@mpipz_cologne
PSL departmental outing to the wine breeders @ geilweilerhof with
@hacquard_st
@ParkerLab_MPIPZ
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Also shows you cant just throw an A. thaliana protocol onto other plants....adjustments adjustments adjustments
1st preprint from my PhD
@mpipz_cologne
with
@Grandpa_Hiro
@watertoland
now on Biorxiv
- Please read!! 🙏❤️
#Marchantia
#interactomics
#membranetrafficking
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#mpipzPS
postdoc symposium
@mpipz_cologne
best project competition: project 1: how to make the world grapes again
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@jonathandgjones
@SpicyBotrytis
@AdamRBentham
actually we have an effector (AVRa13-V2) that shows strong MLA13 interaction but cannot activate Mla13 (cell death or resistance).
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So much happening in NLR research....~ 30 y after cloning the first ones I feel one gets close to understand how they function
#MBP2021
great picture btw
@Farid_El_Kasmi
showed this figure from by
@IzzySaur
- I quite like the resistosome; so much to learn today about NLRs and Co
#MBP2021
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Darf gerne geteilt werden: Unser Lab benötigt weitere Unterstützung im Labor und bei der Orga: TA Stelle (TVL 9b) ab März 2023
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Germans are terrible with commas,,,,,,,they use them everywhere,,,,,,I know what i am talking about; I am one of them,,,,,,,
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Is there anyone that can answer some Qs about Xanthomonas growth and competent cells/transformation? We have a Xoo strain and apparently it won't grow in liquid culture and one cannot freeze competent cells!? Insight/suggestions appreciate from anyone with more experience. Ta
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And on top!!! of his work on Usti,
@cauwhisky
already has AVRa target candidates identified by biotinylation in barley with the help of
@Grandpa_Hiro
. Plus all of them help out the new member Max and the scientists and students that come to visit the Lab (4/4). Great job really!!
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Last keynote
@KielPlant
Center event: Remco
@EvoMPMI
Stam starting with the advantages of studying ‚his‘ model S. chilense : Environm. Adaptation vs R gene evolution
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#Calandro
from
@JKI_Bund
Siebeldingen: enhanced resistance to downy and powdery mildew, up to 60% reduced use of fungicides! Certificate for excellence from
Glückwunsch an unsere Rebenzüchter am
#Geilweilerhof
in Siebeldingen!
#Calandro
zählt zu den
#PIWI
- pilzwiderstandsfähige Rebsorten. Mit ihrer Resistenz gegen echten und falschen
#Mehltau
hat die Sorte bis zu 60 % Einsparpotenzial bei
#Fungiziden
. (2/2)
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Wow...what an unbureaucratic and rapid decision! Think it will make a load of ppl calm down, take a deep breath, which in turn will simply help the containment situation now!
Great decision with a strong message by
@dfg_public
for getting through the current crisis👏 All running projects can be extended for a year without approval. And up to 3 months extra salary for PhDs can be requested.
#COVID2019de
#COVID2019
#coronavirus
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Peter Dodds now at
#ICMPMI2019
on new Avr genes from wheat stem rust fungus Pgt and their suppression of immunity....getting excited!
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I removed a ton of A. thaliana from our front yard and wondered if I had to do the same last spring, i.e. before we started working with it in our Lab
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Wohoo
#Dabringhausen2019
. After my ‘first time’ last year, I knew that I’d hope to go again! So much diversity in only little time and then such a good overview of
@MolPlantSci
/
@PlantScienceDBG
in Germany and beyond
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Emma conquers the ethanol Barrel! 💪💪💪💪💪💪😃 with a screwdriver and a hammer! Epic
The moment when you don't have the special tool to remove a tab seal... but you do have supportive labmates (
@cauwhisky
@MerleBS4
), a random assortment of things that go *thwack* and a touch of verbal encouragement. Perfect recipe for success. Seals are out, lid holes are in 😂
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Possibilities to perform a PhD in Plant Sciences directly after graduation (with a BSc). Really comprehensive insight to the actual daily life in science from early on: Take the chance and apply!
🎉📣Please RT: The call for our PhD program in Plant Sciences/Quantitative Biology just opened! If you are currently doing a BSc or are just finished, check out our website and consider applying!
