Saurabh Shukla, PhD
@DrShuklaHere
Followers
798
Following
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666
Founding Applied Scientist at Stealth Start-up. I work on diffusion models, LLMs and building AI products. Alumni: @UW @UofIllinois @iitdelhi .
Seattle, WA झुँझुनू, भारत
Joined March 2019
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Today is
#Fibbonacci
day. Thread about travesty of scientific credit sharing. Fibonnacci series was invented by Pingala many hundreds of years before Fibonnacci. Fibonnacci himself states that he translated the series. He called it ‘Indian Series’. Read the thread.
Today, the World celebrates
#Fibonacci
day.
"Fibonacci sequence is nature's code. It is in everything from flowers to storm systems to the shape of galaxies"- they said, crediting Mr. Fibonacci for this "discovery"
Yet, they failed to acknowledge their very source. Thread (1)
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If you were born in India and are considering a Ph.D. in the USA, you should know this.
PhDs had a unique immigration advantage of getting an early green card in the EB1 category.
The EB1 green card category is 6 years backlogged now. That advantage is no longer there.
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I successfully defended my Ph.D. thesis today. Presenting, Dr. Shukla.
I thank all my mentors, family, and friends for the support. It feels freaking amazing.
Ma, its for you. 🙏
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Sharing our paper recently published in
@nanoscale_rsc
. I developed a DNA based force sensor to measure forces of walking proteins with picoNewton accuracy. My first attempt to explain my science with a video!!!!!!
(Link to the paper here: )
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If given a choice, where would you get hooded for your Ph.D.?
Me: Next to the custom fluorescent microscope where I spent most of my time during the Ph.D.
Thankful that I could do in person graduation after two years.
@PhysicsIllinois
@Illinois_Alma
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Shachi is joining
@UWChemE
this fall as an assistant professor. I am excited beyond limits. This achievement is the culmination of momentous will, grit, and perseverance despite so many challenges. Shachi’s story will inspire many as it has inspired me. 1/n
I am soo excited to share that I will be joining
@UWChemE
as an Assistant professor this fall! A dream come true! This wouldn't have been possible without the guidance of my mentors and the sacrifices of my family (1/n).
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“PhD is not a sprint, but a marathon”- True. But its not an endless marathon.
Don’t go on for 5 years without checkpoints.
Evaluate progress every 6 months. Double down on whats working. Iterate/pivot from things not working. Define milestones and try to hit them.
@PhDVoice
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Really excited to share our work on the design of a high-throughput force sensor for molecular motors. Our sensor is capable of measuring the forces of individual molecular motors when multiple motors are driving a common cargo. 1/n
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When I was doing PhD, all I cared about was my science.
After coming to corporate world, I realized how oblivious I was about US immigration.
US immigration system affects every international student. If you are one, you must be informed and prepare in advance.
#phdlife
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@AbhiS_Case
I want this information to percolate to all PhD aspirants. First, you devote 5-7 years in PhD, then you get stuck in immigration system endlessly. Important consideration to make a decision about career path.
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2021 came bearing gifts!
Thrilled to share our work on live-cell single-molecule imaging of CRISPR-Cas9 and TALE proteins in
@NatureComms
. We show that TALE proteins outperform Cas9 in editing the heterochromatin region of the genome.
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Met
@ankurg90
after 9 years in AIChE. Ankur is our widely respected batchmate since our undergrad in
@iitdelhi
. Sheer brilliance with utmost humility. Reitrating here,
@CUEngineering
is damn lucky to have him.
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@academic_exit
Post witty science memes on twitter, get a lot of retweets/replies and have search committee chairs notice you.
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Shachi is the first female from my hometown to be a professor at a US university. I am sure Shachi’s story and future work will inspire so many girls who dare to dream big. I am looking forward to seeing how her story unfolds. More power to you and Happy Birthday, Prof. Mittal.
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Most PhD students aspire for a academic tenure track job. However, the number of academic jobs is way less than graduating PhDs and postdocs.
