Gunhild Alvik Nyborg, MD, PhD, BSc
@GANyborg
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7,585
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560
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580
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7,615
MD, PhD, Exam. Oecon. Long COVID research at Koronastudien. Singer/songwriter/producer Albums: Ambient: Jazz:
Oslo, Norway
Joined April 2021
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Pinned Tweet
SARS-CoV-2 is a systemic virus that affects the whole body, but mounting evidence shows that the brain is the organ most consistently affected in the short and long term. Letting this virus roam may prove extremely expensive for our societies.
New important study out in Nature ⬇️
The brain injury 1 year post-Covid hospitalization, systematically assessed with MRI (reduced grey matter), biomarkers, and cognitive deficits "equivalent in magnitude to aging from 50 to 70 years of age."
@NatureMedicine
@gkwood3
@BenedictNeuro
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For all those who still believe herd immunity as a concept applies to SARS-CoV-2: It doesn't. We'll be infected again and again, and the data now tell us that the risk of serious long-term effects increases with each infection. Govts need to re-think & find a new & better plan 1/
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Norway is seeing the world’s first omicron superspreader event after a party downtown Oslo last Friday. Of 120 healthy non-symptomatic fully vaccinated individuals with a negative test, two had recently returned from South Africa and turned out to be positive, omicron. 1/
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Now some 80-90 of the 120 are PCR pos, 13 of these confirmed omicron, the rest waiting for sequencing results. Some of those infected w omicron were not at the party but present at the same restaurant that evening. Not looking good re transmissibility.
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New pre-print that found a very limited immune response after infection with omicron. The desired herd immunity effect may according to this be a far dream still: from this, seems you can be re-infected more or less directly after your last infection
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So it's clear:
SARS-CoV-2 infects T lymphocytes, preferably activated CD4+ cells in vitro, independently of the ACE2 receptor and induces pronounced programmed cell death potentially contributing to the lymphopenia seen in ~80% of hospitalized C19 patients
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Promising results in treatment of
#COVID19
: Oslo team have designed a long-acting viral-entry blocking ACE2 molecule that can be administered needle-free and can block SARS-CoV-2 from getting into cells. Congrats to the team
@AndersenJT
and first author Sopisa Benjakul
Story out! An albumin fused ACE2 design that blocks all SARS-CoV-2 variants. The design has a long plasma half-life and can be delivered in a needle-free manner across mucosal surfaces.
@CoE_PRIMA
@UniOslo_MED
@forskningsradet
@NTNUnorway
@JamesLab9
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Study finds differences in biomarkers in
#longCovid
Using conventional statistics + state-of-the-art machine learning, two vascular transformation biomarkers were identified distinguishing LC patients from acutely ill C19 inpatients +healthy controls (classification accuracy 96%)
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"the risks were evident in those who were unvaccinated, had 1 shot, or 2 or more shots prior to the second infection"
This figure shows clearly that we cannot rely on vaccines to protect us from serious sequelae from COVID. 2/
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@TheClutterer
No. We’re heading for a fall here. Better mask up and order some extra oxygen in case.
This can get really, really, really bad. 😞😞😞
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This is a massive study with a cohort of people with first infection (n = 257,427), reinfection (2 or more infections, n = 38,926), and a non-infected control group (n = 5,396,855) to estimate risks and 6-month burdens of all-cause mortality, hospitalization, and organ sequelae3/
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Almost 120 people are now infected after the party downtown Oslo Nov 26. Around 70 were with the party of 120, 45-50 other guests at the same venue. Omicron suspected in all, still only verified in 13, sequencing slow, screening underway
@Folkehelseinst
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Small study from omicron era:
Researchers consistently detected salivary + airborne SARSCoV2 in air samples + samples from school students over 7 wks. Concentrations of airborne SARSCoV2 were av. 70% lower with mask mandates and 40% lower with air cleaners
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Update. Min. 60 at the party infected. Now nearing 100 cases in total that night, some not with the party but present at the same venue. Screening (likely S gene dropout PCR): about 50 suspected Omicron, the rest not yet screened. 13 confirmed Ο. (paywall)
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Jeg vil igjen understreke:
@espenteigen
har ikke intervjuet meg. Han har diktet fritt fra mine tweets. Ingen steder har jeg skrevet at "viruset raser",at jeg ønsker nye maske- el. vaksinekrav, eller at nordmenn bør bli bedre på hygiene. Saken er meldt PFU.
