Endocrine Pathology
@EndoPath
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Official Twitter Page of the Endocrine Pathology Society and its companion journal, Endocrine Pathology #EndoPath #USCAP #EndoPathSociety #EndocrinePathology
Joined March 2017
New study reveals that separately fixed thyroid tumor samples, including lymph node metastases, preserve DNA and RNA quality better than traditional methods - opening doors for more accurate genomic analysis and targeted therapies in thyroid cancer!
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Rare and fascinating: Pituitary tumors expressing both TPIT and SF1 are extremely uncommon but can cause Cushing disease or remain clinically silent. Dive into the latest research on these multilineage PitNETs and their unique molecular profiles!
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Our journal features two ground-breaking papers in which a molecular link between well-differentiated NETs and high-grade NECs is proposed, arguing that a subset of well-differentiated cases may be at risk of progression!
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We struggle with anti-PD-1 therapy in anaplastic thyroid carcinoma. Most tumors are PD-L1+, but lack PD-1+ T-cells. Barriers like suppressive immune cells is a problem. New hope: alternate targets like TIM3 & CTLA4 for combo therapies! 🙏🏼 A must-read!
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Glucagonomas: rare pancreatic tumors causing a striking skin rash and packing molecular surprises. These large tumors were mostly grade 1, displayed MEN1, ATRX/DAXX mutations, and sometimes high tumor mutational burden - a potential treatment target.
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Study from 🇸🇪 find TERTp mutations in 12% of minimally invasive FTCs. More common in older patients, these (often subclonal) events didn’t impact outcome (yet) - but size alone may not tell the full story! @DrJuhlin @VinCondello
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Oncocytic thyroid tumors are packed with mitochondria, but what do we know about their proteome? Herein, authors link dysregulated mitochondrial proteins - like overexpressed IDH2 - to tumor aggressiveness. And we thought the TCA cycle was a pheo thing!
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Study from 🇨🇳 reporting 22 cases of Epstein-Barr virus (EBV)-positive neuroendocrine carcinoma, an entity mostly associated to the nasopharynx. Key morphology, IHC markers, and response to chemoradiotherapy - all discussed here! 🦠
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High-grade non-anaplastic thyroid carcinomas (PDTC and DHGTC) are associated with poor outcomes and can occur in pediatric and adolescent populations too. But is your knowledge as highly graded as these tumors? 🔬🧬 @MayoClinicPath
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Biomarkers for anaplastic thyroid cancer are urgently needed, as these tumors often lose thyroid lineage markers. One promising option? SATB2! Here's why it could make a difference.
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An expert panel review highlights key gaps in current biomarker testing and presents consensus algorithms for medullary, follicular, and anaplastic thyroid cancers, aiming to improve care with a multidisciplinary approach. Learn more today!
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Is mutation-specific anti-RAS immunocytochemistry in medullary thyroid carcinoma a game-changer? Could it help us make more informed decisions? Find out for yourself! @PathDocBoston @CaDxPath
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Are NETs and NECs of gastroenteropancreatic origin distinct entities, or is there a link between them? Recent studies in morphology and genetics might hold the key to a potential bridging entity. Check out this insightful editorial, now live in @EndoPath!
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RT @RDWhaleyMD: Read our latest #research on #thyroidcancer, in @EndoPath Clinicopathologic and Molecular Analysis of 15 Pediatric and Yo…
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Submit your research to Endocrine Pathology for more than just our impact factor. With an experienced, friendly editorial team, a broad readership, and a lightning-fast median handling time of just 3 days from submission to decision, you'll experience quality like never before!
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