Transesophageal
#ultrasound
guided normothermic regional perfusion in cDCD donors, how we do it: detailed description of technique we use for
#EISOR
(is also worth reading if you use
#REBOA
), just out, open access, on
@asaiojournal
🔓
🖥️ guidewires & EBOA
Pathophysiology of fluid administration in
#ICU
☔️ fluid challenge, bolus, infusion: does rate matter?
💧does type of fluid impact on outcome?
☔️ fluids response in acute circulatory failure: couple macro/micro hemodynamics
#FOAMcc
on
@ICMexperimental
🗞️
MV is like recipe: same ingredients/different dosages may result in perfection vs disaster
Low Vt does NOT guarantee lung protection: could be good starting point, but isn't THE solution, scale to lung size. Vt impacts survival (ARMA) only if really high/low
@Luigi_ICM
#LIVES2020
Everything about fluids
@Manu_Malbrain
#IFAD2020
🔹7⃣Ds & fluid stewardship
🔹(fluids related) definitions
🔹4⃣questions
🔹4⃣indications
🔹4⃣phases & ROSE conceptual model
🔹fluids myths
🔹main references
Graphic
@FOAMecmo
#FOAMcc
Full talks available at
Ever experienced membrane lung failure on
#ECMO
??
📌 mechanisms of ML (function &) dysfunction
📌 ML monitoring
📌 algorithmic approach to troubleshooting
@Crit_Care
#FOAMcc
#FOAMecmo
So proud being among authors
*Hint: do NOT miss supplementary info!
Vasopressors in shock
➡️norepi 1st choice in septic/vasodilatory shock after volume
#resuscitation
, may be followed by vasopressin/epi
➡️angiotensin II/dopamine limited indications
➡️may ⬇️contractility: inotropes may be added, dobuta>milrinone
@yourICM
Serum lactate poorly specific for hypoperfusion, more often associated with impaired tissue O2 use. Levels affected by
⬆️ increased anaerobic glycolysis & ⬆️ aerobic glycolysis production
⬇️ impaired mitochondrial function
⬇️ reduced hepatic clearance
Potential harm may result
Guiding resuscitation on serial lactate measurements? Not an accurate biomarker of hypoperfusion. However integration with clinical phenotyping + peripheral perfusion assessment could better individualize strategies
🔓
Refers to
🔓
Pulmonary shunt in critical care, practical approach w clinical scenarios
📚 background
🫀🫁definitions: shunt, ventilation/perfusion mismatch, dead space
🩸O2 blood content
🫁 pulmonary shunt
🛏️ shunt measurement in practice
🔮 future directions
#FOAMcc
🔓
What is going on here??
Multiple & coalescent round fomations appearing through venous side of this membrane lung during a VV
#ECMO
run in a patient with
#COVID19
, couple of days after emergent cannula replacement.
#FOAMcc
#FOAMecmo
#COVIDFOAM
on
@yourICM
Hemodynamic management in
#COVID19
notes based on A Messina talk
@HumanitasMilano
@ESICM
webinar Start from clinical examination, add
#POCUS
to basic monitoring (ie PPV), complex tools in selected cases only
#COVIDFOAM
video
slides
🌡️Fever
1⃣ measure t° accurately
2⃣definitions vary
3⃣diagnostic workup? only in some pts
4⃣consider non‑infectious causes
5⃣treat MH
6⃣7⃣8⃣ sepsis? careful w control; NO fever? NO good sign; paracetamol/cooling doN'T ⬆️ outcomes
9⃣BI?
🔟 control post CA
🔗
Delayed fluid therapy can lead to ischemic injury, irreversible shock with multisystem organ system; here 10 papers we should know about
#resuscitation
fluids:
#IFAD2020
Rodriguez G
1⃣CRISTAL RCT
@JAMA_current
2⃣SAFE Study
@yourICM
Topical, nebulized, endobronchial, systemic tranexamic acid to manage surgical & medical bleedings on
#ECMO
🩸TXA commonly used as adjunctive hemostatic agent
🩸systemic TXA use low, guided by local protocol involving multidisciplinary approach & rigorous VET monitoring
Unloading LV in VA
#ECMO
:
🎈 physiological basis
🔮 whom to unload? hemodynamic,
#POCUS
& clinical predictors
⚙️ how to unload? noninvasive and pharmacological approaches, venting & unloading strategies
⏰ when to unload?