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Takket være at
@espenteigen
har skrevet nedlatende og usant om meg på , flommer det nå over av trusler og ubehagsmeldinger til og om meg fra ulike kanter fra konspirasjonsfolket. Hvis han vil kalle seg journalist, er det ikke visse regler man skal følge?
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New findings on PEM in
#LongCovid
in Yale study
Invasive cardiopulmonary exercise test (iCPET) measured pressure through right heart catheterizaton
on 55 patients w/post-Covid exercise intolerance.
Result: Oxygen extraction in tissues was compromised 1/
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Important study out in Nature: From this, the mRNA vaccines seem far superior to infection in subsequent protection. IMO, this explains what has been seen on the ground.
See the striking difference. You want to be at zero here. 1/
@Folkehelseinst
@jonasgahrstore
@ingvildkjerkol
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@Forbes
Authorities should be aware of this.
We still don't know the long term impact of this virus for human health. Evidence so far & experience from those affected by SARS1 point to serious long term effects. It would be wise to prevent transmission until new vaccines/more knowledge.
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Preprint from USCF team:
Whole-body PET tracing activated T cells showed significantly higher uptake in post-acute COVID (w & w/o LC symptoms) vs controls: in brain stem, spinal cord, bone marrow, gut wall, lymphoid and cardiopulmonary tissues up to 2.5 years post infection 1/
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@DavidSteadson
@Gab_H_R
Definitely change in testing protocols recently: only adults with 0-1-2 shots of vaccine and with symptoms are required/allowed to test. No testing of kids or those boosted, no testing of asymptomatic. All NPIs stopped. No longer need to isolate or wear mask if pos!!! 1/
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Det kom et virus som var så skadelig at hele verden stengte ned i månedsvis.
Da alle land åpnet opp, var viruset blitt «bare en forkjølelse». Plutselig var ingen lenger redde for at helsevesenet ville knele eller sykefraværet ville øke. Vi kan leve som før viruset kom. Hurra! 1/
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Norway, 2 weeks after schools opened with zero measures to contain the virus. A. Positivity rate (10.2), B. No. of new infections per age group, C. Daily news cases. They say they do it for the kids 😡
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Jeg har lenge mistenkt at russerne spiller en stor rolle i anti-vaxx- og pro-virus-kampanjene i SoMe/YouTube. Nå er det endelig blitt kjent at russerne har sponset mye av desinfoen spredt av MAGA-influenserne i USA. Betalt dem store summer per innslag.
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@DavidSteadson
@Gab_H_R
They’re also saying “everyone shall be infected in the next couple of months”. Clearly! It’s an ethically insane experiment on our population based on flawed scientific premises. Russian roulette. We need luck! w regards to severity, long term disease, neurological affection +++
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Question: What are the long term implications for human health?
Here is
@Forbes
take on the paper in OP⬆️: "As research continues to develop, it will be interesting to discover exactly how this virus attacks and dismantles one of our key defense systems"
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@DavidSteadson
Yes, but so far only 13 confirmed as Omicron. The two travelers returning from SA were the only known source of infection though. So all likely omicron. The event was last Friday, six days ago. In a large restaurant downtown Oslo. W after party at a downtown pub. We’re in deep
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@DavidSteadson
@Gab_H_R
Of course Norway is no longer a deliverer of any form of useful data to the world. We, one of the richest nations in the world, are letting the virus rip through our people, free to mutate, knowing that we’ve been vaxxed &boosted. No solidarity w poorer nations.
@WHO
should know.
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🧵recap:
Several studies have found that the virus causing COVID can infect different cell types in our immune system & many of these cells then die. This may theoretically lead to immune dysfunction/imbalance. It's too early to know the clinical effects from this now& in future.