While working towards that TT job, also upskill yourself for industry jobs. Believe in yourself, but don’t ignore probability theory.
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2024 H1B March lottery selection rate was ~14%.
As an international PhD student, you don’t deserve to be at the mercy of H1B lottery.
Plan in advance, to have enough papers and citations to get O-1 visa. Inform your advisor about your goals and plan accordingly.
@PhDVoice
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Every grad student, irrespective of discipline, should do a few coding projects.
Reality is that coding is a sought after skill in industry of every domain. Also, more job options.
So after you finish that mol bio experiment, also code up the analysis pipeline.
@PhDVoice
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I am excited to share that our work has been featured by
@Illinois_Alma
on its landing page at !
Read the news coverage by
@NewsAtIllinois
here:
@PhDmeetsCoffee
@theSchroederLab
@HuiminZhaoLab
@ChBE_Illinois
@PhysicsIllinois
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"क्या हुआ गर तेरी माटी कि खुशबु मुझे नहीं आती,
क्या हुआ गर तेरी हवा मुझे नहीं सहलाती
ये जान ले, कि तेरी खुशबु को मन में संजो के लाया हूँ ,
तन यहाँ है, पर दिल तो तेरे पास छोड़ के आया हूँ "
Happy Independence Day 🇮🇳
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Nobel week is exciting for all the scientists.
However, this one is very special to me. This one feels personal. I understand the technology and its impact. Cheers to all who work with CRISPR. Congrats
@doudna_lab
@e__charpentier
#NobelPrize2020
#NobelPrize
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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@vikasnavaratna
Pat yourself on back Vikas and appreciate yourself everyday. Its a remarkable feat to be the one who lifts the family up. Saying this here because, such people often forget to appreciate themselves, amidst all the responsibilities. More power to you. 🙏
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O1 visa is the panacea of all immigration related maladies for every international PhD in US.
Getting O1 is tough. You must start preparing for it well in advance, during your PhD.
Stay tuned, I will do a detailed thread on how to prepare yourself for O1 visa.
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Excited to share our work published in
@eLife
. We present a new assay design for studying multiple motors transporting a common cargo. Hope this work will be useful for the broader scientific community.
@cplcillinois
@PhysicsIllinois
@ChBE_Illinois
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I had a lot of fun delivering a guest lecture to
@uw_ece
students about using machine learning in biology and healthcare.
Thanks, Prof. Karthik Mohan for the invitation to his course 'AI and Healthcare' (EE596).
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I will be sharing our work on Force Sensing of Individual Motors (FSIM) assay, a single-stranded DNA based high throughput force sensor at
#MotorsInQuarantine
seminar series.
Co-panelists are Prof.
@ErikaHolzbaur
and
@sydneyecason
. Join us for the exciting session.
No longer fresh - it's our 3⃣0⃣th
#MotorsInQuarantine
this week! Join us on Wednesday for a novelty: a PI & student double-act with
@ErikaHolzbaur
and
@sydneyecason
on neuronal transport. Plus
@shukla_here
talking about how to measure forces using DNA.
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This makes me very happy. Prof. H.C. Verma is not only an icon for engineering students, but also an inspiration for his work with underprivileged kids and school teachers. Very well deserved.
President Kovind presents Padma Shri to Dr Harish Chandra Verma for Science and Engineering. He is a physics educator and researcher, who is famous for his two-volume book "Concepts of Physics" which has revolutionised Physics education at school level.
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Getting a green card for Indian born individuals, even highly extraordinary folks is a nightmare.
Tens of years of wait, 10s of thousands of $$ and hundreds of pages of paper work.
Dates are retrogressing even more now. Everyone must have a backup plan to stay in the US.
Huge personal news! My EB-1A Green Card for Extraordinary Ability was APPROVED today! 🇺🇸
After 12 contiguous yrs in the US, 18yrs in total, $20k+ in legal fees, a Denial, and 3.5yrs of working on this 900 page app, I'll finally be able to travel freely and.. be unemployed!