➡️ unloading targets
@CircAHA
🖇️
Proning pts with severe
#ARDS
on
#ECMO
, PRONECMO RCT:
🫁 170 pts: prone positioning (at least 4 sessions of 16 h) vs supine positioning
⏱️ no difference in time to successful weaning/run duration
📈 no difference in
#ICU
LoS/mortality
⚠️ no serious adverse events during PP
Understanding gas analysis
#eSMART2021
tutorial 🧵Starting from oxygenation:
🩸O2 content Hb bonded + dissolved in plasma
🩸lung capillary? assume Sat 100%; calculate PAO2 alveolar PO2 with alveolar gas equation
🩸enough Hb? CaO2 may be preserved despite low PaO2/SaO2
@Luigi_ICM
Essential of lung/diaphragm
#POCUS
tutorial 🧵
🦇 sign identify lung in ICS (ribs acoustic shadows)
__ pleural line moves w ventilation: visceral/parietal pleura sliding
🅰️ lines horizontal reverberation artifacts similar to pleural line (repeats = distance)
Mongodi S
#eSMART2021
Temporary Mechanical Circulatory Support in refractory cardiogenic shock
♥️ definition & medical management of CS
♥️ overview of devices used in CS
♥️ escalation of tMCS
♥️ management of tMCS in
#ICU
♥️ de-escalating/weaning
@AHAScience
#FOAMcc
#FOAMecmo
📎
🫁 Management of severe
#ARDS
and refractory hypoxemia, narrative review exploring physiology & evidence-based management with focus on mechanical ventilation, adjunctive therapies, VV
#ECMO
🔓
🫁 MV: low tidal volume, ventilator asynchrony, PEEP & its
Before giving fluids, consider:
🔹is CO too low?
🔹should I give fluids?
🔹obvious fluid losses?
Fluid overload is harmful, negatively impacting on prognosis; moreover, effects of fluid infusions are not constant ➡️ assess responsiveness/unresponsiveness!
@PrXaMonnet
#IFAD2020
Left ventricular hemodynamics on VA
#ECMO
?? Physiology insights from catheterization & 3D echo
🫀 high flow VA
#ECLS
decompresses LV by significantly ⬇️ LV preload with minimal ⬆️ in afterload
🫀 this ⬇️ LVEDP, LVEDV, LV stroke work, LV PVA
#FOAMcc
🔓
Oxygenation on VA
#ECMO
, review aimed to highlight physiology, summarize current data reporting association with outcomes & outline an approach to titrate O2
@CritCareMed
📎
🫁complex determinants of systemic oxygenation: key circuit & patient factors
Fluids in sepsis?
💧adaptative to retain H2O/Na+ & ⬆️ lactate
💧few pts have lost/loose fluids
💧most fluids in
#ICU
drugs/nutrition
💧first 30 ml/kg standard care, probably OK in most, then bolus if marked hypoperfusion, stop if no improvement/⬇️ oxygenation
@AndersPerner
@ESICM
Still a place for old monitoring tools in the
#ICU
?? 1/2
📌 what is the problem with CVP? CVP does not tell us about fluid responsiveness, but we may still use for something else... about preload/right heart, so we should measure it!!
@PrXaMonnet
#IFAD2020
@Fluid_Academy
#FOAMcc
🫀🫁Weaning from of V‑AV
#ECMO
?? How to assess readiness for decannulation of both VV & VA components? Here, novel rapid approach using off-sweep + controlled backflow test, to allow for prompt/complete removal of
#ECLS
, which could be appropriate for highly selected patients
About significance of EtCO2 & how it relates to PaCO2, notes based on
@gattinon
talk at
@Smart_Meeting_M
2018... back to physiology here! Waiting for
#SMARTmi2019
full talk open access at
#FOAMcc
#FOAMed
follow the hashtag and see you next May in Milan!
🫁 🫀 Right ventricular injury in the setting of hypoxemia, hypercapnia, elevated RV afterload may impact on mortality in
#ARDS
on VV
#ECMO
: protecting RV to improve survival?? Cardio/(pulmonary) vascular physiological considerations on
@asaiojournal
🖇️
Ventilator settings in
#ICU
: prioritize permissive over aggressive ventilation!