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Could explain observations like this ⬇️
We'll see in the coming weeks what comes out of this.
My latest news is that kids are now getting reinfected within 30 days of their COVID infection...and yes they tested negative in between.
If you are a pediatric provider testing at every illness will give you this data. With this virus we can't pretend to know anything . 😐
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@rdmorris
Yep. They report a 75% case hospitalization rate among 0-2-year olds; among all the registered cases in this age group, about 75% are now hospitalized in SA. However, non-registered cases are likely very high now. Still goes well with the numbers you refer to here. Very worrisome
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"Delta breakthrough infections (n=39) had 57-fold and 3.1-fold titers whereas Omicron breakthrough infections (n=14) had 5.8-fold and 0.32-fold titers compared to uninfected non-boosted and boosted individuals, respectively"
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A total of 19 cases of Omicron verified in Norway by now, around Oslo & elsewhere. Green: No suspected cases. Yellow: Suspected cases. Red: Verified cases (see the tiny red dot on the west coast)
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UBELIEVEABLE. NIPH today published a report predicting 90.000-300.000 new cases + 50-200 new hospitalizations daily in Norway in only 3 weeks bc of Omicron. Now they advise against school closure as THEY THINK CLOSING SCHOOLS MAY INCREASE SPREAD!! INSANITY
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Hvordan kan du lukke øynene for noe du alt har sett?
Hvordan kan du leve med deg selv etterpå, hvis du ikke tør formidle kunnskapen du sitter på, og den kan redde mange liv?
Jeg fortalte det jeg visste, for å redde liv. Mange liv.
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Several recent studies have found SARS-CoV-2 infects several immune cell populations: neutrophils, macrophages, monocytes, plasma B cells, T cells, and NK cells. Here, monocytes were infected independently of ACE2, leading to massive cell death:
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"Every time you get an covid infection, your immune system seems to suffer.
..
Every single time there is an increased chance that something bad is going to happen to the immune system, and I think that this influx of illness we are seeing is related to that.” - Dr. David Putrino
What’s behind the post covid sickness surge? The vaccine? Immunity suppression? Long Covid? The answer is there is not one answer. It’s complicated and we have to keep the conversation going. Dr. David Putrino, Dir. of Rehabilitation Innovation of Mt Sinai Health System joins me
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@kyhwana
@GrrrrAngryShark
No data at all on omicron yet, naturally. For Delta, vaccines have been reported to only give about 50% protection against long Covid symptoms, or less - one study found zero protection.
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Jeg har en kronikk ute på NRK.
Pandemien vil vare lenge. Flokkimmunitet er ikke mulig å oppnå med koronaviruset.
Norge bør skifte strategi til «Skadebegrensning». Her er oppskriften.
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Reminder: It's been in Putin's interest to weaken Western countries by waging a disinformation war with aim that we let own populations be infected by SARS-CoV-2, ill, not protected by vaccines. Investigations should be made into Russian role in pandemic disinformation campaigns.
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Breaking: Norway: 4 - four - days isolation for SARS-CoV-2 positive!! 😳😲😵💫
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"Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis"
If T cells can be infected by SARS-CoV-2 in vivo, leading to apoptosis, this can explain the findings
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What happens over time, and what does this mean?
Here, "Five of 35 cases (14%) had Lymphopenia in the later follow-up range of 80–102 days... subgroup analyses showed that patients with lymphopenia experienced more frequently persistent symptoms"
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@Yash25571056
This paper does not hold. The only author, Alberto Boretti, has written loads of pandemic-related papers on many controversial topics with controversial results (see PubMed). Seems he also has published climate denier papers under the name Albert Parker 1/
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Early in the pandemic, an article reporting infection of Jurkat T cells was retracted due to methodological issues. In the OP, this finding is replicated. Still much is unknown, but in sum, it is clear that SARSCoV2 can lead to substantial disturbances in immune cell populations.