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Attended the first zoom defense of my power collaborator and friend, Surbhi Jain
@PhDmeetsCoffee
from Zhao Lab
@ChBE_Illinois
. Amazing work on Gene editing proteins. Snapshot of post defense celebration. Congratulations Dr. Jain. :)
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If you are an Indian, take a moment and think about this-
We are one of the 5-odd countries in the entire world which have developed covid vaccine within a year. Not just one vaccine, but two.
Think about how long have we come in last 30 years!
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@POTUS
@anshulkundaje
Thank you Mr. president. Indians will always remember your help in these trying times. 🙏
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@Surgeon_General
Dear Dr. Murthy, please help India in this time of dire need. Please ask your admin to lift the ban on vaccine raw materials and help with oxygen supply. You have the power to influence decisions. Indians and Indian-americans will be forever grateful. 🙏
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Congratulations India for electing a tribal woman as President and making history!
Welcome, Madam President!
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All of our (engineering graduates from India) successes are built upon the concepts taught by Prof. HC Verma. As I understand, he still is working to popularize physics among students and educators. An inspiration and guiding light for young scientists like me. Congratulations!
I am delighted to share that Prof. Harish Chandra Verma, our alumnus & retired Professor & now associated as a Adjunct faculty, has been awarded the Padma Shri. He epitomises outstanding teaching ethos of IITK
#Padmashree
#RepublicDay
#PadmaAwards
#Padmashri
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Thanks
@cplcillinois
for organizing the symposium and giving us an opportunity to share our work.
Thanks to participants of the Fall 2019 CPLC/CBQB Graduate Student/Postdoc Symposium. Special thank you to David Winogradoff & Mengyu Wang, the fabulous organizers, and congrats to Kumar Sarthak, Saurabh Shukla, and Mengyu Wang on winning the 1st, 2nd, and 3rd best talk awards!
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In March 2014, Shachi met a life-threatening accident and lost three close friends. She fought for her life for months. As soon as she could start walking, she rushed to the University to finish her coursework and research. Graduated from
@iitdelhi
with a Silver medal. 2/n
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@AravSrinivas
And folks with PhD have a real disadvantage. PhDs apply for I140 after 5-7 years of PhD and postdoc, hence delayed priority dates. These managers get EB2 priority dates years earlier.
EB1 is the new EB2. Sad reality!
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We lost my mom in 2019. Shachi held my hand and supported everyone in my family during these difficult times. Shachi’s journey is a story of a strong woman who supported everybody around her, held her head high, and kept working despite challenges. 4/n
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Congratulations
@Ankur110490
for a new beginning. In our undergrad days, Gupta Ji used to teach fellow students, who were struggling, the concepts of Chem Engg. Not only a brilliant scientist, but an amazing human being. Excited to see his journey as a prof in upcoming years!
Thrilled to announce that I will be joining
@CUEngineering
in Jan 2021 to start my independent research group titled LIFE - Laboratory of Interfaces, Flow & Electrokinetics. . Interested students & postdocs are welcome to contact me via email.
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Virtual conferences and talks are like a miracle for a early career scientist like me. Attending the the talks/making connections that I never would have, had they been physical at distant places.
#AcademicTwitter
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IIT Delhi Alumni of Seattle came together to celebrate Diwali. It was a wonderful evening with lots of music and fun. We reminisced about our days at IIT and met each other’s families. Here is the highlight of the event.
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It was a fantastic collaboration of our lab (Selvin Lab
@PhysicsIllinois
) with
@HuiminZhaoLab
(
@ChBE_Illinois
) and
@theSchroederLab
(
@BeckmanInst
). While we did single-molecule imaging, my co-author Dr. Surbhi Jain (
@PhDmeetsCoffee
), performed the functional studies.
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First Woman. First Black. First Indian. Daughter of an immigrant.
For the Vice President of the United States of America.