1️⃣ use low Vt
2️⃣ do not use high PEEP by default
3️⃣ check delta P & MP
4️⃣ reduce RR
5️⃣ use O2 wisely
6️⃣ integrate
Schlultz M
Utrecht 🇳🇱🫀🫁
@ESICM
#LIVESforum
#FOAMcc
HFNC in acute resp failure: what guidelines say?? recommendations on
@yourICM
➡️hypoxemic failure STRONG
➡️peri-intubation NO
➡️post-extubation CONDITIONAL
➡️postop CONDITIONAL high risk/obese
@Bram_Rochwerg
#ESICMwebinar
Also read
Diaphragm main respiratory muscle: dysfunction frequent/impactful in critically ills
How to assess? diaphragm
#ultrasound
1 diaphragm excursion
2 diaphragmatic thickening/thickening fraction
#DUS
in
#COVID19
? non critical/critical pts NIV/IMV Boero E
#COVID19POCUS
#POCUS
#FOAMus
Difficult weaning from VA
#ECMO
??
🔠 ABCDE structured approach to optimize management identifying impacting factors
A arrhythmias
B blood pressures & loading conditions
C contractility/coronaries
D dysfunction of mechanical origin
E extracardiac factors
🖇
RABECA
#REBOA
as bridge to
#ECMO
in cardiac arrest
🧠 to increase brain prefusion
🫀 to increase coronary prefusion
💉 to achieve higher adrenaline blood concentration with lower dosage
🩸to provide accurate BP monitoring during CPR (if arterial line available)
🩸to stimulate
Surviving Sepsis Campaign guidelines on
#COVID19
critically ills management in one visual abstract
IPC
hemodynamics
Non-Invasive/Invasive ventilation
therapy
check post on
@ESICM
blog for high resolution pics/full text link
#coronavirus
#SARSCoV2
#FOAMcc
Great graphic summary of Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill
Adults with Coronavirus Disease 2019 (COVID-19)
All in one by
@FOAMecmo
free read at
New ARDS definition🫁
What's new👇
1⃣HFNO ≥30 L/m
2⃣SpO2/FiO2 ≤315 & SpO2 ≤97
3⃣Ultrasound diagnosis of bilateral opacities
4⃣Consideration for resource-limited settings
But it's hard to know the consensus process from one-page abstract🤔
🔗
#FOAMcc
How to manage differential gas
#ECMO
??
🫀 mechanism of dual circulation
🫁 impact of dual circulation on gas exchange in different regions of the body
🟥 lack of competitive flow, no dual circulation
🟦🟥 dual circulation with impaired native gas exchange
🟥🟦 dual circulation
What an honour! My drawings showing recirculation on VV
#ECMO
featured on cover page of new issue of
@asaiojournal
!! This graphic is among the illustrations included in
@ELSOOrg
guidelines for
#ECLS
circuit in adults & pediatric pts, free open access at
🖇️
ECPR for refractory
#OHCA
, lessons from 3 RCTs
🖇️
🫀 ARREST demonstrated efficacy of
#ECLS
for
#OHCA
in highly controlled & dedicated environment
🇨🇿 Prague OHCA showed that in similar environment, outcomes of cCPR may exceed presumed estimations by advanced
Cannulation configuration & limb ischemia-related complications on peripheral VA
#ECMO
in adults,
@ELSOOrg
Registry analysis on
@CritCareMed
➡️ bilateral cannulation should be preferred approach if femoral cannulation
🖇️
📊 > 19K patients, about 12k
#POCUS
to assess volume status/manage fluids? Volume is NOT preload, fluid responsiveness does NOT mean give fluids: assess fluids tolerance!
🫀 right: IVC/RV size, portal/renal flows
🫀 left: MV inflow pattern, LA size, IAS, B lines
@iceman_ex
#LIVES2022
How to assess diaphragm with
#ultrasound
??
➡️ visualize diaphragm, hyperechoic line (left: use splenic window)
➡️ M-mode, 2/3 regular breaths
➡️ measure excursion; shallow breaths > 1 cm m/> 0.9 f
➡️ measuring shortening fraction feasible, not so easy
B Cholley
#LIVES2022
#POCUS
Do you think you know anything about edema? to fully understand edema formation take a look at this infograph based on Pietro Caironi talk at
#IFAD2018
meeting
@Fluid_Academy
#FOAMcc
#FOAMed
VA
#ECMO
& LV unloading: what's the evidence?? Noninvasive approaches should be immediately considered for all pts + aggressive catheter/device-based modalities should be considered early after
#ECLS
initiation in a pt-tailored way.
#FOAMcc
#FOAMecmo
📎
🫁 Hemodynamic impact of proning? Let’s protect lung & its circulation to improve prognosis! RV to be evaluated in supine position before/after turning prone ARDS pts if overload? Could RV failure be itself be an indication for PP, whatever blood gases?