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Proof that representatives from the Norwegian Institute of Public Health (FHI) tried to pressure researchers to change the wording of an accepted scientific article because they didn’t like the conclusions: that children are infected as much as adults
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Sykefraværet er på sitt høyeste på 15 år
"Vi har hatt en pandemi hvor holdningene til sykefravær kanskje har endret seg", sier
@DrMarit
Eller... vi har fått et nytt virus som raser gjennom befolkningen og forårsaker økt sykelighet
De VIL ikke se.🤷♀️
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Among those tested in this study, after SARS-CoV-2 infection "CD4+ and CD8+ T lymphocytes almost declined to zero in some patients", while B and NK cells were unaffected. Technically: Both Jurkat and M4 cell lines were infected in vitro.
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@HFentonMudd
@LeftCoastVegan
Several studies have found that the virus causing COVID can infect different cell types in our immune system, & that many of these cells then die. This may theoretically lead to immune dysfunction/imbalance. It is too early to know the clinical effects from this now & in future.
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Så det ser ut som
@folkehelseinst
har slettet sin konto på X.
Da slipper de å få høre om folk som er misfornøyd med at de ikke gjør noe arbeid på langtidsvirkninger av covid-19. Kanskje like greit, hvis de ikke har tenkt å bry seg om hva som skjer med folks helse, uansett.
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Covid-19 has two walls. The Memorial Wall for those killed by the SARS-CoV-2 virus, and the ‘wall of silence’ when questions are asked.
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Covid is a systemic disease
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Through the pandemic I’ve tried to counter the rampant disinformation in my country. For this, I’ve been harassed and ridiculed over >2 years. Some trolls to start with, but they went quiet. So who’s running the show? These days,those related to
@Folkehelseinst
& their friends.1/
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"Our study has identified 14 significantly elevated vascular transformation biomarkers", among them two diagnostic biomarkers (ANG-1 and P-SEL).
The study also finds angiogenesis as a potential therapeutic target
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Here, they found lung-resident macrophages (another immune cell population) were infected by SARS-CoV-2, leading to massive death of these macrophages through pyroptosis. The cells dying prevented further replication of the virus in those cells
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Tokyo of 14 mill. inhabitants reported 13 new SARS-CoV-2 in one day. On Friday, Norway of 5 mill inhabitants reported 5413 cases, two months after the government decided to "learn to live with the virus".
Controlling the virus pays off.
The Tokyo Metropolitan Government reported 13 new positive COVID-19 cases Sunday, down by seven from a week before. The daily tally was below 30 for 31 consecutive days.
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NAV og politikerne synes sykefraværet er for høyt
Samtidig har NAV innført krav om fysisk oppmøte hos legen for de som trenger sykmelding.
Det betyr at smitteførende folk med akutt covid tvinges
- ut på buss og bane
- inn på legens venterom, med sårbare pasienter
- inn til legen
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Meta-analysis and systematic review of 21 studies including a total of 80,071 children & adolescents found a prevalence of long COVID of 25.2%. Of these kids, 16.5% experienced mood symptoms, 10% fatigue, and 8% sleep disorders. Not fun for a child
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Swedish nationwide study: Of app. 12,000 who were on sick leave due to covid during 1st pandemic wave, 85% had min. 1 problem with body function (incl. fatigue, cognition, movement) and 46% experienced problems with daily activities 18 months later
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The Director-General of the
@WHO
,
@DrTedros
, spoke on
#LongCovid
at a media briefing this week: “An estimated one in 10 infections results in post-COVID-19 condition, suggesting that hundreds of millions of people will need longer-term care.”
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Here too CD4+ lymphopenia persisted over some time: A decrease in CD4+ T cells "was observed in 60% (9/15), 60% (9/15), and 46.7% (7/15) of total patients at 0, 8, and 16 weeks after discharge, respectively"
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Parliamentarians in all countries should hear from experts on
#LongCovid
We need to spread this knowledge to those in charge. Hear
@zalaly
‘s outstanding talk before the U. S. Senate today in the next comment ⬇️
Today I testified before the U.S. Senate Committee on Health, Education, Labor & Pensions
I called for the establishment of a new multidisciplinary research institute to address Infection Associated Chronic Conditions
Solving these requires a long-term coordinated approach
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In Norway, two sides have been fighting to win the narrative during the pandemic. One representing science. The other,the GBD stance. For 1.5 years the first won. This summer the second took over. Results are devastating and drawing international attention
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Thank God, the
@Folkehelseinst
/NIPH have now finally acknowledged that aerosols are the main way of transmission for the SARS-CoV-2 virus.