So many glass ceilings broken in one moment. Congratulations and Vanakkam
@KamalaHarris
. 🙏
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Thank you Mr. Vice President.
Navratri (literal meaning is nine nights) is a hindu festival where we worship feminine deity Ma Durga for night days. Ma Durga represents 'SHAKTI', i.e. strength and light within.
Happy Navratri to all. 🙏
As the Hindu festival of Navratri begins, Jill and I send our best wishes to all those celebrating in the U.S. and around the world. May good once again triumph over evil — and usher in new beginnings and opportunity for all.
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Within months of her accident, she flew to the US to start her Ph.D. We got married in 2017. Within a week of our wedding, my mother got diagnosed with ovarian cancer.
For months, she hopped to different hospitals and stood in lines for my mother's treatment. 3/n
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@kaneenikasinha
One advise that I find valuable. When facing a big task, don’t think about the entire task. Just think about the first step and do it. Just do the intro slide and rest automatically follows. I use this technique in my long experiments. I make initial buffers and magic happens.
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The Radiant Sunflower!
May this year be radiant with joy and all the darkness of 2020 disappear. Happy new year 2021.
Movie taken by me. Fluorescent peroxisomes walking in a fruit fly cell with the help of
#MolecularMotors
.
#SciArt
#ScienceMatters
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चाहे नोबेल जीत लिया हो, लेकिन मौसी तो मौसी होती है। 🙂🙂
I am going to embarrass my wonderful fitness trainer (and nephew)
@SamShapeTrain
in
#Pittsburgh
by putting the word out that he is a lovely person who would like to meet a really nice girl. Maybe one of you
#chem
grad students?
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Leaving for Boston for my in-person talk after a long time. I am integrating super-res, atomic force and electron microscopy for biological discovery at highest resolution. Come say hi.
#AICHE2021
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@AnmolPardeshi
Sure. A PhD gets 3 years of OPT post graduation. After OPT, they need to get another visa for continuing working in US. H1B lotteries have become not viable. Now, for PhDs, go to visa is O1, which needs citations and publications.
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I have a joke about 'real Indian history', but it's not been written yet.
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Beautiful thread (and replies) on stories of women in Sciences and impact of supportive parents on thier lives. ♥️
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Those who got stuck in visa cycles of US, should look up Global Talent Visa.
Thanks Shubham for pointing it out.
@DrShuklaHere
One reason why I moved to the UK after my PhD in US. I got a Global Talent visa pretty quickly which is basically like a permanent residence in UK. I will get actual permanent residency after 3 years and UK passport another 2 years later, so total journey being 5 years.
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cc: All PIs, Deans, and Chancellors. And a note to future me.
Back your team in failure, and give credit to them in success. Be a true leader!
Do you remember the first time you failed at something? When was the last time?
#FridayFailures
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Forgot the classic, Steph.
And a Ph.D. Student how the research is going.
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@Sourish_SG
Everybody who does a PhD loves science, to varying degree. But when visa issues hamper your family life, ability to go to your home country, ability to work etc., it does have an effect on you.
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So incredibly proud of you
@ShachiMittal2
. :)
Thanks to
@SocAppSpec
, Coblentz Society and
@FACSSnetworking
for the Hirschfeld and Fataley awards at
#SCIX2019
. My work wouldn't have been possible without the amazing colleagues in
@BhargavaGroup
and
@BeckmanInst
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@mairal
@RoKhanna
Thank you
@mairal
for speaking up. We Indians are a peaceful community. Thats why we are taken for granted, our consulates are attacked. Our silence gives a licence to Indian Am politicians like
@RoKhanna
to be silent. Indians need to speak more and hold politicians accountable
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Data released by
@ICMRDELHI
is spectacular. Everyone get vaccinated.
Now that the data is out, every leader (even those who raised questions earlier about vaccine efficacy) should publically take vaccines and urge everyone to take them.