🖇️
Everything you need to know about fluid therapy:
📌fluids are not innocent
📌fluids are not just bag of water
📌fluids should be treated as drugs
📌fluids status matter: hypovolemia is bad, overload is worst!!
Always consider 7 D's ➡️ fluids stewardship!
@Manu_Malbrain
#IFAD2020
#RESUS21
new
@ERC_resus
guidelines
🫀ACLS priority? high quality compressions/minimal stops early defibrillation, treating reversible causes
🫀consider rescue
#ECPR
(selected pts) if ALS fails or to facilitate procedures
PS look at special circumstances CA
🩸 Anticoagulation in
#ICU
: search for safer anticoagulants continues! Bleeding & thrombosis main cause of morbidity & mortality on short-term percutaneous mechanical circulatory support as
#ECMO
,
#IABP
,
#Impella
, due to interplay of factors influencing haemostatic balance,
🩸Bleeding & thrombotic complications main cause of morbidity/mortality in critically ill pts receiving short-term percutaneous
#MCS
. The holy grail of anticoagulation in
#ICU
? Prevent thrombosis without affecting hemostasis, increasing risk.
#FOAMcc
🖇️
In
#COVID19
you may have severe hypoxemia with low recruitability; as consolidation increases with increased compliance/recruitability, treatment of same patient with same pathology & same degree of hypoxemia need to be adjusted (tailored) accordingly
@Luigi_ICM
@ESICM
#LIVES2020
Gastrointestinal failure & injury in
#ICU
?? We do not have proper definition of enteral feeding intolerance: consensus process needed, potentially leading to proper therapy. But how to define enteral function & GI dysfunction? Concomitant symptoms important!
🍽️ 1 symptom in pt
Theoretical distribution of intravenous fluids on infusion?
consider
🔹1 lt "NS"/balanced crystalloids? ➡️ 820 ml go to interstitial/lymphatic space
🔹1 lt G5%? ➡️ 600ml go to IC space
🔹hypotonic NaCl/G4% ➡️ 480ml IC
check
@bmj_latest
Nijsten M
#IFAD2020
How to write a meaningful paper (& get it published)? Prof M Slaughter
@asaiojournal
EiC
#ELSO2023
The 3️⃣ Cs
🎯 Clarity of the message
🎯 Cohesion
🎯 Conciseness
Common reasons for rejection
➡️ general: topic not of sufficient interest to readership, manuscript does not conform
10 tips to manage severe acute pancreatitis in
#ICU
#FOAMcc
on
@yourICM
@JABERSamir3
🖇️
1️⃣ Identify patients at ⬆️ risk
2️⃣ admit if organ failure
3️⃣ identify etiology
4️⃣ early abdominal CT to exclude differential diagnoses
5️⃣ monitor IAP (bladder P)
🏥 Prevalence of acute pancreatitis continuously ⬆️ over past decades. More than 10% of patients develop severe course requiring
#ICU
admission.
Here 🔟 tips to give a quick guidance on how to manage critically ill patients with SAP.
#FOAMcc
on
@yourICM
🖇️
MV setting guided by waveforms mandatory skill in ICU; as asynchronies are frequent associated with inappropriate treatments/poor outcomes... do not wait them to occur!! Mojoli F at
@Smart_Meeting_M
2018 waiting for
#SMARTmi2019
full talk
#FOAMcc
#FOAMed
One of major advancements in ARDS? understanding
#ARDS
strictly related to concept of baby lung: MV injurious in ARDS due to ⬇️ lung size inflated by Vt
Dynamic strain (impacting on VILI/outcome)? Vt/FRC
Compliance most close FRC estimate (NO PBW)
@DomGrieco
@ESICM
#ESICMwebinar
Drug PK on
#ECMO
: how predict & prevent/limit changes optimizing therapeutic targets & minimizing toxicities/failures infographic based on my talk at EuroELSO2019; bit self-referential, but enjoy waiting for
#ELSO2019
& register
#FOAMcc
#FOAMed
#FOAMecmo
⏱️
#ARDS
? First 24 h = “golden” period which should be time stamped:
1️⃣ 🔍 first 3h of non-invasive/invasive respiratory support: rule in ARDS diagnosis
2️⃣ ⚖️ first 12h: decide to continue NIV or institute IMV
3️⃣ 🫁 first 6h: implement low Vt strategies & optimization based on
⏱️
#ARDS
: critical role of timing & order in standardized management, so that interventions are time-sensitive/sequential to ensure consistent, evidence-based treatments, maintaining open questions & opportunity for timely/finer individualization.
#FOAMcc
🔓