This opens for more appropriate measures to be taken to prevent transmission
#COVIDisAirborne
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Now also a superspreader event in Denmark - 53 Omicron cases (15 found by sequencing, 38 by s gene dropout) after a party with 150 participants
An omicron superspreading event has just been recorded in Denmark:
- 150 high school students at a party
- 55 infected with covid
- 53 of those are omicron positive (38 confirmed via S-gene dropout & 15 via whole genom sequencing)
Link to news story:
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Listen to the
@WHO
and
@DrTedros
.
"Nothing could be further from the truth" than what is being told the citizens of Norway, Denmark, Finland, and Sweden:
@jonasgahrstore
@ingvildkjerkol
@Helsedir
@Folkehelseinst
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Intervju i Dagsavisen: Navn i nyhetene
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At en professor som ikke er lege eller epidemiolog, og ikke forsker på temaet, våger å si at hun mener uttalelsene til en av Norges beste statistikere, som faktisk jobber med disse dataene, er tullprat (?!?) - det er forstemmende på så mange måter.
#hybris
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This is a disgrace. In Norway, 200,000 people have diligently given info on their post Covid health status over time for the large Korona study. But the researchers have to give up their work on analyzing the data due to lack of funding
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Jeg støtter prof Arne Søraas, prof Rebekka Cox og forsker Richard A. White ved
@FHI
100% i det de sier her. Det er uakseptabelt at ledelsen ved FHI ikke oppdaterer seg på den mengden kunnskap om
#LongCovid
som vi kjenner til, og informerer befolkningen.
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This is a very important 🧵 depicting how organized disinformation from the Swedish Inst of Public Health
@Folkhalsomynd
has affected policies in Sweden. This has unfortunately applied to Norway, Denmark, and Finland, too, negatively affecting their handling of the pandemic.
In spring 2020, when other countries closed all schools, Sweden kept primary schools open, with mandatory in-person attendance and without protective measures such as testing or quarantines.
Sweden then told the world COVID didn't spread in schools. It wasn't true. 🧵
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They’re sending out those we _know_ are infected - while we know they’re most likely still contagious 🤯
Unbelievable
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Happy to say our theoretical calculations on mass testing as means to control transmission of a(ny) virus, and corresponding comment, have been published in
@LancetRH_Europe
We must develop more efficient and less restrictive alternatives to protect public health going forward
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Jeg er intervjuet av Nettavisen. Forsøkte å formidle hvorfor det økte sykefraværet er en varslet krise. Vi er flere som har advart mot at dette ville bli det sannsynlige resultat dersom regjeringen ikke ville ta ansvar for å håndtere det nye koronaviruset
@ArSoraas
@raubreywhite
– Jeg har bare ventet på disse tallene, konstaterer forskeren.
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Som lege har jeg fått problemer i karrieren etter å ha insistert på å skaffe hjelp til pasienter som har blitt behandlet slik.
Dette er ikke en enkeltstående hendelse, men en ukultur.
Det ødelegger folks liv.
Vi er milevis unna likestilling i medisinen.
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Jaja. Nå fikk endelig FHI studert dette selv. De fant det samme resultatet som alle andre seriøse studier har funnet før. Heldigvis for oss alle, for nå kommer det trolig til å komme mer hensiktsmessige råd derfra.
#MasksWork
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On pandemic
#disinformation
:
«Even before the first wave peaked, doctors suggested the worst was over and that measures to control the virus were more dangerous than the virus itself. This message was repeated regularly throughout the pandemic.»
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Men nei. La dem bli sjuke. Vi er jo imot smitteverntiltak!! Vi står på barrikadene mot masker! Vaksiner er styggedom. Frisk luft er oppskrytt. Vi tror ikke lenger på vitenskapen, FHI tror heller ikke lenger på vitenskapen!