#SaveLives
#InThisTogether
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@ankurg90
Congratulations and all the best! Aah, transport phenomena. Prof. S.K. Gupta, 8 AM class in MS702. The class was so legendary that I even remember the room number after 12 years! :)
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With existing force measurement assays, such as optical and magnetic tweezers, it is very challenging to reach a single motor resolution when multiple motors are attached to a single cargo/bead. Our assay is designed to overcome this challenge. 4/n
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@AravSrinivas
Ok, your implementation speed is one of the fastest I have seen in Gen AI startup ecosystem.
Tell us. Who doesn’t sleep? You, your engineers or both?
Incredible!
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Satya King!
If you want to get a lesson in opportunity in disaster, this is the one.
1. By hiring Sam and Greg, Satya just saved Microsoft shares from tanking too much just before the market opens on Monday.
continued..
We remain committed to our partnership with OpenAI and have confidence in our product roadmap, our ability to continue to innovate with everything we announced at Microsoft Ignite, and in continuing to support our customers and partners. We look forward to getting to know Emmett
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@DivGarg9
Very unlikely, Div. Brain biology is very complex. We do not have the tools to visualize the whole activity of the brain. Its a complex web of thousands of kinds of receptors, neurotransmitters, synapses, cell-cell connections. However, we may get brain like performance from AI.
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Very well deserved. One of the finest scientist and a great mentor. Another reason to attend BPS meeting this year.
Maybe I should ask him to join twitter.
@jasper_tms
can help set up his twitter account? :)
CPLC faculty Paul Selvin wins 2022 Ignacio Tinoco Award from Biophysical Society! Read more:
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Congratulations Dr. Mayank Garg (
@maysun01
) for your phenomenal PhD defense. It was a privilege to witness your PhD journey as a close friend. Wishing the best for future journey :-)
Congratulations to
@maysun01
on his outstanding thesis defense. Keep the front propagating! Bossman White would be proud.
@IllinoisMatSE
@BeckmanInst
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Excited to be a little part of this effort. :)
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It will be around 5.30 am here in US. Will keep my chai ready.
Lets Go! 🚀
Chandrayaan-3 Mission:
🇮🇳Chandrayaan-3 is set to land on the moon 🌖on August 23, 2023, around 18:04 Hrs. IST.
Thanks for the wishes and positivity!
Let’s continue experiencing the journey together
as the action unfolds LIVE at:
ISRO Website
YouTube
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Happy Janmashtami. 🙏
गोविंदा रे गोपाळा
जय श्रीकृष्ण 🕉️
#Janmashthami
#ShreeKrishna
#Gopalkala
#जन्माष्टमी #गोपाळकाला #श्रीकृष्ण
#RahulAmbekar
#MH15TheBand
#Kiaan
#Ukulele
#Flute
#Basuri
#Unplugged
#Singer
#Song
#Festival
#Indian
#PreRecordedAudio
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Its amazing to see structural biology of microtubules and its adapter proteins picking up. Congratulations
@TheVillaLab
for getting the structure of LRRK2. A shortwhile ago
@NogalesLab
got the structure of tau on MTs. Closing the gap to understand neurodegenerative diseases.
So happy that our paper determining the structure of Parkinson’s Disease linked LRRK2 in situ is now in print. Since I didn’t described it when we posted it to bioRxiv, here it goes.. 1/n
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Absolutely wonderful job
@DrSJaishankar
and others involved in the rescue operation. Well done!
Aboard a C-17 Globemaster with the entire Indian Embassy staff, ITBP personnel and other civilians … Took-off from
#Kabul
earlier today at 6:30 AM IST and landed at Air Force Station, Jamnagar at 11 AM. Expect to land in Delhi by 5:30-6 PM.
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@NavishWadhwa
All credit goes to the Election Commission of India
@ECISVEEP
. What a remarkable conceptualization by the creators of our constitution.
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Great work by
@maysun01
on frontal polimerization. Vasculature and frontal polymerization are the future of aviation. Congratulations Mayank. 🙂
✈️🍃The vascular systems leaves use to self-heal can help strengthen spaceships & airplanes.