#PlantSciJobs
#plantsci
▶️
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After only 7 months of starting lab work,
@MerleBS4
is a pro in AVRa/MLA cell death and bombardment of barley leaves,
@Emma_Crean_
clones just about everything and keeps the lab running and Sophie transfects barley protoplasts as if she had never done anything else
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Today's Wed Seminar
@mpipz_cologne
with
@SaschaLaubinger
on splicing in response to stress: rapid stress response genes are often intronless or intron-poor...splicing may just take too long!
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@Frank_Menke
@jonathandgjones
@manishtanks
Nah decreases annealing temperature. Specificity is reduced and error increased-but better a few wrong sequences than none!
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@Emma_Crean_
and
@MerleBS4
dared to go to the Lab today. They dressed up to not stand out :-) Alaaf!
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more cereal protoplasting, this time for testing gRNAs for CRISPER in wheat! Great to know how that works:
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Great Symposion, take the chance to join!
Excited to announce the keynote speakers at our upcoming PMI Symposium: 📢Prof Wenbo Ma
@wenboEffector
and Dr Ronnie de Jonge
@dejongepmi
will speak about their excellent plant-microbe research. Join us!! Details on registration
@mpipz_cologne
@ceplas_1
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Scholz wirbt in Indien Fachkräfte an während in NRW die Kitas für mehr MitarbeiterGehalt streiken…vll sorgt einfach mal jemand für anständige Bezahlung in Kinderbetreuung (&co), dann wären Kitaplätze vll keine Rarität und Frauen könnten auch mal arbeiten gehen.
#Tarifrunde2023
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#ICMPMI2019
Peter dodds: pulling out Sr27, AvrSr27 and Sr5! Virulent avrSr27 still recognised by Sr27 in transient ox Assays. Potentially due to low expression in the fungus! For for thought when using GWAS...
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@PietroSpanu
starts off his seminar
@mpipz_cologne
with some beautiful pictures and the basics of powdery mildew fungi
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@timminglab
@itjohnstone
No matter what science, your tweet is so wrong! It is just outragous!
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@Grandpa_Hiro
from
@mpipz
at
#MBP2018
on Marchantia as anmodel for plant pathogen interactions. Advantage over A.thaliana: less redundancy
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Day 2/7 my life in pictures.
Rules: no words, no people, nominate someone new each day. I was nominated by
@Bjoern_S
,
@fleissing
and
@Farid_El_Kasmi
and I nominate
@Eli_Thynne
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#BT2022DBG
my word of the day: ‚haustoriogenesis‘ by Guillaume Brun speaking about parasitic plants (root session)
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Thanks so much
@effectomics
&
@Team_Zuccaro
for keeping us all up to date about the
#BT2022DBG
immunity session!
Combination of Chip-seq and RNA-seq identified CsLOB1 target genes. Nice talk by Thi Thu Trang Phan from Thomas Lahaye group
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Whoop whoop 🙌 congrats
Huge congrats to
@KatharinaMel1
for the best talk price! Big surprise at the end and well done 🎉🍾
#MAdLand2021
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Swizerland, Geneva university:Open PostDoc AND PhD positions in the Group of Roman Ulm on UV-B perception: UVR8 signaling in the regulation of flowering time, UVR8-mediated signalling and gene regulation, and RUP1-/RUP2-mediated regulation of UVR8 activity
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Haha :-) I though alpha fold was a bit off - apparently a matter of perspective! Thorough work, enjoy reading!
Great work resolving the 3D structure of AvrSr50! Seems to be a novel fold amongst fungal effectors and Alphafold doesn't get the topology quite right yet. AvrSr50 can escape recognition by Sr50 even by a substitution in a single surface exposed residue.
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@Farid_El_Kasmi
#MBP2021
Hey Farid, do you actually block Cell death of pathways involving NRG1s / or NRG1 autoactive mutants in the presence of chemical Ca2+ influx blockers?
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Yes indeed, why did we not start a hashtag
@PietroSpanu
? Of course everyone can join in an online meeting....but I like to go back and read up on the highlight of the talks :-) Hopefully in person next time!
Great talks and exciting data at the Powdery Mildew Workshop today! I am grateful to have been able to present my work. Thanks to the organisers and all contributors!
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