Elliot H. Choi, MD PhD @ElliotHChoi profile

Elliot H. Choi, MD PhD

@ElliotHChoi

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Ophthalmology PGY-1 at UCLA @UCLASteinEye 👁 | MD/PhD at Case Western @CWRUSOM 🩺🔬 | BA/MS at Johns Hopkins @JohnsHopkins 🧠 | Gene Therapy

Joined May 2020

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

The next chapter of the PhD work is published in @NatureComms . Base editing can rescue the function and survival of cone photoreceptors in an inherited retinal degeneration model. This story was not possible without @susiesuh529 @SethBlackshaw @davidrliu

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Elliot H. Choi, MD PhD

@ElliotHChoi

5 months

Last year, we did not match. This year, my wife matched in dermatology at UC Irvine, and I matched in ophthalmology at UCLA. During the reapplication process, we received the greatest gift from God, our son, who has brought us immense joy. Thank you everyone! #Match2024

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

Humbled and thrilled to match to UCLA @UCLASteinEye for ophthalmology. Sincerely appreciate the mentorship and support from Drs. Palczewski and Kiser @UciCtvr , CWRU MSTP @cwrumstp , Susie Suh @susiesuh529 , David Liu @davidrliu , and Seth Blackshaw @SethBlackshaw . #Ophthalmology

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Elliot H. Choi, MD PhD

@ElliotHChoi

5 months

I am happy to help those who will reapply or go through the couples match. Never give up and believe in yourself. #Ophthalmology #Dermatology

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

I’m so glad to share my co-first author paper from the Palczewski Lab published in Nature Biomedical Engineering ( @natBME ) today. This was one of my PhD thesis projects. Thanks to my lab member @susiesuh529 and collaborator @davidrliu , who made this possible. #baseeditor #CRISPR

Nature Biomedical Engineering

@natBME

4 years

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

Happy to share our article published in #PNAS . We discuss preclinical/clinical genome editing approaches for retinal diseases and important considerations for clinical translation. Great work by @susiesuh529 , Aditya Raguram, @davidrliu , and Dr. Palczewski

Precision genome editing in the eye | PNAS

CRISPR-Cas-based genome editing technologies could, in principle, be used to treat a wide variety of inherited diseases, including genetic disorder...

www.pnas.org

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Elliot H. Choi, MD PhD

@ElliotHChoi

3 years

We developed an inducible Cre mouse that has a recombination efficiency of >99% and absolute RPE specificity. It will be useful in studies of retinal physiology, disease, and therapeutics. Many thanks to Steven Fliesler, @SethBlackshaw , and Neal Peachey. #neuroscience #retina

JCI insight

@JCI_insight

3 years

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease: @UCIrvine #Genetics #Ophthalmology

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Elliot H. Choi, MD PhD

@ElliotHChoi

1 year

Congrats CWRU MSTP, Jennings Luu @cwrumstp & Palclzewski Lab @UciCtvr ! We report a new therapeutic class, stress resilience-enhancing drugs. They are protective in #retinitispigmentosa , #diabeticretinopathy , and acute retinal degeneration models.

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via...

Chronic, progressive retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa, arise from g...

www.pnas.org

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Elliot H. Choi, MD PhD

@ElliotHChoi

3 years

One step closer to the translation of gene editing to the clinical setting. The engineered VLP offers major advantages of viral & non-viral delivery. A great pleasure to contribute to this work. @UciCtvr @UCIrvineSOM

David R. Liu

@davidrliu

3 years

Today we report in @CellCellPress an engineered virus-like particle (eVLP) platform that mediates efficient in vivo delivery of therapeutic proteins, including base editors and Cas9 nuclease, resulting in therapeutic editing in multiple mouse organs. 1/14

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Elliot H. Choi, MD PhD

@ElliotHChoi

3 years

Happy to share a review article on epidural electrical stimulation for spinal cord injury patients. Thanks for your vital work @gattas_sandra @Nolanbrown95 and mentorship from Dr. Michael Y. Oh at @UCINeurosurgery . #neuroscience #neurosurgery #spine

Nolan Brown

@Nolanbrown95

3 years

Congrats @ElliotHChoi on his first author paper in Neural Regeneration Research. We examine human and animal studies reporting on epidural electrical stimulation for SCI. Lot of work to be done, but a very exciting field.

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Elliot H. Choi, MD PhD

@ElliotHChoi

1 year

Today we share the biochemical mechanism that maintains the light sensitivity of the retina under constant bright light and the animal studies using a conditional gene rescue system. Congrats, Aleksander Tworak and Palczewski Lab @UciCtvr

Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia

Tworak et al. report that the RGR-mediated photic visual cycle found in the retinal pigment epithelium and in specialized Müller glia in the mammalian retina constitutes a fast visual-pigment...

www.cell.com

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

Feel honored and humbled that our recent work has been featured by @NEIDirector at @NatEyeInstitute . Hope further studies will provide a new paradigm for treating progressive vision loss in children. #GeneTherapy #CRISPR #retinaldisease #vision

Michael F. Chiang, MD

@NEIDirector

2 years

#NEIfunded work: Base editing may provide long-lasting retinal protection in Leber congenital amaurosis (mouse model). Kris Palczewski: "there is a chance that in 10 years, all inherited retinal diseases could be treatable". @UCIrvine @ElliotHChoi @susiesuh529 @davidrliu 1/2

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 months

Happy to share our study on the physiological role of CRALBP in the retinal pigment epithelium and Müller glia @CellReports . The functional role of these two cellular pools is debated. Congratulations to Marco Bassetto and Philip Kiser at @UciCtvr

Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors

Bassetto et al. report that CRALBP within the retinal pigment epithelium (RPE) plays a primary role in the regeneration of rod and cone visual pigments. Müller glia CRALBP supports cone function...

www.cell.com

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Elliot H. Choi, MD PhD

@ElliotHChoi

1 year

Today we share a review of genome editing in the treatment of ocular diseases. The review covers applications of genome editing to ocular diseases from the anterior to the posterior segment and the current limitations in clinical translation.

Genome editing in the treatment of ocular diseases

Experimental & Molecular Medicine - Using gene editing tools to correct gene mutations and manipulate specific tissues in the eye could revolutionize treatment for multiple eye diseases....

www.nature.com

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

Thanks for featuring our work. Has been a privilege to contribute to #ophthalmology and vision science as an aspiring physician-scientist. Will follow my passion and continue our work to bring a new therapy to patients with blinding retinal disease. #GeneTherapy #CRISPR #retina

Yair Einhorn

@yaireinhorn

2 years

1/The best #Scientific #article that I’ve recently read is “Precision #GeneEditing in the #eye ” - written by @susiesuh529 & @ElliotHChoi in Kris Palczewski #lab at @UCIrvine & @davidrliu . It describes the huge #progress made in #CRISPR , #GeneTherapy & #IRDs 👁️. Here is a 🧵👇

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Elliot H. Choi, MD PhD

@ElliotHChoi

6 months

Congratulations to John Hong @johndhong94 @UCIMedSchool @UciCtvr . The paper highlights the photocycle of 'cone opsins' relative to 'rhodopsin' and the crucial role of RGR in chromophore recycling in daylight. John managed to carry the entire project!

Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins

Rhodopsin (Rho) and cone opsins are essential for detection of light. They respond via photoisomerization, converting their Schiff-base-adducted 11-cis-retinylidene chromophores to the all-trans...

www.jbc.org

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

Thanks for highlighting our work published in Nature Biomedical Engineering ( @natBME )! We could correct a mutation implicated in Leber Congenital Amaurosis and restore the visual function in a mouse model. Proud of Susie @susiesuh529 @CTVR15 @CWRUSOM . #Baseeditor #genetherapy

CRISPR Medicine

@CrisprMedicine

4 years

In vivo #baseediting corrects #Lebercongenitalamaurosis in animal model & points to new treatment modality for this disease. See our interview with co-first author @susiesuh529 from Krzysztof Palczewski's lab at #ucirvine . -> #crisprmedicinenews #crispr

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

#CRISPR #baseeditor #GeneTherapy #neuroscience Thanks for highlighting our work.

Nature Reviews Drug Discovery

@NatRevDrugDisc

4 years

Restoring vision loss with base editing - a new research highlight published today on a paper showing that base editing of the gene coding for RPE65 can be used to restore visual function in a mouse model of Leber congenital amaurosis

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 months

The UCI Eye Mobile offers free vision screenings and comprehensive eye exams to underserved children. Today we share a study on children who required referral to an ophthalmologist from the Eye Mobile and the impact of COVID-19. @UCIrvineHealth @UCIrvine

Exploring Pediatric Vision Care: Insights from Five Years of Referral Cases in the UCI Eye Mobile...

Purpose: To analyze referral rates, patient demographics, referral indications, and the impact of socioeconomic factors on ocular health from the University of California Irvine (UCI) Eye Mobile for...

journals.healio.com

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

Another example showing that the base editor can be applied to treat a genetic disease (in mice), Progeria. Beautiful in vivo work! #CRISPR #BaseEditor #Genetherapy

David R. Liu

@davidrliu

4 years

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

Congrats Nolan @Nolanbrown95 . Proud of your work and achievements. You will be an excellent neurosurgery resident.

Medical School Research Podcast

@MedResearchPod

2 years

Our first episode with @Nolanbrown95 is now live. Nolan is an author of an Amazon-selling book, has published more than almost any medical student to date, and is an all-around amazing guy to listen to! #meded #neurosurgery #medschool #research

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

Feel honored to give a talk with two professors, Dr. Sparrow at Columbia and Dr. Fu at Harvard. #neuroscience #retina #GPCR

ASBMB

@ASBMB

4 years

Lipids and lipid-soluble molecules are essential components of the cells and tissues that form the eye. Join us next week for a special @jlipidres webinar about topics related to lipids and #lipid metabolism in the eye. Register here: .

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Elliot H. Choi, MD PhD

@ElliotHChoi

6 months

Congratulations to Yasmeen and Dr. Kiser @UciCtvr @UCIMedSchool @UCIrvine on the publication of their study in @nchembio . Yasmeen solved the structure of NinaB, a protein found in insects that functions similarly to the RPE65 protein found in humans.

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

@NatureComms @susiesuh529 @SethBlackshaw @davidrliu Thanks to the co-first author, Susie Suh @susiesuh529 , and my mentors, Drs. Palczewski and Kiser. Many other people contributed to this story: @FoikAndrzej , @Dr_HLeinonen , @Gregory_Newby , @danielxingao , @samagyabanskota , Thanh Hoang, Aditya Raguram, @CWRUSOM @cwrumstp @UciCtvr

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

The authors report the first comprehensive systematic review of the range of spine pathologies associated with cervical angina ( #pseudoangina ). Great work, @Nolanbrown95 @ShaneTheShah @brianvlien @ransomsethc @AliRTafreshi @ryanchaseransom @RonSahyouni

Nolan Brown

@Nolanbrown95

4 years

Have you heard of cervical angina? It mimics cardiac angina but is the result of cervical herniation and can require surgery. We wonder, how many patients who pass screening for unstable angina/MI without diagnosis have this etiology? Thank you @TheJNS

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Elliot H. Choi, MD PhD

@ElliotHChoi

6 months

#Ophthalmology #retina #rhodopsin #coneopsin #Vision #OphthoTwitter #MedEd #MedTwitter #MSTP

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

@davidrliu @natBME Prof. Liu, appreciate your help and advice! They were extremely helpful.

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

@Nolanbrown95 @taylor_reardon1 Thank you, Nolan! I am so proud of you and all that you've accomplished.

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 months

#ophthalmology #eye #retina #vision #biochemistry #electrophysiology

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

@fvinberg @neurofim @BWJones @scrippsresearch @salkinstitute @SDEyeBank @LifesharingSD @NatEyeInstitute @RPB_org @DiabetesRsrch @MoranEyeCenter Congrats Frans, Fatima, and the team. Wonderful work!

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

This project has been divided into two parts. Please check out the previous study published in Nature Biomedical Engineering @natBME

Restoration of visual function in adult mice with an inherited retinal disease via adenine base...

Nature Biomedical Engineering - Subretinal viral delivery, in mice, of an adenine base editor and a single-guide RNA targeting a nonsense mutation in the Rpe65 gene restores near-normal levels of...

www.nature.com

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Elliot H. Choi, MD PhD

@ElliotHChoi

1 year

@sangkyun_cho @nih_nhlbi @Joseph_C_Wu @StanfordCVI @heilshornlab Congrats! What a huge accomplishment. Proud of you!

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

From microbial immunity to genome editing: Emmanuelle Charpentier and Jennifer Doudna are the winners of the 2020 Nobel Prize in Chemistry for their work developing new techniques of genome editing. #CRISPR #geneediting #genomeediting #NobelPrize

The Nobel Prize

@NobelPrize

4 years

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

Check out the paper from Dr @SeungminPark_ published in Nature @natBME . I'm grateful for the opportunity to contribute to this project. #DeepLearning #Stanford 'Smart toilet' can detect multiple signs of illness. I'm grateful for the opportunity to have helped.

Nature Biomedical Engineering

@natBME

4 years

A mountable toilet system for personalized health monitoring via the analysis of excreta

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

@DouniaElMaz @ScienceAdvances Beautiful work! Congratulations.

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

@RealWorldOphth @UCLASteinEye @UciCtvr @cwrumstp @susiesuh529 @davidrliu @SethBlackshaw @LisaNijmMDJD Thank you!

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Elliot H. Choi, MD PhD

@ElliotHChoi

6 months

#eye #retina #Vision #Ophthalmology #Biology #MedTwitter #Science

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

@lucieguojam @davidrliu @UCLASteinEye @UciCtvr @cwrumstp @susiesuh529 @SethBlackshaw Hi Lucie, I appreciate your kind words and advice while applying to the residency programs. It means a lot to me. Keep in touch!

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

@nihalsatyadev @UCLASteinEye @UciCtvr @cwrumstp @susiesuh529 @davidrliu @SethBlackshaw Thank you, Nihal! Hope things are going well with you.

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

The role of opsin 5 expressed in the hypothalamic preoptic area #neuroscience #brain #GPCR @nature Light-activated neurons deep in the brain control body heat

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

@NatHarooni @NatureComms @susiesuh529 @SethBlackshaw @davidrliu Appreciate your comment and time!

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

Neurons can induce myelination. TES, TMS, TFUS or DBS can be a potential method for the induction of myelination. #Neuroscience #Myelination #DBS

Frontiers - Neuroscience

@FrontNeurosci

5 years

New Research: Modulation of Neural Activity for Myelination in the Central Nervous System: Electrical stimulation has been playing a significant role in revealing various functions and mechanisms of the nervous system. It is no different… #Neuroscience

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

@dong_wonton @UCLASteinEye @UciCtvr @cwrumstp @susiesuh529 @davidrliu @SethBlackshaw Absolutely, I am grateful to be receiving training from amazing ophthalmologists and residents at Stein.

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Elliot H. Choi, MD PhD

@ElliotHChoi

4 years

How can we continuously detect the light? Check out the role of the retinal G-protein-coupled receptor in the eye. One of my thesis topics is summarized in this review. #VitaminA #GPCR #Retina #neuroscience

Journal of Lipid Research

@jlipidres

4 years

Paper in Press: " #Retinoids in the visual cycle: Role of the retinal G protein-coupled receptor" – #JLRReview #GPCR #VitaminA @cwru @UCIrvine

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

@SethBlackshaw @UCLASteinEye @UciCtvr @cwrumstp @susiesuh529 @davidrliu Thank you very much for your help during my PhD training. The UCLA EyeStar program provides three years of research time, so I will continue to work on vision research. I hope we can collaborate again in the future!

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Elliot H. Choi, MD PhD

@ElliotHChoi

7 months

@davidrliu @UCLASteinEye @UciCtvr @cwrumstp @susiesuh529 @SethBlackshaw Thank you very much for your help with the gene therapy projects. It has been a great pleasure working with your lab members!

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Elliot H. Choi, MD PhD

@ElliotHChoi

2 years

@yaireinhorn Check this list showing ongoing clinical trials for ocular diseases and their phases. Hope this will be helpful.