A new
@NatureComms
study led by
@maysun01
posits frontal polymerization as a tool to apply this biological process to materials.
🗞️
📗
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@KaushikLab
I have listened to you once in a seminar (SciROI). Believe me even if they didn't give you the title, your talk was just like a keynote. Everyone noticed it. More power to you. 🙏
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You come across some papers and you're like "Wow, that's so cool".
Oil droplet chasing another droplet. No cellular machinary, no chemo-sensing receptors. Just two plain oil droplets! Wow!
Super excited to share my first co-authored paper just out in
@NatureChemistry
!
We showed how chemical signaling between dissolving oil droplets can lead to non-reciprocal interactions resembling the chasing behavior between predator and prey:
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India is on the moon. We did it. Our scientists did it.
Historic! 🚀🚀🚀
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AI will have greatest impact not in software or advertising, but in healthcare and biotechnology.
Accessing healthcare info, reducing healthcare costs, analyzing medical images, designing RNA therapeutics, searching new drug targets, possibilities are endless.
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@Sonali_M_19
@upasnakakroo
Kya
@Sonali
Miyan. Not same. There are people who speak shuddh Hindi (🙋♂️).
आशा है कि आप और उपासना जी कुशल मंगल हैं। आपको गणेश चतुर्थी की भी शुभकामनाएँ 🙏
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@jspujji
Every high GPA colleague/friend of mine is super successful. Some average/low GPA colleague of mine are super successful.
High GPA is indicates you are disciplined, focused and responsible. These traits remain in your career as well.
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@foodskop
Meditation (ध्यान).
Can take a 2 hours class with any audience ranging from kids to elderly. :)
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Absolutely brilliant work. This work used ~70 nm germanium particles for optical trap studies (as opposed to micron size polystyrene that are commonly used), increasing the spatial and temporal resolution. Amazing animation
@schaeffer_lab
.
See our new animation: Direct measurement of kinesin's substeps during its waltz on microtubules.
@janetiwasa
,
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@hannes_elefant
I am talking about EB1 and O1 visa. H1B visa lottery success rate is <10%. You can’t rely on it anymore.
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@CeoScientist
@AlaLaunchpad
@nihseed
@CerFlux
@OSUCCC_James
@allantsung
@BCRFAlabama
@ONealCancerUAB
@bhambizjrnl
Wow, congratulations Karim. You are on fire, both in our team meetings and outside! :)
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@Sonali_M_19
@upasnakakroo
@sonali
@vikasnavaratna
@vikasnavaratna
Miyan is a Twitter celebrity nowadays. So many delicious delicacies he keeps sharing. Hope he invites us all to his house for a big feast. :)
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Sewa International raised more than $4 million in just 4 days for shipping oxygen concentrators to India. Kudos to Sewa team and Indian American community for this massive effort. 🙏
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A silver lining during a crisis. So many research groups, with different expertise, focusing on one goal: To fight COVID19 with the maximum possible force. It's so heartening to see new discoveries on a daily basis. Congratulations
@TjianDarzacq
Group.
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World urgently needs an open source foundational LLM. GPTs and BARDs are profiteering with so much opaqueness.
Our best shot is when a team of academic researchers train a foundational model on thousands on GPUs on a super computer. Question is who will do it?
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@chakrabartis
@ivanmartit
This is truly powerful. The biggest concern of the clients we are talking to is 'data privacy'. They really don't want their data to go to OpenAI or Google servers. Can't wait to test this out to see how accurate this is.
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We can also estimate motor forces when motors are bypassing cellular roadblocks. We use artificial (20-100 nanometer beads) as well as physiological roadblocks (tau) to demonstrate the functionality of our assay. I hope our work will enhance the understanding of motor forces. 5/n
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@AravSrinivas
Check out built by team of
@SahilAgg92
. If you wanted to ask any question to Swami Vivekananda.
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We discussed how AI is disrupting healthcare and biological research. Also, how healthcare applications are spurring the development of new AI technologies.
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