RT @MichaelOkun: Is clinically probable REM sleep behavioral disorder (RBD) an early predictor of a malignant non-motor Parkinson's disease…

RT @AMahajanMD: Can you predict the severity of different non-motor features with just clinically probable RBD? Another impressive article…

@RiadRmdn A lot of the science people are moving to Bluesky 👀 Follow @

I know what you are thinking: 💲leep 💲tudies are super expensive and labor intensive And they are. But these phenotypes are based off a standardized questionnaire📋 This is awesome for implementation in clinical studies! 🔥

DBS at the GPi and STN works well for dystonia, with most output reaching the Vo nucleus. Why not target it? Hashimoto et al. shared 4 cases of focal hand dystonia treated with thalamic DBS, showing the most benefit near the Vo—same as dystonic tremor!

@ranivasireddy22 My words are honored to be worthy of your gaze! Thanks Rani 😊

RT @PracticalNeuro: Dr Martinez-Nunez and Dr Mahajan (@AMahajanMD) review the current approach and future directions for the treatment of #…

Patients with AD get a bunch of misfolded proteins in their cortex and sometimes seizures In this @GreenJournal paper, Lam and friends describe 8 patients who had more Tau, amyloid, and atrophy in the epileptogenic hemisphere. Related, or an advanced stage of the same process?

Landmark paper on tau skin biopsies 🚨🚨🚨 Sensitivity of 87% and specificity of 95% Some of the MSA cases test positive, and most CBD test negative. The pathological findings do not always correlate with the disease you are treating! @JAMANeuro

What causes focal hand or cervical dystonia and ataxia? These neat cases from @MDCP_Journal describes the phenotype of 7 patients with SYNE1 mutation. The particular feature of focal dystonia during a broad-based gait is a great point to suspect SYNE1!

Add just ONE MORE gene to your late-onset craniofacial dystonia list. Mahale presents a case of ADAR1 mutation (like Aicardi-Goutiers sx). We have to keep an eye out for these incompletely penetrant variants of well-known phenotypes! @ParkinsonismD

Epidural magnetic stimulation is coming! TMS is awesome, right? Why not have an implanted epidural coil? Better spatial resolution, lower energy delivery needed. We love this demonstration by Lee and his rats on the proof of concept for this.

Pastotter et friends demonstrated increased SMA synch in the beta band after a movement in patients with FND. They link this to a mismatch of action and perception. Amazing work adding a physiological link to this beautiful concept. @braincomms

@AMahajanMD @UFMDFellowship Thank you for coming! 🔥🔥🔥✨✨

Amazing talk by @AMahajanMD about the use in AI in @movedisorder . As he would say: “Let clinicians be clinicians” or the Cyndi Lauper version “clinicians just wanna have fun”.

RT @UFMDFellowship: The action has begun at the @movedisorder conference in Philadelphia! The Swamp represented 🐊🐊🐊