Nei. La oss kutte i sykelønna. Folk er blitt bortskjemt.
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This is not good news.
They report of a person infected with both delta and gamma at the same time. Then the two variants have recombined in that person, meaning they “swapped” some parts of the genes, put bluntly. This smells like trouble.
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For deg som har lest helt hit:
DETTE er den viktigste artikkelen som er skrevet om temaet i Norge siden januar 2022. Les eller lytt! Del!
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And more: In Denmark, altogether 183 cases are now confirmed, 32 by sequencing, the rest by variant PCR (this method now found to be sufficiently precise by Statens serum Institut SSI). Denmark now reports ongoing transmission among people not traveling
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@DavidSteadson
This is from yesterday, when 60 of the 120 were PCR positive.
Of note: of the 13 confirmed omicron cases, some are reported as being other guests not at the party but present at the restaurant the same evening.
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Important 🧵⬇️
Those who think the scientific community are fighting over COVID/long COVID: A huge part of it is not scientific discourse but intended, organized, repeated dis-/misinformation from a couple of handfuls of players supported by big money from far right capitalists.
I want to share my thoughts, as someone who has been so alarmed by the so-called "dissident" scientists like Gupta, Heneghan, Kuldorff, Bhattacharya, & Ioannidis who consider themselves brave Galileos unfairly treated by "establishment scientists." I will try not to swear. 1/n
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@zweinebelkerzen
@F_Lund_Johansen
Covid actually has few similarities to flu aside from transmission via air. Covid is a systemic disease that damages blood vessels and organs around the body, including lungs and brain, and often leads to the creation of autoantibodies; immunological changes may be long lasting1/
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De personlige konsekvensene av å bli hengt ut på den måten er svære. Journalister har et ansvar overfor de som omtales. Han har skrevet sitt innlegg uten kunnskap om saken eller kontakt med meg,og kommenterer i en så nedlatende tone at han innbyr til hets. Takk for
@ARTEIG
s komm
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Kids may not even get T cell responses after mild infection but may brush it off & get little if any protection vs severe disease. Preprint
"rapid clearance of SARS-CoV-2 in children may compromise their cellular immunity and ability to resist reinfection"
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BA.4 and BA.5 are upgraded to variants of concern:
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@music_fan2020
@equibotanica
Yesterday they were 60. Let’s count them again in a few days then ask those remaining…
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Major Norw. hospital stops all elective surgery due to increase in C19 admissions/staff sick leave. A wanted situation: Norway has let the virus loose to «live normally". Too bad the virus won’t listen & science finds herd immunity by infection an illusion
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Er det ingen som ser hva som foregår? En stor andel av befolkningen har nylig gjennomgått minst en COVID-infeksjon. Dette gir kognitive problemer hos mange og økt risiko for slag, arytmier og svimmelhet ⬇️
@tryggtrafikk
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Another side of the coin;"despite Omicron’s extensive mutations and reduced susceptibility to neutralizing antibodies,... Well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19"
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Her har jeg bare hakeslepp.
Er det mulig?
Kan slikt passere, for de som sitter øverst? Er ikke spillereglene like for alle?
«Alle dyr er like, men noen dyr er likere enn andre.» - George Orwell, Animal Farm.
Dette var stygt,
@SFlottorp
🙁
@Folkehelseinst
AVSLØRING:
@SFlottorp
sikret Landmark godkjenning ved å kontakte nye NEM medlemmer personlig. Dette er "kampfiksing".
@forskningsetikk
@akbefring
@KiellandAnne
@HeleneIngierd
@FystroGro
@LvikG
@anineki
@CamillaBIvers1
@AnneHafstad
@TMisje
@anineha
@tv2nyheter
@Klassekampen
/1
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The Norway example: what you get when you, after having controlled the pandemic well through TTI, NPIs, and vaccines, at 50% fully vaxx, 70% 1 dose choose to open schools with Delta in circulation, with no measures to control spread. School started week 33.
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