Moheb Ghobrial
@GhobrialMoheb
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I am very happy to share that my first-author paper from the PhD work is now published in Nature:
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Was delighted to present my work in the
#EVBOSummerSchool2023
@EVB_Org
@CarrerasIJC
Thank you
@MarionaGraupera
and the organizing committee for the great meeting 🙏
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Glad to share our preprint:
Wälchli, Ghobrial et al Molecular atlas of the human brain vasculature at the single-cell level
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How can COVID-19 damage the brain ?
What is the mechanisms underlying SARS-CoV-2 tropism for (brain) vasculature ?
Glad to share our pre-print:
…
#Endothelialcells
#SARSCoV2
#covid19research
#Brain
#CNSangiogenesis
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We have uncovered extensive molecular heterogeneity of healthy fetal and adult human brains and across eight vascular-dependent CNS pathologies including brain tumors and brain vascular malformations.
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Pathological endothelial cells display a loss of CNS-specific properties and reveal an upregulation of MHC class II molecules, indicating atypical features of CNS endothelial cells.
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@Johanna_A_Joyce
@Cancer_Cell
@BejaranoLeire
@unil
@Ludwig_Cancer
@OncoUNILCHUV
@snsf_ch
@BCRFcure
@elamprou_
@Johanna_A_Joyce
congratulations, very excited to see this🤩, it is wonderful👏👏
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Endothelial cells from vascular-dependent central nervous system (CNS) diseases display unique properties, including:
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Our single-cell brain atlas provides insight into the molecular architecture and heterogeneity of the developing, adult/control and diseased human brain vasculature and serves as a powerful reference for future studies.
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This atlas describes the transcriptional heterogeneity of endothelial and perivascular cells across the developing, adult homeostatic, and pathological brain vasculature.
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I am grateful to a great team of scientists that made this work possible
Especially my PhD mentors
@debocklab
,
@garybader1
, Ivan Radovanovic, and
@ThomasWalchli
with whom I extensively discussed🙏
“No one can whistle a symphony. It takes an orchestra to play it.”
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We identify alteration of arteriovenous differentiation and reactivated fetal as well as conserved dysregulated pathways in the diseased vasculature.
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- ii) display common hallmarks of disease including:
- a partial loss of Arterio-Venous (AV)-specification
- a partial loss of CNS-specific properties
- upregulation of MHC class II receptors
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Cell-cell interaction analyses predict numerous endothelial-to-perivascular cell ligand-receptor crosstalk including immune-related and angiogenic pathways, thereby unraveling a central role for the endothelium within brain neurovascular unit signaling networks.
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We performed single-cell RNA sequencing of 599,215 freshly isolated endothelial, perivascular and other tissue-derived cells from 47 fetuses and adult patients to construct a molecular atlas of the developing fetal, adult control and diseased human brain vasculature.
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- iii) they also play a key role in the human brain neurovascular unit a across development, adulthood and disease.
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@danis1337
our sc-atlas describes the transcriptional heterogeneity of endothelial and perivascular cells across the developing, adult homeostatic, and pathological brain vasculature - including brain tumors (LGG, GBM, metastasis, meningioma) and brain vascular malformations (AVMs).
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Was a great meeting
And our conference group photo! Special shout out to
@GPharmatech
, for including their mascot in the photo 😆. And we woudl also like to highlight the staff of
@CarrerasIJC
for taking such good care of us.
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@MichelCayouette
I am personally honored to have met you - and your impressive research profile
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@cleaverlab
Glad to provide a powerful resource to the field, and I hope you enjoyed the read and the figures
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@Johanna_A_Joyce
@EACRnews
Looking forward to it! The role of the microenvironment in cancer is fascinating, and I love the parallel to a scientist’s journey. It's all about the right environment to flourish! Eager to learn more!
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