Excited to share our latest publication on #HDAC inhibitor-based multineurotarget drugs as a potential treatment option for Alzheimer´s disease, now online in ACS Pharmacology & TS! 🎉 Huge congrats to our amazing team and collaborators!

New #PROTAC preprint: In this work, we utilized a non-selective ethyl hydrazide warhead for the selective HDAC6 degradation. Congratulations to co-first authors Daniel @danicious & Irina as well as Felix @fellerflix !

@IzidorSosic @ACSBioMed @fellerflix Thank you, Izidor. JESS in Action 😉

The application period for the second cohort of our RTG 2873 @grk2873 is open! We are now recruiting 12 PhD students. For more information see our homepage: My own project will focus on the development of HDAC #PROTACs. Please RT!

Let´s continue our E3 ligase hopping party! Second stop: DCAF11. The switch from a CRBN to a DCAF11 recruiter converts a selective HDAC6 PROTAC into a pan-degrader. Congrats to first author Felix @fellerflix and my coworkers Heiko, Martina, Irina & Maria!

@DirkTrauner Nice. Does Schatzi like it?

Check out our latest preprint on #PHOTACs: Light-activatable PHOTACs enable the optical control of targeted HDAC6 degradation. Huge congrats to Silas @WurnigSilas , Maria, Shiyang @Vincent_SYZ , and our amazing collaborators in the Nowak lab @RPNowak !

@danicious More to come😉

Happy to announce that our paper on the multicomponent synthesis of quisinostat analogs as anticancer and antiplasmodial #HDAC inhibitors has been published. Congratulations to first author Daniel @danicious and all co-workers and collaborators involved!

RT @ElgendyBE: I stood in line for 3 hours to vote today! 🇺🇸 It’s a small price to pay for democracy and our right to have a voice. Voting…

Very interesting paper written by two young superstars!

@DRLmolpharm @fellerflix Thank you, David!

@IzidorSosic @fellerflix Thank you Izidor! My group did learn a lot from this project. Starting from the Jess capillary immunoblotting (we talked about it😀) to several new assays that we never performed in-house.

RT @ChemEurope: #ChemMedChem #OnTheCover A NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6, CXCR1…

RT @OdedRechavi: PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multi…

Happy that my postdoc Linda could contribute the dual HDAC/BET inhibitor to this very interesting study from the Kassack lab on triple combinations against bladder cancer @HHU_de

Hydrazides Part II: Happy to share our latest preprint, which introduces the ethylhydrazide DS-103. DS-103 completely reverses cisplatin resistance. This work also includes the first alkylhydrazide:HDAC co-crystal structure @ChristiansonLab. @danicious

Hydrazides Part I: Excited that our latest paper on alkylhydrazides capable of reversing cisplatin resistance is now online in J Med Chem. Congratulations to first authors Fabian, Lukas, and Linda and the whole team!