The next chapter of the PhD work is published in
@NatureComms
. Base editing can rescue the function and survival of cone photoreceptors in an inherited retinal degeneration model. This story was not possible without
@susiesuh529
@SethBlackshaw
@davidrliu
Last year, we did not match.
This year, my wife matched in dermatology at UC Irvine, and I matched in ophthalmology at UCLA. During the reapplication process, we received the greatest gift from God, our son, who has brought us immense joy. Thank you everyone!
#Match2024
I’m so glad to share my co-first author paper from the Palczewski Lab published in Nature Biomedical Engineering (
@natBME
) today. This was one of my PhD thesis projects. Thanks to my lab member
@susiesuh529
and collaborator
@davidrliu
, who made this possible.
#baseeditor
#CRISPR
Happy to share our article published in
#PNAS
. We discuss preclinical/clinical genome editing approaches for retinal diseases and important considerations for clinical translation. Great work by
@susiesuh529
, Aditya Raguram,
@davidrliu
, and Dr. Palczewski
We developed an inducible Cre mouse that has a recombination efficiency of >99% and absolute RPE specificity. It will be useful in studies of retinal physiology, disease, and therapeutics. Many thanks to Steven Fliesler,
@SethBlackshaw
, and Neal Peachey.
#neuroscience
#retina
One step closer to the translation of gene editing to the clinical setting. The engineered VLP offers major advantages of viral & non-viral delivery. A great pleasure to contribute to this work.
@UciCtvr
@UCIrvineSOM
Today we report in
@CellCellPress
an engineered virus-like particle (eVLP) platform that mediates efficient in vivo delivery of therapeutic proteins, including base editors and Cas9 nuclease, resulting in therapeutic editing in multiple mouse organs. 1/14
Congrats
@ElliotHChoi
on his first author paper in Neural Regeneration Research. We examine human and animal studies reporting on epidural electrical stimulation for SCI. Lot of work to be done, but a very exciting field.
Today we share the biochemical mechanism that maintains the light sensitivity of the retina under constant bright light and the animal studies using a conditional gene rescue system. Congrats, Aleksander Tworak and Palczewski Lab
@UciCtvr
#NEIfunded
work:
Base editing may provide long-lasting retinal protection in Leber congenital amaurosis (mouse model).
Kris Palczewski: "there is a chance that in 10 years, all inherited retinal diseases could be treatable".
@UCIrvine
@ElliotHChoi
@susiesuh529
@davidrliu
1/2
Happy to share our study on the physiological role of CRALBP in the retinal pigment epithelium and Müller glia
@CellReports
. The functional role of these two cellular pools is debated. Congratulations to Marco Bassetto and Philip Kiser at
@UciCtvr
Today we share a review of genome editing in the treatment of ocular diseases. The review covers applications of genome editing to ocular diseases from the anterior to the posterior segment and the current limitations in clinical translation.
Thanks for featuring our work. Has been a privilege to contribute to
#ophthalmology
and vision science as an aspiring physician-scientist. Will follow my passion and continue our work to bring a new therapy to patients with blinding retinal disease.
#GeneTherapy
#CRISPR
#retina
Congratulations to John Hong
@johndhong94
@UCIMedSchool
@UciCtvr
. The paper highlights the photocycle of 'cone opsins' relative to 'rhodopsin' and the crucial role of RGR in chromophore recycling in daylight. John managed to carry the entire project!
Thanks for highlighting our work published in Nature Biomedical Engineering (
@natBME
)! We could correct a mutation implicated in Leber Congenital Amaurosis and restore the visual function in a mouse model. Proud of Susie
@susiesuh529
@CTVR15
@CWRUSOM
.
#Baseeditor
#genetherapy
Restoring vision loss with base editing - a new research highlight published today on a paper showing that base editing of the gene coding for RPE65 can be used to restore visual function in a mouse model of Leber congenital amaurosis
The UCI Eye Mobile offers free vision screenings and comprehensive eye exams to underserved children. Today we share a study on children who required referral to an ophthalmologist from the Eye Mobile and the impact of COVID-19.
@UCIrvineHealth
@UCIrvine
Another example showing that the base editor can be applied to treat a genetic disease (in mice), Progeria. Beautiful in vivo work!
#CRISPR
#BaseEditor
#Genetherapy
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11
Our first episode with
@Nolanbrown95
is now live. Nolan is an author of an Amazon-selling book, has published more than almost any medical student to date, and is an all-around amazing guy to listen to!
#meded
#neurosurgery
#medschool
#research
Lipids and lipid-soluble molecules are essential components of the cells and tissues that form the eye. Join us next week for a special
@jlipidres
webinar about topics related to lipids and
#lipid
metabolism in the eye. Register here: .
Congratulations to Yasmeen and Dr. Kiser
@UciCtvr
@UCIMedSchool
@UCIrvine
on the publication of their study in
@nchembio
. Yasmeen solved the structure of NinaB, a protein found in insects that functions similarly to the RPE65 protein found in humans.
Have you heard of cervical angina? It mimics cardiac angina but is the result of cervical herniation and can require surgery. We wonder, how many patients who pass screening for unstable angina/MI without diagnosis have this etiology? Thank you
@TheJNS
From microbial immunity to genome editing:
Emmanuelle Charpentier and Jennifer Doudna are the winners of the 2020 Nobel Prize in Chemistry for their work developing new techniques of genome editing.
#CRISPR
#geneediting
#genomeediting
#NobelPrize
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
Check out the paper from Dr
@SeungminPark_
published in Nature
@natBME
. I'm grateful for the opportunity to contribute to this project.
#DeepLearning
#Stanford
'Smart toilet' can detect multiple signs of illness. I'm grateful for the opportunity to have helped.
The role of opsin 5 expressed in the hypothalamic preoptic area
#neuroscience
#brain
#GPCR
@nature
Light-activated neurons deep in the brain control body heat
New Research: Modulation of Neural Activity for Myelination in the Central Nervous System: Electrical stimulation has been playing a significant role in revealing various functions and mechanisms of the nervous system. It is no different…
#Neuroscience
How can we continuously detect the light?
Check out the role of the retinal G-protein-coupled receptor in the eye. One of my thesis topics is summarized in this review.
#VitaminA
#GPCR
#Retina
#neuroscience