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Led by Jared Almazan from Dr. Sheri Holmen (@HolmenLab)'s lab, this work investigates the necessity of focal adhesion kinase in the development of brain metastases from cutaneous #melanoma and its potential as a therapeutic target. 🎯 💡 | @CellRepMed

Using CD4 knockout mice, @yourUMG researchers demonstrated that CD4 expression was essential for maintaining fast-cycling #epidermal stem cells during homeostasis. CD4 loss mitigated the age-related decline in #WoundHealing capacity. 🩹 | @SciReports

Kudos to Dr. Jessie Villanueva's team at @TheWistar, whose recent work established S6K2 and its effector subnetwork as promising targets for NRAS-mutant #melanomas that are resistant to global MAPK pathway inhibitors! 🥼 📚: 📰:

Congratulations to Drs. Meaghan McGeary (@Mk_Mcg5), Marcus Bosenberg, and the team at @Yale for the new @CIR_AACR release. 👏 Their work reveals a role for Setdb1 in potentiating tumor cell–intrinsic immunogenicity in #melanoma. 😎 Check it out:

Dr. Sylvia Lee and collaborators led this @CCR_AACR study evaluating responses to brentuximab vedotin (BV) + pembrolizumab after PD-1 therapy. 💊 58 patients with metastatic #CutaneousMelanoma received ≥1 dose of BV + pembrolizumab. Learn more:

This @cddpress study provides new insights into the function of PARP4 and #melanoma pathogenesis. Scientists with Dr. Chunying Li revealed that PARP4 plays a role in double-strand break repair by regulating the non-homologous end joining pathway. 🧬 🔗

In this new @cddpress study, the authors provide insight on the complexity of regulated cell death modalities in #keratinocytes exposed to UV irradiation. Give it a read:

Congratulations to the @WickstromLab on their new @JCellBiol study! 🤝 This work uncovers a fundamental role for a cell state–specific sphingolipid profile in stem cell homeostasis and in maintaining an intact skin barrier. 🔓

Improve the quality and reproducibility of your research! Apply standardized reporting practices for publishing results with hPSCs. 📌 Request a free @STEMCELLTech wallchart for a quick reference of the @ISSCR Standards for Human Stem Cell Use in Research:

@LabSteroid It's our pleasure. 😊 Congratulations to all the authors on the paper. 👏

🥼 Although adaptive resistance mechanisms re-emerge, PARP14 inhibition combined with PD-1 blockade offers a strategy to enhance treatment outcomes and overcome ICI resistance in #melanoma, reports a team from @OfficialUoM. 🔗 | @jitcancer

Given the contributions of various cell types involved in the process of #psoriasis, a thorough analysis of specific epigenetic patterns in different cell types becomes a key entry point for elucidating the mechanisms of disease development. 🔗

Today in @cddpress! 📣 Anhui Medical University researchers observed conspicuously elevated levels of METTL1 in cutaneous squamous cell carcinoma (#cSCC) tumors and cell lines. 🔎 Learn more:

Join us in celebrating @FoxChaseCancer's Dr. Yash Chhabra, who was recently honored with the @AACR's NextGen Stars Award. 🤝 His research focuses on identifying the molecular signaling pathways that contribute to sex disparities in #melanoma mortality.

Nanjing University scientists identify S1PR3 as a critical regulator of STAT3 activation and #psoriasis pathogenesis, orchestrating a self-amplifying circuit that sustains #keratinocyte hyperproliferation and chronic inflammation. 🔥 More in @cddpress |

Curious about the #cytotoxicity of tattoo ink? 💉 A team of scientists from @UniJena investigate the toxicity of tattoo inks in vitro and describe the use of a human 3D full skin model to evaluate effects of tattooing. | @SciReports 🔓 Find out more:

Skin repair and regeneration are crucial processes in restoring the integrity of the skin after injury. The authors explore the transformative role of #multiomics in elucidating the mechanisms of skin repair and regeneration. 🩹 🔗 Read the review:

Glycans are the "third chain of life" after nucleic acids and proteins. ⛓️ Scattered research suggests that specific glycans are related to #psoriasis. 📖 Read the review: