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A study led by Drs. Laura Siles & Esther Pomares at @imogrupomiranza has explored the rescue of the disease-associated phenotype in CRISPR-corrected hiPSCs as a therapeutic approach for inherited #RetinalDystrophies. 👁️ Learn more:

Drs. Yingnan Lei, Claudia Spits, and @VUBrussel co-authors identified a diminished differentiation capacity to retinal progenitor cells in #hESCs with complex karyotypes that had in common the loss of part of chromosome 18q. 🥼 Check out the full study:

In this study, @idibaps scientists explore the proteome trajectory of #iPSCs differentiation to hepatic stellate cells and identify a key transcription factor, RORA, governing the metabolic reprogramming of HSCs. 🔁 Learn more about RORA:

Leveraging genome editing and stem cell technology, @PKU1898 scientists generated venous malformations models that enable the development of additional therapeutics. Read the #OpenAccess study in @CellStemCell. 📚 👉

Using machine learning, scientists alongside Drs. @denizgoekbuget and @RobertBlelloch quantified 21 chromatin features predicting local DNA replication timing (RT) and RT changes during differentiation in #ESCs. @UCSF 💡 Give it a read in @CellReports |

Hot off the press in @NatureComms! 🤩 Using human #embryonic stem cell models of pseudohypoparathyroidism type-1B, @MassGeneralNews researchers show that the regulatory role of STX16-ICR on GNAS was not confined to the maternal allele. 👀 Get the full story:

🙋 Check out this opportunity with @amandajaynecarr! #iPSCS

A team from @SangamoTx demonstrate an #iPSC-based platform amenable to manufacturing CD4 T cells to complement iPSC-CD8 oncology products and functional iPSC-Tregs. Check out the study in @StemCellsJournl! 👇 📝

Developments in stem cell biology have paved the way for technology translation in medicine. 🧫 In this review, scientists explore recent advances in the generation of stem cell-derived hepatocyte-like cells and insulin-producing β-like cells. 📚

In this work, scientists demonstrate the efficient generation of #blastoids from iPSCs and somatic cell nuclear transfer #embryonic stem cells derived from aged monkeys, achieving an 80% formation efficiency. 🐒 📚 Find out more in @NatureComms |

Introducing the recently inaugurated Stem Cell Research Center, the first of its kind in the academic world in the United Arab Emirates. 🙌 The center aims to support cutting-edge research in stem cells and their therapies. 🗞️ | @UAEU_NEWS

A recent @Nature study investigated the hypothesis that epicardial engineered heart muscle allografts from #iPSC-derived cardiomyocytes remuscularize the chronically failing heart without limiting side effects in rhesus macaques. ❤️ Learn more:

The first mouse with two male parents has reached adulthood! 🐁 Scientists generated adult bi-paternal animals through #ESC complementation, haploid cell nuclear injection, and somatic cell nuclear transfer. @CellStemCell 🔗: 🗞️:

This study demonstrates that NLRP7 plays an essential role in the maintenance of genetic stability during early human #embryonic development by regulating alternative splicing of homologous recombination-related genes. 💡 Check it out in @CommsBio |

In this new @CellDiscovery study, researchers established a fusion system between androgenetic-haploid ESCs (haESCs) and parthenogenetic-haESC lines with parent-of-origin-specific-DMR edits to produce diploid #ESCs carrying DMR-deletion combinations. 🔗

Fudan University researchers propose a human ESC (#hESC) culture system that substitutes the key growth factors, bFGF and TGF-β in E8, with saponins from the soapbark tree. 🌲 Read their protocol here:

Start with the most difficult tasks instead of putting them off until the end of the day. This ensures you make progress on them, and can free up the rest of your day for more exciting work. Increase your productivity with these habits. @STEMCELLTech

Hot off the press in @PNASNews! 🔥 Scientists from the @TakebeLab uncover an intercellular mRNA transfer phenomenon that allows for the adaptation and reprogramming of human primed #pluripotent stem cells. 📝 Read the paper:

Calling all #hPSC researchers! Don't miss this opportunity with @ibetportugal. 🙌

Scientists from @KobeU_Global developed a new protocol for generating human #iPSC-derived Leydig-like cells (LLCs). LLCs were successfully engrafted subcutaneously into mice, resulting in increased serum testosterone levels. 📈 | @stemcellreports