Skip out on the worry of falling behind! 🤸 Hematopoiesis News by @STEMCELLTech delivers the latest research in hematopoiesis, blood, and bone marrow disorders straight to your inbox. 💌 Subscribe here:

.@MicrobioUCLA's Dr. Lili Yang and her team characterized primary patient samples and identified a unique therapeutic opportunity for CAR-engineered invariant natural killer T cells. 😎 Check it out in @NatureComms |

New research from @Harvard reveals a self-reinforcing PSTK-cGAS-STING-ROS loop culminating in an oxidative crisis and ferroptotic cell death of #leukemic stem cells. This work was led by Drs. @LingliHe2, David Scadden, & co-authors! 👏 @BloodJournal |

New this week in @iScience_CP! 🙌 Scientist with Dr. @Martin_Stoddart propose the TSP-1/CD47 pathway as a promising therapeutic target to enhance #HSCT efficacy and reduce endothelial injury syndrome. 🎯 📝 Read the paper:

RT @stemcellpodcast: We're back with another episode! 🩸 Drs. Andrew Elefanty and Elizabeth Ng from @MCRI_for_kids talk about blood develop…

Researchers from the Zhejiang University School of Medicine performed ultra-low-input Ribo-seq in #HSCs, progenitor, and lineage cells. 🔬 Their work provides a facet to our understanding of small nucleolar RNA-mediated regulation in HSC homeostasis.

RT @cancerscnews: 🩸 Researchers at @cityofhope led by Drs. Bin Zhang and Guido Marcucci reported that an acquired miR-142 deficit transform…

@WEHI_research @CureCancerAu Congratulations, Dr. Diepstraten! 🙌

Scientists compared patterns of disease relapse and progression across #lymphoma patients receiving CAR-T as second-line versus third or subsequent lines. 🩺 Results indicated favorable outcomes with CAR-T irrespective of treatment line. | @BMTjournal

Are you looking to move your #hematopoietic cell therapy research to the clinic? 💻 Watch this @STEMCELLTech webinar to learn how to ease your path to the clinic by removing animal components from your workflow.

Led by Zhannan Han, scientists with Dr. Mikhail Nikiforov revealed a metabolic vulnerability of #MultipleMyeloma cells. 🧫 They identified a targetable axis linking very long chain fatty acids metabolism to the regulation of MET and IGF1R activity. 🔗

Don't miss this new @CellDiscovery release! 📣 Findings suggested that placental hemogenic endothelial cells possess the potential to transform into self-renewing induced #HSPCs through retinoic acid treatment. 🔎 Discover more:

This clinical trial evaluated RAPA-201 therapy in combination with fludarabine-sparing low-dose host conditioning for the treatment of patients with relapsed, refractory multiple #myeloma. The study was led by Drs. @bhemato and Daniel Fowler. 🩺

Results from genetic mouse models have revealed the impact of ADARs' catalytic activity on #hematopoietic cells, complemented by insights from human cell studies. 🧬 Learn more about the regulatory mechanisms of RNA editing in normal hematopoiesis: 📚

Mitophagy operates as a double-edged sword in #leukemic stem cells. @RiceUniversity authors discuss the dual role mitophagy plays in #AML survival and the importance of targeting mitophagy to treat AML. 📖 Give it a read in @FrontOncology |

Learn how ancillary materials (also known as raw materials) can impact your #CellTherapy translational research from this talk by Lynn Csontos, @STEMCELLTech's Senior Director, Quality Assurance and Regulatory Affairs.

This work was led by Dr. Fatemeh Alikarami and Dr. Kathrin Bernt. 👏 Alongside their @ChildrensPhila team, they uncovered a direct mechanistic link between expression of the stem cell transcription factor GATA2 and drug resistance. 📝 Read the paper:

Led by Joana Araújo and Dr. John Dick at @PMResearch_UHN, the team established FLT3 as an ideal therapeutic target where ITD+ #leukemic stem cells were eradicated upon FLT3 deletion, while #HSCs were spared. 🎯 🩸 Find the details in @BloodJournal:

Dr. Jorge Cortes (@GCC_Cortes) and team presented a pooled analysis from multiple cohorts of the Phase I/II trial of patients with relapsed #AML who received combination olutasidenib and azacitidine therapy. 💊 Read about their findings:

Findings from this recent @JExpMed article establish a functional link between chromatin relaxation and replication stress tolerance in #HSCs and highlight DEK as a target for Fanconi #anemia. 🔗 🩸 Give it a read:

Scientists with Dr. @LuWangLab explore how BAP1 impacts B cell #lymphoma tumor growth via regulating TME and immune cell infiltration. 📖 Get the full story in @jclinicalinvest! 🔓 | @NUFeinbergMed